ENSMUSG00000040899


Mus musculus
cellCcr6decreasedtincreasedreceptorsecretionchemokinemigrationphysiologycdregulationspermmembranepeyersdendriticactivitypatchsusceptibilitydevelopmentmacrophageintraepithelialinterleukin-responsechemotaxissignalingthymocyteplasmacountb

Features
Gene ID: ENSMUSG00000040899
  
Biological name :Ccr6
  
Synonyms : Ccr6 / Mus musculus chemokine (C-C motif) receptor 6 (Ccr6), transcript variant 7, mRNA. / O54689
  
Possible biological names infered from orthology : C-C motif chemokine receptor 6 / P51684
  
Species: Mus musculus
  
Chr. number: 17
Strand: 1
Band: A1
Gene start: 8236043
Gene end: 8257127
  
Corresponding Affymetrix probe sets: 10441633 (MoGene1.0st)   1450357_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000095029
Ensembl peptide - ENSMUSP00000128529
Ensembl peptide - ENSMUSP00000128559
Ensembl peptide - ENSMUSP00000131153
Ensembl peptide - ENSMUSP00000135945
Ensembl peptide - ENSMUSP00000137249
NCBI entrez gene - 12458     See in Manteia.
MGI - MGI:1333797
RefSeq - XM_017317220
RefSeq - NM_001190333
RefSeq - NM_001190334
RefSeq - NM_001190335
RefSeq - NM_001190336
RefSeq - NM_001190337
RefSeq - NM_001190338
RefSeq - NM_009835
RefSeq - XM_006523286
RefSeq - XM_006523288
RefSeq - XM_006523290
RefSeq - XM_006523291
RefSeq - XM_006523292
RefSeq - XM_011246186
RefSeq - XM_011246188
RefSeq - XM_017317218
RefSeq - XM_017317219
RefSeq Peptide - NP_001177262
RefSeq Peptide - NP_001177264
RefSeq Peptide - NP_001177265
RefSeq Peptide - NP_001177266
RefSeq Peptide - NP_001177267
RefSeq Peptide - NP_033965
RefSeq Peptide - NP_001177263
swissprot - Q542B6
swissprot - O54689
Ensembl - ENSMUSG00000040899
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ccr6aENSDARG00000087474Danio rerio
 ccr6bENSDARG00000038968Danio rerio
 CCR6ENSGALG00000011418Gallus gallus
 CCR6ENSG00000112486Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ccr7 / P47774 / C-C chemokine receptor type 7 / P32248* / C-C motif chemokine receptor 7*ENSMUSG0000003794438
Ccr4 / P51680 / C-C chemokine receptor type 4 / P51679* / C-C motif chemokine receptor 4*ENSMUSG0000004789834
Ccr9 / Q9WUT7 / C-C chemokine receptor type 9 / P51686* / C-C motif chemokine receptor 9*ENSMUSG0000002953033
Ackr4 / Q924I3 / atypical chemokine receptor 4 / Q9NPB9*ENSMUSG0000007935533
Cxcr2 / P35343 / C-X-C chemokine receptor type 2 / P25025* / C-X-C motif chemokine receptor 2*ENSMUSG0000002618032
Ccr3 / P51678 / Probable C-C chemokine receptor type 3 / P51677* / C-C motif chemokine receptor 3*ENSMUSG0000003544832
Cxcr6 / Q9EQ16 / C-X-C chemokine receptor type 6 / O00574* / C-X-C motif chemokine receptor 6*ENSMUSG0000004852132
Ccr2 / P51683 / C-C chemokine receptor type 2 / P41597* / C-C motif chemokine receptor 2*ENSMUSG0000004910332
Ackr2 / O08707 / atypical chemokine receptor 2 / O00590*ENSMUSG0000004453431
Cxcr1 / Q810W6 / C-X-C chemokine receptor type 1 / P25024* / C-X-C motif chemokine receptor 1*ENSMUSG0000004848031
Cxcr3 / O88410 / C-X-C chemokine receptor type 3 / P49682* / C-X-C motif chemokine receptor 3*ENSMUSG0000005023231
Cx3cr1 / Q9Z0D9 / CX3C chemokine receptor 1 / P49238* / C-X3-C motif chemokine receptor 1*ENSMUSG0000005233631
Ccr5 / P51682 / C-C chemokine receptor type 5 / P51681* / C-C motif chemokine receptor 5 (gene/pseudogene)*ENSMUSG0000007922731
Cxcr4 / Mus musculus chemokine (C-X-C motif) receptor 4 (Cxcr4), transcript variant 2, mRNA. / P61073* / C-X-C motif chemokine receptor 4*ENSMUSG0000004538230
Ccr8 / P56484 / C-C chemokine receptor type 8 / P51685* / C-C motif chemokine receptor 8*ENSMUSG0000004226229
Ccr10 / Q9JL21 / C-C chemokine receptor type 10 / P46092* / C-C motif chemokine receptor 10*ENSMUSG0000004405229
Cxcr5 / Q04683 / C-X-C chemokine receptor type 5 / P32302* / C-X-C motif chemokine receptor 5*ENSMUSG0000004788029
Ccr1 / P51675 / C-C chemokine receptor type 1 / P32246* / C-C motif chemokine receptor 1*ENSMUSG0000002580428
Ccr1l1 / P51676 / C-C chemokine receptor 1-like protein 1 / CCR1* / P32246* / C-C motif chemokine receptor 1*ENSMUSG0000006403924
Xcr1 / chemokine (C motif) receptor 1 / P46094* / X-C motif chemokine receptor 1*ENSMUSG0000006050923


