ENSMUSG00000041481


Mus musculus
serpinSerpina3gtcelldegranulationdecreasedmemoryfamilyconservedsitedomainsuperfamilyextracellularspaceplateletneutrophilresponseinfectionproliferationcd-positivealpha-beta

Features
Gene ID: ENSMUSG00000041481
  
Biological name :Serpina3g
  
Synonyms : serine (or cysteine) peptidase inhibitor, clade A, member 3G / Serpina3g
  
Possible biological names infered from orthology : P01011 / SERPINA3 / serpin family A member 3
  
Species: Mus musculus
  
Chr. number: 12
Strand: 1
Band: E
Gene start: 104236245
Gene end: 104241939
  
Corresponding Affymetrix probe sets: 1424923_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000126548
Ensembl peptide - ENSMUSP00000041250
Ensembl peptide - ENSMUSP00000129633
NCBI entrez gene - 20715     See in Manteia.
MGI - MGI:105046
RefSeq - NM_001353612
RefSeq - NM_009251
RefSeq Peptide - NP_033277
RefSeq Peptide - NP_001340541
swissprot - E9Q499
swissprot - F2Z405
Ensembl - ENSMUSG00000041481
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 serpina1ENSDARG00000090286Danio rerio
 serpina1lENSDARG00000090850Danio rerio
 serpina7ENSDARG00000087143Danio rerio
 si:ch211-186e20.2ENSDARG00000074712Danio rerio
 si:ch211-186e20.7ENSDARG00000077960Danio rerio
 zgc:174259ENSDARG00000091136Danio rerio
 ENSGALG00000028598Gallus gallus
 ENSGALG00000020388Gallus gallus
 ENSGALG00000020390Gallus gallus
 ENSGALG00000046409Gallus gallus
 SPIA1ENSGALG00000023070Gallus gallus
 SPIA4ENSGALG00000010969Gallus gallus
 P01011ENSG00000196136Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q80X76 / Serpina3f / Serine protease inhibitor A3F / P01011* / SERPINA3* / serpin family A member 3*ENSMUSG0000006636377
Serpina3n / serine (or cysteine) peptidase inhibitor, clade A, member 3N / P01011* / SERPINA3* / serpin family A member 3*ENSMUSG0000002109169
Serpina3i / P01011* / SERPINA3* / serpin family A member 3*ENSMUSG0000007901469
Q03734 / Serpina3m / Serine protease inhibitor A3M / P01011* / SERPINA3* / serpin family A member 3*ENSMUSG0000007901266
P29621 / Serpina3c / Serine protease inhibitor A3C / P01011* / SERPINA3* / serpin family A member 3*ENSMUSG0000006636165
Serpina3k / serine (or cysteine) peptidase inhibitor, clade A, member 3K / P01011* / SERPINA3* / serpin family A member 3*ENSMUSG0000005820762
Q6P4P1 / Serpina3a / serine (or cysteine) peptidase inhibitor, clade A, member 3A / P01011* / SERPINA3* / serpin family A member 3*ENSMUSG0000004153650
Q8BYY9 / Serpina3b / serine (or cysteine) peptidase inhibitor, clade A, member 3B / P01011* / SERPINA3* / serpin family A member 3*ENSMUSG0000006636449
Serpina3j / serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3J / P01011* / SERPINA3* / serpin family A member 3*ENSMUSG0000007901349
Q9D7D2 / Serpina9 / serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 9 / Q86WD7* / serpin family A member 9*ENSMUSG0000005826039
Serpina11 / serpin family A member 11 / Q86U17*ENSMUSG0000006323239
Q00898 / Serpina1e / serine (or cysteine) peptidase inhibitor, clade A, member 1E / P01009* / SERPINA1* / serpin family A member 1*ENSMUSG0000007284939
P70458 / Serpina5 / serine (or cysteine) peptidase inhibitor, clade A, member 5 / P05154* / serpin family A member 5*ENSMUSG0000004155038
Serpina1c / serine (or cysteine) peptidase inhibitor, clade A, member 1C / P01009* / SERPINA1* / serpin family A member 1*ENSMUSG0000007901537
P07758 / Serpina1a / serine (or cysteine) peptidase inhibitor, clade A, member 1A / P01009* / SERPINA1* / serpin family A member 1*ENSMUSG0000006636636
P22599 / Serpina1b / serine (or cysteine) preptidase inhibitor, clade A, member 1B / P01009* / SERPINA1* / serpin family A member 1*ENSMUSG0000007117836
Q00897 / Serpina1d / serine (or cysteine) peptidase inhibitor, clade A, member 1D / P01009* / SERPINA1* / serpin family A member 1*ENSMUSG0000007117735
Serpina7 / serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7 / P05543* / serpin family A member 7*ENSMUSG0000003127133
Q7TMF5 / Serpina12 / Serpin A12 / Q8IW75* / serpin family A member 12*ENSMUSG0000004156731
Q06770 / Serpina6 / serine (or cysteine) peptidase inhibitor, clade A, member 6 / P08185* / serpin family A member 6*ENSMUSG0000006080730


