ENSMUSG00000040026


Mus musculus

Features
Gene ID: ENSMUSG00000040026
  
Biological name :Saa3
  
Synonyms : P04918 / Saa3 / Serum amyloid A-3 protein
  
Possible biological names infered from orthology :
  
Species: Mus musculus
  
Chr. number: 7
Strand: -1
Band: B3
Gene start: 46711998
Gene end: 46715700
  
Corresponding Affymetrix probe sets: 10563597 (MoGene1.0st)   1450826_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000148151
Ensembl peptide - ENSMUSP00000006956
NCBI entrez gene - 20210     See in Manteia.
MGI - MGI:98223
RefSeq - NM_011315
RefSeq Peptide - NP_035445
swissprot - A0A1B0GT10
swissprot - P04918
Ensembl - ENSMUSG00000040026
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 saaENSDARG00000045999Danio rerio
 ENSGALG00000027716Gallus gallus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Saa1 / P05366 / serum amyloid A 1ENSMUSG0000007411564
Saa2 / P05367 / Mus musculus serum amyloid A 2 (Saa2), transcript variant 2, mRNA.ENSMUSG0000005746561
Saa4 / P31532 / Serum amyloid A-4 protein / P35542* / serum amyloid A4, constitutive*ENSMUSG0000004001754


Protein motifs (from Interpro)
Interpro ID Name
 IPR000096  Serum amyloid A protein


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006953 acute-phase response IEA
 biological_processGO:0007252 I-kappaB phosphorylation IDA
 biological_processGO:0035634 response to stilbenoid IEP
 biological_processGO:0050918 positive chemotaxis IEA
 biological_processGO:0060326 cell chemotaxis IDA
 biological_processGO:0071347 cellular response to interleukin-1 IDA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IDA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0034364 high-density lipoprotein particle IEA
 molecular_functionGO:0035662 Toll-like receptor 4 binding IPI
 molecular_functionGO:0042056 chemoattractant activity IDA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000183 decreased circulating LDL cholesterol level "less than average concentration in the blood of low density lipoprotein, which normally transports cholesterol to tissues other than the liver" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Nt5c2tm1.1Aafo/Nt5c2+,Gt(ROSA)26Sortm1(cre/ERT2)Thl/Gt(ROSA)26Sor+
Genetic Background: involves: 129 * C57BL/6 * SJL

Allelic Composition: Saa3tm1(KOMP)Vlcg/Saa3+
Genetic Background: involves: C57BL/6NTac

 MP:0002644 decreased circulating triglyceride level "lower than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Nt5c2tm1.1Aafo/Nt5c2+,Gt(ROSA)26Sortm1(cre/ERT2)Thl/Gt(ROSA)26Sor+
Genetic Background: involves: 129 * C57BL/6 * SJL

 MP:0003402 decreased liver weight "reduced average weight of the bile-secreting exocrine gland" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Nt5c2tm1.1Aafo/Nt5c2+,Gt(ROSA)26Sortm1(cre/ERT2)Thl/Gt(ROSA)26Sor+
Genetic Background: involves: 129 * C57BL/6 * SJL

 MP:0005179 decreased total circulating cholesterol level "less than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Nt5c2tm1.1Aafo/Nt5c2+,Gt(ROSA)26Sortm1(cre/ERT2)Thl/Gt(ROSA)26Sor+
Genetic Background: involves: 129 * C57BL/6 * SJL

 MP:0005659 resistance to diet-induced obesity "less likely to become excessively fat or to increase fat in the subcutaneous connective tissue as a result of consuming a diet geared to increase body fat " [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator]
Show

Allelic Composition: Nt5c2tm1.1Aafo/Nt5c2+,Gt(ROSA)26Sortm1(cre/ERT2)Thl/Gt(ROSA)26Sor+
Genetic Background: involves: 129 * C57BL/6 * SJL

 MP:0009118 increased white fat cell size "increase in the size of fat cells with light coloration and few mitochondria" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Nt5c2tm1.1Aafo/Nt5c2+,Gt(ROSA)26Sortm1(cre/ERT2)Thl/Gt(ROSA)26Sor+
Genetic Background: involves: 129 * C57BL/6 * SJL

 MP:0010214 abnormal circulating serum amyloid protein level "deviation from the normal blood levels of an acute-phase reaction protein that is a precursor to amyloid A protein; it is present in very high levels during acute inflammatory episodes, and is present in low concentrations in normal sera, but is found at higher concentrations in sera of older persons and in patients with amyloidosis" [MESH:D12.776.049.790, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Nt5c2tm1.1Aafo/Nt5c2+,Gt(ROSA)26Sortm1(cre/ERT2)Thl/Gt(ROSA)26Sor+
Genetic Background: involves: 129 * C57BL/6 * SJL

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
Show

Allelic Composition: F8tm2Kaz/Y
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Saa3l7R3-2R/Saa3l7R3-2R
Genetic Background: involves: BJR

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2025
contact: otassy@igbmc.fr