ENSMUSG00000040820


Mus musculus

Features
Gene ID: ENSMUSG00000040820
  
Biological name :Hlcs
  
Synonyms : Hlcs / holocarboxylase synthetase (biotin- [propriony-Coenzyme A-carboxylase (ATP-hydrolysing)] ligase) / Q920N2
  
Possible biological names infered from orthology : holocarboxylase synthetase / P50747
  
Species: Mus musculus
  
Chr. number: 16
Strand: -1
Band: C4
Gene start: 94128882
Gene end: 94313571
  
Corresponding Affymetrix probe sets: 10441038 (MoGene1.0st)   1425607_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000153773
Ensembl peptide - ENSMUSP00000154056
Ensembl peptide - ENSMUSP00000154157
Ensembl peptide - ENSMUSP00000130981
Ensembl peptide - ENSMUSP00000097112
NCBI entrez gene - 110948     See in Manteia.
MGI - MGI:894646
RefSeq - XM_006522856
RefSeq - NM_139145
RefSeq - XM_006522850
RefSeq - XM_006522851
RefSeq - XM_006522852
RefSeq - XM_006522855
RefSeq Peptide - NP_631884
swissprot - Q3TG10
swissprot - Q3TZ03
swissprot - Q920N2
Ensembl - ENSMUSG00000040820
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 hlcsENSDARG00000039934Danio rerio
 HLCSENSGALG00000016047Gallus gallus
 HLCSENSG00000159267Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR003142  Biotin protein ligase, C-terminal
 IPR004143  Biotinyl protein ligase (BPL) and lipoyl protein ligase (LPL), catalytic domain
 IPR004408  Biotin--acetyl-CoA-carboxylase ligase
 IPR019197  Biotin-protein ligase, N-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006464 cellular protein modification process IEA
 biological_processGO:0008152 metabolic process IEA
 biological_processGO:0008283 cell proliferation ISS
 biological_processGO:0009305 protein biotinylation ISO
 biological_processGO:0016570 histone modification ISO
 biological_processGO:0070781 response to biotin ISO
 biological_processGO:0071110 histone biotinylation ISO
 cellular_componentGO:0000785 chromatin ISS
 cellular_componentGO:0005652 nuclear lamina ISS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion IDA
 cellular_componentGO:0005829 cytosol ISS
 cellular_componentGO:0016363 nuclear matrix ISS
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0004077 biotin-[acetyl-CoA-carboxylase] ligase activity IEA
 molecular_functionGO:0004078 biotin-[methylcrotonoyl-CoA-carboxylase] ligase activity IEA
 molecular_functionGO:0004079 biotin-[methylmalonyl-CoA-carboxytransferase] ligase activity IEA
 molecular_functionGO:0004080 biotin-[propionyl-CoA-carboxylase (ATP-hydrolyzing)] ligase activity ISO
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0009374 biotin binding ISO
 molecular_functionGO:0016874 ligase activity IEA
 molecular_functionGO:0018271 biotin-protein ligase activity ISO
 molecular_functionGO:0019899 enzyme binding ISS
 molecular_functionGO:0042803 protein homodimerization activity ISS


Pathways (from Reactome)
Pathway description
Biotin transport and metabolism


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000020532 Acaca / Q5SWU9 / acetyl-Coenzyme A carboxylase alpha / Q13085* / acetyl-CoA carboxylase alpha*  / reaction
 ENSMUSG00000021646 Mccc2 / Q3ULD5 / Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial / Q9HCC0* / methylcrotonoyl-CoA carboxylase 2*  / reaction
 ENSMUSG00000032527 Pccb / Q99MN9 / Propionyl-CoA carboxylase beta chain, mitochondrial / P05166* / propionyl-CoA carboxylase beta subunit*  / reaction
 ENSMUSG00000041650 Pcca / Q91ZA3 / propionyl-Coenzyme A carboxylase, alpha polypeptide / P05165* / propionyl-CoA carboxylase alpha subunit*  / reaction
 ENSMUSG00000027709 Mccc1 / Q99MR8 / Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial / Q96RQ3* / methylcrotonoyl-CoA carboxylase 1*  / reaction
 ENSMUSG00000042010 Acacb / E9Q4Z2 / acetyl-Coenzyme A carboxylase beta / O00763* / acetyl-CoA carboxylase beta*  / reaction
 ENSMUSG00000024892 Pcx / pyruvate carboxylase / PC* / P11498*  / reaction






 

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