ENSMUSG00000038583


Mus musculus

Features
Gene ID: ENSMUSG00000038583
  
Biological name :Pln
  
Synonyms : Cardiac phospholamban / P61014 / Pln
  
Possible biological names infered from orthology : P26678 / phospholamban
  
Species: Mus musculus
  
Chr. number: 10
Strand: 1
Band: B3
Gene start: 53337667
Gene end: 53345987
  
Corresponding Affymetrix probe sets: 10363157 (MoGene1.0st)   1423359_at (Mouse Genome 430 2.0 Array)   1450952_at (Mouse Genome 430 2.0 Array)   1460332_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000151966
Ensembl peptide - ENSMUSP00000045709
Ensembl peptide - ENSMUSP00000132743
Ensembl peptide - ENSMUSP00000151641
Ensembl peptide - ENSMUSP00000151745
Ensembl peptide - ENSMUSP00000151860
NCBI entrez gene - 18821     See in Manteia.
MGI - MGI:97622
RefSeq - NM_001141927
RefSeq - NM_023129
RefSeq Peptide - NP_001135399
RefSeq Peptide - NP_075618
swissprot - P61014
Ensembl - ENSMUSG00000038583
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 si:ch211-270g19.5ENSDARG00000097256Danio rerio
 PLNENSGALG00000027583Gallus gallus
 PLNENSG00000198523Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR005984  Phospholamban


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002026 regulation of the force of heart contraction IMP
 biological_processGO:0006816 calcium ion transport IEA
 biological_processGO:0006874 cellular calcium ion homeostasis IGI
 biological_processGO:0007219 Notch signaling pathway IDA
 biological_processGO:0008016 regulation of heart contraction IMP
 biological_processGO:0010043 response to zinc ion IEA
 biological_processGO:0010459 negative regulation of heart rate IEA
 biological_processGO:0010880 regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum IMP
 biological_processGO:0010881 regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion IMP
 biological_processGO:0032780 negative regulation of ATPase activity IEA
 biological_processGO:0032868 response to insulin IEA
 biological_processGO:0033574 response to testosterone IEA
 biological_processGO:0045822 negative regulation of heart contraction IMP
 biological_processGO:0048738 cardiac muscle tissue development IGI
 biological_processGO:0051260 protein homooligomerization IEA
 biological_processGO:0051924 regulation of calcium ion transport ISS
 biological_processGO:0051926 negative regulation of calcium ion transport IEA
 biological_processGO:0060314 regulation of ryanodine-sensitive calcium-release channel activity IMP
 biological_processGO:0086004 regulation of cardiac muscle cell contraction IMP
 biological_processGO:0086023 adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process IMP
 biological_processGO:0086092 regulation of the force of heart contraction by cardiac conduction IMP
 biological_processGO:0090279 regulation of calcium ion import IMP
 biological_processGO:1901020 negative regulation of calcium ion transmembrane transporter activity IEA
 biological_processGO:1901077 regulation of relaxation of muscle IMP
 biological_processGO:1901877 negative regulation of calcium ion binding IEA
 biological_processGO:1901894 regulation of calcium-transporting ATPase activity IEA
 biological_processGO:1901895 negative regulation of calcium-transporting ATPase activity IEA
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005789 endoplasmic reticulum membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0016529 sarcoplasmic reticulum IDA
 cellular_componentGO:0031966 mitochondrial membrane IEA
 cellular_componentGO:0031982 vesicle IEA
 cellular_componentGO:0033017 sarcoplasmic reticulum membrane IEA
 cellular_componentGO:0090534 calcium ion-transporting ATPase complex IEA
 molecular_functionGO:0005246 calcium channel regulator activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0042030 ATPase inhibitor activity IEA


Pathways (from Reactome)
Pathway description
Ion homeostasis
Ion transport by P-type ATPases


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000277 abnormal heart shape "malformation of the form or the patterning of the heart" [J:18048]
Show

Allelic Composition: Atp2a2tm1Fwuy/Atp2a2tm1Fwuy,Plntm1Egk/Plntm1Egk
Genetic Background: involves: 129 * FVB/N * Swiss

 MP:0000281 abnormal ventricular septum morphology "abnormality in the wall between the ventricles of the heart, usually incomplete closure" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
Show

Allelic Composition: Adatm1Mw/Adatm1Mw,Tg(Afp-ADA)#Xiay/0
Genetic Background: involves: 129S7/SvEvBrd * C3H/HeJ * C57BL/6J

 MP:0001286 abnormal eye development "malformation or arrest of differentiation of the visual organ" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:49840]
Show

