ENSMUSG00000042677


Mus musculus

Features
Gene ID: ENSMUSG00000042677
  
Biological name :Zc3h12a
  
Synonyms : Q5D1E7 / Zc3h12a / zinc finger CCCH type containing 12A
  
Possible biological names infered from orthology : Q5D1E8
  
Species: Mus musculus
  
Chr. number: 4
Strand: -1
Band: D2.2
Gene start: 125118423
Gene end: 125127840
  
Corresponding Affymetrix probe sets: 10516266 (MoGene1.0st)   1427348_at (Mouse Genome 430 2.0 Array)   1443993_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000037172
NCBI entrez gene - 230738     See in Manteia.
MGI - MGI:2385891
RefSeq - NM_153159
RefSeq Peptide - NP_694799
swissprot - Q5D1E7
Ensembl - ENSMUSG00000042677
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 si:dkey-206d17.12ENSDARG00000101034Danio rerio
 zc3h12aENSDARG00000005271Danio rerio
 ZC3H12AENSGALG00000002021Gallus gallus
 Q5D1E8ENSG00000163874Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q5DTV4 / Zc3h12c / zinc finger CCCH type containing 12C / Q9C0D7*ENSMUSG0000003516447
Zc3h12b / zinc finger CCCH-type containing 12B / Q5HYM0*ENSMUSG0000003504545
Zc3h12d / zinc finger CCCH type containing 12D / A2A288*ENSMUSG0000003998138
N4bp1 / Q6A037 / NEDD4-binding protein 1 / O75113*ENSMUSG0000003165221
Nynrin / Q5DTZ0 / Protein NYNRIN / Q9P2P1* / NYN domain and retroviral integrase containing*ENSMUSG0000007559221
Khnyn / Q80U38 / Protein KHNYN / O15037* / KH and NYN domain containing*ENSMUSG0000004715320


