ENSMUSG00000037075


Mus musculus

Features
Gene ID: ENSMUSG00000037075
  
Biological name :Rnf139
  
Synonyms : ring finger protein 139 / Rnf139
  
Possible biological names infered from orthology : Q8WU17
  
Species: Mus musculus
  
Chr. number: 15
Strand: 1
Band: D1
Gene start: 58889229
Gene end: 58907057
  
Corresponding Affymetrix probe sets: 10424335 (MoGene1.0st)   1429425_at (Mouse Genome 430 2.0 Array)   1429426_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000046467
NCBI entrez gene - 75841     See in Manteia.
MGI - MGI:1923091
RefSeq - NM_175226
RefSeq Peptide - NP_780435
swissprot - A0A0R4J0K8
Ensembl - ENSMUSG00000037075
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rnf139ENSDARG00000036929Danio rerio
 RNF139ENSGALG00000032734Gallus gallus
 Q8WU17ENSG00000170881Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q5SWK7 / Rnf145 / ring finger protein 145 / Q96MT1*ENSMUSG0000001918924
Syvn1 / synovial apoptosis inhibitor 1, synoviolin / Q86TM6* / synoviolin 1*ENSMUSG0000002480711
Amfr / Q9R049 / E3 ubiquitin-protein ligase AMFR / Q9UKV5* / autocrine motility factor receptor*ENSMUSG0000003175111


Protein motifs (from Interpro)
Interpro ID Name
 IPR001841  Zinc finger, RING-type
 IPR011016  Zinc finger, RING-CH-type
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR025754  TRC8 N-terminal domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0008285 negative regulation of cell proliferation IEA
 biological_processGO:0016567 protein ubiquitination IEA
 biological_processGO:0017148 negative regulation of translation IEA
 biological_processGO:0031396 regulation of protein ubiquitination IEA
 biological_processGO:0031648 protein destabilization IEA
 biological_processGO:0036503 ERAD pathway IEA
 biological_processGO:0060628 regulation of ER to Golgi vesicle-mediated transport IEA
 biological_processGO:0070613 regulation of protein processing IEA
 biological_processGO:2000060 positive regulation of ubiquitin-dependent protein catabolic process IEA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0036513 Derlin-1 retrotranslocation complex IEA
 molecular_functionGO:0002020 protease binding IEA
 molecular_functionGO:0004842 ubiquitin-protein transferase activity IEA
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0019787 ubiquitin-like protein transferase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
ER Quality Control Compartment (ERQC)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001860 liver inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the liver" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Shh+/Shhtm1Chg,Zic2Ku/Zic2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/cAnNCrl * C3H/HeH

 MP:0003333 liver fibrosis "invasion of fibrous connective tissue into the liver, often resulting from inflammation or injury " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request]
Show

Allelic Composition: Shh+/Shhtm1Chg,Zic2Ku/Zic2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/cAnNCrl * C3H/HeH

 MP:0003887 increased hepatocyte apoptosis "increase in the number of hepatocytes undergoing programmed cell death" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
Show

Allelic Composition: Shh+/Shhtm1Chg,Zic2Ku/Zic2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/cAnNCrl * C3H/HeH

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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