ENSMUSG00000038696


Mus musculus

Features
Gene ID: ENSMUSG00000038696
  
Biological name :Mapkap1
  
Synonyms : Mapkap1 / Q8BKH7 / Target of rapamycin complex 2 subunit MAPKAP1
  
Possible biological names infered from orthology : mitogen-activated protein kinase associated protein 1 / Q9BPZ7
  
Species: Mus musculus
  
Chr. number: 2
Strand: 1
Band: B
Gene start: 34406771
Gene end: 34624950
  
Corresponding Affymetrix probe sets: 10471571 (MoGene1.0st)   1417284_at (Mouse Genome 430 2.0 Array)   1427212_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000123301
Ensembl peptide - ENSMUSP00000116494
Ensembl peptide - ENSMUSP00000141308
Ensembl peptide - ENSMUSP00000142280
Ensembl peptide - ENSMUSP00000141407
Ensembl peptide - ENSMUSP00000108748
Ensembl peptide - ENSMUSP00000108749
Ensembl peptide - ENSMUSP00000108751
NCBI entrez gene - 227743     See in Manteia.
MGI - MGI:2444554
RefSeq - XM_017317446
RefSeq - XM_006497980
RefSeq - XM_006497982
RefSeq - XM_006497983
RefSeq - XM_011239082
RefSeq - XM_011239083
RefSeq - XM_011239084
RefSeq - XM_011239085
RefSeq - XM_017317443
RefSeq - NM_001290625
RefSeq - NM_001290626
RefSeq - NM_177345
RefSeq - XM_006497975
RefSeq - XM_006497978
RefSeq Peptide - NP_796319
RefSeq Peptide - NP_001277554
RefSeq Peptide - NP_001277555
swissprot - A2AR15
swissprot - A0A0A6YVX6
swissprot - Q8BKH7
swissprot - A0A0A6YY51
swissprot - A0A0A6YW60
Ensembl - ENSMUSG00000038696
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 mapkap1ENSDARG00000091777Danio rerio
 Q9W6S3ENSGALG00000000977Gallus gallus
 Q9BPZ7ENSG00000119487Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR031313  SAPK-interacting protein 1, Pleckstrin-homology domain
 IPR031567  Sin1, middle CRIM domain
 IPR032679  Sin1, N-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0030950 establishment or maintenance of actin cytoskeleton polarity IBA
 biological_processGO:0031098 stress-activated protein kinase signaling cascade IBA
 biological_processGO:0038203 TORC2 signaling IBA
 biological_processGO:0046580 negative regulation of Ras protein signal transduction ISO
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm ISO
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005794 Golgi apparatus ISO
 cellular_componentGO:0005829 cytosol ISO
 cellular_componentGO:0005886 plasma membrane IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 cellular_componentGO:0031932 TORC2 complex IBA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005546 phosphatidylinositol-4,5-bisphosphate binding ISO
 molecular_functionGO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding ISO
 molecular_functionGO:0017016 Ras GTPase binding ISO
 molecular_functionGO:0019901 protein kinase binding ISS
 molecular_functionGO:0043325 phosphatidylinositol-3,4-bisphosphate binding ISO
 molecular_functionGO:0070300 phosphatidic acid binding ISO
 molecular_functionGO:0080025 phosphatidylinositol-3,5-bisphosphate binding ISO


Pathways (from Reactome)
Pathway description
PIP3 activates AKT signaling
CD28 dependent PI3K/Akt signaling
VEGFR2 mediated vascular permeability
Regulation of TP53 Degradation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001697 abnormal embryo size "anomalous proportions of embryo compared to littermates" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Lysttm1b(EUCOMM)Wtsi/Lysttm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Lysttm1b(EUCOMM)Wtsi/Tcp

 MP:0002753 dilated left ventricle "an expansion in the volume of the lower left chamber of the heart" [J:82859, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Lysttm1b(EUCOMM)Wtsi/Lysttm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Lysttm1b(EUCOMM)Wtsi/Tcp

 MP:0008406 increased cellular sensitivity to hydrogen peroxide "greater incidence of cell death following exposure to hydrogen peroxide" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Pax6tm1Lan/Pax6+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0011091 complete prenatal lethality "death of all organisms of a given genotype in a population between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Pax6tm1Lan/Pax6+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Lysttm1b(EUCOMM)Wtsi/Lysttm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Lysttm1b(EUCOMM)Wtsi/Tcp

Allelic Composition: Mapkap1tm1b(EUCOMM)Wtsi/Mapkap1tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Mapkap1tm1b(EUCOMM)Wtsi/Bay

 MP:0011951 increased cardiac stroke volume "increase in the volume of blood pushed into the aorta with each beat of the heart" [MGI:csmith]
Show

Allelic Composition: Lysttm1b(EUCOMM)Wtsi/Lysttm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Lysttm1b(EUCOMM)Wtsi/Tcp

 MP:0011965 decreased total retina thickness "decreased width of the retina through the center plane" [MGI:csmith]
Show

Allelic Composition: Lysttm1b(EUCOMM)Wtsi/Lysttm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Lysttm1b(EUCOMM)Wtsi/Tcp

 MP:0013293 embryonic lethality prior to tooth bud stage "death prior to the appearance of tooth buds (Mus: E12-E12.5)" [MGI:smb]
Show

Allelic Composition: Mapkap1tm1b(EUCOMM)Wtsi/Mapkap1tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Mapkap1tm1b(EUCOMM)Wtsi/Bay

 MP:0013294 prenatal lethality prior to heart atrial septation "death prior to the completion of heart atrial septation (Mus: E14.5-15.5)" [MGI:smb]
Show

Allelic Composition: Mapkap1tm1b(EUCOMM)Wtsi/Mapkap1tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Mapkap1tm1b(EUCOMM)Wtsi/Bay

 MP:0013501 increased fibroblast apoptosis "increase in the timing or the number of fibroblast cells undergoing programmed cell death" [MGI:csmith]
Show

Allelic Composition: Pax6tm1Lan/Pax6+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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