ENSMUSG00000039474


Mus musculus
regulationWfs1decreasedproteinincreasedendoplasmicreticulumresponsehomeostasisbehaviorbindingcirculatinglevelglucosecellfactorprocessgrowthpancreaticmembranetranscriptioncalciumionactivityapoptoticinsulin-likeweightimpairedsecretionbetawolframin

Features
Gene ID: ENSMUSG00000039474
  
Biological name :Wfs1
  
Synonyms : P56695 / Wfs1 / wolframin ER transmembrane glycoprotein
  
Possible biological names infered from orthology : O76024
  
Species: Mus musculus
  
Chr. number: 5
Strand: -1
Band: B3
Gene start: 36966104
Gene end: 36989205
  
Corresponding Affymetrix probe sets: 10529605 (MoGene1.0st)   1448411_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000048053
Ensembl peptide - ENSMUSP00000125779
Ensembl peptide - ENSMUSP00000132404
NCBI entrez gene - 22393     See in Manteia.
MGI - MGI:1328355
RefSeq - NM_011716
RefSeq Peptide - NP_035846
swissprot - F7D926
swissprot - P56695
swissprot - Q3TDI2
swissprot - Q3UN10
Ensembl - ENSMUSG00000039474
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 wfs1aENSDARG00000062341Danio rerio
 wfs1bENSDARG00000074617Danio rerio
 WFS1ENSGALG00000015529Gallus gallus
 WFS1ENSG00000109501Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR026208  Wolframin
 IPR026209  Wolframin family