Protein motifs (from Interpro)
Interpro ID Name
 IPR000276  G protein-coupled receptor, rhodopsin-like
 IPR000355  Chemokine receptor family
 IPR004067  CC chemokine receptor 6
 IPR017452  GPCR, rhodopsin-like, 7TM


Gene Ontology (GO)
response to stresslocalization of cellmovement of cell or subcellular componentresponse to external stimulusresponse to chemicalimmune responsecell communicationcellular response to stimulusregulation of biological qualitytissue migrationnitrogen compound metabolic processproduction of molecular mediator of immune responsecellular metabolic processprimary metabolic processorganic substance metabolic processanatomical structure developmentcell activationimmune effector processcellular developmental processmulticellular organism reproductiondevelopmental maturationresponse to stresslocalization of cellmovement of cell or subcellular componentresponse to external stimulusresponse to chemicalimmune responsecell communicationcellular response to stimulusregulation of biological qualitytissue migrationnitrogen compound metabolic processproduction of molecular mediator of immune responsecellular metabolic processprimary metabolic processorganic substance metabolic processanatomical structure developmentcell activationimmune effector processcellular developmental processmulticellular organism reproductiondevelopmental maturationresponse to stresslocalization of cellmovement of cell or subcellular componentresponse to external stimulusresponse to chemicalimmune responsecell communicationcellular response to stimulusregulation of biological qualitytissue migrationnitrogen compound metabolic processproduction of molecular mediator of immune responsecellular metabolic processprimary metabolic processorganic substance metabolic processanatomical structure developmentcell activationimmune effector processcellular developmental processmulticellular organism reproductiondevelopmental maturationresponse to stresslocalization of cellmovement of cell or subcellular componentresponse to external stimulusresponse to chemicalimmune responsecell communicationcellular response to stimulusregulation of biological qualitytissue migrationnitrogen compound metabolic processproduction of molecular mediator of immune responsecellular metabolic processprimary metabolic processorganic substance metabolic processanatomical structure developmentcell activationimmune effector processcellular developmental processmulticellular organism reproductiondevelopmental maturationresponse to stresslocalization of cellmovement of cell or subcellular componentresponse to external stimulusresponse to chemicalimmune responsecell communicationcellular response to stimulusregulation of biological qualitytissue migrationnitrogen compound metabolic processproduction of molecular mediator of immune responsecellular metabolic processprimary metabolic processorganic substance metabolic processanatomical structure developmentcell activationimmune effector processcellular developmental processmulticellular organism reproductiondevelopmental maturationresponse to stresslocalization of cellmovement of cell or subcellular componentresponse to external stimulusresponse to chemicalimmune responsecell communicationcellular response to stimulusregulation of biological qualitytissue migrationnitrogen compound metabolic processproduction of molecular mediator of immune responsecellular metabolic processprimary metabolic processorganic substance metabolic processanatomical structure developmentcell activationimmune effector processcellular developmental processmulticellular organism reproductiondevelopmental maturationresponse to stresslocalization of cellmovement of cell or subcellular componentresponse to external stimulusresponse to chemicalimmune responsecell communicationcellular response to stimulusregulation of biological qualitytissue migrationnitrogen compound metabolic processproduction of molecular mediator of immune responsecellular metabolic processprimary metabolic processorganic substance metabolic processanatomical structure developmentcell activationimmune effector processcellular developmental processmulticellular organism reproductiondevelopmental maturationresponse to stresslocalization of cellmovement of cell or subcellular componentresponse to external stimulusresponse to chemicalimmune responsecell communicationcellular response to stimulusregulation of biological qualitytissue migrationnitrogen compound metabolic processproduction of molecular mediator of immune responsecellular metabolic processprimary metabolic processorganic substance metabolic