ENSMUSG00000039883


Mus musculus

Features
Gene ID: ENSMUSG00000039883
  
Biological name :Lrrc17
  
Synonyms : Leucine-rich repeat-containing protein 17 / Lrrc17 / Q9CXD9
  
Possible biological names infered from orthology : leucine rich repeat containing 17 / Q8N6Y2
  
Species: Mus musculus
  
Chr. number: 5
Strand: 1
Band: A3
Gene start: 21543559
Gene end: 21575904
  
Corresponding Affymetrix probe sets: 10519998 (MoGene1.0st)   1429679_at (Mouse Genome 430 2.0 Array)   1454076_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000038569
NCBI entrez gene - 74511     See in Manteia.
MGI - MGI:1921761
RefSeq - NM_028977
RefSeq Peptide - NP_083253
swissprot - Q9CXD9
Ensembl - ENSMUSG00000039883
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 lrrc17ENSDARG00000037960Danio rerio
 LRRC17ENSGALG00000008298Gallus gallus
 LRRC17ENSG00000128606Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Lrrc3 / P59034 / Leucine-rich repeat-containing protein 3 / Q9BY71* / leucine rich repeat containing 3*ENSMUSG0000005165213
Lrrc3b / Q8VCH9 / leucine rich repeat containing 3B / Q96PB8*ENSMUSG0000004520112
Lrrc3c / leucine rich repeat containing 3C / A6NJW4*ENSMUSG0000008654512


Protein motifs (from Interpro)
Interpro ID Name
 IPR000483  Cysteine-rich flanking region, C-terminal
 IPR001611  Leucine-rich repeat
 IPR003591  Leucine-rich repeat, typical subtype
 IPR032675  Leucine-rich repeat domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001503 ossification IEA
 biological_processGO:0045671 negative regulation of osteoclast differentiation IDA
 biological_processGO:0048539 bone marrow development IDA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IEA
 molecular_functionGO:0003674 molecular_function ND
 molecular_functionGO:0005515 protein binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000218 increased WBC count "greater than normal WBC numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Krastm4Tyj/Kras+,Lrrc17tm1Nik/Lrrc17+,Srpk2tm1Nik/Srpk2+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * CBA

Allelic Composition: Lrrc17tm1Nik/Lrrc17+,Nf1tm1Par/Nf1tm1Par,Srpk2tm1Nik/Srpk2+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0001577 anemia "less than normal levels of red blood cells, hemoglobin or volume of packed red blood cells " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
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Allelic Composition: Krastm4Tyj/Kras+,Lrrc17tm1Nik/Lrrc17+,Srpk2tm1Nik/Srpk2+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * CBA

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Msh2tm2.2Rak/Msh2tm2.2Rak
Genetic Background: involves: 129/Sv * C57BL/6 * FVB/N * SJL

Allelic Composition: Lrrc17tm1Nik/Lrrc17+,Nf1tm1Par/Nf1tm1Par,Srpk2tm1Nik/Srpk2+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Msh2tm2.2Rak/Msh2tm2.2Rak
Genetic Background: involves: 129/Sv * C57BL/6 * FVB/N * SJL

 MP:0002429 abnormal blood cell morphology/development "anomalous structure, differentiation, or number of any of the cells found in the blood" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Krastm4Tyj/Kras+,Lrrc17tm1Nik/Lrrc17+,Srpk2tm1Nik/Srpk2+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * CBA

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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