Protein motifs (from Interpro)
Interpro ID Name
 IPR021869  Ribonuclease Zc3h12a-like, NYN domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000294 nuclear-transcribed mRNA catabolic process, endonucleolytic cleavage-dependent decay IDA
 biological_processGO:0001525 angiogenesis IEA
 biological_processGO:0001933 negative regulation of protein phosphorylation IDA
 biological_processGO:0002230 positive regulation of defense response to virus by host IEA
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0002757 immune response-activating signal transduction IEA
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0006954 inflammatory response IEA
 biological_processGO:0006974 cellular response to DNA damage stimulus ISO
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007399 nervous system development IEA
 biological_processGO:0010468 regulation of gene expression IEA
 biological_processGO:0010508 positive regulation of autophagy IMP
 biological_processGO:0010595 positive regulation of endothelial cell migration IEA
 biological_processGO:0010628 positive regulation of gene expression IEA
 biological_processGO:0010629 negative regulation of gene expression IEA
 biological_processGO:0010656 negative regulation of muscle cell apoptotic process IDA
 biological_processGO:0010884 positive regulation of lipid storage IMP
 biological_processGO:0010942 positive regulation of cell death IEA
 biological_processGO:0016579 protein deubiquitination IEA
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0032088 negative regulation of NF-kappaB transcription factor activity IEA
 biological_processGO:0032715 negative regulation of interleukin-6 production IEA
 biological_processGO:0032720 negative regulation of tumor necrosis factor production IEA
 biological_processGO:0034599 cellular response to oxidative stress IDA
 biological_processGO:0042149 cellular response to glucose starvation IDA
 biological_processGO:0042307 positive regulation of protein import into nucleus IEA
 biological_processGO:0043124 negative regulation of I-kappaB kinase/NF-kappaB signaling IEA
 biological_processGO:0044828 negative regulation by host of viral genome replication IEA
 biological_processGO:0045019 negative regulation of nitric oxide biosynthetic process ISS
 biological_processGO:0045600 positive regulation of fat cell differentiation IEA
 biological_processGO:0045766 positive regulation of angiogenesis IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0050713 negative regulation of interleukin-1 beta secretion IDA
 biological_processGO:0050852 T cell receptor signaling pathway IDA
 biological_processGO:0051259 protein complex oligomerization IEA
 biological_processGO:0055118 negative regulation of cardiac muscle contraction IDA
 biological_processGO:0061014 positive regulation of mRNA catabolic process IEA
 biological_processGO:0061158 3"-UTR-mediated mRNA destabilization IEA
 biological_processGO:0071222 cellular response to lipopolysaccharide IEA
 biological_processGO:0071347 cellular response to interleukin-1 IDA
 biological_processGO:0071356 cellular response to tumor necrosis factor IEA
 biological_processGO:0090501 RNA phosphodiester bond hydrolysis IDA
 biological_processGO:0090502 RNA phosphodiester bond hydrolysis, endonucleolytic IEA
 biological_processGO:0090503 RNA phosphodiester bond hydrolysis, exonucleolytic IEA
 biological_processGO:0098586 cellular response to virus IEA
 biological_processGO:1900016 negative regulation of cytokine production involved in inflammatory response IDA
 biological_processGO:1900119 positive regulation of execution phase of apoptosis IDA
 biological_processGO:1900165 negative regulation of interleukin-6 secretion IDA
 biological_processGO:1900745 positive regulation of p38MAPK cascade IEA
 biological_processGO:1902714 negative regulation of interferon-gamma secretion IDA
 biological_processGO:1903003 positive regulation of protein deubiquitination IEA
 biological_processGO:1903799 negative regulation of production of miRNAs involved in gene silencing by miRNA IEA
 biological_processGO:1903936 cellular response to sodium arsenite IDA
 biological_processGO:1904468 negative regulation of tumor necrosis factor secretion IDA
 biological_processGO:1904628 cellular response to phorbol 13-acetate 12-myristate ISO
 biological_processGO:1904637 cellular response to ionomycin IDA
 biological_processGO:1990869 cellular response to chemokine IEA
 biological_processGO:2000379 positive regulation of reactive oxygen species metabolic process IEA
 biological_processGO:2000627 positive regulation of miRNA catabolic process IEA
 cellular_componentGO:0000932 P-body ISO
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005791 rough endoplasmic reticulum IDA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030867 rough endoplasmic reticulum membrane IEA
 cellular_componentGO:0032991 protein-containing complex IEA
 cellular_componentGO:0036464 cytoplasmic ribonucleoprotein granule IEA
 cellular_componentGO:0042406 extrinsic component of endoplasmic reticulum membrane IDA
 molecular_functionGO:0003677 DNA binding ISO
 molecular_functionGO:0003682 chromatin binding IEA
 molecular_functionGO:0003723 RNA binding ISO
 molecular_functionGO:0003729 mRNA binding IEA
 molecular_functionGO:0003730 mRNA 3"-UTR binding IDA
 molecular_functionGO:0004518 nuclease activity IEA
 molecular_functionGO:0004519 endonuclease activity IEA
 molecular_functionGO:0004521 endoribonuclease activity IDA
 molecular_functionGO:0004532 exoribonuclease activity IDA
 molecular_functionGO:0004540 ribonuclease activity IEA
 molecular_functionGO:0004843 thiol-dependent ubiquitin-specific protease activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0035198 miRNA binding IEA
 molecular_functionGO:0035613 RNA stem-loop binding IDA
 molecular_functionGO:0035925 mRNA 3"-UTR AU-rich region binding IDA
 molecular_functionGO:0043022 ribosome binding IDA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000208 decreased hematocrit "less than the average percentage of a volume of a blood sample occupied by red blood cells" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Vpreb1tm1Ilm/Vpreb1tm1Ilm
Genetic Background: B6.129P2-Vpreb1tm1Ilm

 MP:0000218 increased WBC count "greater than normal WBC numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Vpreb1tm1Ilm/Vpreb1tm1Ilm
Genetic Background: B6.129P2-Vpreb1tm1Ilm

 MP:0000691 enlarged spleen "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Vpreb1tm1Ilm/Vpreb1tm1Ilm
Genetic Background: B6.129P2-Vpreb1tm1Ilm

Allelic Composition: Zc3h12atm1Fum/Zc3h12atm1Fum
Genetic Background: C57BL/6-Zc3h12atm1Fum

 MP:0000702 enlarged lymph nodes "lymph nodes of increased size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Vpreb1tm1Ilm/Vpreb1tm1Ilm
Genetic Background: B6.129P2-Vpreb1tm1Ilm

Allelic Composition: Zc3h12atm1Fum/Zc3h12atm1Fum
Genetic Background: C57BL/6-Zc3h12atm1Fum