processanatomical structure developmentcell activationimmune effector processcellular developmental processmulticellular organism reproductiondevelopmental maturationresponse to stresslocalization of cellmovement of cell or subcellular componentresponse to external stimulusresponse to chemicalimmune responsecell communicationcellular response to stimulusregulation of biological qualitytissue migrationnitrogen compound metabolic processproduction of molecular mediator of immune responsecellular metabolic processprimary metabolic processorganic substance metabolic processanatomical structure developmentcell activationimmune effector processcellular developmental processmulticellular organism reproductiondevelopmental maturationresponse to stresslocalization of cellmovement of cell or subcellular componentresponse to external stimulusresponse to chemicalimmune responsecell communicationcellular response to stimulusregulation of biological qualitytissue migrationnitrogen compound metabolic processproduction of molecular mediator of immune responsecellular metabolic processprimary metabolic processorganic substance metabolic processanatomical structure developmentcell activationimmune effector processcellular developmental processmulticellular organism reproductiondevelopmental maturationresponresponse to stresslocalilocalization of cellmovememovement of cell or subcellular componentresponresponse to external stimulusresponresponse to chemicalimmuneimmune responsecell ccell communicationcellulcellular response to stimulusregularegulation of biological qualitytissuetissue migrationnitrognitrogen compound metabolic processproducproduction of molecular mediator of immune responsecellulcellular metabolic processprimarprimary metabolic processorganiorganic substance metabolic processanatomanatomical structure developmentcell acell activationimmuneimmune effector processcellulcellular developmental processmulticmulticellular organism reproductiondevelodevelopmental maturation
signaling receptor activityprotein bindingsignaling receptor activityprotein bindingsignaling receptor activityprotein bindingsignaling receptor activityprotein bindingsignaling receptor activityprotein bindingsignaling receptor activityprotein bindingsignaling receptor activityprotein bindingsignaling receptor activityprotein bindingsignaling receptor activityprotein bindingsignaling receptor activityprotein bindingsignaling receptor activitysignaling receptor activityprotein bindingprotein binding
cellmembraneorganellecellmembraneorganellecellmembraneorganellecellmembraneorganellecellmembraneorganellecellmembraneorganellecellmembraneorganellecellmembraneorganellecellmembraneorganellecellmembraneorganellecellcellmembranemembraneorganelleorganelle
TypeGO IDTermEv.Code
 biological_processGO:0002523 leukocyte migration involved in inflammatory response IMP
 biological_processGO:0006935 chemotaxis ISO
 biological_processGO:0006955 immune response IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IEA
 biological_processGO:0007204 positive regulation of cytosolic calcium ion concentration IEA
 biological_processGO:0010634 positive regulation of epithelial cell migration IEA
 biological_processGO:0019722 calcium-mediated signaling ISO
 biological_processGO:0048290 isotype switching to IgA isotypes IMP
 biological_processGO:0060326 cell chemotaxis ISS
 biological_processGO:0060474 positive regulation of flagellated sperm motility involved in capacitation IDA
 biological_processGO:0070098 chemokine-mediated signaling pathway IEA
 biological_processGO:0072676 lymphocyte migration IMP
 biological_processGO:0072678 T cell migration IDA
 biological_processGO:0072679 thymocyte migration IDA
 biological_processGO:1904155 DN2 thymocyte differentiation IMP
 biological_processGO:1904156 DN3 thymocyte differentiation IMP
 biological_processGO:2000404 regulation of T cell migration IMP
 biological_processGO:2000510 positive regulation of dendritic cell chemotaxis IEA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0009897 external side of plasma membrane IDA
 cellular_componentGO:0009986 cell surface IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0036126 sperm flagellum IDA
 cellular_componentGO:0097225 sperm midpiece ISO
 cellular_componentGO:0097228 sperm principal piece ISO
 cellular_componentGO:0097524 sperm plasma membrane IDA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity IEA
 molecular_functionGO:0004950 chemokine receptor activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016493 C-C chemokine receptor activity IDA
 molecular_functionGO:0019957 C-C chemokine binding IDA


