MP:0000208 | decreased hematocrit | "less than the average percentage of a volume of a blood sample occupied by red blood cells" [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Vpreb1tm1Ilm/Vpreb1tm1Ilm Genetic Background: B6.129P2-Vpreb1tm1Ilm
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MP:0000218 | increased WBC count | "greater than normal WBC numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Vpreb1tm1Ilm/Vpreb1tm1Ilm Genetic Background: B6.129P2-Vpreb1tm1Ilm
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MP:0000691 | enlarged spleen | "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Vpreb1tm1Ilm/Vpreb1tm1Ilm Genetic Background: B6.129P2-Vpreb1tm1Ilm
Allelic Composition: Zc3h12atm1Fum/Zc3h12atm1Fum Genetic Background: C57BL/6-Zc3h12atm1Fum
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MP:0000702 | enlarged lymph nodes | "lymph nodes of increased size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Vpreb1tm1Ilm/Vpreb1tm1Ilm Genetic Background: B6.129P2-Vpreb1tm1Ilm
Allelic Composition: Zc3h12atm1Fum/Zc3h12atm1Fum Genetic Background: C57BL/6-Zc3h12atm1Fum
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MP:0001577 | anemia | "less than normal levels of red blood cells, hemoglobin or volume of packed red blood cells " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370] |
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Allelic Composition: Vpreb1tm1Ilm/Vpreb1tm1Ilm Genetic Background: B6.129P2-Vpreb1tm1Ilm
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MP:0001732 | postnatal growth retardation | "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Vpreb1tm1Ilm/Vpreb1tm1Ilm Genetic Background: B6.129P2-Vpreb1tm1Ilm
Allelic Composition: Zc3h12atm1Fum/Zc3h12atm1Fum Genetic Background: C57BL/6-Zc3h12atm1Fum
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MP:0002083 | premature death | "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Vpreb1tm1Ilm/Vpreb1tm1Ilm Genetic Background: B6.129P2-Vpreb1tm1Ilm
Allelic Composition: Zc3h12atm1Fum/Zc3h12atm1Fum Genetic Background: C57BL/6-Zc3h12atm1Fum
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MP:0002416 | abnormal proerythroblast morphology/development | "anomalous structure, formation, or numbers of the immature, nucleated erythrocyte precursors that give rise to reticulocytes " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Vpreb1tm1Ilm/Vpreb1tm1Ilm Genetic Background: B6.129P2-Vpreb1tm1Ilm
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MP:0002461 | increased circulating immunoglobulin concentration | "greater than normal immunoglobulin level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Vpreb1tm1Ilm/Vpreb1tm1Ilm Genetic Background: B6.129P2-Vpreb1tm1Ilm
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MP:0002494 | increased IgM | "greater than normal immunoglobulin class M level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Vpreb1tm1Ilm/Vpreb1tm1Ilm Genetic Background: B6.129P2-Vpreb1tm1Ilm
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MP:0002495 | increased IgA | "greater than normal immunoglobulin class A level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Vpreb1tm1Ilm/Vpreb1tm1Ilm Genetic Background: B6.129P2-Vpreb1tm1Ilm
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MP:0002498 | abnormal acute inflammation | "aberrant early and often transient reaction of the microcirculation, characterized by movement of fluid and leukocytes from the blood into extravascular tissues; initiated by injury, infection, or local immune response " [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, Pathology:ISBN 0-397-51047-0] |
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Allelic Composition: Vpreb1tm1Ilm/Vpreb1tm1Ilm Genetic Background: B6.129P2-Vpreb1tm1Ilm
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MP:0002500 | granulomatous inflammation | "chronic inflammation resulting from the failure of the acute inflammatory response and persistance of the injurious agent; characterized by a central area of marcophages, often fused into giant cells, and surrounded by T cells " [Pathology:ISBN 0-397-51047-0, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7] |
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Allelic Composition: Vpreb1tm1Ilm/Vpreb1tm1Ilm Genetic Background: B6.129P2-Vpreb1tm1Ilm
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MP:0002874 | decreased hemoglobin content | "decrease in the total hemoglobin content in the circulating blood" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Vpreb1tm1Ilm/Vpreb1tm1Ilm Genetic Background: B6.129P2-Vpreb1tm1Ilm
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MP:0004762 | increased anti-double stranded DNA antibody level | "increase in the level of antibodies that recognize double stranded DNA" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Vpreb1tm1Ilm/Vpreb1tm1Ilm Genetic Background: B6.129P2-Vpreb1tm1Ilm
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MP:0004794 | increased anti-nuclear antigen antibody level | "elevated level of antibodies to nuclear antigens present in the sera" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Vpreb1tm1Ilm/Vpreb1tm1Ilm Genetic Background: B6.129P2-Vpreb1tm1Ilm
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MP:0004816 | abnormal class switch recombination | "anomaly in the rearrangement of the heavy chain genes of differentiating B cells such that the initially encoded heavy chain IgM molecule is altered to one encoding IgG, IgA or IgE; normally, this allows the body to produce antibodies with different effector functions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Vpreb1tm1Ilm/Vpreb1tm1Ilm Genetic Background: B6.129P2-Vpreb1tm1Ilm
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MP:0005505 | increased platelet count | "greater than the normal numbers of the non-nucleated cells found in the blood and involved in blood coagulation " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Vpreb1tm1Ilm/Vpreb1tm1Ilm Genetic Background: B6.129P2-Vpreb1tm1Ilm