 MP:0001577 anemia "less than normal levels of red blood cells, hemoglobin or volume of packed red blood cells " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
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Allelic Composition: Vpreb1tm1Ilm/Vpreb1tm1Ilm
Genetic Background: B6.129P2-Vpreb1tm1Ilm

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Vpreb1tm1Ilm/Vpreb1tm1Ilm
Genetic Background: B6.129P2-Vpreb1tm1Ilm

Allelic Composition: Zc3h12atm1Fum/Zc3h12atm1Fum
Genetic Background: C57BL/6-Zc3h12atm1Fum

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Vpreb1tm1Ilm/Vpreb1tm1Ilm
Genetic Background: B6.129P2-Vpreb1tm1Ilm

Allelic Composition: Zc3h12atm1Fum/Zc3h12atm1Fum
Genetic Background: C57BL/6-Zc3h12atm1Fum

 MP:0002416 abnormal proerythroblast morphology/development "anomalous structure, formation, or numbers of the immature, nucleated erythrocyte precursors that give rise to reticulocytes " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Vpreb1tm1Ilm/Vpreb1tm1Ilm
Genetic Background: B6.129P2-Vpreb1tm1Ilm

 MP:0002461 increased circulating immunoglobulin concentration "greater than normal immunoglobulin level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Vpreb1tm1Ilm/Vpreb1tm1Ilm
Genetic Background: B6.129P2-Vpreb1tm1Ilm

 MP:0002494 increased IgM "greater than normal immunoglobulin class M level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Vpreb1tm1Ilm/Vpreb1tm1Ilm
Genetic Background: B6.129P2-Vpreb1tm1Ilm

 MP:0002495 increased IgA "greater than normal immunoglobulin class A level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Vpreb1tm1Ilm/Vpreb1tm1Ilm
Genetic Background: B6.129P2-Vpreb1tm1Ilm

 MP:0002498 abnormal acute inflammation "aberrant early and often transient reaction of the microcirculation, characterized by movement of fluid and leukocytes from the blood into extravascular tissues; initiated by injury, infection, or local immune response " [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, Pathology:ISBN 0-397-51047-0]
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Allelic Composition: Vpreb1tm1Ilm/Vpreb1tm1Ilm
Genetic Background: B6.129P2-Vpreb1tm1Ilm

 MP:0002500 granulomatous inflammation "chronic inflammation resulting from the failure of the acute inflammatory response and persistance of the injurious agent; characterized by a central area of marcophages, often fused into giant cells, and surrounded by T cells " [Pathology:ISBN 0-397-51047-0, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Vpreb1tm1Ilm/Vpreb1tm1Ilm
Genetic Background: B6.129P2-Vpreb1tm1Ilm

 MP:0002874 decreased hemoglobin content "decrease in the total hemoglobin content in the circulating blood" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Vpreb1tm1Ilm/Vpreb1tm1Ilm
Genetic Background: B6.129P2-Vpreb1tm1Ilm

 MP:0004762 increased anti-double stranded DNA antibody level "increase in the level of antibodies that recognize double stranded DNA" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Vpreb1tm1Ilm/Vpreb1tm1Ilm
Genetic Background: B6.129P2-Vpreb1tm1Ilm

 MP:0004794 increased anti-nuclear antigen antibody level "elevated level of antibodies to nuclear antigens present in the sera" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Vpreb1tm1Ilm/Vpreb1tm1Ilm
Genetic Background: B6.129P2-Vpreb1tm1Ilm

 MP:0004816 abnormal class switch recombination "anomaly in the rearrangement of the heavy chain genes of differentiating B cells such that the initially encoded heavy chain IgM molecule is altered to one encoding IgG, IgA or IgE; normally, this allows the body to produce antibodies with different effector functions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Vpreb1tm1Ilm/Vpreb1tm1Ilm
Genetic Background: B6.129P2-Vpreb1tm1Ilm

 MP:0005505 increased platelet count "greater than the normal numbers of the non-nucleated cells found in the blood and involved in blood coagulation " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Vpreb1tm1Ilm/Vpreb1tm1Ilm
Genetic Background: B6.129P2-Vpreb1tm1Ilm

 MP:0005621 abnormal cell physiology "aberration in the vital processes of the cell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator]
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Allelic Composition: Vpreb1tm1Ilm/Vpreb1tm1Ilm
Genetic Background: B6.129P2-Vpreb1tm1Ilm

