ENSMUSG00000045991


Mus musculus

Features
Gene ID: ENSMUSG00000045991
  
Biological name :Onecut2
  
Synonyms : Onecut2 / One cut domain family member 2 / Q6XBJ3
  
Possible biological names infered from orthology : O95948 / one cut homeobox 2
  
Species: Mus musculus
  
Chr. number: 18
Strand: 1
Band: E1
Gene start: 64340364
Gene end: 64398488
  
Corresponding Affymetrix probe sets: 10456248 (MoGene1.0st)   1440005_at (Mouse Genome 430 2.0 Array)   1444980_at (Mouse Genome 430 2.0 Array)   1460044_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000110798
Ensembl peptide - ENSMUSP00000135692
NCBI entrez gene - 225631     See in Manteia.
MGI - MGI:1891408
RefSeq - NM_194268
RefSeq Peptide - NP_919244
swissprot - H3BL85
swissprot - Q6XBJ3
Ensembl - ENSMUSG00000045991
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 onecut2ENSDARG00000090387Danio rerio
 ONECUT2ENSGALG00000035751Gallus gallus
 O95948ENSG00000119547Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
O08755 / Onecut1 / one cut domain, family member 1 / Q9UBC0* / one cut homeobox 1*ENSMUSG0000004301362
Q8K557 / Onecut3 / One cut domain family member 3 / O60422* / one cut homeobox 3*ENSMUSG0000004551853
Cux1 / cut-like homeobox 1 / P39880* / Q13948*ENSMUSG0000002970523
Cux2 / P70298 / Homeobox protein cut-like 2 / O14529* / cut like homeobox 2*ENSMUSG0000004258920


Protein motifs (from Interpro)
Interpro ID Name
 IPR001356  Homeobox domain
 IPR003350  CUT domain
 IPR009057  Homeobox-like domain superfamily
 IPR010982  Lambda repressor-like, DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001889 liver development IGI
 biological_processGO:0001952 regulation of cell-matrix adhesion IGI
 biological_processGO:0002064 epithelial cell development IMP
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0009653 anatomical structure morphogenesis IMP
 biological_processGO:0030335 positive regulation of cell migration IGI
 biological_processGO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway IGI
 biological_processGO:0031016 pancreas development IGI
 biological_processGO:0031018 endocrine pancreas development IGI
 biological_processGO:0045165 cell fate commitment IGI
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0048935 peripheral nervous system neuron development IMP
 biological_processGO:0060271 cilium assembly IMP
 cellular_componentGO:0005634 nucleus IBA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0015629 actin cytoskeleton IEA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0003677 DNA binding IDA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IDA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000598 abnormal liver morphology "malformation or absence of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:23170]
Show

Allelic Composition: Vangl2Lp/Vangl2+,MkksGt(OST367255)Lex/Mkks+
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J * LPT/LeJ

 MP:0002929 abnormal bile duct development "incomplete or aberrant differentiation of the channels that secrete bile from the liver to the gall bladder and intestines" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission]
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Allelic Composition: Vangl2Lp/Vangl2+,MkksGt(OST367255)Lex/Mkks+
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J * LPT/LeJ

 MP:0003934 abnormal pancreas development "anomaly in the formation of the organ that secretes pancreatic juice into the duodenum and secretes glucagon and insulin into the bloodstream" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Onecut1tm1Flem/Onecut1tm1Flem,Onecut2tm1Flem/Onecut2tm1Flem
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Swiss

 MP:0012242 abnormal hepatoblast differentiation "developmental anomaly or inability of hepatoblasts to differentiate into hepatocytes and cholangiocytes" [MGI:anna]
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Allelic Composition: Onecut1tm1Flem/Onecut1tm1Flem,Onecut2tm1Flem/Onecut2tm1Flem
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Swiss

 MP:0012246 abnormal hepatic cord morphology "any structural anomaly of the three-dimensional arrangement formed by plates of hepatocytes, usually one cell thick, that radiates from the center of the liver lobule; hepatic laminae are highly branched, irregular structures bordered by endothelial lined vascular spaces called hepatic sinusoids" [MGI:anna]
Show

Allelic Composition: Onecut1tm1Flem/Onecut1tm1Flem,Onecut2tm1Flem/Onecut2tm1Flem
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Swiss

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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