| MP:0000088 | short mandible | "reduced length of the lower bony framework of the mouth where the inferior teeth are held" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Sosttm1Dgen/Sosttm1Dgen
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
|
| MP:0000111 | cleft palate | "congenital fissure of the tissues normally uniting to form the palate" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840] |
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Allelic Composition: Sosttm1Dgen/Sosttm1Dgen
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
|
| MP:0000180 | abnormal circulating cholesterol level | "anomalous concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Pdss2tm1Dalg/Pdss2tm1Dalg,Tg(NPHS2-cre)295Lbh/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
|
| MP:0000358 | abnormal cell content/ morphology | "structural anomalies of the minute protoplasmic masses that make up organized tissues and which are the fundamental structural and functional units of living organisms" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Sosttm1Dgen/Sosttm1Dgen
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
|
| MP:0000751 | myopathy | "any abnormal condition or disease of the skeletal muscle" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:42574] |
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Allelic Composition: Psen1tm1Dgf/Psen1tm1Dgf,Tg(APPSWE)2576Kha/?
Genetic Background: involves: 129 * C57BL/6 * CD-1 * SJL
|
| MP:0000759 | abnormal skeletal muscle morphology | "anomalous structure of any of the striated muscle fibers connected at either or both extremeties with the bony framework of the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Sosttm1Dgen/Sosttm1Dgen
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
|
| MP:0000849 | abnormal cerebellum morphology | "any malformation or absence of the part of the metencephalon that lies in the posterior cranial fossa dorsal to the pons and medulla that is concerned with the coordination of movement and learning of motor skills" [J:50311, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3] |
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Allelic Composition: Sosttm1Dgen/Sosttm1Dgen
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
|
| MP:0000851 | cerebellum hypoplasia | "reduced cell number in the cerebellum" [MGI:CLS, J:45302] |
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Allelic Composition: Sosttm1Dgen/Sosttm1Dgen
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
|
| MP:0000852 | small cerebellum | "reduced size of cerebellum" [MGI:CLS, J:17203, J:67524] |
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Allelic Composition: Sosttm1Dgen/Sosttm1Dgen
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
|
| MP:0000854 | abnormal cerebellum development | "malformed or incomplete differentiation of the part of the metencephalon that lies dorsal to the pons and medulla behind the brain stem and controls balance for walking and standing, modulates the force and range of movement and is involved in the learning of motor skills " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Sosttm1Dgen/Sosttm1Dgen
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
|
| MP:0000857 | abnormal cerebellar foliation | "malformation of small offshoots of the cerebellar lobules" [Principles of Neural Science:ISBN 0-8385-8034-3, J:52951] |
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Allelic Composition: Sosttm1Dgen/Sosttm1Dgen
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
|
| MP:0000866 | vermis hypoplasia | "reduced cell number in the vermis" [J:61509] |
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Allelic Composition: Sosttm1Dgen/Sosttm1Dgen
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
|
| MP:0000876 | Purkinje cell degeneration | "a retrogressive impairment of function or destruction of the large neurons located at the interface of the molecular and internal granule layers of the cerebellar cortex" [J:46854] |
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Allelic Composition: Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+,Pdss2tm1.1Jdhu/Pdss2tm1.2Jdhu,Tg(Pcp2-cre)3555Jdhu/0
Genetic Background: involves: 129 * C3H/HeNCr MMTV- * C57BL/6N * FVB/N
|
| MP:0000880 | decreased Purkinje cell number | "fewer than normal neuronal cells that are located in the interface of the molecular and granular layers of the cerebellar cortex" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:45302] |
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Allelic Composition: Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+,Pdss2tm1.1Jdhu/Pdss2tm1.2Jdhu,Tg(Pcp2-cre)3555Jdhu/0
Genetic Background: involves: 129 * C3H/HeNCr MMTV- * C57BL/6N * FVB/N
|
| MP:0001263 | weight loss | "progressive reduction of body weight below normal average for age" [J:45400] |
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Allelic Composition: Psen1tm1Dgf/Psen1tm1Dgf,Tg(APPSWE)2576Kha/?
