ENSMUSG00000041488


Mus musculus

Features
Gene ID: ENSMUSG00000041488
  
Biological name :Stx3
  
Synonyms : Q64704 / Stx3 / Syntaxin-3
  
Possible biological names infered from orthology : Q13277
  
Species: Mus musculus
  
Chr. number: 19
Strand: -1
Band: A
Gene start: 11775118
Gene end: 11819403
  
Corresponding Affymetrix probe sets: 10466248 (MoGene1.0st)   1425530_a_at (Mouse Genome 430 2.0 Array)   1425536_at (Mouse Genome 430 2.0 Array)   1426151_a_at (Mouse Genome 430 2.0 Array)   1434559_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000037317
Ensembl peptide - ENSMUSP00000074776
Ensembl peptide - ENSMUSP00000147398
Ensembl peptide - ENSMUSP00000147461
Ensembl peptide - ENSMUSP00000069529
NCBI entrez gene - 20908     See in Manteia.
MGI - MGI:103077
RefSeq - XM_017318109
RefSeq - NM_001025307
RefSeq - NM_001286543
RefSeq - NM_011502
RefSeq - NM_152220
RefSeq - XM_006526844
RefSeq - XM_006526845
RefSeq - XM_017318108
RefSeq Peptide - NP_689344
RefSeq Peptide - NP_001020478
RefSeq Peptide - NP_001273472
RefSeq Peptide - NP_035632
swissprot - Q64704
swissprot - A0A1C7CYU4
swissprot - A0A1B0GRC2
Ensembl - ENSMUSG00000041488
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 STX3ENSDARG00000051981Danio rerio
 stx3aENSDARG00000001880Danio rerio
 STX3ENSG00000166900Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Stx1a / O35526 / syntaxin 1A (brain) / Q16623* / syntaxin 1A*ENSMUSG0000000720763
Stx2 / syntaxin 2 / P32856*ENSMUSG0000002942861
Stx1b / P61264 / Syntaxin-1B / P61266*ENSMUSG0000003080660
Stx4a / P70452 / Syntaxin-4 / STX4* / Q12846*ENSMUSG0000003080539
Stx11 / syntaxin 11 / O75558*ENSMUSG0000003923229
Stx19 / Q8R1Q0 / Syntaxin-19 / Q8N4C7*ENSMUSG0000004785428
Gm379ENSMUSG0000009391626


Protein motifs (from Interpro)
Interpro ID Name
 IPR000727  Target SNARE coiled-coil homology domain
 IPR006011  Syntaxin, N-terminal domain
 IPR006012  Syntaxin/epimorphin, conserved site
 IPR010989  SNARE
 IPR031186  Syntaxin-3


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006836 neurotransmitter transport IEA
 biological_processGO:0006886 intracellular protein transport IEA
 biological_processGO:0006887 exocytosis IEA
 biological_processGO:0006906 vesicle fusion IDA
 biological_processGO:0008284 positive regulation of cell proliferation IEA
 biological_processGO:0016081 synaptic vesicle docking IEA
 biological_processGO:0016192 vesicle-mediated transport IEA
 biological_processGO:0031175 neuron projection development IEA
 biological_processGO:0031629 synaptic vesicle fusion to presynaptic active zone membrane IBA
 biological_processGO:0045785 positive regulation of cell adhesion IEA
 biological_processGO:0048278 vesicle docking IBA
 biological_processGO:0050921 positive regulation of chemotaxis IEA
 biological_processGO:0060291 long-term synaptic potentiation IMP
 biological_processGO:0061025 membrane fusion IEA
 biological_processGO:0098967 exocytic insertion of neurotransmitter receptor to postsynaptic membrane IMP
 biological_processGO:1903078 positive regulation of protein localization to plasma membrane IEA
 biological_processGO:2000010 positive regulation of protein localization to cell surface IEA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005911 cell-cell junction IEA
 cellular_componentGO:0008021 synaptic vesicle IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0016324 apical plasma membrane IEA
 cellular_componentGO:0030027 lamellipodium IEA
 cellular_componentGO:0030141 secretory granule IDA
 cellular_componentGO:0030425 dendrite IDA
 cellular_componentGO:0030426 growth cone IEA
 cellular_componentGO:0031201 SNARE complex IEA
 cellular_componentGO:0042470 melanosome IDA
 cellular_componentGO:0042581 specific granule IEA
 cellular_componentGO:0042582 azurophil granule IEA
 cellular_componentGO:0042589 zymogen granule membrane IDA
 cellular_componentGO:0042734 presynaptic membrane IDA
 cellular_componentGO:0043005 neuron projection IEA
 cellular_componentGO:0097470 ribbon synapse IDA
 cellular_componentGO:0098793 presynapse IEA
 cellular_componentGO:0098794 postsynapse IDA
 cellular_componentGO:1990796 photoreceptor cell terminal bouton IDA
 molecular_functionGO:0000149 SNARE binding IBA
 molecular_functionGO:0005484 SNAP receptor activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0050544 arachidonic acid binding IEA


Pathways (from Reactome)
Pathway description
Other interleukin signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0005387 immune system phenotype 
Show

Allelic Composition: Spns2tm1b(KOMP)Wtsi/Spns2tm1b(KOMP)Wtsi
Genetic Background: B6Brd;B6Dnk;B6N-Tyrc-Brd-Spns2tm1b(KOMP)Wtsi/WtsiH

 MP:0010025 decreased total body fat amount "less than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Spns2tm1b(KOMP)Wtsi/Spns2tm1b(KOMP)Wtsi
Genetic Background: B6Brd;B6Dnk;B6N-Tyrc-Brd-Spns2tm1b(KOMP)Wtsi/WtsiH

 MP:0010052 increased grip strength "greater ability to grasp and hold objects, often measured as time spent hanging from an object or wire" [ISBN:0471316393 "Crawley, JN, What s Wrong with my Mouse: Behavioral Phenotyping of Transgenic and Knockout Mice"]
Show

Allelic Composition: Spns2tm1b(KOMP)Wtsi/Spns2tm1b(KOMP)Wtsi
Genetic Background: B6Brd;B6Dnk;B6N-Tyrc-Brd-Spns2tm1b(KOMP)Wtsi/WtsiH

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Rpgrip1ltm1a(EUCOMM)Wtsi/Rpgrip1ltm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Rpgrip1ltm1a(EUCOMM)Wtsi/Wtsi

 MP:0013292 embryonic lethality prior to organogenesis "death prior to the completion of embryo turning (Mus: E9-9.5)" [MGI:smb]
Show

Allelic Composition: Rpgrip1ltm1a(EUCOMM)Wtsi/Rpgrip1ltm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Rpgrip1ltm1a(EUCOMM)Wtsi/Wtsi

 MP:0013293 embryonic lethality prior to tooth bud stage "death prior to the appearance of tooth buds (Mus: E12-E12.5)" [MGI:smb]
Show

Allelic Composition: Rpgrip1ltm1a(EUCOMM)Wtsi/Rpgrip1ltm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Rpgrip1ltm1a(EUCOMM)Wtsi/Wtsi

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000053841 Txlna / Q6PAM1 / taxilin alpha / P40222*  / complex / reaction






 

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