ENSMUSG00000050730


Mus musculus

Features
Gene ID: ENSMUSG00000050730
  
Biological name :Arhgap42
  
Synonyms : Arhgap42 / B2RQE8 / Rho GTPase activating protein 42
  
Possible biological names infered from orthology : A6NI28 / Q9H2Q1
  
Species: Mus musculus
  
Chr. number: 9
Strand: -1
Band: A1
Gene start: 8994329
Gene end: 9239101
  
Corresponding Affymetrix probe sets: 10590844 (MoGene1.0st)   10590860 (MoGene1.0st)   1453638_at (Mouse Genome 430 2.0 Array)   1457682_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000091419
Ensembl peptide - ENSMUSP00000149949
Ensembl peptide - ENSMUSP00000138500
NCBI entrez gene - 71544     See in Manteia.
MGI - MGI:1918794
RefSeq - NM_027823
RefSeq - XM_006509884
RefSeq Peptide - NP_082099
swissprot - B2RQE8
swissprot - Q9D333
swissprot - A0A1L1SSL0
Ensembl - ENSMUSG00000050730
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 arhgap42aENSDARG00000056619Danio rerio
 arhgap42bENSDARG00000010654Danio rerio
 ARHGAP42ENSGALG00000017196Gallus gallus
 A6NI28ENSG00000165895Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q6ZQ82 / Arhgap26 / Rho GTPase activating protein 26 / Q9UNA1*ENSMUSG0000003645247
Ophn1 / Q99J31 / Oligophrenin-1 / O60890*ENSMUSG0000003121446
Q6Y5D8 / Arhgap10 / Rho GTPase-activating protein 10 / A1A4S6*ENSMUSG0000003714846
Q8CGF1 / Arhgap29 / Mus musculus Rho GTPase activating protein 29 (Arhgap29), transcript variant 2, mRNA. / Q52LW3* / Rho GTPase activating protein 29*ENSMUSG0000003983116
Q3TBD2 / Arhgap45 / Mus musculus Rho GTPase activating protein 45 (Arhgap45), transcript variant 3, mRNA. / Q92619* / Rho GTPase activating protein 45*ENSMUSG0000003569715
Q811P8 / Arhgap32 / Rho GTPase-activating protein 32 / A7KAX9*ENSMUSG0000004144415
Gmip / Q6PGG2 / Gem-interacting protein / Q9P107*ENSMUSG0000003624614
Q80YF9 / Arhgap33 / Rho GTPase-activating protein 33 / O14559*ENSMUSG0000003688214
A6X8Z5 / Arhgap31 / Rho GTPase activating protein 31 / Q2M1Z3*ENSMUSG0000002279913
Arhgap30 / Rho GTPase activating protein 30 / Q7Z6I6*ENSMUSG0000004886511
Q9WVM1 / Racgap1 / Rac GTPase-activating protein 1 / Q9H0H5*ENSMUSG0000002301510
Q62172 / Ralbp1 / ralA binding protein 1 / Q15311*ENSMUSG0000002409610


Protein motifs (from Interpro)
Interpro ID Name
 IPR000198  Rho GTPase-activating protein domain
 IPR001452  SH3 domain
 IPR001849  Pleckstrin homology domain
 IPR008936  Rho GTPase activation protein
 IPR011993  PH-like domain superfamily
 IPR027267  AH/BAR domain superfamily
 IPR036028  SH3-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0003085 negative regulation of systemic arterial blood pressure IGI
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0035024 negative regulation of Rho protein signal transduction IMP
 biological_processGO:0090630 activation of GTPase activity IEA
 biological_processGO:1904694 negative regulation of vascular smooth muscle contraction IMP
 molecular_functionGO:0005096 GTPase activator activity ISO
 molecular_functionGO:0005515 protein binding IEA


Pathways (from Reactome)
Pathway description
Rho GTPase cycle


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002842 increased blood pressure "increased tension of the blood within the systemic arteries" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Tsc1tm1Djk/Tsc1tm1Djk,Gt(ROSA)26Sortm1Sho/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * 129S4/SvJaeSor

 MP:0003025 increased vascular smooth muscle contraction "greater ability to constrict the nonstriated, involuntary muscle tissue of the blood vessels" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission]
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Allelic Composition: Tsc1tm1Djk/Tsc1tm1Djk,Gt(ROSA)26Sortm1Sho/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * 129S4/SvJaeSor

 MP:0004875 increased mean arterial blood pressure "increase in the average arterial pressure during a single cardiac cycle" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Tsc1tm1Djk/Tsc1tm1Djk,Gt(ROSA)26Sortm1Sho/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * 129S4/SvJaeSor

 MP:0006143 increased diastolic blood pressure "abnormal increase in the pressure in the arteries between heart beats when the heart is relaxed" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Tsc1tm1Djk/Tsc1tm1Djk,Gt(ROSA)26Sortm1Sho/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * 129S4/SvJaeSor

 MP:0006144 increased systolic blood pressure "abnormal increase in the pressure in the arteries as the heart contracts and pumps blood into the arteries" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Tsc1tm1Djk/Tsc1tm1Djk,Gt(ROSA)26Sortm1Sho/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * 129S4/SvJaeSor

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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