ENSMUSG00000041229


Mus musculus

Features
Gene ID: ENSMUSG00000041229
  
Biological name :Phf8
  
Synonyms : Histone lysine demethylase PHF8 / Phf8 / Q80TJ7
  
Possible biological names infered from orthology : PHD finger protein 8 / Q9UPP1
  
Species: Mus musculus
  
Chr. number: X
Strand: 1
Band: F3
Gene start: 151520672
Gene end: 151633859
  
Corresponding Affymetrix probe sets: 10602474 (MoGene1.0st)   1439132_at (Mouse Genome 430 2.0 Array)   1459392_at (Mouse Genome 430 2.0 Array)   1460398_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000041312
Ensembl peptide - ENSMUSP00000108281
Ensembl peptide - ENSMUSP00000108285
Ensembl peptide - ENSMUSP00000108287
Ensembl peptide - ENSMUSP00000108289
Ensembl peptide - ENSMUSP00000116792
Ensembl peptide - ENSMUSP00000122974
Ensembl peptide - ENSMUSP00000127653
Ensembl peptide - ENSMUSP00000040765
NCBI entrez gene - 320595     See in Manteia.
MGI - MGI:2444341
RefSeq - XM_006528877
RefSeq - XM_006528878
RefSeq - NM_001113354
RefSeq - XM_006528880
RefSeq - XM_006528879
RefSeq - NM_177201
RefSeq - XM_006528875
RefSeq Peptide - NP_001106825
RefSeq Peptide - NP_796175
swissprot - Z4YL84
swissprot - A2ABU9
swissprot - A2ABV1
swissprot - A2ABV3
swissprot - F7BTQ5
swissprot - Q80TJ7
Ensembl - ENSMUSG00000041229
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 kdm7aaENSDARG00000018111Danio rerio
 phf8ENSDARG00000006584Danio rerio
 PHF8ENSG00000172943Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
4921501E09Rik / RIKEN cDNA 4921501E09 geneENSMUSG0000002335059
Phf2 / Q9WTU0 / Lysine-specific demethylase PHF2 / O75151* / PHD finger protein 2*ENSMUSG0000003802551
Kdm7a / Q3UWM4 / Lysine-specific demethylase 7A / Q6ZMT4* / lysine demethylase 7A*ENSMUSG0000004259939
Kdm2b / Q6P1G2 / Lysine-specific demethylase 2B / Q8NHM5* / lysine demethylase 2B*ENSMUSG0000002947524
Kdm2a / lysine demethylase 2A / Q9Y2K7*ENSMUSG0000005461123
Fbxl19 / Q6PB97 / F-box/LRR-repeat protein 19 / Q6PCT2* / F-box and leucine rich repeat protein 19*ENSMUSG000000308116


Protein motifs (from Interpro)
Interpro ID Name
 IPR001965  Zinc finger, PHD-type
 IPR003347  JmjC domain
 IPR011011  Zinc finger, FYVE/PHD-type
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR019786  Zinc finger, PHD-type, conserved site
 IPR019787  Zinc finger, PHD-finger


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000082 G1/S transition of mitotic cell cycle IEA
 biological_processGO:0006325 chromatin organization IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007420 brain development ISS
 biological_processGO:0033169 histone H3-K9 demethylation IEA
 biological_processGO:0035574 histone H4-K20 demethylation IEA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IEA
 biological_processGO:0045943 positive regulation of transcription by RNA polymerase I IEA
 biological_processGO:0055114 oxidation-reduction process IEA
 biological_processGO:0061188 negative regulation of chromatin silencing at rDNA IEA
 biological_processGO:0070544 histone H3-K36 demethylation IEA
 biological_processGO:0071557 histone H3-K27 demethylation IEA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005730 nucleolus ISS
 cellular_componentGO:0031965 nuclear membrane IEA
 molecular_functionGO:0003682 chromatin binding IEA
 molecular_functionGO:0005506 iron ion binding IEA
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0016706 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors IEA
 molecular_functionGO:0032452 histone demethylase activity IEA
 molecular_functionGO:0032454 histone demethylase activity (H3-K9 specific) IEA
 molecular_functionGO:0035064 methylated histone binding IEA
 molecular_functionGO:0035575 histone demethylase activity (H4-K20 specific) IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0051213 dioxygenase activity IEA
 molecular_functionGO:0051864 histone demethylase activity (H3-K36 specific) ISO
 molecular_functionGO:0071558 histone demethylase activity (H3-K27 specific) IEA


Pathways (from Reactome)
Pathway description
Condensation of Prophase Chromosomes
HDMs demethylate histones


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000019942 Cdk1 / P11440 / Cyclin-dependent kinase 1 / P06493*  / reaction
 ENSMUSG00000049327 Kmt5a / lysine methyltransferase 5A / Q9NQR1*  / reaction
 ENSMUSG00000041431 Ccnb1 / P24860 / G2/mitotic-specific cyclin-B1 / P14635* / cyclin B1*  / reaction
 ENSMUSG00000060981 P62806 / Hist1h4h / Histone H4   / complex / reaction






 

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