ENSMUSG00000033774


Mus musculus
receptorNpbwr1neuropeptidecoupledmembraneactivityg-proteinsignalingpathwaygrhodopsin-likebwsignalplasmaintegralcomponentliverincreasedcirculatinglevelsusceptibilityobesityprotein-coupledfamilygpcrtmtransductioncyclicnucleotidesecond

Features
Gene ID: ENSMUSG00000033774
  
Biological name :Npbwr1
  
Synonyms : Neuropeptides B/W receptor type 1 / Npbwr1 / P49681
  
Possible biological names infered from orthology : neuropeptides B and W receptor 1 / P48145
  
Species: Mus musculus
  
Chr. number: 1
Strand: -1
Band: A1
Gene start: 5913707
Gene end: 5917398
  
Corresponding Affymetrix probe sets: 10352969 (MoGene1.0st)   
  
Cross references: Ensembl peptide - ENSMUSP00000046233
NCBI entrez gene - 226304     See in Manteia.
MGI - MGI:891989
RefSeq - NM_010342
RefSeq Peptide - NP_034472
swissprot - P49681
Ensembl - ENSMUSG00000033774
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 NPBWR1ENSGALG00000015261Gallus gallus
 NPBWR1ENSG00000183729Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Sstr3 / P30935 / Somatostatin receptor type 3 / P32745* / somatostatin receptor 3*ENSMUSG0000004493340
Sstr5 / O08858 / Somatostatin receptor type 5 / P35346* / somatostatin receptor 5*ENSMUSG0000005082440
Oprl1 / P35377 / opioid receptor-like 1 / P41146* / opioid related nociceptin receptor 1*ENSMUSG0000002758436
Sstr1 / P30873 / somatostatin receptor 1 / P30872*ENSMUSG0000003543136
Sstr2 / P30875 / Somatostatin receptor type 2 / P30874* / somatostatin receptor 2*ENSMUSG0000004790435
Oprk1 / P33534 / Kappa-type opioid receptor / P41145* / opioid receptor kappa 1*ENSMUSG0000002590534
Sstr4 / somatostatin receptor 4 / P31391*ENSMUSG0000003701434
Oprd1 / P32300 / opioid receptor, delta 1 / P41143*ENSMUSG0000005051134
Oprm1 / P42866 / opioid receptor, mu 1 / P35372*ENSMUSG0000000076633
Mchr1 / Q8JZL2 / Melanin-concentrating hormone receptor 1 / Q99705*ENSMUSG0000005016431


Protein motifs (from Interpro)
Interpro ID Name
 IPR000276  G protein-coupled receptor, rhodopsin-like
 IPR009150  Neuropeptide B/W receptor family
 IPR017452  GPCR, rhodopsin-like, 7TM
 IPR027348  Neuropeptide B/W receptor 1


Gene Ontology (GO)
cell communicationcellular response to stimuluscell communicationcellular response to stimuluscell communicationcellular response to stimuluscell communicationcellular response to stimuluscell communicationcellular response to stimuluscell communicationcellular response to stimuluscell communicationcellular response to stimuluscell communicationcellular response to stimuluscell communicationcellular response to stimuluscell communicationcellular response to stimuluscell communicationcell communicationcellular response to stimuluscellular response to stimulus
signaling receptor activityamide bindingsignaling receptor activityamide bindingsignaling receptor activityamide bindingsignaling receptor activityamide bindingsignaling receptor activityamide bindingsignaling receptor activityamide bindingsignaling receptor activityamide bindingsignaling receptor activityamide bindingsignaling receptor activityamide bindingsignaling receptor activityamide bindingsignaling receptor activitysignaling receptor activityamide bindingamide binding
cellmembranecellmembranecellmembranecellmembranecellmembranecellmembranecellmembranecellmembranecellmembranecellmembranecellcellmembranemembrane
TypeGO IDTermEv.Code
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway ISO
 biological_processGO:0007187 G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger IBA
 biological_processGO:0007218 neuropeptide signaling pathway IBA
 biological_processGO:0007268 chemical synaptic transmission IBA
 biological_processGO:0019222 regulation of metabolic process IMP
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005887 integral component of plasma membrane IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0043005 neuron projection IBA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity IBA
 molecular_functionGO:0008188 neuropeptide receptor activity IEA
 molecular_functionGO:0042923 neuropeptide binding IBA


