ENSMUSG00000042589


Mus musculus

Features
Gene ID: ENSMUSG00000042589
  
Biological name :Cux2
  
Synonyms : Cux2 / Homeobox protein cut-like 2 / P70298
  
Possible biological names infered from orthology : cut like homeobox 2 / O14529
  
Species: Mus musculus
  
Chr. number: 5
Strand: -1
Band: F
Gene start: 121856366
Gene end: 122050102
  
Corresponding Affymetrix probe sets: 10533401 (MoGene1.0st)   10533403 (MoGene1.0st)   1447500_at (Mouse Genome 430 2.0 Array)   1447821_at (Mouse Genome 430 2.0 Array)   1450181_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000107381
Ensembl peptide - ENSMUSP00000120095
Ensembl peptide - ENSMUSP00000130302
Ensembl peptide - ENSMUSP00000083497
Ensembl peptide - ENSMUSP00000114948
NCBI entrez gene - 13048     See in Manteia.
MGI - MGI:107321
RefSeq - XM_017320655
RefSeq - XM_011248171
RefSeq - XM_011248172
RefSeq - XM_011248173
RefSeq - XM_011248174
RefSeq - XM_011248176
RefSeq - NM_001312908
RefSeq - NM_007804
RefSeq - XM_006530157
RefSeq - XM_011248164
RefSeq - XM_011248166
RefSeq - XM_011248167
RefSeq - XM_011248168
RefSeq - XM_011248169
RefSeq - XM_011248170
RefSeq Peptide - NP_001299837
RefSeq Peptide - NP_031830
swissprot - F6YIR2
swissprot - P70298
swissprot - D3YUK2
Ensembl - ENSMUSG00000042589
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cux2bENSDARG00000086345Danio rerio
 CUX2ENSGALG00000004598Gallus gallus
 CUX2ENSG00000111249Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Cux1 / cut-like homeobox 1 / P39880* / Q13948*ENSMUSG0000002970543
O08755 / Onecut1 / one cut domain, family member 1 / Q9UBC0* / one cut homeobox 1*ENSMUSG000000430137
Q8K557 / Onecut3 / One cut domain family member 3 / O60422* / one cut homeobox 3*ENSMUSG000000455187
Q6XBJ3 / Onecut2 / One cut domain family member 2 / O95948* / one cut homeobox 2*ENSMUSG000000459917


Protein motifs (from Interpro)
Interpro ID Name
 IPR001356  Homeobox domain
 IPR003350  CUT domain
 IPR009057  Homeobox-like domain superfamily
 IPR010982  Lambda repressor-like, DNA-binding domain superfamily
 IPR017970  Homeobox, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IDA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0007614 short-term memory IMP
 biological_processGO:0010628 positive regulation of gene expression IMP
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IDA
 biological_processGO:0048193 Golgi vesicle transport IBA
 biological_processGO:0050775 positive regulation of dendrite morphogenesis IMP
 biological_processGO:0050890 cognition ISO
 biological_processGO:0051965 positive regulation of synapse assembly IMP
 biological_processGO:0061003 positive regulation of dendritic spine morphogenesis IMP
 biological_processGO:0071310 cellular response to organic substance IDA
 biological_processGO:2000463 positive regulation of excitatory postsynaptic potential IMP
 cellular_componentGO:0000139 Golgi membrane IBA
 cellular_componentGO:0005634 nucleus ISO
 molecular_functionGO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IMP
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0001078 transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0003677 DNA binding IDA
 molecular_functionGO:0043565 sequence-specific DNA binding ISO


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000352 decreased cell proliferation "less than the normal growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Arxtm1.1Jno/Arxtm1.1Jno
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0000788 abnormal cerebral cortex morphology "malformed gray cellular mantle covering the surface of the brain" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:38857]
Show

Allelic Composition: Stat3tm1Dlv/Stat3tm1Dlv,Tg(Csf1r-icre)1Jwp/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB

 MP:0000789 thickened cerebral cortex "Increased depth of the mantle coveringthe surface of the cerebral hemispheres" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:49481]
Show

Allelic Composition: Stat3tm1Dlv/Stat3tm1Dlv,Tg(Csf1r-icre)1Jwp/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB

 MP:0002151 abnormal neural tube morphology/development "anomalous structure of or development of the embryonic neural tube resulting in structural anomaly" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Arxtm1.1Jno/Arxtm1.1Jno
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0003077 abnormal cell cycle "failure to progress or abnormal progression through the stages of of the cell cycle" [smb:Susan M. Bello, Mouse Genome Informatics Curator, J:91266]
Show

Allelic Composition: Arxtm1.1Jno/Arxtm1.1Jno
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0003993 abnormal ventral spinal root morphology "any anomaly, deformity, or malformation of the anterior bundle of nerves emerging from the spinal cord to join with the posterior/dorsal nerve bundle at each spinal cord segment to form one of the 31 paired peripheral nerves" [brs:Beverly Richards-Smith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Arxtm1.1Jno/Arxtm1.1Jno
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0004100 abnormal spinal cord interneuron morphology "malformation or absence of neurons that exclusively interact with other neurons in the spinal cord" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Arxtm1.1Jno/Arxtm1.1Jno
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0004274 abnormal embryonic/fetal subventricular zone morphology "any structural anomaly in the transient proliferative population of neurons that expands exponentially during late prenatal development; it is a continuous germinal zone distinct from the ventricular zone that surrounds the brain ventricles" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:12637172]
Show

Allelic Composition: Stat3tm1Dlv/Stat3tm1Dlv,Tg(Csf1r-icre)1Jwp/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB

 MP:0004948 abnormal neuronal precursor proliferation "any anomaly in the ability of a neuroblast population to undergo rapid expansion by cell division" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Stat3tm1Dlv/Stat3tm1Dlv,Tg(Csf1r-icre)1Jwp/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB

 MP:0005238 increased brain size "larger than the normal physical proportions of the brain" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:57958]
Show

Allelic Composition: Stat3tm1Dlv/Stat3tm1Dlv,Tg(Csf1r-icre)1Jwp/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB

 MP:0006009 abnormal neuronal migration "defective or impaired movement of immature neurons from germinal zones to specific positions where they will reside as they mature" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Dab1tm1.1Mull/Dab1tm1.1Mull,Cux2tm2.1(cre)Mull/Cux2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * SJL

 MP:0008547 abnormal neocortex morphology "any structural anomaly of the larger part of the mammalian cerebral cortex, distinguished from the allocortex by being composed of a larger number of nerve cells arranged in six layers" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MESH:A08.186.211.730.885.213.420]
Show

Allelic Composition: Stat3tm1Dlv/Stat3tm1Dlv,Tg(Csf1r-icre)1Jwp/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB

Allelic Composition: Dab1tm1.1Mull/Dab1tm1.1Mull,Cux2tm2.1(cre)Mull/Cux2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * SJL

 MP:0008947 increased neuron number "greater than normal numbers of the cells of the nervous system that receive, conduct, and transmit impulses" [MESH:A08.663]
Show

Allelic Composition: Stat3tm1Dlv/Stat3tm1Dlv,Tg(Csf1r-icre)1Jwp/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB

Allelic Composition: Cux1tm2Ejn/Cux1tm2Ejn,Cux2tm1.1Nieto/Cux2tm1.1Nieto
Genetic Background: involves: 129S4/SvJae * C57BL6 * FVB/N * Swiss Webster

 MP:0009689 abnormal neural tube ventricular layer morphology "any structural anomaly of the layer of undifferentiated, proliferating cells that line the neural tube lumen" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Arxtm1.1Jno/Arxtm1.1Jno
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0009691 abnormal neural tube marginal layer morphology "any structural anomaly of the outermost layer of the neural tube that contains nerve fibers and will form the white matter" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Arxtm1.1Jno/Arxtm1.1Jno
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0011101 partial prenatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Arxtm1.1Jno/Arxtm1.1Jno
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0011109 partial lethality throughout fetal growth and development "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Cux1tm2Ejn/Cux1tm2Ejn,Cux2tm1.1Nieto/Cux2tm1.1Nieto
Genetic Background: involves: 129S4/SvJae * C57BL6 * FVB/N * Swiss Webster

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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