ENSMUSG00000037447


Mus musculus

Features
Gene ID: ENSMUSG00000037447
  
Biological name :Arid5a
  
Synonyms : Arid5a / AT-rich interactive domain-containing protein 5A / Q3U108
  
Possible biological names infered from orthology : AT-rich interaction domain 5A / Q03989
  
Species: Mus musculus
  
Chr. number: 1
Strand: 1
Band: B
Gene start: 36307733
Gene end: 36324029
  
Corresponding Affymetrix probe sets: 10345445 (MoGene1.0st)   1451340_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000115490
Ensembl peptide - ENSMUSP00000117810
Ensembl peptide - ENSMUSP00000136037
Ensembl peptide - ENSMUSP00000119953
Ensembl peptide - ENSMUSP00000095385
Ensembl peptide - ENSMUSP00000110681
Ensembl peptide - ENSMUSP00000110683
Ensembl peptide - ENSMUSP00000110684
NCBI entrez gene - 214855     See in Manteia.
MGI - MGI:2443039
RefSeq - XM_017319751
RefSeq - NM_001172205
RefSeq - NM_001172206
RefSeq - NM_001290726
RefSeq - NM_001290727
RefSeq - NM_145996
RefSeq Peptide - NP_666108
RefSeq Peptide - NP_001165676
RefSeq Peptide - NP_001165677
RefSeq Peptide - NP_001277655
RefSeq Peptide - NP_001277656
swissprot - D3Z0W0
swissprot - Q3U108
swissprot - D3Z7U1
swissprot - J3KMU9
swissprot - D3Z085
Ensembl - ENSMUSG00000037447
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 arid5aENSDARG00000077120Danio rerio
 ARID5AENSGALG00000039206Gallus gallus
 ARID5AENSG00000196843Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Arid5b / Q8BM75 / AT-rich interactive domain-containing protein 5B / Q14865* / AT-rich interaction domain 5B*ENSMUSG0000001994734
A2CG63 / Arid4b / AT-rich interactive domain-containing protein 4B / Q4LE39* / AT-rich interaction domain 4B*ENSMUSG0000003921918
Arid4a / AT rich interactive domain 4A (RBP1-like) / P29374* / AT-rich interaction domain 4A*ENSMUSG0000004811815


Protein motifs (from Interpro)
Interpro ID Name
 IPR001606  ARID DNA-binding domain
 IPR036431  ARID DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II ISO
 biological_processGO:0002062 chondrocyte differentiation IDA
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0035066 positive regulation of histone acetylation IDA
 biological_processGO:0045087 innate immune response IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IGI
 biological_processGO:0071222 cellular response to lipopolysaccharide IMP
 biological_processGO:0071391 cellular response to estrogen stimulus ISO
 biological_processGO:1902715 positive regulation of interferon-gamma secretion IMP
 biological_processGO:1904469 positive regulation of tumor necrosis factor secretion IMP
 biological_processGO:1905078 positive regulation of interleukin-17 secretion IMP
 biological_processGO:2000318 positive regulation of T-helper 17 type immune response IMP
 biological_processGO:2000556 positive regulation of T-helper 1 cell cytokine production IMP
 biological_processGO:2000778 positive regulation of interleukin-6 secretion IMP
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005654 nucleoplasm ISO
 cellular_componentGO:0005667 transcription factor complex IPI
 cellular_componentGO:0005730 nucleolus ISO
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003682 chromatin binding IDA
 molecular_functionGO:0003714 transcription corepressor activity ISO
 molecular_functionGO:0003723 RNA binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008134 transcription factor binding ISO
 molecular_functionGO:0030331 estrogen receptor binding ISO
 molecular_functionGO:0035613 RNA stem-loop binding IMP
 molecular_functionGO:0043565 sequence-specific DNA binding ISO
 molecular_functionGO:0044212 transcription regulatory region DNA binding IBA
 molecular_functionGO:0046965 retinoid X receptor binding ISO
 molecular_functionGO:0046966 thyroid hormone receptor binding ISO
 molecular_functionGO:0050681 androgen receptor binding ISO


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0004800 decreased susceptibility to experimental autoimmune encephalomyelitis "reduced likelihood that an organism will develop disease symptoms similar to human multiple sclerosis upon induction with antigens to Myelin Basic Protein (MBP), Proteolipid Protein (PLP), and/or Myelin Oligodendrocyte glycoprotein (MOG)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Tex19.1tm1.2Ics/Tex19.1tm1.2Ics
Genetic Background: involves: C57BL/6

 MP:0005015 increased T cell number "greater than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Tex19.1tm1.2Ics/Tex19.1tm1.2Ics
Genetic Background: involves: C57BL/6

 MP:0008554 decreased circulating tumor necrosis factor level "reduction in the amount in the blood of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]
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Allelic Composition: Tex19.1tm1.2Ics/Tex19.1tm1.2Ics
Genetic Background: involves: C57BL/6

 MP:0008597 decreased circulating interleukin-6 level "reduction in the amount in the blood of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506]
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Allelic Composition: Tex19.1tm1.2Ics/Tex19.1tm1.2Ics
Genetic Background: involves: C57BL/6

 MP:0010220 decreased T-helper 17 cell number "reduced number of CD4-positive, alpha-beta T cells with the phenotype RORgamma-t-positive that produces IL-17" [CL:0000899]
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Allelic Composition: Tex19.1tm1.2Ics/Tex19.1tm1.2Ics
Genetic Background: involves: C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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