Genetic Background: involves: 129 * C57BL/6 * CD-1 * SJL
|
| MP:0001393 | ataxia | "inability to coordinate voluntary muscular movements" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:67231] |
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Allelic Composition: Pdss2tm1.1Jdhu/Pdss2tm1.2Jdhu,Tg(Pax2-cre)1Akg/0
Genetic Background: involves: 129 * C57BL/6N * FVB/N
|
| MP:0001406 | abnormal gait | "unusual or distinctive way of walking" [J:65038] |
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Allelic Composition: Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+,Pdss2tm1.1Jdhu/Pdss2tm1.2Jdhu,Tg(Pcp2-cre)3555Jdhu/0
Genetic Background: involves: 129 * C3H/HeNCr MMTV- * C57BL/6N * FVB/N
|
| MP:0001407 | short stride length | "reduced average distance between steps" [J:34193] |
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Allelic Composition: Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+,Pdss2tm1.1Jdhu/Pdss2tm1.2Jdhu,Tg(Pcp2-cre)3555Jdhu/0
Genetic Background: involves: 129 * C3H/HeNCr MMTV- * C57BL/6N * FVB/N
|
| MP:0001426 | polydipsia | "excessive thirst that is relatively prolonged" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Psen1tm1Dgf/Psen1tm1Dgf,Tg(APPSWE)2576Kha/?
Genetic Background: involves: 129 * C57BL/6 * CD-1 * SJL
|
| MP:0001488 | increased startle reflex | "reduced threshold or more severe reflex response to variable stimuli, often auditory; usually measured by amplitude of whole body flinch" [What s Wrong With My Mouse?:ISBN 0-471-31639-3, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Padi6tm1b(KOMP)Wtsi/Padi6tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Padi6tm1b(KOMP)Wtsi/Ucd
|
| MP:0001505 | hunched posture | "stooped low with the limbs pulled in close to the body and arched back" [J:67231, J:30404] |
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Allelic Composition: Psen1tm1Dgf/Psen1tm1Dgf,Tg(APPSWE)2576Kha/?
Genetic Background: involves: 129 * C57BL/6 * CD-1 * SJL
|
| MP:0001516 | abnormal motor coordination/ balance | "altered ability of an animal to maintain skillful and effective interaction of movements or maintenance of equilibrium" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
Show
Allelic Composition: Pdss2tm1.1Jdhu/Pdss2tm1.2Jdhu,Tg(Pax2-cre)1Akg/0
Genetic Background: involves: 129 * C57BL/6N * FVB/N
|
| MP:0001525 | impaired balance | "reduced ability of an animal to maintain equilibrium" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:64962, J:17123] |
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Allelic Composition: Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+,Pdss2tm1.1Jdhu/Pdss2tm1.2Jdhu,Tg(Pcp2-cre)3555Jdhu/0
Genetic Background: involves: 129 * C3H/HeNCr MMTV- * C57BL/6N * FVB/N
|
| MP:0001954 | respiratory distress | "physical difficulty or inability to breathe" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931] |
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Allelic Composition: Sosttm1Dgen/Sosttm1Dgen
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
|
| MP:0002083 | premature death | "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Psen1tm1Dgf/Psen1tm1Dgf,Tg(APPSWE)2576Kha/?
Genetic Background: involves: 129 * C57BL/6 * CD-1 * SJL
|
| MP:0002100 | abnormal tooth morphology | "atypical size, shape or hard tissue structure of the teeth " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Padi6tm1b(KOMP)Wtsi/Padi6tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Padi6tm1b(KOMP)Wtsi/Ucd
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| MP:0002135 | abnormal kidney morphology | "abnormal development of the kidney resulting in structural abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Psen1tm1Dgf/Psen1tm1Dgf,Tg(APPSWE)2576Kha/?
