ENSMUSG00000038760


Mus musculus

Features
Gene ID: ENSMUSG00000038760
  
Biological name :Trhr
  
Synonyms : P21761 / thyrotropin releasing hormone receptor / Trhr
  
Possible biological names infered from orthology : P34981
  
Species: Mus musculus
  
Chr. number: 15
Strand: 1
Band: B3.2
Gene start: 44196135
Gene end: 44235912
  
Corresponding Affymetrix probe sets: 10423953 (MoGene1.0st)   1449571_at (Mouse Genome 430 2.0 Array)   1449572_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000036320
Ensembl peptide - ENSMUSP00000105918
Ensembl peptide - ENSMUSP00000154140
Ensembl peptide - ENSMUSP00000154650
NCBI entrez gene - 22045     See in Manteia.
MGI - MGI:98824
RefSeq - NM_013696
RefSeq - XM_006520747
RefSeq Peptide - NP_038724
swissprot - P21761
swissprot - Q32MS1
Ensembl - ENSMUSG00000038760
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 trhraENSDARG00000076546Danio rerio
 trhrbENSDARG00000036159Danio rerio
 TRHRENSGALG00000033701Gallus gallus
 TRHRENSG00000174417Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Trhr2 / thyrotropin releasing hormone receptor 2ENSMUSG0000003907950
Nmur2 / Q8BZ39 / Neuromedin-U receptor 2 / Q9GZQ4*ENSMUSG0000003739326
Ghsr / Q99P50 / Growth hormone secretagogue receptor type 1 / Q92847* / growth hormone secretagogue receptor*ENSMUSG0000005113623
Nmur1 / O55040 / Neuromedin-U receptor 1 / Q9HB89*ENSMUSG0000002623722
Ntsr1 / O88319 / neurotensin receptor 1 / P30989*ENSMUSG0000002756821
Gpr39 / G protein-coupled receptor 39 / O43194*ENSMUSG0000002634320
Ntsr2 / P70310 / Neurotensin receptor type 2 / O95665* / neurotensin receptor 2*ENSMUSG0000002059117


Protein motifs (from Interpro)
Interpro ID Name
 IPR000276  G protein-coupled receptor, rhodopsin-like
 IPR002120  Thyrotropin-releasing hormone receptor
 IPR017452  GPCR, rhodopsin-like, 7TM


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity IEA
 molecular_functionGO:0004997 thyrotropin-releasing hormone receptor activity IEA


Pathways (from Reactome)
Pathway description
Peptide ligand-binding receptors
G alpha (q) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Qkqk-2J/Qkqk-shk
Genetic Background: involves: 129 * C57BL/6 * C57BLKS/J

 MP:0001263 weight loss "progressive reduction of body weight below normal average for age" [J:45400]
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Allelic Composition: Qkqk-2J/Qkqk-shk
Genetic Background: involves: 129 * C57BL/6 * C57BLKS/J

 MP:0001363 increased anxiety-related response "when compared to controls, subjects exhibit more responses thought to be indicative of anxiety in behavioral tests" [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator, J:49752, J:53060]
Show

Allelic Composition: Dnmt1tm2Jrc/Dnmt1tm2Jrc
Genetic Background: involves: 129S1/Sv

 MP:0002573 behavioral despair "depression assayed by reduced escape attempts and/or immobility when placed in a stressful situation such as a forced swim test or a suspension test; or failure to seek pleasurable stimuli" [J:80395]
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Allelic Composition: Dnmt1tm2Jrc/Dnmt1tm2Jrc
Genetic Background: involves: 129S1/Sv

 MP:0003351 decreased circulating levels of thyroid hormone "reduced concentration of hormones in the blood that are synthesized and secreted by the thyroid" [ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Trhrtm1Bau/Trhrtm1Bau
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0003503 decreased activity of thyroid 
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Allelic Composition: Trhrtm1Bau/Trhrtm1Bau
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0005121 decreased circulating prolactin level "less than expected blood concentration of the hormone that stimulates milk secretion " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Fgfr2tm1.1Dor/Fgfr2tm1.1Dor
Genetic Background: involves: 129X1/SvJ

 MP:0005289 increased oxygen consumption "greater than the normal rate at which oxygen enters the blood from alveolar gas; this is equal in the steady state to the consumption of oxygen by tissue metabolism throughout the body" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Qkqk-2J/Qkqk-shk
Genetic Background: involves: 129 * C57BL/6 * C57BLKS/J

 MP:0005471 decreased thyroxine level "less than the normal concentration of the major hormone dervied from the thryoid gland; it normally affects cellular metabolism" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:13923]
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Allelic Composition: Fgfr2tm1.1Dor/Fgfr2tm1.1Dor
Genetic Background: involves: 129X1/SvJ

 MP:0005473 decreased triiodothyronine level "less than the normal concentration of this hormone synthesized and secreted by the thyroid; normally, this is the main thyroid hormone used by the tissues " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Fgfr2tm1.1Dor/Fgfr2tm1.1Dor
Genetic Background: involves: 129X1/SvJ

 MP:0005478 decreased circulating thyroxine level "less than the normal blood concentration of the major hormone dervied from the thryoid gland; it normally affects cellular metabolism" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Dnmt1tm2Jrc/Dnmt1tm2Jrc
Genetic Background: involves: 129S1/Sv

Allelic Composition: Trhrtm1Bau/Trhrtm1Bau
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0005479 decreased circulating triiodothyronine level "less than the normal blood concentration of this hormone synthesized and secreted by the thyroid; normally, this is the main thyroid hormone used by the tissues " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Trhrtm1Bau/Trhrtm1Bau
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0005559 increased circulating glucose level "greater than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, RGD:Rat Genome Database submission]
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Allelic Composition: Dnmt1tm2Jrc/Dnmt1tm2Jrc
Genetic Background: involves: 129S1/Sv

 MP:0011611 abnormal circulating ghrelin level "any anomaly in the blood concentration of the peptide hormone produced mainly by P/D1 cells lining the fundus of the stomach and epsilon cells of the pancreas that stimulates hunger and serves as a potent stimulator of growth hormone from the anterior pituitary gland; in addition to stimulating appetite and growth, ghrelin also plays various roles in energy homeostasis, neuropathy, and in the cardiovascular and immune systems" [MGI:anna]
Show

Allelic Composition: Trhrtm1Bau/Trhrtm1Bau
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0011612 increased circulating ghrelin level "greater than the normal blood concentration of the peptide hormone produced mainly by P/D1 cells lining the fundus of the stomach and epsilon cells of the pancreas that normally stimulates hunger and serves as a potent stimulator of growth hormone from the anterior pituitary gland" [MGI:anna]
Show

Allelic Composition: Trhrtm1Bau/Trhrtm1Bau
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0011613 decreased circulating ghrelin level "less than the normal blood concentration of the peptide hormone produced mainly by P/D1 cells lining the fundus of the stomach and epsilon cells of the pancreas that normally stimulates hunger and serves as a potent stimulator of growth hormone from the anterior pituitary gland" [MGI:anna]
Show

Allelic Composition: Trhrtm1Bau/Trhrtm1Bau
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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