ENSMUSG00000027568


Mus musculus

Features
Gene ID: ENSMUSG00000027568
  
Biological name :Ntsr1
  
Synonyms : neurotensin receptor 1 / Ntsr1 / O88319
  
Possible biological names infered from orthology : P30989
  
Species: Mus musculus
  
Chr. number: 2
Strand: 1
Band: H4
Gene start: 180499976
Gene end: 180544980
  
Corresponding Affymetrix probe sets: 10479397 (MoGene1.0st)   1420799_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000127548
Ensembl peptide - ENSMUSP00000029084
NCBI entrez gene - 18216     See in Manteia.
MGI - MGI:97386
RefSeq - NM_018766
RefSeq Peptide - NP_061236
swissprot - A2ACT4
swissprot - O88319
Ensembl - ENSMUSG00000027568
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ntsr1ENSDARG00000077577Danio rerio
 NTSR1ENSGALG00000005524Gallus gallus
 NTSR1ENSG00000101188Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ntsr2 / P70310 / Neurotensin receptor type 2 / O95665* / neurotensin receptor 2*ENSMUSG0000002059137
Gpr39 / G protein-coupled receptor 39 / O43194*ENSMUSG0000002634326
Nmur2 / Q8BZ39 / Neuromedin-U receptor 2 / Q9GZQ4*ENSMUSG0000003739326
Nmur1 / O55040 / Neuromedin-U receptor 1 / Q9HB89*ENSMUSG0000002623725
Ghsr / Q99P50 / Growth hormone secretagogue receptor type 1 / Q92847* / growth hormone secretagogue receptor*ENSMUSG0000005113625
Trhr / P21761 / thyrotropin releasing hormone receptor / P34981*ENSMUSG0000003876020
Trhr2 / thyrotropin releasing hormone receptor 2ENSMUSG0000003907919


Protein motifs (from Interpro)
Interpro ID Name
 IPR000276  G protein-coupled receptor, rhodopsin-like
 IPR003984  Neurotensin receptor
 IPR003985  Neurotensin type 1 receptor
 IPR017452  GPCR, rhodopsin-like, 7TM


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001659 temperature homeostasis IEA
 biological_processGO:0003085 negative regulation of systemic arterial blood pressure IEA
 biological_processGO:0003254 regulation of membrane depolarization IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IEA
 biological_processGO:0007218 neuropeptide signaling pathway ISO
 biological_processGO:0007612 learning IEA
 biological_processGO:0008344 adult locomotory behavior IGI
 biological_processGO:0014049 positive regulation of glutamate secretion IEA
 biological_processGO:0014054 positive regulation of gamma-aminobutyric acid secretion IEA
 biological_processGO:0033993 response to lipid IEA
 biological_processGO:0043065 positive regulation of apoptotic process IEA
 biological_processGO:0043066 negative regulation of apoptotic process ISS
 biological_processGO:0043576 regulation of respiratory gaseous exchange IEA
 biological_processGO:0050965 detection of temperature stimulus involved in sensory perception of pain IEA
 biological_processGO:0051280 negative regulation of release of sequestered calcium ion into cytosol IEA
 biological_processGO:0051281 positive regulation of release of sequestered calcium ion into cytosol IEA
 biological_processGO:0051930 regulation of sensory perception of pain IEA
 biological_processGO:0060732 positive regulation of inositol phosphate biosynthetic process IEA
 biological_processGO:0070779 D-aspartate import across plasma membrane IEA
 biological_processGO:0071545 inositol phosphate catabolic process IEA
 biological_processGO:0090238 positive regulation of arachidonic acid secretion IEA
 biological_processGO:0097151 positive regulation of inhibitory postsynaptic potential IEA
 biological_processGO:0098712 L-glutamate import across plasma membrane IEA
 biological_processGO:0098900 regulation of action potential IEA
 biological_processGO:2001259 positive regulation of cation channel activity IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005887 integral component of plasma membrane ISS
 cellular_componentGO:0009898 cytoplasmic side of plasma membrane IEA
 cellular_componentGO:0009986 cell surface IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030424 axon IEA
 cellular_componentGO:0030425 dendrite IEA
 cellular_componentGO:0032280 symmetric synapse IEA
 cellular_componentGO:0043025 neuronal cell body IEA
 cellular_componentGO:0043195 terminal bouton IEA
 cellular_componentGO:0043197 dendritic spine IEA
 cellular_componentGO:0043198 dendritic shaft IEA
 cellular_componentGO:0043204 perikaryon IEA
 cellular_componentGO:0043679 axon terminus IEA
 cellular_componentGO:0044309 neuron spine IEA
 cellular_componentGO:0045121 membrane raft ISO
 cellular_componentGO:0045202 synapse IEA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity IEA
 molecular_functionGO:0008188 neuropeptide receptor activity TAS
 molecular_functionGO:0016492 G-protein coupled neurotensin receptor activity ISO
 molecular_functionGO:0042802 identical protein binding ISO
 molecular_functionGO:0042803 protein homodimerization activity IEA
 molecular_functionGO:0046982 protein heterodimerization activity IEA
 molecular_functionGO:0047485 protein N-terminus binding IEA


Pathways (from Reactome)
Pathway description
Peptide ligand-binding receptors
G alpha (q) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000008 increased white fat amount "increased quantity of fat-storing cells/tissue" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ttc26hop-hpy/Ttc26hop-hpy,Oca2p-s/Oca2p-s
Genetic Background: Not Specified

