ENSMUSG00000038770


Mus musculus

Features
Gene ID: ENSMUSG00000038770
  
Biological name :Kpna7
  
Synonyms : C0LLJ0 / Importin subunit alpha-8 / Kpna7
  
Possible biological names infered from orthology : A9QM74 / karyopherin subunit alpha 7
  
Species: Mus musculus
  
Chr. number: 5
Strand: -1
Band: G2
Gene start: 144983519
Gene end: 145084030
  
Corresponding Affymetrix probe sets: 10535608 (MoGene1.0st)   1437754_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000106301
Ensembl peptide - ENSMUSP00000121515
Ensembl peptide - ENSMUSP00000120277
Ensembl peptide - ENSMUSP00000112155
Ensembl peptide - ENSMUSP00000106300
NCBI entrez gene - 381686     See in Manteia.
MGI - MGI:2141165
RefSeq - XM_017320944
RefSeq - NM_001013774
RefSeq - XM_017320943
RefSeq Peptide - NP_001013796
RefSeq Peptide - NP_001334460
swissprot - D3Z2P7
swissprot - C0LLJ0
swissprot - D3Z0I2
Ensembl - ENSMUSG00000038770
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 kpna7ENSDARG00000027169Danio rerio
 KPNA7ENSGALG00000004665Gallus gallus
 KPNA7ENSG00000185467Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Kpna2 / P52293 / Importin subunit alpha-1 / P52292* / karyopherin subunit alpha 2*ENSMUSG0000001836247
P52293 / Gm10184 / predicted pseudogene 10184 / KPNA2* / P52292* / karyopherin subunit alpha 2*ENSMUSG0000006687847
Kpna4 / O35343 / karyopherin (importin) alpha 4 / O00629* / karyopherin subunit alpha 4*ENSMUSG0000002778239
Kpna3 / O35344 / Importin subunit alpha-4 / O00505* / karyopherin subunit alpha 3*ENSMUSG0000002192938
Kpna6 / O35345 / Importin subunit alpha-7 / O60684* / karyopherin subunit alpha 6*ENSMUSG0000000373136
Kpna1 / Q60960 / Importin subunit alpha-5 / P52294* / karyopherin subunit alpha 1*ENSMUSG0000002290536


Protein motifs (from Interpro)
Interpro ID Name
 IPR000225  Armadillo
 IPR002652  Importin-alpha, importin-beta-binding domain
 IPR011989  Armadillo-like helical
 IPR016024  Armadillo-type fold
 IPR024931  Importin subunit alpha
 IPR032413  Atypical Arm repeat


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006606 protein import into nucleus IEA
 biological_processGO:0006607 NLS-bearing protein import into nucleus IBA
 biological_processGO:0015031 protein transport IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005643 nuclear pore IBA
 cellular_componentGO:0005654 nucleoplasm IBA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IBA
 molecular_functionGO:0005488 binding IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0008139 nuclear localization sequence binding IBA
 molecular_functionGO:0008565 protein transporter activity IBA
 molecular_functionGO:0061608 nuclear import signal receptor activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001923 reduced female fertility "reduced ability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: ApcMin/Apc+,Hltftm1.1Hdin/Hltftm1.1Hdin
Genetic Background: involves: 129 * C57BL/6 * FVB/N

Allelic Composition: Kpna7tm1.1Sgao/Kpna7+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001935 reduced litter size "fewer live born pups in a litter compared to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: ApcMin/Apc+,Hltftm1.1Hdin/Hltftm1.1Hdin
Genetic Background: involves: 129 * C57BL/6 * FVB/N

Allelic Composition: Kpna7tm1.1Sgao/Kpna7+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0003077 abnormal cell cycle "failure to progress or abnormal progression through the stages of of the cell cycle" [smb:Susan M. Bello, Mouse Genome Informatics Curator, J:91266]
Show

Allelic Composition: ApcMin/Apc+,Hltftm1.1Hdin/Hltftm1.1Hdin
Genetic Background: involves: 129 * C57BL/6 * FVB/N

 MP:0011104 partial embryonic lethality before implantation "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and implantation (Mus: E0 to less than E4.5)" [MGI:csmith]
Show

Allelic Composition: ApcMin/Apc+,Hltftm1.1Hdin/Hltftm1.1Hdin
Genetic Background: involves: 129 * C57BL/6 * FVB/N

 MP:0011110 partial preweaning lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
Show

Allelic Composition: ApcMin/Apc+,Hltftm1.1Hdin/Hltftm1.1Hdin
Genetic Background: involves: 129 * C57BL/6 * FVB/N

Allelic Composition: Kpna7tm1.1Sgao/Kpna7+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0020364 abnormal female germ cell physiology "any functional anomaly female germ cells whether they are undifferentiated or fully differentiated" [ORCID: orcid.org/0000-0003-4606-0597]
Show

Allelic Composition: ApcMin/Apc+,Hltftm1.1Hdin/Hltftm1.1Hdin
Genetic Background: involves: 129 * C57BL/6 * FVB/N

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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