Genetic Background: involves: 129 * C57BL/6 * CD-1 * SJL
|
| MP:0002639 | micrognathia | "abnormally reduced size of the jaws, especially of the mandible" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator] |
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Allelic Composition: Sosttm1Dgen/Sosttm1Dgen
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
|
| MP:0002703 | abnormal renal tubules | "anomalous structure or development of the loops of Henle and collecting ducts in the kidney" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Bub1tm2Jvd/Bub1tm2Jvd
Genetic Background: involves: 129/Sv * C57BL/6
|
| MP:0002705 | dilated renal tubules | "enlarged lumens of the loops of Henle and/or collecting ducts of the kidney" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Psen1tm1Dgf/Psen1tm1Dgf,Tg(APPSWE)2576Kha/?
Genetic Background: involves: 129 * C57BL/6 * CD-1 * SJL
Allelic Composition: Pdss2kd/Pdss2kd
Genetic Background: B6.CBACaH(CAST)-Pdss2kd
Allelic Composition: Pdss2tm1Dalg/Pdss2tm1Dalg,Tg(NPHS2-cre)295Lbh/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
|
| MP:0002871 | albuminuria | "presence of excess albumin in the urine" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
Show
Allelic Composition: Psen1tm1Dgf/Psen1tm1Dgf,Tg(APPSWE)2576Kha/?
Genetic Background: involves: 129 * C57BL/6 * CD-1 * SJL
Allelic Composition: Pdss2tm1Dalg/Pdss2tm1Dalg,Tg(NPHS2-cre)295Lbh/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
|
| MP:0003158 | dysphagia | "difficulty in swallowing food or liquid" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
Show
Allelic Composition: Sosttm1Dgen/Sosttm1Dgen
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
|
| MP:0003203 | increased neuron apoptosis | "increase in the number of neurons undergoing programmed cell death" [RGD:Rat Genome Database submission] |
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Allelic Composition: Pdss2tm1.1Jdhu/Pdss2tm1.2Jdhu,Tg(Pax2-cre)1Akg/0
Genetic Background: involves: 129 * C57BL/6N * FVB/N
Allelic Composition: Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+,Pdss2tm1.1Jdhu/Pdss2tm1.2Jdhu,Tg(Pcp2-cre)3555Jdhu/0
Genetic Background: involves: 129 * C3H/HeNCr MMTV- * C57BL/6N * FVB/N
|
| MP:0003215 | renal interstitial fibrosis | "formation of fibrous tissue within the interstices of the kidney as a result of repair or a reactive process" [RGD:Rat Genome Database submission] |
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Allelic Composition: Pdss2kd/Pdss2kd
Genetic Background: involves: C57BL/6 * CBA/H
|
| MP:0003648 | abnormal radial glial cell morphology | "anomalous structure, number, or composition of the supporting cells of the developing central nervous system that guide neuronal migration during development and exchange metabolites with developing and migrating neurons; these cells differentiate into astrocytes and some neuronal types in the adult" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Pdss2tm1.1Jdhu/Pdss2tm1.2Jdhu,Tg(Pax2-cre)1Akg/0
Genetic Background: involves: 129 * C57BL/6N * FVB/N
|
| MP:0003674 | oxidative stress | "condition characterized by an accumulation of free radical groups in the body, which creates a potentially unstable and damaging cellular environment linked to tissue damage, accelerated aging, and degenerative disease; can result from many factors, including exposure to alcohol, medications, poor nutrition, trauma, cold or toxins; may be indicated by low antioxidant levels measured in blood plasma" [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Psen1tm1Dgf/Psen1tm1Dgf,Tg(APPSWE)2576Kha/?
Genetic Background: involves: 129 * C57BL/6 * CD-1 * SJL
|
| MP:0003675 | kidney cysts | "abnormal membranous sacs in any portion of the pair of organs responsible for urine secretion" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
Show
Allelic Composition: Psen1tm1Dgf/Psen1tm1Dgf,Tg(APPSWE)2576Kha/?
