ENSMUSG00000044042


Mus musculus

Features
Gene ID: ENSMUSG00000044042
  
Biological name :Fmn1
  
Synonyms : Fmn1 / Formin-1 / Q05860
  
Possible biological names infered from orthology : Q68DA7
  
Species: Mus musculus
  
Chr. number: 2
Strand: 1
Band: E4
Gene start: 113327736
Gene end: 113716767
  
Corresponding Affymetrix probe sets: 10474619 (MoGene1.0st)   1427671_a_at (Mouse Genome 430 2.0 Array)   1439397_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000080093
Ensembl peptide - ENSMUSP00000097171
Ensembl peptide - ENSMUSP00000099606
Ensembl peptide - ENSMUSP00000125052
NCBI entrez gene - 14260     See in Manteia.
MGI - MGI:101815
RefSeq - XM_011239295
RefSeq - NM_001285458
RefSeq - NM_001285459
RefSeq - NM_010230
RefSeq - XM_006498750
RefSeq - XM_011239294
RefSeq Peptide - NP_034360
RefSeq Peptide - NP_001272387
RefSeq Peptide - NP_001272388
swissprot - Q05860
swissprot - E9Q7P6
Ensembl - ENSMUSG00000044042
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 si:ch1073-209e23.1ENSDARG00000100805Danio rerio
 FMN1ENSGALG00000009723Gallus gallus
 FMN1ENSG00000248905Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Fmn2 / Q9JL04 / Formin-2 / Q9NZ56*ENSMUSG0000002835430
Fhod3 / Q76LL6 / FH1/FH2 domain-containing protein 3 / Q2V2M9* / formin homology 2 domain containing 3*ENSMUSG0000003429516
Q0QWG9 / Grid2ip / Mus musculus glutamate receptor, ionotropic, delta 2 (Grid2) interacting protein 1 (Grid2ip), transcript variant 3, mRNA. / A4D2P6* / Grid2 interacting protein*ENSMUSG0000001082513
Fhod1 / Q6P9Q4 / FH1/FH2 domain-containing protein 1 / Q9Y613* / formin homology 2 domain containing 1*ENSMUSG0000001477813


Protein motifs (from Interpro)
Interpro ID Name
 IPR001265  Formin homology family, Cappuccino subfamily
 IPR015425  Formin, FH2 domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001822 kidney development IMP
 biological_processGO:0010467 gene expression IMP
 biological_processGO:0030838 positive regulation of actin filament polymerization IDA
 biological_processGO:0035136 forelimb morphogenesis IMP
 biological_processGO:0035137 hindlimb morphogenesis IMP
 biological_processGO:0045010 actin nucleation IEA
 biological_processGO:0048705 skeletal system morphogenesis IMP
 biological_processGO:0048813 dendrite morphogenesis IMP
 biological_processGO:0051127 positive regulation of actin nucleation IDA
 biological_processGO:0051894 positive regulation of focal adhesion assembly IMP
 biological_processGO:0060173 limb development IMP
 biological_processGO:0072092 ureteric bud invasion IMP
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005884 actin filament IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005912 adherens junction IEA
 cellular_componentGO:0015630 microtubule cytoskeleton IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030054 cell junction IEA
 molecular_functionGO:0003779 actin binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008017 microtubule binding IDA
 molecular_functionGO:0017124 SH3 domain binding IPI


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000519 hydronephrosis "dilation of the pelvis and calices of one or both kidneys" [J:56641]
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Allelic Composition: ajIs(17;In2)1Gso/ajIs(17;In2)1Gso,Fmn1ld-Is(17;In2)1Gso/Fmn1ld-Is(17;In2)1Gso
Genetic Background: involves: 101/Rl * C3H/Rl * C57BL/E * SEC/Rl

 MP:0000520 absent kidney "missing paired organs that excrete urine" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49471]
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Allelic Composition: Acdacd/Acdacd
Genetic Background: DW/J-Acdacd Pou1f1+

Allelic Composition: Fmn1ld-TgBri137/Fmn1tm1Led
Genetic Background: involves: 129S6/SvEvTac * Black Swiss * C57BL/6 * SJL

Allelic Composition: Fmn1tm1Awb/Fmn1tm1Awb
Genetic Background: involves: 129S4/SvJae * NIH Black Swiss

Allelic Composition: Fmn1ld-TgHD/Fmn1ld-TgHD
Genetic Background: involves: BALB/c * C57BL/6 * CD-1 * FVB/N

