ENSMUSG00000039981


Mus musculus

Features
Gene ID: ENSMUSG00000039981
  
Biological name :Zc3h12d
  
Synonyms : Zc3h12d / zinc finger CCCH type containing 12D
  
Possible biological names infered from orthology : A2A288
  
Species: Mus musculus
  
Chr. number: 10
Strand: 1
Band: A1
Gene start: 7832470
Gene end: 7870396
  
Corresponding Affymetrix probe sets: 10361698 (MoGene1.0st)   1458504_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000040217
NCBI entrez gene - 237256     See in Manteia.
MGI - MGI:3045313
RefSeq - XM_006512724
RefSeq - NM_172785
RefSeq - XM_006512723
RefSeq Peptide - NP_766373
swissprot - E9QNR7
Ensembl - ENSMUSG00000039981
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ZC3H12DENSGALG00000038782Gallus gallus
 A2A288ENSG00000178199Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q5D1E7 / Zc3h12a / zinc finger CCCH type containing 12A / Q5D1E8*ENSMUSG0000004267742
Zc3h12b / zinc finger CCCH-type containing 12B / Q5HYM0*ENSMUSG0000003504540
Q5DTV4 / Zc3h12c / zinc finger CCCH type containing 12C / Q9C0D7*ENSMUSG0000003516440
N4bp1 / Q6A037 / NEDD4-binding protein 1 / O75113*ENSMUSG0000003165223
Nynrin / Q5DTZ0 / Protein NYNRIN / Q9P2P1* / NYN domain and retroviral integrase containing*ENSMUSG0000007559222
Khnyn / Q80U38 / Protein KHNYN / O15037* / KH and NYN domain containing*ENSMUSG0000004715320


Protein motifs (from Interpro)
Interpro ID Name
 IPR000571  Zinc finger, CCCH-type
 IPR021869  Ribonuclease Zc3h12a-like, NYN domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 cellular_componentGO:0000932 P-body IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0036464 cytoplasmic ribonucleoprotein granule IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0004799 increased susceptibility to experimental autoimmune encephalomyelitis "greater likelihood that an organism will develop disease symptoms similar to human multiple sclerosis upon induction with antigens to Myelin Basic Protein (MBP), Proteolipid Protein (PLP), and/or Myelin Oligodendrocyte glycoprotein (MOG)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Stat1tm2.1Uvin/Stat1tm2.1Uvin
Genetic Background: B6.129P2-Stat1tm2.1Uvin

 MP:0005348 increased T cell proliferation "increased clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Stat1tm2.1Uvin/Stat1tm2.1Uvin
Genetic Background: B6.129P2-Stat1tm2.1Uvin

 MP:0008660 increased interleukin-10 secretion "increase in the production or release of a cytokine produced by a variety of cell types, including T-cells, monocytes, dendritic cells and epithelial cells that exerts a variety of effects on immunoregulation and inflammation" [MESH:D12.644.276.374.465.510]
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Allelic Composition: Stat1tm2.1Uvin/Stat1tm2.1Uvin
Genetic Background: B6.129P2-Stat1tm2.1Uvin

 MP:0008705 increased interleukin-6 secretion "increase in the production or release of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506]
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Allelic Composition: Stat1tm2.1Uvin/Stat1tm2.1Uvin
Genetic Background: B6.129P2-Stat1tm2.1Uvin

 MP:0010219 increased T-helper 17 cell number "increased number of CD4-positive, alpha-beta T cells with the phenotype RORgamma-t-positive that produces IL-17" [CL:0000899]
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Allelic Composition: Stat1tm2.1Uvin/Stat1tm2.1Uvin
Genetic Background: B6.129P2-Stat1tm2.1Uvin

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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