Gene Ontology (GO)
nitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processanatomical structure developmentregulation of biological qualitysystem processresponse to stresscatabolic processresponse to chemicalcellular response to stimuluscell communicationcell deathregulation of molecular functioncell cycleestablishment of localizationnitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processanatomical structure developmentregulation of biological qualitysystem processresponse to stresscatabolic processresponse to chemicalcellular response to stimuluscell communicationcell deathregulation of molecular functioncell cycleestablishment of localizationnitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processanatomical structure developmentregulation of biological qualitysystem processresponse to stresscatabolic processresponse to chemicalcellular response to stimuluscell communicationcell deathregulation of molecular functioncell cycleestablishment of localizationnitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processanatomical structure developmentregulation of biological qualitysystem processresponse to stresscatabolic processresponse to chemicalcellular response to stimuluscell communicationcell deathregulation of molecular functioncell cycleestablishment of localizationnitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processanatomical structure developmentregulation of biological qualitysystem processresponse to stresscatabolic processresponse to chemicalcellular response to stimuluscell communicationcell deathregulation of molecular functioncell cycleestablishment of localizationnitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processanatomical structure developmentregulation of biological qualitysystem processresponse to stresscatabolic processresponse to chemicalcellular response to stimuluscell communicationcell deathregulation of molecular functioncell cycleestablishment of localizationnitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processanatomical structure developmentregulation of biological qualitysystem processresponse to stresscatabolic processresponse to chemicalcellular response to stimuluscell communicationcell deathregulation of molecular functioncell cycleestablishment of localizationnitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processanatomical structure developmentregulation of biological qualitysystem processresponse to stresscatabolic processresponse to chemicalcellular response to stimuluscell communicationcell deathregulation of molecular functioncell cycleestablishment of localizationnitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processanatomical structure developmentregulation of biological qualitysystem processresponse to stresscatabolic processresponse to chemicalcellular response to stimuluscell communicationcell deathregulation of molecular functioncell cycleestablishment of localizationnitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processanatomical structure developmentregulation of biological qualitysystem processresponse to stresscatabolic processresponse to chemicalcellular response to stimuluscell communicationcell deathregulation of molecular functioncell cycleestablishment of localizationnitrogennitrogen compound metabolic processbiosynthbiosynthetic processcellularcellular metabolic processprimary primary metabolic processorganic organic substance metabolic processanatomicanatomical structure developmentregulatiregulation of biological qualitysystem psystem processresponseresponse to stresscatabolicatabolic processresponseresponse to chemicalcellularcellular response to stimuluscell comcell communicationcell deacell deathregulatiregulation of molecular functioncell cyccell cycleestablisestablishment of localization
protein bindingprotein bindingprotein bindingprotein bindingprotein bindingprotein bindingprotein bindingprotein bindingprotein bindingprotein bindingprotein bindingprotein binding
cellprotein-containing complexorganellemembranecellprotein-containing complexorganellemembranecellprotein-containing complexorganellemembranecellprotein-containing complexorganellemembranecellprotein-containing complexorganellemembranecellprotein-containing complexorganellemembranecellprotein-containing complexorganellemembranecellprotein-containing complexorganellemembranecellprotein-containing complexorganellemembranecellprotein-containing complexorganellemembranecellcellprotein-containing complexprotein-containing complexorganelleorganellemembranemembrane
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0001822 kidney development IEA
 biological_processGO:0003091 renal water homeostasis IEA
 biological_processGO:0007601 visual perception IEA
 biological_processGO:0007605 sensory perception of sound IEA
 biological_processGO:0030433 ubiquitin-dependent ERAD pathway IMP
 biological_processGO:0030968 endoplasmic reticulum unfolded protein response IMP
 biological_processGO:0031016 pancreas development IEA
 biological_processGO:0031398 positive regulation of protein ubiquitination IMP
 biological_processGO:0032469 endoplasmic reticulum calcium ion homeostasis IEA
 biological_processGO:0034976 response to endoplasmic reticulum stress IDA
 biological_processGO:0042048 olfactory behavior IEA
 biological_processGO:0042593 glucose homeostasis IEA
 biological_processGO:0043069 negative regulation of programmed cell death IEA
 biological_processGO:0043433 negative regulation of DNA-binding transcription factor activity IEA
 biological_processGO:0043524 negative regulation of neuron apoptotic process IEA
 biological_processGO:0045927 positive regulation of growth IMP
 biological_processGO:0050821 protein stabilization IEA
 biological_processGO:0050877 nervous system process IEA
 biological_processGO:0051247 positive regulation of protein metabolic process IEA
 biological_processGO:0051726 regulation of cell cycle NAS
 biological_processGO:0051928 positive regulation of calcium ion transport IEA
 biological_processGO:0055074 calcium ion homeostasis IEA
 biological_processGO:1902236 negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway IMP
 biological_processGO:1903892 negative regulation of ATF6-mediated unfolded protein response IEA
 biological_processGO:2000675 negative regulation of type B pancreatic cell apoptotic process IMP
 cellular_componentGO:0000502 proteasome complex IEA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005789 endoplasmic reticulum membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030176 integral component of endoplasmic reticulum membrane IEA
 cellular_componentGO:0030425 dendrite ISS
 molecular_functionGO:0005516 calmodulin binding IEA
 molecular_functionGO:0031625 ubiquitin protein ligase binding IEA
 molecular_functionGO:0033613 activating transcription factor binding IEA
 molecular_functionGO:0048306 calcium-dependent protein binding IEA
 molecular_functionGO:0051117 ATPase binding IDA


Pathways (from Reactome)
Pathway description
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Post-translational protein phosphorylation


