ENSMUSG00000046354


Mus musculus

Features
Gene ID: ENSMUSG00000046354
  
Biological name :Defb14
  
Synonyms : Beta-defensin 14 / Defb14 / Q7TNV9
  
Possible biological names infered from orthology : DEFB103A / DEFB103B / defensin beta 103A / defensin beta 103B / P81534
  
Species: Mus musculus
  
Chr. number: 8
Strand: 1
Band: A1.3
Gene start: 19194357
Gene end: 19195212
  
Corresponding Affymetrix probe sets: 10570606 (MoGene1.0st)   
  
Cross references: Ensembl peptide - ENSMUSP00000062781
NCBI entrez gene - 244332     See in Manteia.
MGI - MGI:2675345
RefSeq - XM_006508797
RefSeq - NM_183026
RefSeq - XM_006508794
RefSeq - XM_006508795
RefSeq - XM_006508792
RefSeq Peptide - NP_898847
swissprot - Q7TNV9
Ensembl - ENSMUSG00000046354
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 P81534ENSG00000177243Homo sapiens
 P81534ENSG00000176797Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR001855  Beta defensin type


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006952 defense response IEA
 biological_processGO:0042742 defense response to bacterium ISO
 biological_processGO:0050918 positive chemotaxis IEA
 biological_processGO:0060326 cell chemotaxis IDA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space ISO
 molecular_functionGO:0042056 chemoattractant activity IDA


Pathways (from Reactome)
Pathway description
Beta defensins
Defensins


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000062 increased bone density "increased mineral content of bone; indicator of bone strength" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61295]
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Allelic Composition: Dbn1tm1b(KOMP)Wtsi/Dbn1tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Dbn1tm1b(KOMP)Wtsi/Ucd

 MP:0000182 increased circulating LDL cholesterol level "greater than average concentration in the blood of low density lipoprotein, which normally transports cholesterol to tissues other than the liver" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Dbn1tm1b(KOMP)Wtsi/Dbn1tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Dbn1tm1b(KOMP)Wtsi/Ucd

 MP:0003442 decreased circulating glycerol level "lower than normal concentration of glycerol in the blood" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Dbn1tm1b(KOMP)Wtsi/Dbn1tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Dbn1tm1b(KOMP)Wtsi/Ucd

 MP:0010052 increased grip strength "greater ability to grasp and hold objects, often measured as time spent hanging from an object or wire" [ISBN:0471316393 "Crawley, JN, What s Wrong with my Mouse: Behavioral Phenotyping of Transgenic and Knockout Mice"]
Show

Allelic Composition: Dbn1tm1b(KOMP)Wtsi/Dbn1tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Dbn1tm1b(KOMP)Wtsi/Ucd

 MP:0010093 decreased circulating magnesium level "a reduction in the blood concentration of magnesium" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Dbn1tm1b(KOMP)Wtsi/Dbn1tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Dbn1tm1b(KOMP)Wtsi/Ucd

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000027995 Tlr2 / toll-like receptor 2 / O60603*  / complex / reaction
 ENSMUSG00000040899 Ccr6 / O54689 / Mus musculus chemokine (C-C motif) receptor 6 (Ccr6), transcript variant 7, mRNA. / P51684* / C-C motif chemokine receptor 6*  / complex / reaction
 ENSMUSG00000049103 Ccr2 / P51683 / C-C chemokine receptor type 2 / P41597* / C-C motif chemokine receptor 2*  / complex / reaction
 ENSMUSG00000044827 Tlr1 / Q9EPQ1 / toll-like receptor 1 / Q15399*  / complex / reaction






 

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