ENSMUSG00000036899


Mus musculus

Features
Gene ID: ENSMUSG00000036899
  
Biological name :Trpv5
  
Synonyms : P69744 / Transient receptor potential cation channel subfamily V member 5 / Trpv5
  
Possible biological names infered from orthology : Q9NQA5
  
Species: Mus musculus
  
Chr. number: 6
Strand: -1
Band: B2.1
Gene start: 41652173
Gene end: 41680769
  
Corresponding Affymetrix probe sets: 10544365 (MoGene1.0st)   
  
Cross references: Ensembl peptide - ENSMUSP00000031901
Ensembl peptide - ENSMUSP00000141421
NCBI entrez gene - 194352     See in Manteia.
MGI - MGI:2429764
RefSeq - XM_017321464
RefSeq - NM_001007572
RefSeq - XM_006505770
RefSeq - XM_006505771
RefSeq - XM_017321463
RefSeq Peptide - NP_001007573
swissprot - P69744
swissprot - A0A0A6YW69
Ensembl - ENSMUSG00000036899
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 trpv6ENSDARG00000014496Danio rerio
 ENSGALG00000014746Gallus gallus
 TRPV5ENSG00000127412Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Trpv6 / Q91WD2 / transient receptor potential cation channel, subfamily V, member 6 / Q9H1D0*ENSMUSG0000002986874
Trpv4 / Q9EPK8 / Transient receptor potential cation channel subfamily V member 4 / Q9HBA0*ENSMUSG0000001415828
Trpv1 / Q704Y3 / Transient receptor potential cation channel subfamily V member 1 / Q8NER1*ENSMUSG0000000595225
Trpv3 / Q8K424 / Transient receptor potential cation channel subfamily V member 3 / Q8NET8*ENSMUSG0000004302925
Trpv2 / Q9WTR1 / Transient receptor potential cation channel subfamily V member 2 / Q9Y5S1*ENSMUSG0000001850724


Protein motifs (from Interpro)
Interpro ID Name
 IPR002110  Ankyrin repeat
 IPR004729  Transient receptor potential channel
 IPR005821  Ion transport domain
 IPR008344  Transient receptor potential cation channel subfamily V member 5/6
 IPR008346  Transient receptor potential cation channel subfamily V member 5
 IPR020683  Ankyrin repeat-containing domain
 IPR024862  Transient receptor potential cation channel subfamily V
 IPR036770  Ankyrin repeat-containing domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006816 calcium ion transport IEA
 biological_processGO:0006874 cellular calcium ion homeostasis NAS
 biological_processGO:0034220 ion transmembrane transport IEA
 biological_processGO:0035809 regulation of urine volume IMP
 biological_processGO:0051262 protein tetramerization IDA
 biological_processGO:0051289 protein homotetramerization ISS
 biological_processGO:0055074 calcium ion homeostasis IMP
 biological_processGO:0055085 transmembrane transport IEA
 biological_processGO:0060402 calcium ion transport into cytosol IEA
 biological_processGO:0070588 calcium ion transmembrane transport IEA
 biological_processGO:0098703 calcium ion import across plasma membrane ISO
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005887 integral component of plasma membrane IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0016324 apical plasma membrane IEA
 cellular_componentGO:0031226 intrinsic component of plasma membrane IEA
 molecular_functionGO:0005216 ion channel activity IEA
 molecular_functionGO:0005262 calcium channel activity IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0005516 calmodulin binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
TRP channels


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000135 reduced cortical bone thickness "thinner than normal superficial layer of compact bone " [J:61509]
Show

Allelic Composition: Hcn4tm1.1Jsr/Hcn4tm1.1Jsr
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0000195 hypocalcemia "subnormal concentrations of calcium ions in the circulating blood " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Trpv5Hcalc1/Trpv5Hcalc1
Genetic Background: involves: C3H/HeH * C57BL/6J

 MP:0000198 hypophosphatemia "abnormally low concentrations of phosphates in the circulating blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Trpv5Hcalc1/Trpv5Hcalc1
Genetic Background: involves: C3H/HeH * C57BL/6J