 MP:0000536 hydroureter "distention of the ureter with urine, due to blockage from any cause" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:Cml, J:13044]
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Allelic Composition: ajIs(17;In2)1Gso/ajIs(17;In2)1Gso,Fmn1ld-Is(17;In2)1Gso/Fmn1ld-Is(17;In2)1Gso
Genetic Background: involves: 101/Rl * C3H/Rl * C57BL/E * SEC/Rl

 MP:0000547 short limbs "reduced average length of the extremities" [MGI:CLS, J:61509]
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Allelic Composition: Apoa2tm1Bres/Apoa2+,Apoetm1Bres/Apoetm1Bres
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

 MP:0000550 abnormal forelimb morphology "malformation of the entire anterior extremities" [MGI:tc]
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Allelic Composition: ajIs(17;In2)1Gso/ajIs(17;In2)1Gso,Fmn1ld-Is(17;In2)1Gso/Fmn1ld-Is(17;In2)1Gso
Genetic Background: involves: 101/Rl * C3H/Rl * C57BL/E * SEC/Rl

Allelic Composition: Fmn1ld-TgHD/Fmn1ld-TgHD
Genetic Background: involves: C57BL/6 * CD-1

 MP:0000552 abnormal radius morphology "malformation of the short bone of the lateral forearm" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Fmn1ld-Lsk/Fmn1ld-Lsk
Genetic Background: C.Cg-Fmn1ld-Lsk

Allelic Composition: ajIs(17;In2)1Gso/ajIs(17;In2)1Gso,Fmn1ld-Is(17;In2)1Gso/Fmn1ld-Is(17;In2)1Gso
Genetic Background: involves: 101/Rl * C3H/Rl * C57BL/E * SEC/Rl

Allelic Composition: Fmn1ld-TgHD/Fmn1ld-TgHD
Genetic Background: involves: C57BL/6 * CD-1

 MP:0000554 abnormal carpal bone morphology "malformation of the nine nodular bones of the joint between the forelimb bones and the front paws consisting of the scapholunar, triangular, greater multiangular, lesser multiangular, capitate, hamate, centrale and the sesamoids" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, Anatomy of the Rat:Greene, EC, Hafner Publishing Co, 1935]
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Allelic Composition: Apoa2tm1Bres/Apoa2+,Apoetm1Bres/Apoetm1Bres
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

Allelic Composition: ajIs(17;In2)1Gso/ajIs(17;In2)1Gso,Fmn1ld-Is(17;In2)1Gso/Fmn1ld-Is(17;In2)1Gso
Genetic Background: involves: 101/Rl * C3H/Rl * C57BL/E * SEC/Rl

 MP:0000556 abnormal hindlimb morphology "malformation of the entire posterior extremities" [MGI:tc]
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Allelic Composition: ajIs(17;In2)1Gso/ajIs(17;In2)1Gso,Fmn1ld-Is(17;In2)1Gso/Fmn1ld-Is(17;In2)1Gso
Genetic Background: involves: 101/Rl * C3H/Rl * C57BL/E * SEC/Rl

Allelic Composition: Fmn1ld-TgHD/Fmn1ld-TgHD
Genetic Background: involves: C57BL/6 * CD-1

 MP:0000558 abnormal tibia morphology "atructural anomaly of the medial and larger of the two bones of the lower leg" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Fmn1ld-TgHD/Fmn1ld-TgHD
Genetic Background: involves: C57BL/6 * CD-1

 MP:0000564 syndactyly "any degree of webbing or fusion of the digits, may involve only soft tissues or also can include bone" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Apoa2tm1Bres/Apoa2+,Apoetm1Bres/Apoetm1Bres
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

Allelic Composition: Fmn1tm1.1Zlr/Fmn1tm1.1Zlr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: ajIs(17;In2)1Gso/ajIs(17;In2)1Gso,Fmn1ld-Is(17;In2)1Gso/Fmn1ld-Is(17;In2)1Gso
Genetic Background: involves: 101/Rl * C3H/Rl * C57BL/E * SEC/Rl

Allelic Composition: Fmn1ld-TgHD/Fmn1ld-TgHD
Genetic Background: involves: C57BL/6 * CD-1

 MP:0000565 oligodactyly "congenital condition in which some digits or parts of digits are missing" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
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Allelic Composition: Apoa2tm1Bres/Apoa2+,Apoetm1Bres/Apoetm1Bres
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