Pathways (from Reactome)
Pathway description
Beta defensins
Chemokine receptors bind chemokines
G alpha (i) signalling events


Phenotype (from MGI, Zfin or HPO)
immune system phenotypehematopoietic system phenotypenervous system phenotypehomeostasis/metabolism phenotypeimmune system phenotypehematopoietic system phenotypenervous system phenotypehomeostasis/metabolism phenotypeimmune system phenotypehematopoietic system phenotypenervous system phenotypehomeostasis/metabolism phenotypeimmune system phenotypehematopoietic system phenotypenervous system phenotypehomeostasis/metabolism phenotypeimmune system phenotypehematopoietic system phenotypenervous system phenotypehomeostasis/metabolism phenotypeimmune system phenotypehematopoietic system phenotypenervous system phenotypehomeostasis/metabolism phenotypeimmune system phenotypehematopoietic system phenotypenervous system phenotypehomeostasis/metabolism phenotypeimmune system phenotypehematopoietic system phenotypenervous system phenotypehomeostasis/metabolism phenotypeimmune system phenotypehematopoietic system phenotypenervous system phenotypehomeostasis/metabolism phenotypeimmune system phenotypehematopoietic system phenotypenervous system phenotypehomeostasis/metabolism phenotypeimmune system phenotypeimmune system phenotypehematopoietic system phenotypehematopoietic system phenotypenervous system phenotypenervous system phenotypehomeostasis/metabolism phenotypehomeostasis/metabolism phenotype
IDPhenotypeDefinition Genetic BG
 MP:0000218 increased WBC count "greater than normal WBC numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Runx1tm1(RUNX1)Gcg/Runx1tm1(RUNX1)Gcg,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA

 MP:0000221 decreased WBC count "fewer than normal numbers of WBCs" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Runx1tm1(RUNX1)Gcg/Runx1tm1(RUNX1)Gcg,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA

 MP:0000696 abnormal Peyer s patches morphology "anomalous structure, development, or cellular make-up of the lymphoid tissue located on the mucosa of the small intestine" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Runx1tm1(RUNX1)Gcg/Runx1tm1(RUNX1)Gcg,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA

Allelic Composition: Ccr6tm1(EGFP)Irw/Ccr6tm1(EGFP)Irw
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: Ccr6tm1Lira/Ccr6tm1Lira
Genetic Background: involves: 129 * C57BL/6

 MP:0000820 abnormal choroid plexus morphology "malformed or absent fringe of the tela choroidea of the cerebral ventricles" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:45302]
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Allelic Composition: Ccr6tm1Lira/Ccr6tm1Lira
Genetic Background: involves: 129 * C57BL/6

 MP:0001807 decreased IgA "less than normal immunoglobulin class A level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ccr6tm1Lira/Ccr6tm1Lira
Genetic Background: involves: 129 * C57BL/6

 MP:0001829 increased activated T cell number "greater than normal numbers of effector T cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ccr6tm1Lira/Ccr6tm1Lira
Genetic Background: involves: 129 * C57BL/6

 MP:0001876 decreased inflammatory response "less than expected response to injury, infection, or insult" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Runx1tm1(RUNX1)Gcg/Runx1tm1(RUNX1)Gcg,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA

Allelic Composition: Ccr6tm1Lira/Ccr6tm1Lira
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Ccr6tm1.1Jmf/Ccr6tm1.1Jmf
Genetic Background: B6.129-Ccr6tm1.1Jmf

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ccl11tm1Mer/Ccl11tm1Mer,Ccl24tm1Mer/Ccl24tm1Mer
Genetic Background: 129S.129S6(Cg)-Ccl24tm1Mer Ccl11tm1Mer

 MP:0002376 abnormal dendritic cell physiology "failure or atypical function of the immunocompetent cells of the lymphoid and hemopoietic systems and skin, which function to process antigens and present them to T cells, thus stimulating cellular immunity" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, J:85808]
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Allelic Composition: Ccr6tm1.1Jmf/Ccr6tm1.1Jmf
Genetic Background: B6.129-Ccr6tm1.1Jmf

