ENSMUSG00000043153


Mus musculus

Features
Gene ID: ENSMUSG00000043153
  
Biological name :Ispd
  
Synonyms : D-ribitol-5-phosphate cytidylyltransferase / Ispd / Q5RJG7
  
Possible biological names infered from orthology : A4D126 / isoprenoid synthase domain containing
  
Species: Mus musculus
  
Chr. number: 12
Strand: 1
Band: A3
Gene start: 36381450
Gene end: 36689503
  
Corresponding Affymetrix probe sets: 10395394 (MoGene1.0st)   1430316_at (Mouse Genome 430 2.0 Array)   1443549_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000152823
Ensembl peptide - ENSMUSP00000152423
Ensembl peptide - ENSMUSP00000152872
Ensembl peptide - ENSMUSP00000061646
Ensembl peptide - ENSMUSP00000152115
Ensembl peptide - ENSMUSP00000152318
Ensembl peptide - ENSMUSP00000152392
NCBI entrez gene - 75847     See in Manteia.
MGI - MGI:1923097
RefSeq - XM_011243910
RefSeq - NM_001289502
RefSeq - NM_001289503
RefSeq - NM_001289504
RefSeq - NM_178629
RefSeq - XM_006515244
RefSeq - XM_011243907
RefSeq - XM_011243909
RefSeq Peptide - NP_848744
RefSeq Peptide - NP_001276431
RefSeq Peptide - NP_001276432
RefSeq Peptide - NP_001276433
swissprot - Q5RJG7
swissprot - A0A1Y7VM96
swissprot - A0A1Y7VK76
Ensembl - ENSMUSG00000043153
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ispdENSDARG00000005034Danio rerio
 ISPDENSGALG00000010795Gallus gallus
 ISPDENSG00000214960Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR018294  4-diphosphocytidyl-2C-methyl-D-erythritol synthase, conserved site
 IPR029044  Nucleotide-diphospho-sugar transferases
 IPR034683  Cytidylyltransferase IspD/TarI


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006486 protein glycosylation IMP
 biological_processGO:0007411 axon guidance IMP
 biological_processGO:0008299 isoprenoid biosynthetic process IEA
 biological_processGO:0035269 protein O-linked mannosylation ISS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol ISS
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0016779 nucleotidyltransferase activity IEA
 molecular_functionGO:0042803 protein homodimerization activity ISS
 molecular_functionGO:0047349 D-ribitol-5-phosphate cytidylyltransferase activity ISO
 molecular_functionGO:0070567 cytidylyltransferase activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000778 abnormal tract 
Show

Allelic Composition: Hoxa2tm2.1Fmr/Hoxa2tm2.1Fmr,Hoxb2tm2.2Fmr/Hoxb2tm2.2Fmr
Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL

 MP:0001953 respiratory failure "cessation of or failure to commence breathing" [MGI:cls, J:60159]
Show

Allelic Composition: Hoxa2tm2.1Fmr/Hoxa2tm2.1Fmr,Hoxb2tm2.2Fmr/Hoxb2tm2.2Fmr
Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL

 MP:0002961 abnormal axon guidance "defect in the signaling mechanisms that allow precise navigation and connections of axonal growth cones to effector tissues " [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Hoxa2tm2.1Fmr/Hoxa2tm2.1Fmr,Hoxb2tm2.2Fmr/Hoxb2tm2.2Fmr
Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL

 MP:0004272 abnormal basement membrane morphology "anomaly in the structure, organization and/or placement of the extracellular supportive tissue adjacent to the basal surface of the epithelia, including the epithelium of muscle cells, fat cells and Schwann cells; it is comprised of type IV collagen, laminin, and sulfated proteoglycans and other components and consists of two layers, the basal lamina and the lamina reticularis" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MESH:A10.272.220]
Show

Allelic Composition: Hoxa2tm2.1Fmr/Hoxa2tm2.1Fmr,Hoxb2tm2.2Fmr/Hoxb2tm2.2Fmr
Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL

 MP:0009450 abnormal axon fasiculation "anomaly in the process by which axons form into bundles" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hoxa2tm2.1Fmr/Hoxa2tm2.1Fmr,Hoxb2tm2.2Fmr/Hoxb2tm2.2Fmr
Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL

 MP:0009677 abnormal spinal cord dorsal column morphology "any structural anomaly of the wedge-shaped fiber bundle of white matter in the dorsomedial side of the spinal cord that is made up of the fasciculus gracilis and fasciculus cuneatus; it is part of the ascending posterior column-medial lemniscus pathway that is important for well-localized fine touch and conscious proprioception" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", ISBN-10:0940780577 "Goldberg, S, Clinical Neuroanatomy Made Ridiculously Simple, 3rd edition"]
Show

Allelic Composition: Hoxa2tm2.1Fmr/Hoxa2tm2.1Fmr,Hoxb2tm2.2Fmr/Hoxb2tm2.2Fmr
Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL

 MP:0009695 abnormal spinal cord ventral commissure morphology "any structural anomaly of the band of nerve fibers which cross the midline of the spinal cord ventral to the central canal and posterior grey commissure" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Hoxa2tm2.1Fmr/Hoxa2tm2.1Fmr,Hoxb2tm2.2Fmr/Hoxb2tm2.2Fmr
Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Hoxa2tm2.1Fmr/Hoxa2tm2.1Fmr,Hoxb2tm2.2Fmr/Hoxb2tm2.2Fmr
Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL

 MP:0011723 ectopic neuron "appearance of a neuron or group of neurons in a region where it is not normally found" [MGI:csmith]
Show

Allelic Composition: Hoxa2tm2.1Fmr/Hoxa2tm2.1Fmr,Hoxb2tm2.2Fmr/Hoxb2tm2.2Fmr
Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL

 MP:0020391 radial glial endfoot detachment "detachment of the radial glia cell endfoot from the pial basement membrane" [MGI:anna, PMID:17715063, PMID:23217742, PMID:24256719]
Show

Allelic Composition: Hoxa2tm2.1Fmr/Hoxa2tm2.1Fmr,Hoxb2tm2.2Fmr/Hoxb2tm2.2Fmr
Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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