Phenotype (from MGI, Zfin or HPO)
endocrine/exocrine gland phenotypegrowth/size phenotypebehavior/neurological phenotypehomeostasis/metabolism phenotypedigestive/alimentary phenotypeintegument phenotypemortality/agingendocrine/exocrine gland phenotypegrowth/size phenotypebehavior/neurological phenotypehomeostasis/metabolism phenotypedigestive/alimentary phenotypeintegument phenotypemortality/agingendocrine/exocrine gland phenotypegrowth/size phenotypebehavior/neurological phenotypehomeostasis/metabolism phenotypedigestive/alimentary phenotypeintegument phenotypemortality/agingendocrine/exocrine gland phenotypegrowth/size phenotypebehavior/neurological phenotypehomeostasis/metabolism phenotypedigestive/alimentary phenotypeintegument phenotypemortality/agingendocrine/exocrine gland phenotypegrowth/size phenotypebehavior/neurological phenotypehomeostasis/metabolism phenotypedigestive/alimentary phenotypeintegument phenotypemortality/agingendocrine/exocrine gland phenotypegrowth/size phenotypebehavior/neurological phenotypehomeostasis/metabolism phenotypedigestive/alimentary phenotypeintegument phenotypemortality/agingendocrine/exocrine gland phenotypegrowth/size phenotypebehavior/neurological phenotypehomeostasis/metabolism phenotypedigestive/alimentary phenotypeintegument phenotypemortality/agingendocrine/exocrine gland phenotypegrowth/size phenotypebehavior/neurological phenotypehomeostasis/metabolism phenotypedigestive/alimentary phenotypeintegument phenotypemortality/agingendocrine/exocrine gland phenotypegrowth/size phenotypebehavior/neurological phenotypehomeostasis/metabolism phenotypedigestive/alimentary phenotypeintegument phenotypemortality/agingendocrine/exocrine gland phenotypegrowth/size phenotypebehavior/neurological phenotypehomeostasis/metabolism phenotypedigestive/alimentary phenotypeintegument phenotypemortality/agingendocrine/exocrine gendocrine/exocrine gland phenotypegrowth/size phenotypgrowth/size phenotypebehavior/neurologicabehavior/neurological phenotypehomeostasis/metabolihomeostasis/metabolism phenotypedigestive/alimentarydigestive/alimentary phenotypeintegument phenotypeintegument phenotypemortality/agingmortality/aging
IDPhenotypeDefinition Genetic BG
 MP:0000681 abnormal thyroid gland morphology "anomalous structure of the endocrine gland located in the front and to the sides of the upper part of the trachea and which secretes thyroid hormone and calcitonin" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Gt(ROSA)26Sortm5(ACTB-tTA)Luo/Gt(ROSA)26Sor+,Tg(Col2a1-cre)1Bhr/0,Tg(tetO/CMV-Col2a1*R992C,-GFP)#Afe/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/6J * SJL

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Sim1tm1Jlmd/Sim1tm1Jlmd,Sim2tm1Fan/Sim2tm1Fan
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Wfs1tm1Koks/Wfs1tm1Koks
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: Wfs1tm1Koks/Wfs1+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: Wfs1tm1Koks/Wfs1tm1Koks
Genetic Background: 129S6/SvEvTac-Wfs1tm1Koks

Allelic Composition: Wfs1tm1Koks/Wfs1+
Genetic Background: 129S6/SvEvTac-Wfs1tm1Koks

 MP:0001263 weight loss "progressive reduction of body weight below normal average for age" [J:45400]
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Allelic Composition: Wfs1tm1Koks/Wfs1tm1Koks
Genetic Background: 129S6/SvEvTac-Wfs1tm1Koks

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Gt(ROSA)26Sortm1(PDGFRA*)Hsc/Gt(ROSA)26Sor+,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129/Sv * C57BL/6 * CBA

Allelic Composition: Wfs1tm1Koks/Wfs1tm1Koks
Genetic Background: 129S6/SvEvTac-Wfs1tm1Koks

 MP:0001360 abnormal social investigation "altered behavior of animals to approach and examine other animals" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Atxn10Gt(OST237477)Lex/Atxn10Gt(OST237477)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

 MP:0001363 increased anxiety-related response "when compared to controls, subjects exhibit more responses thought to be indicative of anxiety in behavioral tests" [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator, J:49752, J:53060]
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Allelic Composition: Gt(ROSA)26Sortm1(PDGFRA*)Hsc/Gt(ROSA)26Sor+,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129/Sv * C57BL/6 * CBA

 MP:0001399 hyperactivity "general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125]
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Allelic Composition: Wfs1tm1Koks/Wfs1tm1Koks
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0001402 hypoactivity "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]
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Allelic Composition: Wfs1tm1Koks/Wfs1tm1Koks
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0001417 decreased exploration in new environment "less amount of time spent investigating a new location" [J:79870]
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Allelic Composition: Wfs1tm1Koks/Wfs1tm1Koks
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0001431 abnormal eating behavior "inability to consume or atypical consumption pattern" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:19212]
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Allelic Composition: Gt(ROSA)26Sortm1(PDGFRA*)Hsc/Gt(ROSA)26Sor+,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129/Sv * C57BL/6 * CBA