Genetic Background: involves: 129 * C57BL/6 * CD-1 * SJL
Allelic Composition: Pdss2kd/Pdss2kd
Genetic Background: involves: C57BL/6 * CBA/H
|
| MP:0004274 | abnormal embryonic/fetal subventricular zone morphology | "any structural anomaly in the transient proliferative population of neurons that expands exponentially during late prenatal development; it is a continuous germinal zone distinct from the ventricular zone that surrounds the brain ventricles" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:12637172] |
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Allelic Composition: Pdss2tm1.1Jdhu/Pdss2tm1.2Jdhu,Tg(Pax2-cre)1Akg/0
Genetic Background: involves: 129 * C57BL/6N * FVB/N
|
| MP:0004537 | abnormal palatine shelf | "any structural anomaly of the palatine bone; normally fuses with maxillary shelf to form secondary (hard) palate" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Pdss2tm1.1Jdhu/Pdss2tm1.2Jdhu,Tg(Pax2-cre)1Akg/0
Genetic Background: involves: 129 * C57BL/6N * FVB/N
|
| MP:0004609 | vertebral fusion | "the union of one or more vertebrae into a single structure" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Padi6tm1b(KOMP)Wtsi/Padi6tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Padi6tm1b(KOMP)Wtsi/Ucd
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| MP:0004969 | pale kidney | "kidney lacks normal reddish coloration; often occurs with a bloodless or reduced vasculature condition" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Psen1tm1Dgf/Psen1tm1Dgf,Tg(APPSWE)2576Kha/?
Genetic Background: involves: 129 * C57BL/6 * CD-1 * SJL
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| MP:0004970 | kidney atrophy | "wasting of the kidney due to injury or disease, resulting in reduced size" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Psen1tm1Dgf/Psen1tm1Dgf,Tg(APPSWE)2576Kha/?
Genetic Background: involves: 129 * C57BL/6 * CD-1 * SJL
|
| MP:0005178 | increased total circulating cholesterol level | "greater than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
Show
Allelic Composition: Pdss2tm1Dalg/Pdss2tm1Dalg,Tg(NPHS2-cre)295Lbh/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
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| MP:0005264 | glomerulosclerosis | "hyaline deposits or scarring within the renal glomeruli, often occurring with renal arteriosclerosis or diabetes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Psen1tm1Dgf/Psen1tm1Dgf,Tg(APPSWE)2576Kha/?
Genetic Background: involves: 129 * C57BL/6 * CD-1 * SJL
Allelic Composition: Pdss2kd/Pdss2kd
Genetic Background: involves: C57BL/6 * CBA/H
|
| MP:0005319 | abnormal enzyme/ coenzyme level | "altered concentration of any of these proteins, or their cofactors, that act as catalysts to induce chemical changes in other substances" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Psen1tm1Dgf/Psen1tm1Dgf,Tg(APPSWE)2576Kha/?
Genetic Background: involves: 129 * C57BL/6 * CD-1 * SJL
|
| MP:0005325 | abnormal glomerulus | "anomalous structure of the capillary loops of the kidney that normally function as a filtration unit" [J:57971, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Psen1tm1Dgf/Psen1tm1Dgf,Tg(APPSWE)2576Kha/?
Genetic Background: involves: 129 * C57BL/6 * CD-1 * SJL
Allelic Composition: Pdss2kd/Pdss2kd
Genetic Background: involves: C57BL/6 * CBA/H
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| MP:0005326 | abnormal podocytes | "anomalous structure of the foot processes of the epithelial cells of the glomerulus" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:57971] |
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Allelic Composition: Psen1tm1Dgf/Psen1tm1Dgf,Tg(APPSWE)2576Kha/?