 MP:0001260 increased body weight "greater than normal average weight " [J:33400]
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Allelic Composition: Ttc26hop-hpy/Ttc26hop-hpy,Oca2p-s/Oca2p-s
Genetic Background: Not Specified

 MP:0001405 impaired coordination "reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Kcnj10tm1Kdmc/Kcnj10tm1Kdmc,Tg(GFAP-cre)1Kdmc/?
Genetic Background: involves: 129S6/SvEvTac * C3H * C57BL/6 * C57BL/6J * SJL

 MP:0001433 polyphagia "eating to excess" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ttc26hop-hpy/Ttc26hop-hpy,Oca2p-s/Oca2p-s
Genetic Background: Not Specified

 MP:0001486 abnormal startle reflex "abberant threshold or reflex response to variable stimuli, often auditory; usually measured by amplitude of whole body flinch" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, What s Wrong With My Mouse?:ISBN 0-471-31639-3]
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Allelic Composition: Trpm5tm1Dgen/Trpm5tm1Dgen
Genetic Background: B6.129P2-Trpm5tm1Dgen

 MP:0001489 decreased startle reflex "greater threshold or less severe reflex response to variable stimuli, often auditory; usually measured by amplitude of whole body flinch" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, What s Wrong With My Mouse?:ISBN 0-471-31639-3]
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Allelic Composition: Trpm5tm1Dgen/Trpm5tm1Dgen
Genetic Background: B6.129P2-Trpm5tm1Dgen

 MP:0001777 abnormal body temperature regulation "anomalous control of the body s heat" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Apba2tm1Tsuz/Apba2tm1Tsuz,Tg(Camk2a-tTA)1Mmay/0,Tg(tetO-APBA2,-lacZ)1Ito/0
Genetic Background: B6.Cg-Apba2tm1Tsuz Tg(Camk2a-tTA)1Mmay Tg(tetO-APBA2,-lacZ)1Ito

 MP:0001905 abnormal dopamine level "greater or less than the normal concentration of this catecholamine neurotransmitter, dervied from tyrosine and the precursor to norepinephrine and epinephrine" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Ccnd1tm1Dsn/Ccnd1tm1Dsn
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0001982 reduced chemically-elicited antinociception "less than the normal analgesic effect of chemical substances" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Kcnj10tm1Kdmc/Kcnj10tm1Kdmc,Tg(GFAP-cre)1Kdmc/?
Genetic Background: involves: 129S6/SvEvTac * C3H * C57BL/6 * C57BL/6J * SJL

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Pck1tm1.1Mgn/Pck1tm1.1Mgn,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S6/SvEvTac

Allelic Composition: Ntsr1tm1Dgen/Ntsr1tm1Dgen
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002574 increased vertical activity "greater than average time spent jumping or rearing " [J:72576, cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator]
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Allelic Composition: Apba2tm1Tsuz/Apba2tm1Tsuz,Tg(Camk2a-tTA)1Mmay/0,Tg(tetO-APBA2,-lacZ)1Ito/0
Genetic Background: B6.Cg-Apba2tm1Tsuz Tg(Camk2a-tTA)1Mmay Tg(tetO-APBA2,-lacZ)1Ito

 MP:0002733 abnormal thermal nociception "abnormal capability to sense pain elicited by thermal stimulation" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Apba2tm1Tsuz/Apba2tm1Tsuz,Tg(Camk2a-tTA)1Mmay/0,Tg(tetO-APBA2,-lacZ)1Ito/0
Genetic Background: B6.Cg-Apba2tm1Tsuz Tg(Camk2a-tTA)1Mmay Tg(tetO-APBA2,-lacZ)1Ito

 MP:0003088 abnormal prepulse inhibition "increase or decrease in the ability of a relatively mild stimulus to suppress the response to a strong, startle-eliciting stimulus" [smb:Susan M. Bello, Mouse Genome Informatics Curator, J:91131]
Show

Allelic Composition: Trpm5tm1Dgen/Trpm5tm1Dgen
Genetic Background: B6.129P2-Trpm5tm1Dgen

 MP:0003290 hypoperistalsis "reduced intestinal movement characterized by waves of alternate circular contraction and relaxation of the muscular walls of the bowel that move bowel contents forward" [ncbi:Matthew Mailman, NCBI request, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Kcnj10tm1Kdmc/Kcnj10tm1Kdmc,Tg(GFAP-cre)1Kdmc/?
Genetic Background: involves: 129S6/SvEvTac * C3H * C57BL/6 * C57BL/6J * SJL

Allelic Composition: Ntsr1tm2Dgen/Ntsr1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0005533 increased body temperature "greater than the level of heat natural to a living being" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
Show

Allelic Composition: Ttc26hop-hpy/Ttc26hop-hpy,Oca2p-s/Oca2p-s
Genetic Background: Not Specified

 MP:0005534 decreased body temperature "less than the level of heat natural to a living being" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Kcnj10tm1Kdmc/Kcnj10tm1Kdmc,Tg(GFAP-cre)1Kdmc/?
Genetic Background: involves: 129S6/SvEvTac * C3H * C57BL/6 * C57BL/6J * SJL

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000019890 Nts / Q9D3P9 / Neurotensin/neuromedin N Large neuromedin N Neuromedin N Neurotensin Tail peptide / P30990* / neurotensin*  / complex / reaction






 

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