 MP:0001263 weight loss "progressive reduction of body weight below normal average for age" [J:45400]
Show

Allelic Composition: Hrm4Btlr/Hrm4Btlr
Genetic Background: C57BL/6J-Hrm4Btlr

 MP:0001426 polydipsia "excessive thirst that is relatively prolonged" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Hrm4Btlr/Hrm4Btlr
Genetic Background: C57BL/6J-Hrm4Btlr

Allelic Composition: Trpv5Hcalc1/Trpv5Hcalc1
Genetic Background: involves: C3H/HeH * C57BL/6J

 MP:0001762 polyuria "increased volume of urine produced and excreted" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Hcn4tm1.1Jsr/Hcn4tm1.1Jsr
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Trpv5m1Btlr/Trpv5m1Btlr
Genetic Background: C57BL/6J-Trpv5m1Btlr

Allelic Composition: Trpv5Hcalc1/Trpv5Hcalc1
Genetic Background: involves: C3H/HeH * C57BL/6J

 MP:0001858 intestinal inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the intestine" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Hrm4Btlr/Hrm4Btlr
Genetic Background: C57BL/6J-Hrm4Btlr

 MP:0001859 kidney inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the kidney" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Nfkbiztm1Aki/Nfkbiztm1Aki,Tnftm1Sek/Tnftm1Sek
Genetic Background: involves: 129P2/OlaHsd * C57BL/6NCrlj * CBA/JNCrlj

Allelic Composition: Trpv5Hcalc1/Trpv5Hcalc1
Genetic Background: involves: C3H/HeH * C57BL/6J

 MP:0002135 abnormal kidney morphology "abnormal development of the kidney resulting in structural abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Nfkbiztm1Aki/Nfkbiztm1Aki,Tnftm1Sek/Tnftm1Sek
Genetic Background: involves: 129P2/OlaHsd * C57BL/6NCrlj * CBA/JNCrlj

Allelic Composition: Trpv5Hcalc1/Trpv5Hcalc1
Genetic Background: involves: C3H/HeH * C57BL/6J

 MP:0002703 abnormal renal tubules "anomalous structure or development of the loops of Henle and collecting ducts in the kidney" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Nfkbiztm1Aki/Nfkbiztm1Aki,Tnftm1Sek/Tnftm1Sek
Genetic Background: involves: 129P2/OlaHsd * C57BL/6NCrlj * CBA/JNCrlj

Allelic Composition: Trpv5Hcalc1/Trpv5Hcalc1
Genetic Background: involves: C3H/HeH * C57BL/6J

 MP:0002705 dilated renal tubules "enlarged lumens of the loops of Henle and/or collecting ducts of the kidney" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Nfkbiztm1Aki/Nfkbiztm1Aki,Tnftm1Sek/Tnftm1Sek
Genetic Background: involves: 129P2/OlaHsd * C57BL/6NCrlj * CBA/JNCrlj

Allelic Composition: Trpv5Hcalc1/Trpv5Hcalc1
Genetic Background: involves: C3H/HeH * C57BL/6J

 MP:0002901 hyperphosphaturia "an increase of excretion of phosphates in the urine" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Hcn4tm1.1Jsr/Hcn4tm1.1Jsr
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Trpv5Hcalc1/Trpv5Hcalc1
Genetic Background: involves: C3H/HeH * C57BL/6J

 MP:0002989 small kidney "reduced physical bulk one or both of the organs responsible for urine secretion" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Trpv5Hcalc1/Trpv5+
Genetic Background: involves: C3H/HeH * C57BL/6J

Allelic Composition: Trpv5Hcalc1/Trpv5Hcalc1
Genetic Background: involves: C3H/HeH * C57BL/6J

 MP:0003215 renal interstitial fibrosis "formation of fibrous tissue within the interstices of the kidney as a result of repair or a reactive process" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Trpv5Hcalc1/Trpv5+
Genetic Background: involves: C3H/HeH * C57BL/6J

Allelic Composition: Trpv5Hcalc1/Trpv5Hcalc1
Genetic Background: involves: C3H/HeH * C57BL/6J