 MP:0002378 abnormal gut-associated lymphoid tissue morphology "anomalous structure or development of the regional immune system located in the gut" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Cptm1Samd/Cptm1Samd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Ccr6tm1Lira/Ccr6tm1Lira
Genetic Background: involves: 129 * C57BL/6

 MP:0002389 abnormal Peyer s patch follicle morphology "anomaly of the structure, development, or size of the Peyer s patch normally occupied by B cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Runx1tm1(RUNX1)Gcg/Runx1tm1(RUNX1)Gcg,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA

 MP:0002391 abnormal Peyer s patch germinal center morphology "anomalous structure or differentiation of the area of the Peyer s patch where B cells proliferate and differentiate into plasma cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Ccr6tm1Lira/Ccr6tm1Lira
Genetic Background: involves: 129 * C57BL/6

 MP:0002392 abnormal Peyer s patch T cell area "anomalous structure or development of the Peyer s patch normally occupied by T lymphcytes" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ccr6tm1Lira/Ccr6tm1Lira
Genetic Background: involves: 129

 MP:0002411 decreased susceptibility to bacterial infection "reduced likelihood that an organism will develop ill effects from a bacterial infection or from components of or toxins produced by bacteria " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Gpd2tm1Tka/Gpd2tm1Tka
Genetic Background: involves: C57BL/6 * CBA

 MP:0002418 increased susceptibility to viral infection "greater likelihood that an organism will develop ill effects from a viral infection or from components of or toxins produced by a virus" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ccr6tm1Lira/Ccr6tm1Lira
Genetic Background: involves: 129 * C57BL/6

 MP:0002432 abnormal CD4+ T cell morphology/development "anomalous structure, differentiation, or number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ccr6tm1Lira/Ccr6tm1Lira
Genetic Background: involves: 129 * C57BL/6

 MP:0002435 abnormal effector T cell morphology/development "anomalous structure, formation, or numbers of the set of T lymphocytes that are able to respond immediately upon contact with cells bearing the appropriate peptide:MHC complex for the cell" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Lrig3tm1.1Good/Lrig3tm1.1Good
Genetic Background: involves: BALB/cJ

 MP:0002444 abnormal T cell physiology "anomalous response of T lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cptm1Samd/Cptm1Samd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Ccr6tm1Lira/Ccr6tm1Lira
Genetic Background: involves: 129

 MP:0002451 abnormal macrophage physiology "abnormal function or response of the phagocytic leukocytes involved in innate immunity, early non-adaptive phases of host-defense, antigen presentation, and which act as effector cells in humoral and cell-mediated immunity" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ccr6tm1Lira/Ccr6tm1Lira
Genetic Background: involves: 129 * C57BL/6

 MP:0002459 abnormal B cell physiology "abnormal function of B lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cptm1Samd/Cptm1Samd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002492 decreased IgE "less than normal immunoglobulin class E level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ccr6tm1Lira/Ccr6tm1Lira
Genetic Background: involves: 129 * C57BL/6

 MP:0002494 increased IgM "greater than normal immunoglobulin class M level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ccr6tm1Lira/Ccr6tm1Lira
Genetic Background: involves: 129 * C57BL/6

 MP:0002619 abnormal lymphocyte morphology/development "anomalous structure, differentiation, or number of the white blood cells formed in the body s lymphoid tissue" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Ccr6tm1Lira/Ccr6tm1Lira
Genetic Background: involves: 129 * C57BL/6

 MP:0004800 decreased susceptibility to experimental autoimmune encephalomyelitis "reduced likelihood that an organism will develop disease symptoms similar to human multiple sclerosis upon induction with antigens to Myelin Basic Protein (MBP), Proteolipid Protein (PLP), and/or Myelin Oligodendrocyte glycoprotein (MOG)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ccr6tm1Lira/Ccr6tm1Lira
Genetic Background: involves: 129 * C57BL/6

 MP:0004977 increased B-1 B cell number "greater number of the subset of B cells found predominantly in the peritoneum, pleural cavities, and spleen, and enriched for self-reactivity" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ccr6tm1Lira/Ccr6tm1Lira
Genetic Background: involves: 129 * C57BL/6

