ENSMUSG00000038264


Mus musculus

Features
Gene ID: ENSMUSG00000038264
  
Biological name :Sema7a
  
Synonyms : Q9QUR8 / Sema7a / Semaphorin-7A
  
Possible biological names infered from orthology : O75326 / semaphorin 7A (John Milton Hagen blood group)
  
Species: Mus musculus
  
Chr. number: 9
Strand: 1
Band: B
Gene start: 57940112
Gene end: 57962865
  
Corresponding Affymetrix probe sets: 10585778 (MoGene1.0st)   1422040_at (Mouse Genome 430 2.0 Array)   1459903_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000042211
Ensembl peptide - ENSMUSP00000148893
NCBI entrez gene - 20361     See in Manteia.
MGI - MGI:1306826
RefSeq - XM_006510889
RefSeq - NM_011352
RefSeq - XM_006510888
RefSeq Peptide - NP_035482
swissprot - Q9QUR8
swissprot - A0A1L1SQ43
Ensembl - ENSMUSG00000038264
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 sema7aENSDARG00000078707Danio rerio
 SEMA7AENSGALG00000001412Gallus gallus
 O75326ENSG00000138623Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Sema5a / sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A / Q13591* / semaphorin 5A*ENSMUSG0000002223123
Q60519 / Sema5b / Semaphorin-5B / Q9P283*ENSMUSG0000005213323
O35464 / Sema6a / Semaphorin-6A / Q9H2E6*ENSMUSG0000001964722
Q76KF0 / Sema6d / Semaphorin-6D / Q8NFY4*ENSMUSG0000002720021
Q9WTM3 / Sema6c / sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6C / Q9H3T2* / semaphorin 6C*ENSMUSG0000003877721
O54951 / Sema6b / sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6B / Q9H3T3* / semaphorin 6B*ENSMUSG0000000122720


Protein motifs (from Interpro)
Interpro ID Name
 IPR001627  Sema domain
 IPR002165  Plexin repeat
 IPR007110  Immunoglobulin-like domain
 IPR013783  Immunoglobulin-like fold
 IPR015943  WD40/YVTN repeat-like-containing domain superfamily
 IPR016201  PSI domain
 IPR027231  Semaphorin
 IPR036179  Immunoglobulin-like domain superfamily
 IPR036352  Sema domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001934 positive regulation of protein phosphorylation IDA
 biological_processGO:0006954 inflammatory response IEA
 biological_processGO:0007229 integrin-mediated signaling pathway IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007399 nervous system development IEA
 biological_processGO:0021988 olfactory lobe development IMP
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0031175 neuron projection development IMP
 biological_processGO:0045773 positive regulation of axon extension IEA
 biological_processGO:0048675 axon extension IMP
 biological_processGO:0050727 regulation of inflammatory response IDA
 biological_processGO:0050919 negative chemotaxis IBA
 biological_processGO:0060907 positive regulation of macrophage cytokine production IDA
 biological_processGO:0070374 positive regulation of ERK1 and ERK2 cascade IEA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0009897 external side of plasma membrane IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0031225 anchored component of membrane IEA
 molecular_functionGO:0005178 integrin binding IPI
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0038191 neuropilin binding IBA


Pathways (from Reactome)
Pathway description
Other semaphorin interactions


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0003651 abnormal axon outgrowth "defect/abnormality in the ability of an axon to extend from a neuron cell body" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator, J:96121]
Show

Allelic Composition: Blmtm1Ches/Blmtm3Brd
Genetic Background: involves: 129S/SvEv * C57BL/6 * NIH Black Swiss

 MP:0005237 abnormal olfactory tract morphology "structural anomaly of the nervelike, white band composed primarily of nerve fibers originating from the mitral cells and tufted cells of the olfactory bulb, but also containing the scattered cells of the anterior olfactory nucleus " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:34460]
Show

Allelic Composition: Blmtm1Ches/Blmtm3Brd
Genetic Background: involves: 129S/SvEv * C57BL/6 * NIH Black Swiss

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000074785 Plxnc1 / Q9QZC2 / Plexin-C1 / O60486*  / complex / reaction
 ENSMUSG00000042284 Itga1 / Q3V3R4 / Integrin alpha-1 / P56199* / integrin subunit alpha 1*  / complex / reaction
 ENSMUSG00000025809 Itgb1 / P09055 / Integrin beta-1 / P05556* / integrin subunit beta 1*  / complex / reaction






 

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