 MP:0001454 abnormal cued conditioning behavior "defect in the ability of an animal to learn and remember an association between an an aversive experience (the unconditioned stimulus (US), ususally a shock) and a neutral stimulus (the conditioned stimulus (CS), usually an auditory cue or light)" [CFG:Center for Functional Genomics , Northwestern University]
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Allelic Composition: Gt(ROSA)26Sortm1(PDGFRA*)Hsc/Gt(ROSA)26Sor+,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129/Sv * C57BL/6 * CBA

 MP:0001463 abnormal spatial learning "defects in the abilibity to navigate using behavioraly meaningful locations" [CFG:Center for Functional Genomics , Northwestern University]
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Allelic Composition: Gt(ROSA)26Sortm1(PDGFRA*)Hsc/Gt(ROSA)26Sor+,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129/Sv * C57BL/6 * CBA

Allelic Composition: Wfs1tm1Yoka/Wfs1tm1Yoka
Genetic Background: B6J.129-Wfs1tm1Yoka

 MP:0001522 impaired swimming "reduced ability or inability to swim" [J:45446, J:39081]
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Allelic Composition: Wfs1tm1Koks/Wfs1tm1Koks
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0001529 abnormal vocalization "an inability, decreased ability or altered ability to produce sound from the vocal organs; or a general increase or decrease in the production of vocal sound" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator, J:85479]
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Allelic Composition: Gt(ROSA)26Sortm1(PDGFRA*)Hsc/Gt(ROSA)26Sor+,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129/Sv * C57BL/6 * CBA

 MP:0001559 hyperglycemia "abnormally high concentration of glucose in the blood; generally refers to a pathological state" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Sim1tm1Jlmd/Sim1tm1Jlmd,Sim2tm1Fan/Sim2tm1Fan
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Wfs1tm1Koks/Wfs1tm1Koks
Genetic Background: 129S6/SvEvTac-Wfs1tm1Koks

 MP:0001745 increased circulating corticosterone level "greater than the normal concentration of this adrenocortical steroid; induces glycogen deposition and regulates sodium conservation and potassium secretion" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:54931]
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Allelic Composition: Wfs1tm1Koks/Wfs1tm1Koks
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0002062 abnormal conditioning behavior "inability to change the frequency or form of a behavior as a result of the influence of the environment " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Atxn10Gt(OST237477)Lex/Atxn10Gt(OST237477)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

 MP:0002078 abnormal glucose homeostasis "anomaly in the state of equilibrium or processing in the body with respect to glucose in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Sim1tm1Jlmd/Sim1tm1Jlmd,Sim2tm1Fan/Sim2tm1Fan
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002574 increased vertical activity "greater than average time spent jumping or rearing " [J:72576, cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator]
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Allelic Composition: Wfs1tm1Koks/Wfs1tm1Koks
Genetic Background: 129S6/SvEvTac-Wfs1tm1Koks

 MP:0002694 abnormal pancreas secretion "altered ability of the pancreas to release its products" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Fgfr2tm1Dor/Fgfr2tm1.1Dor,Twist2tm1(cre)Dor/Twist2+
Genetic Background: involves: 129X1/SvJ

 MP:0002710 increased glucagon secretion "greater than normal release of this hormone secreted by the alpha cells of the islets of Langerhans; it normally plays a role in regulation of blood glucose concentration, ketone metabolism, and other biochemical and physiological processes " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Fgfr2tm1Dor/Fgfr2tm1.1Dor,Twist2tm1(cre)Dor/Twist2+
Genetic Background: involves: 129X1/SvJ

Allelic Composition: Wfs1tm1Yoka/Wfs1tm1Yoka
Genetic Background: B6.Cg-Wfs1tm1Yoka

 MP:0002727 decreased circulating insulin level "less than normal levels of insulin in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator]
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Allelic Composition: Wfs1tm1Yoka/Wfs1tm1Yoka
Genetic Background: B6.Cg-Wfs1tm1Yoka

Allelic Composition: Wfs1tm1Perm/Wfs1tm1Perm,Tg(Ins2-cre)23Herr/0
Genetic Background: involves: 129X1/SvJ * C57BL/6J * CBA/J

Allelic Composition: Wfs1tm1Koks/Wfs1tm1Koks
Genetic Background: 129S6/SvEvTac-Wfs1tm1Koks