Genetic Background: involves: 129 * C57BL/6 * CD-1 * SJL
Allelic Composition: Pdss2kd/Pdss2kd
Genetic Background: involves: C57BL/6 * CBA/H
|
| MP:0005448 | abnormal energy balance | "aberrant intake or expenditure of calories as compared to the normal state" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Pdss2tm1Dalg/Pdss2tm1Dalg,Tg(NPHS2-cre)295Lbh/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
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| MP:0006035 | abnormal mitochondrial morphology | "anomalous structure of the mitochondria" [smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Pdss2kd/Pdss2kd
Genetic Background: B6.CBACaH(CAST)-Pdss2kd
Allelic Composition: Pdss2tm1.1Jdhu/Pdss2tm1.2Jdhu,Tg(Pax2-cre)1Akg/0
Genetic Background: involves: 129 * C57BL/6N * FVB/N
|
| MP:0008140 | podocyte foot process effacement | "thinning of the footlike extension of podocytes that interdigitate with one another to form the walls of the glomerular capillaries" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"] |
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Allelic Composition: Pdss2kd/Pdss2kd
Genetic Background: involves: C57BL/6 * CBA/H
|
| MP:0009546 | absent gastric milk in neonates | "failure of nursing offspring to ingest milk as indicated by stomach content" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"] |
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Allelic Composition: Pdss2tm1.1Jdhu/Pdss2tm1.2Jdhu,Tg(Pax2-cre)1Akg/0
Genetic Background: involves: 129 * C57BL/6N * FVB/N
|
| MP:0009718 | absent Purkinje cell layer | "there is no evidence of the cell layer that lies just underneath the molecular layer of the cerebellar cortex, normally containing the neuronal cell bodies of the Purkinje cells arranged side by side in a single layer, and candelabrum interneurons vertically oriented between the Purkinje cells" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"] |
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Allelic Composition: Pdss2tm1.1Jdhu/Pdss2tm1.2Jdhu,Tg(Pax2-cre)1Akg/0
Genetic Background: involves: 129 * C57BL/6N * FVB/N
|
| MP:0010008 | abnormal Purkinje cell migration | "defective or impaired movement of immature Purkinje cells from the ventricular zone of the fourth ventricle to the forming Purkinje cell layer during development of the cerebellar cortex" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Pdss2tm1.1Jdhu/Pdss2tm1.2Jdhu,Tg(Pax2-cre)1Akg/0
Genetic Background: involves: 129 * C57BL/6N * FVB/N
|
| MP:0010954 | abnormal cellular respiration | "anomaly in the enzymatic release of energy from organic compounds (especially carbohydrates and fats) which either requires oxygen (aerobic respiration) or does not (anaerobic respiration)" [GO:0045333] |
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Allelic Composition: Pdss2kd/Pdss2kd
Genetic Background: involves: C57BL/6 * CBA/H
|
| MP:0010955 | abnormal respiratory electron transport chain | "anomaly in the process in which a series of electron carriers operate together to transfer electrons from donors such as NADH and FADH2 to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient" [GO:0022904] |
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Allelic Composition: Psen1tm1Dgf/Psen1tm1Dgf,Tg(APPSWE)2576Kha/?
Genetic Background: involves: 129 * C57BL/6 * CD-1 * SJL
Allelic Composition: Pdss2tm1Dalg/Pdss2tm1Dalg,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
|
| MP:0010956 | abnormal mitochondrial ATP synthesis coupled electron transport | "anomaly in the transfer of electrons through a series of electron donors and acceptors, generating energy that is ultimately used for synthesis of ATP, as it occurs in the mitochondrial inner membrane and mediated by multisubunit enzyme complexes known as complex I-IV" [GO:0042775, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Psen1tm1Dgf/Psen1tm1Dgf,Tg(APPSWE)2576Kha/?