 MP:0005015 increased T cell number "greater than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ccr6tm1Lira/Ccr6tm1Lira
Genetic Background: involves: 129 * C57BL/6

 MP:0005017 decreased B cell number "fewer than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ccr6tm1(EGFP)Irw/Ccr6tm1(EGFP)Irw
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: Ccr6tm1Lira/Ccr6tm1Lira
Genetic Background: involves: 129 * C57BL/6

 MP:0005091 increased double-positive T cell count "greater than the expected number of the subset of T cells found in the thymus that express both CD4 and CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Ccr6tm1Lira/Ccr6tm1Lira
Genetic Background: involves: 129 * C57BL/6

 MP:0005348 increased T cell proliferation "increased clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ccr6tm1(EGFP)Irw/Ccr6tm1(EGFP)Irw
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0005463 abnormal CD4+ T cell physiology "anomalous response of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Runx1tm1(RUNX1)Gcg/Runx1tm1(RUNX1)Gcg,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA

Allelic Composition: Ccr6tm1Lira/Ccr6tm1Lira
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Ccr6tm1.1Jmf/Ccr6tm1.1Jmf
Genetic Background: B6.129-Ccr6tm1.1Jmf

 MP:0005597 decreased susceptibility to type I hypersensitivity reaction "less likelihood or resistance to developing a response manifested by localized or generalized reaction that occurs immediately (minutes) after exposure to an antigen to which the person/animal was previously sensitized; it is IgE-mediated, and mast cell activation and degranulation are hallmarks" [Pathology:ISBN 0-397-51047-0, J:68588, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ccr6tm1Lira/Ccr6tm1Lira
Genetic Background: involves: 129 * C57BL/6

 MP:0006173 abnormal Langerhans cell morphology/development "anomaly in the formation or structure of phagocytic dendritic cells principally found in the epidemis and mucosal epithelium" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:95147]
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Allelic Composition: Runx1tm1(RUNX1)Gcg/Runx1tm1(RUNX1)Gcg,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA

Allelic Composition: Ccr6tm1Lira/Ccr6tm1Lira
Genetic Background: involves: 129 * C57BL/6

 MP:0008075 decreased CD4-positive T cell number "reduced number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ccr6tm1Lira/Ccr6tm1Lira
Genetic Background: involves: 129 * C57BL/6

 MP:0008079 decreased CD8-positive T cell number "reduction in the number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ccr6tm1Lira/Ccr6tm1Lira
Genetic Background: involves: 129 * C57BL/6

 MP:0008133 decreased Peyer s patch number "reduction in the number of the protruding lymphoid tissue located on the mucosa of the small intestine that is composed of densly packed B cell follicles" [PMID:15841100]
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Allelic Composition: Ccr6tm1(EGFP)Irw/Ccr6tm1(EGFP)Irw
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0008197 abnormal follicular dendritic cell physiology "abnormal function of a cell with extensive dendritic processes found in the B cell areas (primary follicles and germinal centers) of lymphoid tissue; follicular dendritic cells have Fc receptors and C3b receptors, and hold antigen in the form of immune complexes on their surfaces for long periods and can present antigen to B cells during an immune response" [CL:0000442, MESH:A10.549.250.200, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ccr6tm1(EGFP)Irw/Ccr6tm1(EGFP)Irw
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0008198 abnormal follicular dendritic cell antigen presentation "anomaly in the ability of follicular dendritic cells to process and present antigen to B lymphocytes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ccr6tm1Lira/Ccr6tm1Lira
Genetic Background: involves: 129

 MP:0008244 abnormal peritoneal macrophage morphology "any structural anomaly of a mononuclear phagocyte that develops from bone marrow precursors but is resident in the peritoneum" [CL:0000581, MESH:A.11.329.372.630]
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Allelic Composition: Ccr6tm1Lira/Ccr6tm1Lira
Genetic Background: involves: 129 * C57BL/6

