ENSMUSG00000046295


Mus musculus

Features
Gene ID: ENSMUSG00000046295
  
Biological name :Ankle1
  
Synonyms : A8VU90 / Ankle1 / Ankyrin repeat and LEM domain-containing protein 1
  
Possible biological names infered from orthology : ankyrin repeat and LEM domain containing 1 / Q8NAG6
  
Species: Mus musculus
  
Chr. number: 8
Strand: 1
Band: B3.3
Gene start: 71406010
Gene end: 71409904
  
Corresponding Affymetrix probe sets: 10572605 (MoGene1.0st)   1443978_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000112797
Ensembl peptide - ENSMUSP00000113162
NCBI entrez gene - 234396     See in Manteia.
MGI - MGI:1918775
RefSeq - XM_006509662
RefSeq - NM_001310502
RefSeq - NM_172756
RefSeq - XM_006509661
RefSeq Peptide - NP_766344
RefSeq Peptide - NP_001297431
swissprot - A8VU90
Ensembl - ENSMUSG00000046295
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 zgc:85936ENSDARG00000087529Danio rerio
 ANKLE1ENSG00000160117Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000305  GIY-YIG endonuclease
 IPR002110  Ankyrin repeat
 IPR003887  LEM domain
 IPR011015  LEM/LEM-like domain superfamily
 IPR020683  Ankyrin repeat-containing domain
 IPR034998  Ankyrin repeat and LEM domain-containing protein 1
 IPR036770  Ankyrin repeat-containing domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006611 protein export from nucleus ISO
 biological_processGO:0006974 cellular response to DNA damage stimulus IEA
 biological_processGO:0006998 nuclear envelope organization IBA
 biological_processGO:0045950 negative regulation of mitotic recombination IGI
 biological_processGO:0070197 meiotic attachment of telomere to nuclear envelope IBA
 biological_processGO:0090305 nucleic acid phosphodiester bond hydrolysis IEA
 biological_processGO:1905453 regulation of myeloid progenitor cell differentiation IMP
 biological_processGO:1905456 regulation of lymphoid progenitor cell differentiation IMP
 biological_processGO:2001022 positive regulation of response to DNA damage stimulus ISO
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005639 integral component of nuclear inner membrane IBA
 cellular_componentGO:0005737 cytoplasm IEA
 molecular_functionGO:0004518 nuclease activity IEA
 molecular_functionGO:0004519 endonuclease activity ISO
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0031490 chromatin DNA binding IBA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0011101 partial prenatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
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Allelic Composition: Nodaltm1Rob/Nodal+,Zic2Ku/Zic2Ku
Genetic Background: 129S.Cg-Nodaltm1Rob Zic2Ku

Allelic Composition: Ankle1tm1.2(KOMP)Wtsi/Ankle1tm1.2(KOMP)Wtsi
Genetic Background: involves: C57BL/6J * C57BL/6N

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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