ENSMUSG00000027709


Mus musculus

Features
Gene ID: ENSMUSG00000027709
  
Biological name :Mccc1
  
Synonyms : Mccc1 / Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial / Q99MR8
  
Possible biological names infered from orthology : methylcrotonoyl-CoA carboxylase 1 / Q96RQ3
  
Species: Mus musculus
  
Chr. number: 3
Strand: -1
Band: B
Gene start: 35959312
Gene end: 36000678
  
Corresponding Affymetrix probe sets: 10497773 (MoGene1.0st)   1417227_at (Mouse Genome 430 2.0 Array)   1458208_s_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000029259
Ensembl peptide - ENSMUSP00000143396
Ensembl peptide - ENSMUSP00000143266
Ensembl peptide - ENSMUSP00000143039
NCBI entrez gene - 72039     See in Manteia.
MGI - MGI:1919289
RefSeq - NM_023644
RefSeq Peptide - NP_076133
swissprot - A0A0G2JFQ5
swissprot - A0A0G2JF64
swissprot - A0A0G2JG24
swissprot - Q99MR8
Ensembl - ENSMUSG00000027709
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 mccc1ENSDARG00000102538Danio rerio
 MCCC1ENSGALG00000008785Gallus gallus
 MCCC1ENSG00000078070Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Pcca / Q91ZA3 / propionyl-Coenzyme A carboxylase, alpha polypeptide / P05165* / propionyl-CoA carboxylase alpha subunit*ENSMUSG0000004165037


Protein motifs (from Interpro)
Interpro ID Name
 IPR000089  Biotin/lipoyl attachment
 IPR001882  Biotin-binding site
 IPR005479  Carbamoyl-phosphate synthetase large subunit-like, ATP-binding domain
 IPR005481  Biotin carboxylase-like, N-terminal domain
 IPR005482  Biotin carboxylase, C-terminal
 IPR011053  Single hybrid motif
 IPR011054  Rudiment single hybrid motif
 IPR011761  ATP-grasp fold
 IPR011764  Biotin carboxylation domain
 IPR013815  ATP-grasp fold, subdomain 1
 IPR016185  Pre-ATP-grasp domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006552 leucine catabolic process IEA
 cellular_componentGO:0002169 3-methylcrotonyl-CoA carboxylase complex, mitochondrial ISO
 cellular_componentGO:0005739 mitochondrion ISO
 cellular_componentGO:0005743 mitochondrial inner membrane IDA
 cellular_componentGO:0005759 mitochondrial matrix ISO
 cellular_componentGO:1905202 methylcrotonoyl-CoA carboxylase complex IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004075 biotin carboxylase activity IEA
 molecular_functionGO:0004485 methylcrotonoyl-CoA carboxylase activity ISO
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016874 ligase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Biotin transport and metabolism
Branched-chain amino acid catabolism


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000021646 Mccc2 / Q3ULD5 / Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial / Q9HCC0* / methylcrotonoyl-CoA carboxylase 2*  / complex
 ENSMUSG00000027709 Mccc1 / Q99MR8 / Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial / Q96RQ3* / methylcrotonoyl-CoA carboxylase 1*  / complex
 ENSMUSG00000040820 Hlcs / Q920N2 / holocarboxylase synthetase (biotin- [propriony-Coenzyme A-carboxylase (ATP-hydrolysing)] ligase) / P50747* / holocarboxylase synthetase*  / reaction






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2025
contact: otassy@igbmc.fr