 MP:0002757 reduced vertical activity "lesser than average time spent jumping or rearing" [J:82829, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Wfs1tm1Koks/Wfs1tm1Koks
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0002797 thigmotaxis "preference of a mouse for the side walls of a cage or box; usually an indicator of increased anxiety response" [J:56814]
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Allelic Composition: Wfs1tm1Koks/Wfs1tm1Koks
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0003059 decreased insulin secretion "less than normal release of this hormone secreted by beta cells of the pancreas, that promotes glucose utilization, protein synthesis, and the formation and storage of neutral lipids " [MeSH:National Library of Medicine - Medical Subject Headings, 2003, RGD:Rat Genome Database submission]
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Allelic Composition: Wfs1tm1Perm/Wfs1tm1Perm,Tg(Ins2-cre)23Herr/0
Genetic Background: involves: 129X1/SvJ * C57BL/6J * CBA/J

 MP:0003063 increased coping response "enhanced ability to respond productively to a stressful situation" [RGD:Rat Genome Database submission]
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Allelic Composition: Wfs1tm1Yoka/Wfs1tm1Yoka
Genetic Background: B6J.129-Wfs1tm1Yoka

 MP:0003339 decreased number of pancreatic beta cells "fewer than normal number of the cells of the pancreas that secrete insulin" [ncbi:Matthew Mailman, NCBI request, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Fgfr2tm1Dor/Fgfr2tm1.1Dor,Twist2tm1(cre)Dor/Twist2+
Genetic Background: involves: 129X1/SvJ

Allelic Composition: Wfs1tm1Yoka/Wfs1tm1Yoka
Genetic Background: B6.Cg-Wfs1tm1Yoka

Allelic Composition: Wfs1tm1Perm/Wfs1tm1Perm,Tg(Ins2-cre)23Herr/0
Genetic Background: involves: 129X1/SvJ * C57BL/6J * CBA/J

 MP:0003562 abnormal beta cell physiology "anomaly in the function of the insulin-producing cells of the islets of Langerhans in the pancreas" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Wfs1tm1Perm/Wfs1tm1Perm,Tg(Ins2-cre)23Herr/0
Genetic Background: involves: 129X1/SvJ * C57BL/6J * CBA/J

 MP:0003866 abnormal defecation "anomaly in the production and excretion of feces" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Wfs1tm1Yoka/Wfs1tm1Yoka
Genetic Background: B6J.129-Wfs1tm1Yoka

 MP:0003999 improved passive avoidance behavior "increase in the latency of an animal to enter an hostile environment where it receives a unpleasant or punishing stimuli applied previously" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Wfs1tm1Yoka/Wfs1tm1Yoka
Genetic Background: B6J.129-Wfs1tm1Yoka

 MP:0004270 analgesia "inability to sense pain" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Wfs1tm1Koks/Wfs1tm1Koks
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0004696 abnormal thyroid follicle morphology "any structural abnormality of the small spherical vesicular components of the thyroid gland that are lined with epithelium and contain a colloid substance that both serves as a reservoir of materials for thyroid hormone production and stores thyroid hormones" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Wfs1tm1Koks/Wfs1tm1Koks
Genetic Background: 129S6/SvEvTac-Wfs1tm1Koks

 MP:0004702 increased circulating insulin-like growth factor I level "increased blood concentration of this polypeptide hormone with growth-regulating, insulin-like, and mitogenic activities" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Wfs1tm1Koks/Wfs1tm1Koks
Genetic Background: 129S6/SvEvTac-Wfs1tm1Koks

 MP:0005215 abnormal islet of Langerhans morphology "anomalous morphology of these structures that are scattered throughout the pancreas and comprise its endocrine portion; within each islet there are three cell types: alpha, beta, and delta " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Wfs1tm1Perm/Wfs1tm1Perm,Tg(Ins2-cre)23Herr/0
Genetic Background: involves: 129X1/SvJ * C57BL/6J * CBA/J

 MP:0005289 increased oxygen consumption "greater than the normal rate at which oxygen enters the blood from alveolar gas; this is equal in the steady state to the consumption of oxygen by tissue metabolism throughout the body" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Wfs1tm1Koks/Wfs1tm1Koks
Genetic Background: 129S6/SvEvTac-Wfs1tm1Koks