Pathways (from Reactome)
Pathway description
Peptide ligand-binding receptors
G alpha (i) signalling events


Phenotype (from MGI, Zfin or HPO)
liver/biliary system phenotypegrowth/size phenotypebehavior/neurological phenotypehomeostasis/metabolism phenotypeliver/biliary system phenotypegrowth/size phenotypebehavior/neurological phenotypehomeostasis/metabolism phenotypeliver/biliary system phenotypegrowth/size phenotypebehavior/neurological phenotypehomeostasis/metabolism phenotypeliver/biliary system phenotypegrowth/size phenotypebehavior/neurological phenotypehomeostasis/metabolism phenotypeliver/biliary system phenotypegrowth/size phenotypebehavior/neurological phenotypehomeostasis/metabolism phenotypeliver/biliary system phenotypegrowth/size phenotypebehavior/neurological phenotypehomeostasis/metabolism phenotypeliver/biliary system phenotypegrowth/size phenotypebehavior/neurological phenotypehomeostasis/metabolism phenotypeliver/biliary system phenotypegrowth/size phenotypebehavior/neurological phenotypehomeostasis/metabolism phenotypeliver/biliary system phenotypegrowth/size phenotypebehavior/neurological phenotypehomeostasis/metabolism phenotypeliver/biliary system phenotypegrowth/size phenotypebehavior/neurological phenotypehomeostasis/metabolism phenotypeliver/biliary system phenotypeliver/biliary system phenotypegrowth/size phenotypegrowth/size phenotypebehavior/neurological phenotypebehavior/neurological phenotypehomeostasis/metabolism phenotypehomeostasis/metabolism phenotype
IDPhenotypeDefinition Genetic BG
 MP:0000599 enlarged liver "larger than average size of the liver" [J:65146]
Show

Allelic Composition: Mrvi1tm1Jens/Mrvi1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001261 obese "excessively fat; an increase in fat in the subcutaneous connective tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
Show

Allelic Composition: Hes1tm1Fgu/Hes1tm1Fgu,Hes3tm1Kag/Hes3tm1Kag,Hes5tm1Fgu/Hes5tm1Fgu
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

Allelic Composition: Ay/a,Npbwr1tm1Rck/Npbwr1tm1Rck
Genetic Background: involves: 129P/Ola * C57BL/6J

 MP:0001392 abnormal locomotor activity "altered ability or inability to move from place to place" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Mrvi1tm1Jens/Mrvi1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001433 polyphagia "eating to excess" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Mrvi1tm1Jens/Mrvi1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001559 hyperglycemia "abnormally high concentration of glucose in the blood; generally refers to a pathological state" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Mrvi1tm1Jens/Mrvi1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002079 increased circulating insulin level "greater than normal levels of insulin in blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Mrvi1tm1Jens/Mrvi1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002118 abnormal lipid homeostasis "anomaly in the state of equilibrium in the body with respect to lipids in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Mrvi1tm1Jens/Mrvi1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002628 fatty liver "an accumulation of fat deposits in the liver " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Mrvi1tm1Jens/Mrvi1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0003212 susceptibility to age related obesity "increased probability of excessive weight gain that is progressive with age" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Mrvi1tm1Jens/Mrvi1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0005290 decreased oxygen consumption "less than the normal rate at which oxygen enters the blood from alveolar gas; this is equal in the steady state to the consumption of oxygen by tissue metabolism throughout the body" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Mrvi1tm1Jens/Mrvi1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0005658 susceptibility to diet-induced obesity "more likely to become excessively fat or to increase fat in the subcutaneous connective tissue as a result of consuming a diet geared to increase body fat " [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator]
Show

Allelic Composition: Mrvi1tm1Jens/Mrvi1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0005669 increased circulating leptin level "greater than the normal blood concentration of the peptide hormone secreted by white adipocytes and believed to regulate food intake and energy balance" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, J:34751]
Show

Allelic Composition: Mrvi1tm1Jens/Mrvi1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000044034 Npb / Q8K4P1 / Mus musculus neuropeptide B (Npb), transcript variant 3, mRNA. / Q8NG41* / neuropeptide B*  / complex / reaction
 ENSMUSG00000071230 Npw / neuropeptide W preproprotein / Q8N729* / neuropeptide W*  / complex / reaction






 

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