ENSDARG00000006584


Danio rerio

Features
Gene ID: ENSDARG00000006584
  
Biological name :phf8
  
Synonyms : P0CH95 / PHD finger protein 8 / phf8
  
Possible biological names infered from orthology : 4921501E09Rik / Histone lysine demethylase PHF8 / Q80TJ7 / Q9UPP1 / RIKEN cDNA 4921501E09 gene
  
Species: Danio rerio
  
Chr. number: 23
Strand: -1
Band:
Gene start: 27591366
Gene end: 27608257
  
Corresponding Affymetrix probe sets: Dr.17929.1.A1_at (Zebrafish Array)   Dr.19421.1.A1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000007140
Ensembl peptide - ENSDARP00000148598
NCBI entrez gene - 566534     See in Manteia.
RefSeq - XM_005162265
RefSeq - NM_001202447
RefSeq Peptide - NP_001189376
swissprot - P0CH95
ZFIN ID - ZDB-GENE-060419-1
Ensembl - ENSDARG00000006584
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 PHF8ENSG00000172943Homo sapiens
 4921501E09RikENSMUSG00000023350Mus musculus
 Phf8ENSMUSG00000041229Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
phf2 / PHD finger protein 2 / O75151* / Q9WTU0* / Lysine-specific demethylase PHF2 *ENSDARG0000001869146
kdm7ab / lysine (K)-specific demethylase 7Ab / KDM7A* / Q3UWM4* / Q6ZMT4* / lysine demethylase 7A* / Lysine-specific demethylase 7A *ENSDARG0000001855933
kdm2bb / lysine (K)-specific demethylase 2Bb / KDM2B* / Q6P1G2* / Q8NHM5* / lysine demethylase 2B* / Lysine-specific demethylase 2B *ENSDARG0000004601021
kdm2aa / lysine (K)-specific demethylase 2Aa / KDM2A* / Q9Y2K7* / lysine demethylase 2A*ENSDARG0000005965320
kdm2ab / lysine (K)-specific demethylase 2Ab / KDM2A* / Q9Y2K7* / lysine demethylase 2A*ENSDARG0000007813320
kdm7aa / Q5RHD1 / lysine (K)-specific demethylase 7Aa / PHF8* / Q80TJ7* / Q9UPP1* / 4921501E09Rik* / PHD finger protein 8* / RIKEN cDNA 4921501E09 gene* / Histone lysine demethylase PHF8 *ENSDARG000000181119
kdm2ba / lysine (K)-specific demethylase 2BaENSDARG000000365937
btr30 / FBXL19 / zgc:158376 / Q6PCT2* / F-box and leucine rich repeat protein 19*ENSDARG000001033625


Protein motifs (from Interpro)
Interpro ID Name
 IPR001965  Zinc finger, PHD-type
 IPR003347  JmjC domain
 IPR011011  Zinc finger, FYVE/PHD-type
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR019786  Zinc finger, PHD-type, conserved site
 IPR019787  Zinc finger, PHD-finger


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000082 G1/S transition of mitotic cell cycle ISS
 biological_processGO:0006325 chromatin organization IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007420 brain development IMP
 biological_processGO:0033169 histone H3-K9 demethylation ISS
 biological_processGO:0035574 histone H4-K20 demethylation ISS
 biological_processGO:0043523 regulation of neuron apoptotic process IGI
 biological_processGO:0045893 positive regulation of transcription, DNA-templated ISS
 biological_processGO:0045943 positive regulation of transcription by RNA polymerase I ISS
 biological_processGO:0048703 embryonic viscerocranium morphogenesis IMP
 biological_processGO:0055114 oxidation-reduction process IEA
 biological_processGO:0060319 primitive erythrocyte differentiation IMP
 biological_processGO:0061188 negative regulation of chromatin silencing at rDNA ISS
 biological_processGO:0070544 histone H3-K36 demethylation ISS
 biological_processGO:0071557 histone H3-K27 demethylation ISS
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005730 nucleolus ISS
 molecular_functionGO:0003682 chromatin binding ISS
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0032454 histone demethylase activity (H3-K9 specific) ISS
 molecular_functionGO:0035064 methylated histone binding ISS
 molecular_functionGO:0035575 histone demethylase activity (H4-K20 specific) ISS
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0051213 dioxygenase activity IEA
 molecular_functionGO:0051864 histone demethylase activity (H3-K36 specific) ISS
 molecular_functionGO:0071558 histone demethylase activity (H3-K27 specific) ISS


Pathways (from Reactome)
Pathway description
Condensation of Prophase Chromosomes
HDMs demethylate histones


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0001273 ventral mandibular arch ventral mandibular arch decreased size , abnormal
ventral mandibular arch aplastic , abnormal
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 ZFA:0001405 ethmoid cartilage ethmoid cartilage immature , abnormal
Show

 ZFA:0001606 pharyngeal arch 3 pharyngeal arch 3 deformed , abnormal
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 ZFA:0001607 pharyngeal arch 4 pharyngeal arch 4 deformed , abnormal
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 ZFA:0001608 pharyngeal arch 5 pharyngeal arch 5 deformed , abnormal
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 ZFA:0001611 pharyngeal arch 2 pharyngeal arch 2 inverted , abnormal
Show

 ZFA:0001612 pharyngeal arch 1 pharyngeal arch 1 decreased size , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000104114 kmt5ab / lysine methyltransferase 5Ab / KMT5A* / Q9NQR1* / lysine methyltransferase 5A*  / reaction
 ENSDARG00000105231 kmt5aa / lysine methyltransferase 5Aa / KMT5A* / Q9NQR1* / lysine methyltransferase 5A*  / reaction






 

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