Allelic Composition: Plntm1Egk/Plntm1Egk,Zdhhc16tm1Goff/Zdhhc16tm1Goff
Genetic Background: involves: 129S1/Sv * 129S2/SvPas

 MP:0001625 cardiac hypertrophy "an increase in size of the cardiac tissue, not due to increased cell number " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Csrp3tm1Crni/Csrp3tm1Crni,Plntm1Egk/Plntm1Egk
Genetic Background: involves: 129S2/SvPas * CF1

Allelic Composition: Atp2a2tm1Fwuy/Atp2a2tm1Fwuy,Plntm1Egk/Plntm1Egk
Genetic Background: involves: 129 * FVB/N * Swiss

 MP:0001627 abnormal cardiac output "anomaly in the blood volume pumped by each ventricle per minute (stroke volume x heart rate)" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Atp2a2tm1Fwuy/Atp2a2tm1Fwuy,Plntm1Egk/Plntm1Egk
Genetic Background: involves: 129 * FVB/N * Swiss

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Foxd3tm1Lby/Foxd3tm1Lby
Genetic Background: involves: 129S6/SvEvTac * CD-1

 MP:0002753 dilated left ventricle "an expansion in the volume of the lower left chamber of the heart" [J:82859, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Plntm1Egk/Plntm1Egk,Tnnt2tm2.1Feah/Tnnt2+
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * FVB/N

 MP:0002795 dilated cardiomyopathy "decreased function of the heart associated with cardiac enlargement and congestive heart failure" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Plntm1Egk/Plntm1Egk,Tnnt2tm2.1Feah/Tnnt2+
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * FVB/N

 MP:0002833 increased heart weight "greater than average weight of the heart compared to the average for a particular strain" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Atp2a2tm1Fwuy/Atp2a2tm1Fwuy,Plntm1Egk/Plntm1Egk
Genetic Background: involves: 129 * FVB/N * Swiss

Allelic Composition: Plntm1Egk/Plntm1Egk
Genetic Background: involves: 129S2/SvPas * CF-1 * FVB/N

Allelic Composition: Plntm1Egk/Plntm1Egk,Tg(Myh6*)140Lnwd/0
Genetic Background: involves: 129S2/SvPas * CBA * CF-1 * FVB/N

Allelic Composition: Plntm1Egk/Plntm1Egk,Tg(Myh6/tetO-Tnnc1*I61Q)1Jmol/0,Tg(Myh6-tTA)55Rbns/0
Genetic Background: involves: 129S2/SvPas * FVB

 MP:0002953 thick ventricular wall "increased depth of the cardiac wall of the heart ventricles" [ava:Anna V. Anagnostopoulos , Mouse Genome Informatics Curator]
Show

Allelic Composition: Atp2a2tm1Fwuy/Atp2a2tm1Fwuy,Plntm1Egk/Plntm1Egk
Genetic Background: involves: 129 * FVB/N * Swiss

 MP:0002972 abnormal cardiac muscle contractility "altered ability of the heart muscle to shorten or to develop increased tension, often measured by dP/dT max" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Artm1Verh/Y,Rnase10tm1(cre)Hht/Rnase10+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0003313 abnormal locomotor activation "altered ability or desire of an animal to initiate locomotor activity" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Atp2a2tm1Fwuy/Atp2a2tm1Fwuy,Plntm1Egk/Plntm1Egk
Genetic Background: involves: 129 * FVB/N * Swiss

 MP:0004084 abnormal cardiac muscle relaxation "altered ability of the cardiac/heart muscle to lengthen following contractions, often measured by dP/dt min" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
Show

Allelic Composition: Plntm1Egk/Plntm1Egk
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Hprttm1Dhm/Hprttm1Dhm,Plntm1Egk/Plntm1Egk
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas

Allelic Composition: Hprttm1Dhm/Y,Plntm1Egk/Plntm1Egk
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas

Allelic Composition: Atp2a2tm1Fwuy/Atp2a2tm1Fwuy,Plntm1Egk/Plntm1Egk
Genetic Background: involves: 129 * FVB/N * Swiss

 MP:0004215 abnormal myocardial fiber physiology "anomaly in the function of the multinucleated muscle cells of the heart" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Plntm1Egk/Plntm1Egk
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Hprttm1Dhm/Hprttm1Dhm,Plntm1Egk/Plntm1Egk
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas

Allelic Composition: Hprttm1Dhm/Y,Plntm1Egk/Plntm1Egk
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas

Allelic Composition: Plntm1Egk/Plntm1Egk,Tg(Myh6-Pln)11Egk/?
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Plntm1Egk/Plntm1Egk,Tg(Myh6/tetO-Tnnc1*I61Q)1Jmol/0,Tg(Myh6-tTA)55Rbns/0
Genetic Background: involves: 129S2/SvPas * FVB

