ENSMUSG00000037014


Mus musculus

Features
Gene ID: ENSMUSG00000037014
  
Biological name :Sstr4
  
Synonyms : somatostatin receptor 4 / Sstr4
  
Possible biological names infered from orthology : P31391
  
Species: Mus musculus
  
Chr. number: 2
Strand: 1
Band: G3
Gene start: 148395344
Gene end: 148396767
  
Corresponding Affymetrix probe sets: 10476886 (MoGene1.0st)   1422281_at (Mouse Genome 430 2.0 Array)   1457440_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000105588
NCBI entrez gene - 20608     See in Manteia.
MGI - MGI:105372
RefSeq - NM_009219
RefSeq Peptide - NP_033245
swissprot - A0A0R4J1D6
Ensembl - ENSMUSG00000037014
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 sstr1bENSDARG00000067925Danio rerio
 SSTR4ENSGALG00000008362Gallus gallus
 SSTR4ENSG00000132671Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Sstr1 / P30873 / somatostatin receptor 1 / P30872*ENSMUSG0000003543158
Sstr5 / O08858 / Somatostatin receptor type 5 / P35346* / somatostatin receptor 5*ENSMUSG0000005082446
Sstr2 / P30875 / Somatostatin receptor type 2 / P30874* / somatostatin receptor 2*ENSMUSG0000004790443
Sstr3 / P30935 / Somatostatin receptor type 3 / P32745* / somatostatin receptor 3*ENSMUSG0000004493342
Oprd1 / P32300 / opioid receptor, delta 1 / P41143*ENSMUSG0000005051135
Oprl1 / P35377 / opioid receptor-like 1 / P41146* / opioid related nociceptin receptor 1*ENSMUSG0000002758434
Oprk1 / P33534 / Kappa-type opioid receptor / P41145* / opioid receptor kappa 1*ENSMUSG0000002590533
Oprm1 / P42866 / opioid receptor, mu 1 / P35372*ENSMUSG0000000076632
Npbwr1 / P49681 / Neuropeptides B/W receptor type 1 / P48145* / neuropeptides B and W receptor 1*ENSMUSG0000003377429
Mchr1 / Q8JZL2 / Melanin-concentrating hormone receptor 1 / Q99705*ENSMUSG0000005016426


Protein motifs (from Interpro)
Interpro ID Name
 IPR000276  G protein-coupled receptor, rhodopsin-like
 IPR000586  Somatostatin receptor family
 IPR001512  Somatostatin receptor 4
 IPR017452  GPCR, rhodopsin-like, 7TM


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IEA
 biological_processGO:0016477 cell migration IEA
 biological_processGO:0019369 arachidonic acid metabolic process IEA
 biological_processGO:0030815 obsolete negative regulation of cAMP metabolic process IEA
 biological_processGO:0030900 forebrain development IEA
 biological_processGO:0038170 somatostatin signaling pathway IEA
 biological_processGO:0043410 positive regulation of MAPK cascade IEA
 biological_processGO:0071385 cellular response to glucocorticoid stimulus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity IEA
 molecular_functionGO:0004994 somatostatin receptor activity IEA


Pathways (from Reactome)
Pathway description
Peptide ligand-binding receptors
G alpha (i) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001785 edema "an accumulation of an excessive amount of watery fluid in cells or intercellular tissues" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54065]
Show

Allelic Composition: Dync2h1mmi/Dync2h1mmi,Tg(Hlxb9-GFP)1Tmj/?
Genetic Background: involves: C57BL/6J * FVB/N

 MP:0001952 increased airway responsiveness "more easily provoked into bronchoconstriction in bronchial provocation tests" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Dync2h1mmi/Dync2h1mmi,Tg(Hlxb9-GFP)1Tmj/?
Genetic Background: involves: C57BL/6J * FVB/N

 MP:0002441 abnormal granulocyte morphology/development "anomalous structure, differentiation, or number of leukocytes that have abundant granules in the cytoplasm: basophils, neutrophils, or eosinophils" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Dync2h1mmi/Dync2h1mmi,Tg(Hlxb9-GFP)1Tmj/?
Genetic Background: involves: C57BL/6J * FVB/N

 MP:0002463 abnormal neutrophil physiology "abnormal function of these granular leukocytes, which stain with neutral dyes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Dync2h1mmi/Dync2h1mmi,Tg(Hlxb9-GFP)1Tmj/?
Genetic Background: involves: C57BL/6J * FVB/N

 MP:0003828 pulmonary edema "an accumulation of an excessive amount of watery fluid in the lung " [J:44108, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Dync2h1mmi/Dync2h1mmi,Tg(Hlxb9-GFP)1Tmj/?
Genetic Background: involves: C57BL/6J * FVB/N

 MP:0005292 improved glucose tolerance "better than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin sensitivity; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Spata22tm1b(KOMP)Wtsi/Spata22tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Spata22tm1b(KOMP)Wtsi/Ucd

 MP:0005407 hyperalgesia "increased sensation to painful stimuli that may follow damage to soft tissue containing nociceptors or injury to a peripheral nerve; it can be primary (at the site of the injury) or secondary (in the surrounding undamaged area)" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Dync2h1mmi/Dync2h1mmi,Tg(Hlxb9-GFP)1Tmj/?
Genetic Background: involves: C57BL/6J * FVB/N

 MP:0005617 increased susceptibility to type IV hypersensitivity reaction "greater likelihood of developing an antigen-elicited cellular immune reaction that results in tissue damage, but does not require Ab participation; the response is seen at the area of contact " [Pathology:ISBN 0-397-51047-0, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Dync2h1mmi/Dync2h1mmi,Tg(Hlxb9-GFP)1Tmj/?
Genetic Background: involves: C57BL/6J * FVB/N

 MP:0008560 increased tumor necrosis factor secretion "increase in the production or release of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]
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Allelic Composition: Dync2h1mmi/Dync2h1mmi,Tg(Hlxb9-GFP)1Tmj/?
Genetic Background: involves: C57BL/6J * FVB/N

 MP:0008566 increased interferon-gamma secretion "increase in the production or release of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
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Allelic Composition: Dync2h1mmi/Dync2h1mmi,Tg(Hlxb9-GFP)1Tmj/?
Genetic Background: involves: C57BL/6J * FVB/N

 MP:0008657 increased interleukin-1 beta secretion "increase in the production or release of an interleukin-1 subtype that is synthesized as an inactive membrane-bound pro-protein on monocytes, macrophages and other cells; proteolytic processing of the precursor form by caspase 1 results in release of the active form of interleukin-1beta from the membrane" [MESH:D12.644.276.374.465.501.600]
Show

Allelic Composition: Dync2h1mmi/Dync2h1mmi,Tg(Hlxb9-GFP)1Tmj/?
Genetic Background: involves: C57BL/6J * FVB/N

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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