 MP:0005293 impaired glucose tolerance "less than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin resistance; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Wfs1tm1Yoka/Wfs1tm1Yoka
Genetic Background: B6.Cg-Wfs1tm1Yoka

Allelic Composition: Wfs1tm1Perm/Wfs1tm1Perm,Tg(Ins2-cre)23Herr/0
Genetic Background: involves: 129X1/SvJ * C57BL/6J * CBA/J

Allelic Composition: Wfs1tm1Koks/Wfs1tm1Koks
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: Wfs1tm1Koks/Wfs1+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: Wfs1tm1Koks/Wfs1tm1Koks
Genetic Background: 129S6/SvEvTac-Wfs1tm1Koks

 MP:0005559 increased circulating glucose level "greater than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, RGD:Rat Genome Database submission]
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Allelic Composition: Fgfr2tm1Dor/Fgfr2tm1.1Dor,Twist2tm1(cre)Dor/Twist2+
Genetic Background: involves: 129X1/SvJ

 MP:0005560 decreased circulating glucose level "less than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [RGD:Rat Genome Database submission, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Wfs1tm1Koks/Wfs1tm1Koks
Genetic Background: 129S6/SvEvTac-Wfs1tm1Koks

 MP:0005668 decreased circulating leptin level "less than the normal blood concentration of the peptide hormone secreted by white adipocytes and believed to regulate food intake and energy balance" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, J:34751]
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Allelic Composition: Wfs1tm1Koks/Wfs1tm1Koks
Genetic Background: 129S6/SvEvTac-Wfs1tm1Koks

 MP:0008489 postnatal slow weight gain "the weight gain over a span of postnatal developmental time is slower than controls, with or without ever attaining a similar weight to controls as adults" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Wfs1tm1Koks/Wfs1tm1Koks
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: Wfs1tm1Koks/Wfs1tm1Koks
Genetic Background: 129S6/SvEvTac-Wfs1tm1Koks

 MP:0009114 decreased pancreatic beta cell mass "reduced total physical bulk or volume of a pancreatic beta cell compared to the normal state" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Wfs1tm1Perm/Wfs1tm1Perm,Tg(Ins2-cre)23Herr/0
Genetic Background: involves: 129X1/SvJ * C57BL/6J * CBA/J

 MP:0009254 disorganized pancreatic islets "derangement of the normal pattern of the hormone-producing cells within an islet; normally, the beta cells occupy the central portion of the islet and are surrounded by a corona of alpha and delta cells" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Wfs1tm1Perm/Wfs1tm1Perm,Tg(Ins2-cre)23Herr/0
Genetic Background: involves: 129X1/SvJ * C57BL/6J * CBA/J

 MP:0009642 abnormal blood homeostasis "anomaly in the processes involved in the maintenance of an internal equilibrium of various functions or chemical or protein composition of the blood" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Wfs1tm1Koks/Wfs1tm1Koks
Genetic Background: 129S6/SvEvTac-Wfs1tm1Koks

 MP:0009748 abnormal behavioral response to addictive substance "any anomaly in the behavioral response induced by an addictive substance, such as induced hyperactivity or stereotypic behavior" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Wfs1tm1Koks/Wfs1tm1Koks
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0009750 impaired behavioral response to addictive substance "decreased sensitivity to an addictive substance capable of inducing the appearance of behavioral response, such as induced hyperactivity or stereotypic behavior, or increased dosage threshold for the appearance of the behavioral response" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Wfs1tm1Koks/Wfs1+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0011101 partial prenatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
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Allelic Composition: Wfs1tm1Koks/Wfs1tm1Koks
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0011940 decreased food intake "reduction in the total number of calories/food amount taken in over time when compared to the normal state" [MGI:csmith]
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Allelic Composition: Wfs1tm1Koks/Wfs1tm1Koks
Genetic Background: 129S6/SvEvTac-Wfs1tm1Koks

 MP:0012294 enhanced active avoidance behavior "enhanced ability to escape a hostile environment to actively avoid the unpleasant or punishing stimuli ( e.g. shock) previously encountered in this environment" [MGI:csmith]
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Allelic Composition: Wfs1tm1Yoka/Wfs1tm1Yoka
Genetic Background: B6J.129-Wfs1tm1Yoka

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
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