 MP:0004231 abnormal calcium ion homeostasis "anomaly in the processes involved in the maintenance of an internal equilibrium of calcium ions within the body or between a cell and its external environment" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Atp2a2tm1Fwuy/Atp2a2tm1Fwuy,Plntm1Egk/Plntm1Egk
Genetic Background: involves: 129 * FVB/N * Swiss

 MP:0004564 enlarged myocardial fiber "increased size of cardiac muscle fibers, the multinucleated muscle cells of the heart" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Atp2a2tm1Fwuy/Atp2a2tm1Fwuy,Plntm1Egk/Plntm1Egk
Genetic Background: involves: 129 * FVB/N * Swiss

 MP:0005140 decreased cardiac muscle contractility "inability or reduced ability of the heart muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Plntm1Egk/Plntm1Egk,Tnnt2tm2.1Feah/Tnnt2+
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * FVB/N

 MP:0005333 decreased heart rate "fewer than average resting heart beats per minute" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:84764]
Show

Allelic Composition: Pou2f2tm1Lmc/Pou2f2tm1Lmc
Genetic Background: involves: C57BL/6

Allelic Composition: Atp2a2tm1Fwuy/Atp2a2tm1Fwuy,Plntm1Egk/Plntm1Egk
Genetic Background: involves: 129 * FVB/N * Swiss

 MP:0005599 increased cardiac muscle contractility "greater than the normal ability of the heart muscle to shorten or to develop increased tension " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
Show

Allelic Composition: Csrp3tm1Crni/Csrp3tm1Crni,Plntm1Egk/Plntm1Egk
Genetic Background: involves: 129S2/SvPas * CF1

Allelic Composition: Plntm1Egk/Plntm1Egk
Genetic Background: involves: 129S2/SvPas * CF1

Allelic Composition: Hprttm1Dhm/Hprttm1Dhm,Plntm1Egk/Plntm1Egk
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas

Allelic Composition: Hprttm1Dhm/Y,Plntm1Egk/Plntm1Egk
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas

 MP:0006138 congestive heart failure "the heart is unable to adequately pump blood throughout the body" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Atp2a2tm1Fwuy/Atp2a2tm1Fwuy,Plntm1Egk/Plntm1Egk
Genetic Background: involves: 129 * FVB/N * Swiss

 MP:0008543 atrial fibrillation "asynchronous contraction or quivering of individual cardiac muscle fibers in the atria" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Plntm1Egk/Plntm1Egk
Genetic Background: involves: 129S2/SvPas

 MP:0010579 increased heart left ventricle size "greater than average size of the left ventricle" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Plntm1Egk/Plntm1Egk,Tg(Myh6/tetO-Tnnc1*I61Q)1Jmol/0,Tg(Myh6-tTA)55Rbns/0
Genetic Background: involves: 129S2/SvPas * FVB

 MP:0010754 abnormal heart left ventricle pressure "any anomaly in the pressure within the left cardiac ventricle" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Plntm1Egk/Plntm1Egk
Genetic Background: involves: 129S2/SvPas * CF1

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Plntm1Egk/Plntm1Egk,Zdhhc16tm1Goff/Zdhhc16tm1Goff
Genetic Background: involves: 129S1/Sv * 129S2/SvPas

 MP:0011952 decreased cardiac stroke volume "reduction in the volume of blood pushed into the aorta with each beat of the heart" [MGI:csmith]
Show

Allelic Composition: Atp2a2tm1Fwuy/Atp2a2tm1Fwuy,Plntm1Egk/Plntm1Egk
Genetic Background: involves: 129 * FVB/N * Swiss

 MP:0020346 abnormal mycardial fiber calcium currents "any anomaly in the electrical currents produced by cardiac calcium ion channels, typically measured using whole-cell patch-clamp techniques" [ORCID: orcid.org/0000-0003-4606-0597]
Show

Allelic Composition: Plntm1Egk/Plntm1Egk,Tg(Myh6/tetO-Tnnc1*I61Q)1Jmol/0,Tg(Myh6-tTA)55Rbns/0
Genetic Background: involves: 129S2/SvPas * FVB

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000005469 P05132 / Prkaca / protein kinase, cAMP dependent, catalytic, alpha / P17612* / protein kinase cAMP-activated catalytic subunit alpha*  / reaction
 ENSMUSG00000030409 Dmpk / P54265 / Myotonin-protein kinase / Q09013* / DM1 protein kinase*  / reaction
 ENSMUSG00000038583 Pln / P61014 / Cardiac phospholamban / P26678* / phospholamban*  / complex






 

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