 MP:0008049 increased memory T cell number "greater number of the set of long-lived T cells differentiated from T cells activated by a specific antigen encountered during a past immune response" [adiehl:Alex Diehl_MGI GO curator, Biology-Online.org:http://www.biology-online.org/, MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Vpreb1tm1Ilm/Vpreb1tm1Ilm
Genetic Background: B6.129P2-Vpreb1tm1Ilm

 MP:0008097 increased plasma cell number "greater number of terminally differentiated, post-mitotic, short-lived cells of the B cell lineage devoted to producing large amounts of immunoglobulin" [CL:0000786, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Vpreb1tm1Ilm/Vpreb1tm1Ilm
Genetic Background: B6.129P2-Vpreb1tm1Ilm

 MP:0008499 increased IgG1 level "greater than normal immunoglobulin class G1 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Vpreb1tm1Ilm/Vpreb1tm1Ilm
Genetic Background: B6.129P2-Vpreb1tm1Ilm

 MP:0008500 increased IgG2a level "greater than normal immunoglobulin class G2a level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Vpreb1tm1Ilm/Vpreb1tm1Ilm
Genetic Background: B6.129P2-Vpreb1tm1Ilm

 MP:0008501 increased IgG2b level "greater than normal immunoglobulin class G2b level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Vpreb1tm1Ilm/Vpreb1tm1Ilm
Genetic Background: B6.129P2-Vpreb1tm1Ilm

 MP:0008502 increased IgG3 level "greater than normal immunoglobulin class G3 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Vpreb1tm1Ilm/Vpreb1tm1Ilm
Genetic Background: B6.129P2-Vpreb1tm1Ilm

 MP:0008553 increased circulating tumor necrosis factor level "greater amount in the blood of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]
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Allelic Composition: Zc3h12atm1Fum/Zc3h12atm1Fum
Genetic Background: C57BL/6-Zc3h12atm1Fum

 MP:0008560 increased tumor necrosis factor secretion "increase in the production or release of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]
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Allelic Composition: Zc3h12atm1Fum/Zc3h12atm1Fum
Genetic Background: C57BL/6-Zc3h12atm1Fum

 MP:0008566 increased interferon-gamma secretion "increase in the production or release of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
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Allelic Composition: Vpreb1tm1Ilm/Vpreb1tm1Ilm
Genetic Background: B6.129P2-Vpreb1tm1Ilm

 MP:0008657 increased interleukin-1 beta secretion "increase in the production or release of an interleukin-1 subtype that is synthesized as an inactive membrane-bound pro-protein on monocytes, macrophages and other cells; proteolytic processing of the precursor form by caspase 1 results in release of the active form of interleukin-1beta from the membrane" [MESH:D12.644.276.374.465.501.600]
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Allelic Composition: Zc3h12atm1Fum/Zc3h12atm1Fum
Genetic Background: C57BL/6-Zc3h12atm1Fum

 MP:0008669 increased interleukin-12b secretion "increase in the production or release of the p40 cytokine subunit that is a component of both interleukin-12 and interleukin-23" [MESH:D12.644.276.374.465.512.500]
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Allelic Composition: Vpreb1tm1Ilm/Vpreb1tm1Ilm
Genetic Background: B6.129P2-Vpreb1tm1Ilm

 MP:0008705 increased interleukin-6 secretion "increase in the production or release of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506]
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Allelic Composition: Vpreb1tm1Ilm/Vpreb1tm1Ilm
Genetic Background: B6.129P2-Vpreb1tm1Ilm

Allelic Composition: Zc3h12atm1Fum/Zc3h12atm1Fum
Genetic Background: C57BL/6-Zc3h12atm1Fum

 MP:0008722 abnormal chemokine secretion "anomaly in the production or cellular release of any of the class of pro-inflammatory cytokines that attract and activate leukocytes" [MESH:D12.644.276.374.200]
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Allelic Composition: Zc3h12atm1Fum/Zc3h12atm1Fum
Genetic Background: C57BL/6-Zc3h12atm1Fum

 MP:0010209 abnormal circulating chemokine level "deviation from the normal levels of any of the class of pro-inflammatory cytokines that attract and activate leukocytes in the circulation" [MESH:D12.644.276.374.200, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Zc3h12atm1Fum/Zc3h12atm1Fum
Genetic Background: C57BL/6-Zc3h12atm1Fum

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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