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MP:0005621 | abnormal cell physiology | "aberration in the vital processes of the cell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator] |
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Allelic Composition: Vpreb1tm1Ilm/Vpreb1tm1Ilm Genetic Background: B6.129P2-Vpreb1tm1Ilm
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MP:0008049 | increased memory T cell number | "greater number of the set of long-lived T cells differentiated from T cells activated by a specific antigen encountered during a past immune response" [adiehl:Alex Diehl_MGI GO curator, Biology-Online.org:http://www.biology-online.org/, MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"] |
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Allelic Composition: Vpreb1tm1Ilm/Vpreb1tm1Ilm Genetic Background: B6.129P2-Vpreb1tm1Ilm
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MP:0008097 | increased plasma cell number | "greater number of terminally differentiated, post-mitotic, short-lived cells of the B cell lineage devoted to producing large amounts of immunoglobulin" [CL:0000786, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Vpreb1tm1Ilm/Vpreb1tm1Ilm Genetic Background: B6.129P2-Vpreb1tm1Ilm
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MP:0008499 | increased IgG1 level | "greater than normal immunoglobulin class G1 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"] |
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Allelic Composition: Vpreb1tm1Ilm/Vpreb1tm1Ilm Genetic Background: B6.129P2-Vpreb1tm1Ilm
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MP:0008500 | increased IgG2a level | "greater than normal immunoglobulin class G2a level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"] |
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Allelic Composition: Vpreb1tm1Ilm/Vpreb1tm1Ilm Genetic Background: B6.129P2-Vpreb1tm1Ilm
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MP:0008501 | increased IgG2b level | "greater than normal immunoglobulin class G2b level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"] |
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Allelic Composition: Vpreb1tm1Ilm/Vpreb1tm1Ilm Genetic Background: B6.129P2-Vpreb1tm1Ilm
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MP:0008502 | increased IgG3 level | "greater than normal immunoglobulin class G3 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"] |
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Allelic Composition: Vpreb1tm1Ilm/Vpreb1tm1Ilm Genetic Background: B6.129P2-Vpreb1tm1Ilm
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MP:0008553 | increased circulating tumor necrosis factor level | "greater amount in the blood of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800] |
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Allelic Composition: Zc3h12atm1Fum/Zc3h12atm1Fum Genetic Background: C57BL/6-Zc3h12atm1Fum
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MP:0008560 | increased tumor necrosis factor secretion | "increase in the production or release of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800] |
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Allelic Composition: Zc3h12atm1Fum/Zc3h12atm1Fum Genetic Background: C57BL/6-Zc3h12atm1Fum
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MP:0008566 | increased interferon-gamma secretion | "increase in the production or release of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893] |
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Allelic Composition: Vpreb1tm1Ilm/Vpreb1tm1Ilm Genetic Background: B6.129P2-Vpreb1tm1Ilm
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MP:0008657 | increased interleukin-1 beta secretion | "increase in the production or release of an interleukin-1 subtype that is synthesized as an inactive membrane-bound pro-protein on monocytes, macrophages and other cells; proteolytic processing of the precursor form by caspase 1 results in release of the active form of interleukin-1beta from the membrane" [MESH:D12.644.276.374.465.501.600] |
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Allelic Composition: Zc3h12atm1Fum/Zc3h12atm1Fum Genetic Background: C57BL/6-Zc3h12atm1Fum
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MP:0008669 | increased interleukin-12b secretion | "increase in the production or release of the p40 cytokine subunit that is a component of both interleukin-12 and interleukin-23" [MESH:D12.644.276.374.465.512.500] |
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Allelic Composition: Vpreb1tm1Ilm/Vpreb1tm1Ilm Genetic Background: B6.129P2-Vpreb1tm1Ilm
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MP:0008705 | increased interleukin-6 secretion | "increase in the production or release of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506] |
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Allelic Composition: Vpreb1tm1Ilm/Vpreb1tm1Ilm Genetic Background: B6.129P2-Vpreb1tm1Ilm
Allelic Composition: Zc3h12atm1Fum/Zc3h12atm1Fum Genetic Background: C57BL/6-Zc3h12atm1Fum
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MP:0008722 | abnormal chemokine secretion | "anomaly in the production or cellular release of any of the class of pro-inflammatory cytokines that attract and activate leukocytes" [MESH:D12.644.276.374.200] |
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Allelic Composition: Zc3h12atm1Fum/Zc3h12atm1Fum Genetic Background: C57BL/6-Zc3h12atm1Fum
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MP:0010209 | abnormal circulating chemokine level | "deviation from the normal levels of any of the class of pro-inflammatory cytokines that attract and activate leukocytes in the circulation" [MESH:D12.644.276.374.200, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Zc3h12atm1Fum/Zc3h12atm1Fum Genetic Background: C57BL/6-Zc3h12atm1Fum
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