ENSG00000101188


Homo sapiens

Features
Gene ID: ENSG00000101188
  
Biological name :NTSR1
  
Synonyms : neurotensin receptor 1 / NTSR1 / P30989
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 20
Strand: 1
Band: q13.33
Gene start: 62708837
Gene end: 62762771
  
Corresponding Affymetrix probe sets: 207360_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000359532
NCBI entrez gene - 4923     See in Manteia.
OMIM - 162651
RefSeq - NM_002531
RefSeq - XM_011528827
RefSeq Peptide - NP_002522
swissprot - P30989
Ensembl - ENSG00000101188
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ntsr1ENSDARG00000077577Danio rerio
 NTSR1ENSGALG00000005524Gallus gallus
 Ntsr1ENSMUSG00000027568Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
NTSR2 / O95665 / neurotensin receptor 2ENSG0000016900635
MLNR / O43193 / motilin receptorENSG0000010253927
GHSR / Q92847 / growth hormone secretagogue receptorENSG0000012185326
NMUR1 / Q9HB89 / neuromedin U receptor 1ENSG0000017159626
NMUR2 / Q9GZQ4 / neuromedin U receptor 2ENSG0000013291124
GPR39 / O43194 / G protein-coupled receptor 39ENSG0000018384024
TRHR / P34981 / thyrotropin releasing hormone receptorENSG0000017441720


Protein motifs (from Interpro)
Interpro ID Name
 IPR000276  G protein-coupled receptor, rhodopsin-like
 IPR003984  Neurotensin receptor
 IPR003985  Neurotensin type 1 receptor
 IPR017452  GPCR, rhodopsin-like, 7TM


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001659 temperature homeostasis IEA
 biological_processGO:0003085 negative regulation of systemic arterial blood pressure IEA
 biological_processGO:0003254 regulation of membrane depolarization IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway TAS
 biological_processGO:0007218 neuropeptide signaling pathway IDA
 biological_processGO:0007268 chemical synaptic transmission TAS
 biological_processGO:0007612 learning IEA
 biological_processGO:0008344 adult locomotory behavior IEA
 biological_processGO:0014049 positive regulation of glutamate secretion IEA
 biological_processGO:0014054 positive regulation of gamma-aminobutyric acid secretion IEA
 biological_processGO:0033993 response to lipid IEA
 biological_processGO:0043065 positive regulation of apoptotic process IEA
 biological_processGO:0043066 negative regulation of apoptotic process IMP
 biological_processGO:0043576 regulation of respiratory gaseous exchange IEA
 biological_processGO:0050965 detection of temperature stimulus involved in sensory perception of pain IEA
 biological_processGO:0051280 negative regulation of release of sequestered calcium ion into cytosol IEA
 biological_processGO:0051281 positive regulation of release of sequestered calcium ion into cytosol IEA
 biological_processGO:0051930 regulation of sensory perception of pain IEA
 biological_processGO:0060732 positive regulation of inositol phosphate biosynthetic process IEA
 biological_processGO:0070779 D-aspartate import across plasma membrane IEA
 biological_processGO:0071545 inositol phosphate catabolic process IEA
 biological_processGO:0090238 positive regulation of arachidonic acid secretion IEA
 biological_processGO:0097151 positive regulation of inhibitory postsynaptic potential IEA
 biological_processGO:0098712 L-glutamate import across plasma membrane IEA
 biological_processGO:0098900 regulation of action potential IEA
 biological_processGO:2001259 positive regulation of cation channel activity IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005887 integral component of plasma membrane TAS
 cellular_componentGO:0009898 cytoplasmic side of plasma membrane IEA
 cellular_componentGO:0009986 cell surface IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030424 axon IEA
 cellular_componentGO:0030425 dendrite IEA
 cellular_componentGO:0032280 symmetric synapse IEA
 cellular_componentGO:0043025 neuronal cell body IEA
 cellular_componentGO:0043195 terminal bouton IEA
 cellular_componentGO:0043197 dendritic spine IEA
 cellular_componentGO:0043198 dendritic shaft IEA
 cellular_componentGO:0043204 perikaryon IEA
 cellular_componentGO:0043679 axon terminus IEA
 cellular_componentGO:0044309 neuron spine IEA
 cellular_componentGO:0045121 membrane raft IEA
 cellular_componentGO:0045202 synapse IEA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016492 G-protein coupled neurotensin receptor activity IMP
 molecular_functionGO:0042802 identical protein binding IPI
 molecular_functionGO:0042803 protein homodimerization activity IEA
 molecular_functionGO:0046982 protein heterodimerization activity IEA
 molecular_functionGO:0047485 protein N-terminus binding IEA


Pathways (from Reactome)
Pathway description
Peptide ligand-binding receptors
G alpha (q) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000133636 NTS / P30990 / neurotensin  / complex / reaction






 

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