Genetic Background: involves: 129 * C57BL/6 * CD-1 * SJL
Allelic Composition: Pdss2kd/Pdss2kd
Genetic Background: involves: C57BL/6 * CBA/H
|
| MP:0010957 | abnormal aerobic respiration | "any anomaly in the process of enzymatic release of energy from organic compounds (especially carbohydrates and fats) which requires oxygen as the terminal electron acceptor" [GO:0009060] |
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Allelic Composition: Pdss2tm1Dalg/Pdss2tm1Dalg,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
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| MP:0011085 | complete postnatal lethality | "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith] |
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Allelic Composition: Pdss2tm1.1Jdhu/Pdss2tm1.2Jdhu,Tg(Pax2-cre)1Akg/0
Genetic Background: involves: 129 * C57BL/6N * FVB/N
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| MP:0011098 | complete embryonic lethality during organogenesis | "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith] |
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Allelic Composition: Bub1tm2Jvd/Bub1tm2Jvd
Genetic Background: involves: 129/Sv * C57BL/6
Allelic Composition: Pdss2tm1.2Jdhu/Pdss2tm1.2Jdhu
Genetic Background: involves: 129 * C57BL/6N * FVB/N
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| MP:0011100 | complete preweaning lethality | "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith] |
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Allelic Composition: Nphp1tm1.1(KOMP)Vlcg/Nphp1tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Nphp1tm1.1(KOMP)Vlcg/Ucd
|
| MP:0011346 | renal tubule atrophy | "acquired diminution of the size of the loops of Henle, the proximal convoluted tubule or the distal convoluted tubule associated with wasting as from death and reabsorbtion of cells, diminished cellular proliferation, decreased cellular volume, pressure, ischemia, malnutrition, reduced function or malfunction, or hormonal changes" [MGI:anna] |
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Allelic Composition: Psen1tm1Dgf/Psen1tm1Dgf,Tg(APPSWE)2576Kha/?
Genetic Background: involves: 129 * C57BL/6 * CD-1 * SJL
Allelic Composition: Pdss2kd/Pdss2kd
Genetic Background: involves: C57BL/6 * CBA/H
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| MP:0011348 | abnormal renal glomerulus basement membrane morphology | "any structural anomaly of the layer of extracellular matrix that lies between the endothelium of the glomerular capillaries and the podocytes of the inner or visceral layer of the Bowman capsule; it is a fusion of the endothelial cell and podocyte basal laminas and acts as a physical barrier and an ion-selective filter" [MGI:anna] |
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Allelic Composition: Pdss2kd/Pdss2kd
Genetic Background: involves: C57BL/6 * CBA/H
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| MP:0011402 | renal cast | "any of the various casts formed from gelled protein precipitated in the distal convoluted tubules and collecting ducts of nephrons and molded to the tubular or duct lumen which dislodge and pass into the urine; types named for their constituent material include acellular casts (e.g. granular, hyaline, waxy, or fatty casts) and cellular casts (e.g. red or white blood cell casts)" [MGI:anna] |
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Allelic Composition: Psen1tm1Dgf/Psen1tm1Dgf,Tg(APPSWE)2576Kha/?
Genetic Background: involves: 129 * C57BL/6 * CD-1 * SJL
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| MP:0011405 | tubulointerstitial nephritis | "diffuse or local inflammation and edema of the interstitial tissue of the kidney, including the renal tubules; usually secondary to drug sensitization, systemic infection, graft rejection, or autoimmune disease" [MGI:anna] |
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Allelic Composition: Psen1tm1Dgf/Psen1tm1Dgf,Tg(APPSWE)2576Kha/?
Genetic Background: involves: 129 * C57BL/6 * CD-1 * SJL
Allelic Composition: Pdss2kd/Pdss2kd
Genetic Background: B6.CBACaH(CAST)-Pdss2kd
Allelic Composition: Pdss2tm1Dalg/Pdss2tm1Dalg,Tg(NPHS2-cre)295Lbh/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
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| MP:0011413 | colorless urine | "absence of the usual straw-coloration of the urine" [MGI:anna] |
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Allelic Composition: Psen1tm1Dgf/Psen1tm1Dgf,Tg(APPSWE)2576Kha/?
