ENSMUSG00000038147


Mus musculus

Features
Gene ID: ENSMUSG00000038147
  
Biological name :Cd84
  
Synonyms : Cd84 / CD84 antigen
  
Possible biological names infered from orthology : CD84 molecule / Q9UIB8
  
Species: Mus musculus
  
Chr. number: 1
Strand: 1
Band: H3
Gene start: 171839697
Gene end: 171890718
  
Corresponding Affymetrix probe sets: 10351679 (MoGene1.0st)   1422875_at (Mouse Genome 430 2.0 Array)   1446505_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000115674
Ensembl peptide - ENSMUSP00000122951
Ensembl peptide - ENSMUSP00000120881
Ensembl peptide - ENSMUSP00000047024
NCBI entrez gene - 12523     See in Manteia.
MGI - MGI:1336885
RefSeq - XM_011238747
RefSeq - NM_001252472
RefSeq - NM_001289470
RefSeq - NM_013489
RefSeq - XM_006496639
RefSeq Peptide - NP_001239401
RefSeq Peptide - NP_001276399
RefSeq Peptide - NP_038517
swissprot - E9Q9E8
swissprot - A0A0R4J1S4
swissprot - A0A0R4J0K5
Ensembl - ENSMUSG00000038147
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CD84ENSG00000066294Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ly9 / Q01965 / T-lymphocyte surface antigen Ly-9 / Q9HBG7* / lymphocyte antigen 9*ENSMUSG0000000470731
Slamf9 / SLAM family member 9 / Q96A28*ENSMUSG0000002654827
Slamf7 / SLAM family member 7 / Q9NQ25*ENSMUSG0000003817927
Q9ET39 / Slamf6 / SLAM family member 6 / Q96DU3*ENSMUSG0000001531425


Protein motifs (from Interpro)
Interpro ID Name
 IPR003599  Immunoglobulin subtype
 IPR007110  Immunoglobulin-like domain
 IPR013783  Immunoglobulin-like fold
 IPR036179  Immunoglobulin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0032685 negative regulation of granulocyte macrophage colony-stimulating factor production IEA
 biological_processGO:0032701 negative regulation of interleukin-18 production IEA
 biological_processGO:0033004 negative regulation of mast cell activation IEA
 biological_processGO:0043305 negative regulation of mast cell degranulation IEA
 biological_processGO:2001256 regulation of store-operated calcium entry IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0042802 identical protein binding IEA


Pathways (from Reactome)
Pathway description
Cell surface interactions at the vascular wall


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001805 decreased IgG "less than normal immunoglobulin class G level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Sh2d1atm1Pls/Sh2d1atm1Pls
Genetic Background: involves: 129S6/SvEvTac

 MP:0002644 decreased circulating triglyceride level "lower than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cbx2tm1b(KOMP)Wtsi/Cbx2+
Genetic Background: C57BL/6N-Cbx2tm1b(KOMP)Wtsi/H

 MP:0002942 decreased circulating alanine transaminase level "decreased concentration in the blood of this enzyme, which transfers amino groups from l-alanine to 2 ketoglutarate, or the reverse (from l-glutamate to pyruvate); serum concentration is increased in viral hepatitis and myocardial infarction" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Cbx2tm1b(KOMP)Wtsi/Cbx2+
Genetic Background: C57BL/6N-Cbx2tm1b(KOMP)Wtsi/H

 MP:0005463 abnormal CD4+ T cell physiology "anomalous response of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Sh2d1atm1Pls/Sh2d1atm1Pls
Genetic Background: involves: 129S6/SvEvTac

Allelic Composition: Cd84tm1Pls/Cd84tm1Pls,Tg(TcraTcrb)425Cbn/?
Genetic Background: B6.Cg-Cd84tm1Pls Tg(TcraTcrb)425Cbn

 MP:0005633 increased circulating sodium level "greater than the normal concentration in the blood of this metallic element, the most plentiful extracellular ion in the body and the principal determinant of extracellular fluid volume" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
Show

Allelic Composition: Cbx2tm1b(KOMP)Wtsi/Cbx2+
Genetic Background: C57BL/6N-Cbx2tm1b(KOMP)Wtsi/H

 MP:0008075 decreased CD4-positive T cell number "reduced number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Sh2d1atm1Pls/Sh2d1atm1Pls
Genetic Background: involves: 129S6/SvEvTac

 MP:0008178 decreased germinal center B cell number "reduced number of rapidly cycling mature B cells which have downregulated IgD expression and exhibit high levels of binding by peanut agglutinin (PNA), and are involved in T-dependent immune responses; germinal center B cells are found typically in the germinal centers of lymph nodes and spleen" [CL:0000844, GO:0002314, ISBN:0781735149]
Show

Allelic Composition: Sh2d1atm1Pls/Sh2d1atm1Pls
Genetic Background: involves: 129S6/SvEvTac

 MP:0008484 decreased spleen germinal center size "reduced size of spleen secondary B follicles where rapid B-cell proliferation, somatic hypermutation, and selection for antigen binding occurs" [PMID:17495967]
Show

Allelic Composition: Sh2d1atm1Pls/Sh2d1atm1Pls
Genetic Background: involves: 129S6/SvEvTac

 MP:0009058 decreased interleukin-21 secretion "reduction in the production or release of a pleiotropic cytokine that regulates immunoglobulin production, plasma cell and Th17 T cell differentiation, CD8+ T cell expansion, and inhibits antigen presentation by dendritic cells" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Sh2d1atm1Pls/Sh2d1atm1Pls
Genetic Background: involves: 129S6/SvEvTac

 MP:0010025 decreased total body fat amount "less than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cbx2tm1b(KOMP)Wtsi/Cbx2+
Genetic Background: C57BL/6N-Cbx2tm1b(KOMP)Wtsi/H

 MP:0010084 abnormal long lived plasma cell morphology "any structural anomaly of a fully differentiated plasma cell that lives for years, as opposed to months, secretes immunoglobulin, and has the phenotype weakly CD19-positive, CD20-negative, CD38-negative, strongly CD138-positive, MHC Class II-negative, surface immunoglobulin-negative, IgD-negative, and strongly CXCR4-positive; the majority of these cells of this type reside in the bone marrow" [CL:0000974]
Show

Allelic Composition: Sh2d1atm1Pls/Sh2d1atm1Pls
Genetic Background: involves: 129S6/SvEvTac

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000038147 Cd84 / CD84 antigen / Q9UIB8* / CD84 molecule*  / complex / reaction






 

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