Allelic Composition: Fmn1tm1.1Zlr/Fmn1tm1.1Zlr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: ajIs(17;In2)1Gso/ajIs(17;In2)1Gso,Fmn1ld-Is(17;In2)1Gso/Fmn1ld-Is(17;In2)1Gso
Genetic Background: involves: 101/Rl * C3H/Rl * C57BL/E * SEC/Rl

Allelic Composition: Fmn1tm2Made/Fmn1tm2Made
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

Allelic Composition: Fmn1tm2Made/Fmn1tm2Made
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * FVB/N

Allelic Composition: Fmn1ld-TgHD/Fmn1ld-TgHD
Genetic Background: involves: C57BL/6 * CD-1

 MP:0000566 synostosis "osseous union of two bones that are not normally connected" [J:13049]
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Allelic Composition: ajIs(17;In2)1Gso/ajIs(17;In2)1Gso,Fmn1ld-Is(17;In2)1Gso/Fmn1ld-Is(17;In2)1Gso
Genetic Background: involves: 101/Rl * C3H/Rl * C57BL/E * SEC/Rl

 MP:0000572 abnormal autopod morphology "malformation of the hand or foot" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Fmn1ld-Lsk/Fmn1ld-Lsk
Genetic Background: C.Cg-Fmn1ld-Lsk

Allelic Composition: ajIs(17;In2)1Gso/ajIs(17;In2)1Gso,Fmn1ld-Is(17;In2)1Gso/Fmn1ld-Is(17;In2)1Gso
Genetic Background: involves: 101/Rl * C3H/Rl * C57BL/E * SEC/Rl

Allelic Composition: Fmn1tm2Made/Fmn1tm2Made
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

Allelic Composition: Fmn1tm2Made/Fmn1tm2Made
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * FVB/N

Allelic Composition: Fmn1ld-TgHD/Fmn1ld-TgHD
Genetic Background: involves: C57BL/6 * CD-1

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
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Allelic Composition: Apoa2tm1Bres/Apoa2+,Apoetm1Bres/Apoetm1Bres
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

 MP:0002109 abnormal limb morphology "abnormal development of limbs resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cdkn1atm2(HBx)Xya/Cdkn1a+
Genetic Background: either: (involves: 129S6/SvEvTac * C57BL/6) or (involves: 129S6/SvEvTac * Black Swiss)

Allelic Composition: Fmn1ld-Lsk/Fmn1ld-Lsk
Genetic Background: C.Cg-Fmn1ld-Lsk

 MP:0002110 abnormal digit morphology "abnormal development of the digits resulting in structural abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cdkn1atm2(HBx)Xya/Cdkn1a+
Genetic Background: either: (involves: 129S6/SvEvTac * C57BL/6) or (involves: 129S6/SvEvTac * Black Swiss)

 MP:0002135 abnormal kidney morphology "abnormal development of the kidney resulting in structural abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Fmn1ld-TgHD/Fmn1ld-TgHD
Genetic Background: involves: C57BL/6 * CD-1

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cdkn1atm2(HBx)Xya/Cdkn1a+
Genetic Background: either: (involves: 129S6/SvEvTac * C57BL/6) or (involves: 129S6/SvEvTac * Black Swiss)

 MP:0002187 abnormal fibula morphology "malformation of the lateral and smaller bone of the lower limb" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Apoa2tm1Bres/Apoa2+,Apoetm1Bres/Apoetm1Bres
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

Allelic Composition: Fmn1ld-TgHD/Fmn1ld-TgHD
Genetic Background: involves: C57BL/6 * CD-1

 MP:0002544 brachydactyly "abnormally short digits" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: ajIs(17;In2)1Gso/ajIs(17;In2)1Gso,Fmn1ld-Is(17;In2)1Gso/Fmn1ld-Is(17;In2)1Gso
Genetic Background: involves: 101/Rl * C3H/Rl * C57BL/E * SEC/Rl

 MP:0002764 short tibia " reduced length of the medial and larger bone of the lower leg" [J:12736, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Fmn1ld-Lsk/Fmn1ld-Lsk
Genetic Background: C.Cg-Fmn1ld-Lsk

 MP:0003073 abnormal metacarpal bone morphology "anomaly in the five bones of the forepaws that articulate proximally with the carpal bones and distally with the phlanges" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8, Anatomy of the Rat:Greene, EC, Hafner Publishing Co, 1935]
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Allelic Composition: Apoa2tm1Bres/Apoa2+,Apoetm1Bres/Apoetm1Bres
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