 MP:0003795 abnormal bone structure 
Show

Allelic Composition: Hcn4tm1.1Jsr/Hcn4tm1.1Jsr
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Trpv5Hcalc1/Trpv5Hcalc1
Genetic Background: involves: C3H/HeH * C57BL/6J

 MP:0004153 increased renal tubule apoptosis "increase in the number of renal tubule cells undergoing programmed cell death" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
Show

Allelic Composition: Trpv5Hcalc1/Trpv5+
Genetic Background: involves: C3H/HeH * C57BL/6J

Allelic Composition: Trpv5Hcalc1/Trpv5Hcalc1
Genetic Background: involves: C3H/HeH * C57BL/6J

 MP:0004214 abnormal long bone diaphysis morphology "any structural anomaly of the main or mid section (shaft) of a long bone" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hcn4tm1.1Jsr/Hcn4tm1.1Jsr
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0004231 abnormal calcium ion homeostasis "anomaly in the processes involved in the maintenance of an internal equilibrium of calcium ions within the body or between a cell and its external environment" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hcn4tm1.1Jsr/Hcn4tm1.1Jsr
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0004984 increased osteoclast cell number "greater than average number of the bone resorpting cells that remove bone tissue by degrading the mineralized matrix" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hcn4tm1.1Jsr/Hcn4tm1.1Jsr
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0005036 diarrhea "abnormally frequent discharge of semi-solid or fluid fecal matter from the bowel" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Trpv5m1Btlr/Trpv5m1Btlr
Genetic Background: C57BL/6J-Trpv5m1Btlr

 MP:0005441 hypercalciuria "excretion of abnormally large amounts of calcium in the urine" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:86949]
Show

Allelic Composition: Hcn4tm1.1Jsr/Hcn4tm1.1Jsr
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Trpv5Hcalc1/Trpv5+
Genetic Background: involves: C3H/HeH * C57BL/6J

Allelic Composition: Trpv5Hcalc1/Trpv5Hcalc1
Genetic Background: involves: C3H/HeH * C57BL/6J

 MP:0008537 increased susceptibility to induced colitis "increased severity or induction threshold of colitis upon treatment of an organism with intestinal inflammation agents such as dextran sodium sulfate (DSS)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Trpv5m1Btlr/Trpv5m1Btlr
Genetic Background: C57BL/6J-Trpv5m1Btlr

 MP:0009346 decreased cancellous bone thickness "thinner than normal bone with a lattice-like or spongy structure" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hcn4tm1.1Jsr/Hcn4tm1.1Jsr
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Trpv5Hcalc1/Trpv5Hcalc1
Genetic Background: involves: C3H/HeH * C57BL/6J

 MP:0009350 decreased urine pH "increased urine acidity" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hcn4tm1.1Jsr/Hcn4tm1.1Jsr
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Trpv5Hcalc1/Trpv5Hcalc1
Genetic Background: involves: C3H/HeH * C57BL/6J

 MP:0009640 abnormal renal tubule epithelium morphology "any structural anomaly of the cellular avascular layer of the renal tubule luminar surfaces" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Trpv5Hcalc1/Trpv5+
Genetic Background: involves: C3H/HeH * C57BL/6J

Allelic Composition: Trpv5Hcalc1/Trpv5Hcalc1
Genetic Background: involves: C3H/HeH * C57BL/6J

 MP:0010111 abnormal renal calcium reabsorption "any anomaly in the process by which calcium ions are transported out of the renal tubules back into the bloodstream" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hcn4tm1.1Jsr/Hcn4tm1.1Jsr
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0011228 abnormal vitamin D level "any anomaly in the concentration of vitamin D, any of a group of related, fat-soluble compounds that are derived from delta-5,7 steroids and play a central role in calcium metabolism; specific forms of vitamin D include calciferol (ergocalciferol; vitamin D2) and cholecalciferol (calciol; vitamin D3)" [GO:0042368]
Show

Allelic Composition: Hcn4tm1.1Jsr/Hcn4tm1.1Jsr
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Trpv5Hcalc1/Trpv5Hcalc1
Genetic Background: involves: C3H/HeH * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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