Protein motifs (from Interpro)
Interpro ID Name
 IPR000215  Serpin family
 IPR023795  Serpin, conserved site
 IPR023796  Serpin domain
 IPR036186  Serpin superfamily


Gene Ontology (GO)
extracellular regionextracellular regionextracellular regionextracellular regionextracellular regionextracellular regionextracellular regionextracellular regionextracellular regionextracellular regionextracellular regionextracellular region
TypeGO IDTermEv.Code
 cellular_componentGO:0005615 extracellular space IEA


Pathways (from Reactome)
Pathway description
Platelet degranulation
Neutrophil degranulation


Phenotype (from MGI, Zfin or HPO)
immune system phenotypehematopoietic system phenotypeimmune system phenotypehematopoietic system phenotypeimmune system phenotypehematopoietic system phenotypeimmune system phenotypehematopoietic system phenotypeimmune system phenotypehematopoietic system phenotypeimmune system phenotypehematopoietic system phenotypeimmune system phenotypehematopoietic system phenotypeimmune system phenotypehematopoietic system phenotypeimmune system phenotypehematopoietic system phenotypeimmune system phenotypehematopoietic system phenotypeimmune system phenotypeimmune system phenotypehematopoietic system phenotypehematopoietic system phenotype
IDPhenotypeDefinition Genetic BG
 MP:0005025 response to infection "the body s reaction to invasion and multiplication of microorganisms in its tissues, or the body s reaction to components of or toxins produced by pathogenic mircroorganisms " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Nlrp3tm1Bhk/Nlrp3tm1Bhk
Genetic Background: involves: 129S6/SvEvTac

 MP:0005095 decreased T cell proliferation "reduced clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Nlrp3tm1Bhk/Nlrp3tm1Bhk
Genetic Background: involves: 129S6/SvEvTac

Allelic Composition: Serpina3gtm1.1Arp/Serpina3gtm1.1Arp,Tg(TcrLCMV)#Sdz/0
Genetic Background: involves: C57BL/6 * DBA/2

 MP:0010833 abnormal memory T cell morphology "any structural anomaly of distinctly differentiated long-lived T cells that have the phenotype CD45RO-positive and CD127-positive" [CL:0000813, GO_REF:0000031, GOC:add, GOC:pam, GOC:tfm, ISBN:0781735149]
Show

Allelic Composition: Nlrp3tm1Bhk/Nlrp3tm1Bhk
Genetic Background: involves: 129S6/SvEvTac

 MP:0010839 decreased CD8-positive, alpha-beta memory T cell number "decreased number of CD8-positive, alpha-beta T cells with memory phenotype indicated by being CD45RO and CD127-positive, or also described as being CD25-negative, CD44-high, and CD122- high" [CL:0000909, GO_REF:0000031, GOC:tfm, PMID:20146720]
Show

Allelic Composition: Nlrp3tm1Bhk/Nlrp3tm1Bhk
Genetic Background: involves: 129S6/SvEvTac

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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