 MP:0003446 renal hypoplasia "decreased cell number in the kidney leading to reduced size" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
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Allelic Composition: ajIs(17;In2)1Gso/ajIs(17;In2)1Gso,Fmn1ld-Is(17;In2)1Gso/Fmn1ld-Is(17;In2)1Gso
Genetic Background: involves: 101/Rl * C3H/Rl * C57BL/E * SEC/Rl

 MP:0003586 ureter dilation "abnormal distention of the ureter due to accumulation of fluid" [ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: ajIs(17;In2)1Gso/ajIs(17;In2)1Gso,Fmn1ld-Is(17;In2)1Gso/Fmn1ld-Is(17;In2)1Gso
Genetic Background: involves: 101/Rl * C3H/Rl * C57BL/E * SEC/Rl

 MP:0003604 single kidney 
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Allelic Composition: Apoa2tm1Bres/Apoa2+,Apoetm1Bres/Apoetm1Bres
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

Allelic Composition: Fmn1tm1Led/Fmn1tm1Led
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

Allelic Composition: Fmn1tm2Led/Fmn1tm2Led
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

Allelic Composition: Fmn1ld-TgBri137/Fmn1tm1Led
Genetic Background: involves: 129S6/SvEvTac * Black Swiss * C57BL/6 * SJL

Allelic Composition: Fmn1tm1Awb/Fmn1tm1Awb
Genetic Background: involves: 129S4/SvJae * NIH Black Swiss

Allelic Composition: Fmn1tm1Awb/Fmn1ld-TgBri137
Genetic Background: involves: 129S4/SvJae * C57BL/6 * NIH Black Swiss * SJL

Allelic Composition: ajIs(17;In2)1Gso/ajIs(17;In2)1Gso,Fmn1ld-Is(17;In2)1Gso/Fmn1ld-Is(17;In2)1Gso
Genetic Background: involves: 101/Rl * C3H/Rl * C57BL/E * SEC/Rl

Allelic Composition: Fmn1tm2Made/Fmn1tm2Made
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

Allelic Composition: Fmn1tm2Made/Fmn1tm2Made
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * FVB/N

Allelic Composition: Fmn1ld-TgHD/Fmn1ld-TgHD
Genetic Background: involves: BALB/c * C57BL/6 * CD-1 * FVB/N

 MP:0003722 absent ureter "missing the tube that conducts the urine from the renal pelvis to the bladder" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Fmn1tm1Awb/Fmn1tm1Awb
Genetic Background: involves: 129S4/SvJae * NIH Black Swiss

 MP:0004356 radius hypoplasia "underdevelopment or reduced size, usually due to a reduced number of cells, in the short bone of the lateral forearm" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: ajIs(17;In2)1Gso/ajIs(17;In2)1Gso,Fmn1ld-Is(17;In2)1Gso/Fmn1ld-Is(17;In2)1Gso
Genetic Background: involves: 101/Rl * C3H/Rl * C57BL/E * SEC/Rl

 MP:0004642 fused metatarsal bones "improper union of the five bones of the hindpaws/feet that articulate proximally with the cuneiform and cuboid bones of the tarsus and distally with the phalanges" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Fmn1tm2Made/Fmn1tm2Made
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

Allelic Composition: Fmn1tm2Made/Fmn1tm2Made
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * FVB/N

 MP:0005104 abnormal tarsus morphology "malformation or absence of any of the eight bones of the instep of the paw: tibiale, talus, calcaneus, navicular, 3 cuneiform, and cuboid bones" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:83132, Anatomy of the Rat:Greene, EC, Hafner Publishing Co, 1935]
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Allelic Composition: ajIs(17;In2)1Gso/ajIs(17;In2)1Gso,Fmn1ld-Is(17;In2)1Gso/Fmn1ld-Is(17;In2)1Gso
Genetic Background: involves: 101/Rl * C3H/Rl * C57BL/E * SEC/Rl

 MP:0005108 abnormal ulna morphology "malformation of the medial and larger of the two bones of the forearm" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:83132]
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Allelic Composition: Apoa2tm1Bres/Apoa2+,Apoetm1Bres/Apoetm1Bres
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

Allelic Composition: Fmn1ld-Lsk/Fmn1ld-Lsk
Genetic Background: C.Cg-Fmn1ld-Lsk

Allelic Composition: ajIs(17;In2)1Gso/ajIs(17;In2)1Gso,Fmn1ld-Is(17;In2)1Gso/Fmn1ld-Is(17;In2)1Gso
Genetic Background: involves: 101/Rl * C3H/Rl * C57BL/E * SEC/Rl