Genetic Background: involves: 129 * C57BL/6 * CD-1 * SJL
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| MP:0011498 | abnormal glomerular capsule parietal layer morphology | "any structural anomaly of the outer layer of the glomerular capsule composed of a single layer of simple squamous epithelium" [MGI:anna] |
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Allelic Composition: Pdss2kd/Pdss2kd
Genetic Background: involves: C57BL/6 * CBA/H
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| MP:0011534 | granular kidney | "a kidney in which fairly uniform, diffusely and evenly situated foci of scarring of the interstitial tissue of the cortex (and sometimes scarring of glomeruli), and the associated slight degree of bulging of groups of dilated tubules, leads to the development of a minutely bosselated surface; such kidneys are seen in arteriolar nephrosclerosis or chronic glomerulonephritis" [MGI:anna] |
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Allelic Composition: Psen1tm1Dgf/Psen1tm1Dgf,Tg(APPSWE)2576Kha/?
Genetic Background: involves: 129 * C57BL/6 * CD-1 * SJL
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| MP:0011638 | abnormal mitochondrial chromosome morphology | "any structrual anomaly of the chromosome found in the mitochondrion of a eukaryotic cell" [GO:0000262] |
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Allelic Composition: Psen1tm1Dgf/Psen1tm1Dgf,Tg(APPSWE)2576Kha/?
Genetic Background: involves: 129 * C57BL/6 * CD-1 * SJL
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| MP:0011639 | decreased mitochondrial DNA content | "less than expected amount of DNA contained within the mirochondria of a eukaryotic cell" [MGI:csmith] |
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Allelic Composition: Psen1tm1Dgf/Psen1tm1Dgf,Tg(APPSWE)2576Kha/?
Genetic Background: involves: 129 * C57BL/6 * CD-1 * SJL
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| MP:0012089 | decreased midbrain size | "size reduction or truncation of the brain region derived from the middle of the three cerebral vesicles of the embryo; this region controls sensory and motor functions in the adult, including eye movement and coordination of auditory and visual reflexes" [MGI:anna, MGI:csmith] |
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Allelic Composition: Pdss2tm1.1Jdhu/Pdss2tm1.2Jdhu,Tg(Pax2-cre)1Akg/0
Genetic Background: involves: 129 * C57BL/6N * FVB/N
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| MP:0012090 | midbrain hypoplasia | "underdevelopment or reduced size, usually due to a reduced number of cells, of the brain region derived from the middle of the three cerebral vesicles of the embryo; this region controls sensory and motor functions in the adult, including eye movement and coordination of auditory and visual reflexes" [MGI:anna, MGI:csmith] |
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Allelic Composition: Pdss2tm1.1Jdhu/Pdss2tm1.2Jdhu,Tg(Pax2-cre)1Akg/0
Genetic Background: involves: 129 * C57BL/6N * FVB/N
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| MP:0013292 | embryonic lethality prior to organogenesis | "death prior to the completion of embryo turning (Mus: E9-9.5)" [MGI:smb] |
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Allelic Composition: Nphp1tm1.1(KOMP)Vlcg/Nphp1tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Nphp1tm1.1(KOMP)Vlcg/Ucd
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| MP:0013293 | embryonic lethality prior to tooth bud stage | "death prior to the appearance of tooth buds (Mus: E12-E12.5)" [MGI:smb] |
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Allelic Composition: Nphp1tm1.1(KOMP)Vlcg/Nphp1tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Nphp1tm1.1(KOMP)Vlcg/Ucd
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| MP:0014046 | abnormal mitophagy | "any anomaly in the autophagic process in which mitochondria are delivered to the vacuole and degraded in response to changing cellular conditions" [MGI:Anna, PMID:22743996] |
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Allelic Composition: Pdss2tm1Dalg/Pdss2tm1Dalg,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
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| MP:0020388 | decreased radial glial cell number | "reduction in the number of the supporting cells of the developing central nervous system that guide neuronal migration during development and exchange metabolites with developing and migrating neurons; these cells differentiate into astrocytes and some neuronal types in the adult" [MGI:anna, PMID:25698753] |
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Allelic Composition: Pdss2tm1.1Jdhu/Pdss2tm1.2Jdhu,Tg(Pax2-cre)1Akg/0
Genetic Background: involves: 129 * C57BL/6N * FVB/N
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