Allelic Composition: Fmn1ld-TgHD/Fmn1ld-TgHD
Genetic Background: involves: C57BL/6 * CD-1

 MP:0005353 abnormal patella morphology "anomalous structure of the large sesamoid bone that covers the anterior surface of the knee" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:47316]
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Allelic Composition: ajIs(17;In2)1Gso/ajIs(17;In2)1Gso,Fmn1ld-Is(17;In2)1Gso/Fmn1ld-Is(17;In2)1Gso
Genetic Background: involves: 101/Rl * C3H/Rl * C57BL/E * SEC/Rl

 MP:0005409 darkened coat color "amount and distribution of yellow pigment (phaeomelanin) relative to black or brown pigment (eumelanin) is decreasesd when compared to wild-type agouti" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
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Allelic Composition: ajIs(17;In2)1Gso/ajIs(17;In2)1Gso,Fmn1ld-Is(17;In2)1Gso/Fmn1ld-Is(17;In2)1Gso
Genetic Background: involves: 101/Rl * C3H/Rl * C57BL/E * SEC/Rl

 MP:0005430 absent fibula "missing the lateral and shorter of the two bones of the lower leg" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:86196]
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Allelic Composition: Fmn1ld-Lsk/Fmn1ld-Lsk
Genetic Background: C.Cg-Fmn1ld-Lsk

Allelic Composition: ajIs(17;In2)1Gso/ajIs(17;In2)1Gso,Fmn1ld-Is(17;In2)1Gso/Fmn1ld-Is(17;In2)1Gso
Genetic Background: involves: 101/Rl * C3H/Rl * C57BL/E * SEC/Rl

Allelic Composition: Fmn1tm2Made/Fmn1tm2Made
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

Allelic Composition: Fmn1tm2Made/Fmn1tm2Made
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * FVB/N

 MP:0005621 abnormal cell physiology "aberration in the vital processes of the cell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator]
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Allelic Composition: Tnfsf11tm1Ywc/Tnfsf11+
Genetic Background: involves: 129P2/OlaHsd

 MP:0006279 abnormal limb development "anomaly in the formation of the limbs" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Fmn1tm2Made/Fmn1+,Grem1tm1Azun/Grem1+
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6J

 MP:0008528 polycystic kidney "the development of innumerable cysts in the kidneys filled with fluid replacing much of the mass of the kidneys leading to reduction in kidney function and frequently kidney failure" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Apoc3tm1Unc/Apoc3tm1Unc
Genetic Background: B6.129-Apoc3tm1Unc/J

 MP:0008730 fused phalanges "anomaly of the long bones of the digits resulting in some or all the bones being joined together" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Fmn1ld-TgHD/Fmn1ld-TgHD
Genetic Background: involves: C57BL/6 * CD-1

 MP:0008915 fused carpal bones "anomaly of the nine nodular bones of the joint between the forelimb bones and the front paws/hands resulting in some or all the bones being joined together" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: ajIs(17;In2)1Gso/ajIs(17;In2)1Gso,Fmn1ld-Is(17;In2)1Gso/Fmn1ld-Is(17;In2)1Gso
Genetic Background: involves: 101/Rl * C3H/Rl * C57BL/E * SEC/Rl

 MP:0008919 fused tarsal bones "anomaly of the eight bones of the instep of the paw/foot resulting in some or all the bones being joined together" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: ajIs(17;In2)1Gso/ajIs(17;In2)1Gso,Fmn1ld-Is(17;In2)1Gso/Fmn1ld-Is(17;In2)1Gso
Genetic Background: involves: 101/Rl * C3H/Rl * C57BL/E * SEC/Rl

Allelic Composition: Fmn1ld-TgHD/Fmn1ld-TgHD
Genetic Background: involves: C57BL/6 * CD-1

 MP:0009728 abnormal calcaneum morphology "any structural anomaly of the largest quadrangular bone at the back of the tarsus; it forms the heel or hock and articulates with the talus above it" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Fmn1ld-Lsk/Fmn1ld-Lsk
Genetic Background: C.Cg-Fmn1ld-Lsk

 MP:0011090 partial perinatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
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Allelic Composition: Apoa2tm1Bres/Apoa2+,Apoetm1Bres/Apoetm1Bres
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

 MP:0011797 blind ureter "a ureter ending in a blind-ended segment or pouch" [MGI:anna]
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Allelic Composition: Fmn1tm1Awb/Fmn1tm1Awb
Genetic Background: involves: 129S4/SvJae * NIH Black Swiss

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
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