 MP:0008399 abnormal alpha-beta intraepithelial T cell morphology "any structural anomaly of a alpha-beta T cell present in columnar epithelia such as in the gastrointestinal tract; intraepithelial T cells often have distinct developmental pathways and activation requirements" [ISBN:0781735149]
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Allelic Composition: Ccr6tm1(EGFP)Irw/Ccr6tm1(EGFP)Irw
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0008400 abnormal CD4-positive, alpha-beta intraepithelial T cell morphology "any structural anomaly of a CD4-positive, alpha-beta T cell of the columnar epithelia such as in the gastrointestinal tract; intraepithelial T cells often have distinct developmental pathways and activation requirements" [ISBN:0781735149]
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Allelic Composition: Ccr6tm1(EGFP)Irw/Ccr6tm1(EGFP)Irw
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0008401 abnormal CD8 positive, alpha-beta intraepithelial T cell morphology "any structural anomaly of a CD8-positive, alpha-beta T cell of the columnar epithelia such as in the gastrointestinal tract; intraepithelial T cells often have distinct developmental pathways and activation requirements" [ISBN:0781735149]
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Allelic Composition: Ccr6tm1(EGFP)Irw/Ccr6tm1(EGFP)Irw
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0008498 decreased IgG3 level "less than normal immunoglobulin class G3 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Ccr6tm1Lira/Ccr6tm1Lira
Genetic Background: involves: 129 * C57BL/6

 MP:0008561 decreased tumor necrosis factor secretion "reduction in the production or release of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]
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Allelic Composition: Gpd2tm1Tka/Gpd2tm1Tka
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Ccr6tm1Lira/Ccr6tm1Lira
Genetic Background: involves: 129 * C57BL/6

 MP:0008566 increased interferon-gamma secretion "increase in the production or release of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
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Allelic Composition: Gpd2tm1Tka/Gpd2tm1Tka
Genetic Background: involves: C57BL/6 * CBA

 MP:0008568 abnormal interleukin secretion "anomaly in the production or cellular release of soluble factors which stimulate growth-related activities of leukocytes and other cell types, that can act to enhance cell proliferation and differentiation, DNA synthesis, secretion of other biologically active molecules and responses to immune and inflammatory stimuli" [MESH:D12.644.276.374.465]
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Allelic Composition: Ccr6tm1.1Jmf/Ccr6tm1.1Jmf
Genetic Background: B6.129-Ccr6tm1.1Jmf

 MP:0008661 decreased interleukin-10 secretion "reduction in the production or release of a cytokine produced by a variety of cell types, including T-cells, monocytes, dendritic cells and epithelial cells that exerts a variety of effects on immunoregulation and inflammation" [MESH:D12.644.276.374.465.510]
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Allelic Composition: Ccr6tm1Lira/Ccr6tm1Lira
Genetic Background: involves: 129 * C57BL/6

 MP:0008664 decreased interleukin-12 secretion "reduction in the production or release of a heterodimeric cytokine that plays a role in innate and adaptive immune responses; it is produced by dendritic cells, macrophages and a variety of other immune cells and plays a role in the stimulation of interferon-gamma production by T-cells and natural killer cells" [MESH:D12.644.276.374.465.512]
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Allelic Composition: Gpd2tm1Tka/Gpd2tm1Tka
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Ccr6tm1Lira/Ccr6tm1Lira
Genetic Background: involves: 129 * C57BL/6

 MP:0008700 decreased interleukin-4 secretion "reduction in the production or release of a soluble factor produced by activated T-cells that induces the expression of MHC class II genes and FC receptors on B-cells and causes their proliferation and differentiation; it also acts on T-cells, mast cells and several other hematopoietic lineage cells" [MESH:D12.644.276.374.465.504]
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Allelic Composition: Gpd2tm1Tka/Gpd2tm1Tka
Genetic Background: involves: C57BL/6 * CBA

 MP:0008703 decreased interleukin-5 secretion "reduction in the production or release of a cytokine that promotes differentiation and activation of eosinophils; it also triggers activated B-cells to differentiate into immunoglobulin-secreting cells" [MESH:D12.644.276.374.465.505]
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Allelic Composition: Ccr6tm1Lira/Ccr6tm1Lira
Genetic Background: involves: 129 * C57BL/6

 MP:0008723 impaired eosinophil recruitment "reduced diffusion or accumulation of eosinophils in tissues or cells in response to a wide variety of substances released at the sites of inflammatory reactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ccr6tm1Lira/Ccr6tm1Lira
Genetic Background: involves: 129 * C57BL/6

 MP:0008895 abnormal intraepithelial T cell number "reduced number of T cell present in columnar epithelia such as in the gastrointestinal tract; intraepithelial T cells often have distinct developmental pathways and activation requirements" [ISBN:0781735149]
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Allelic Composition: Ccr6tm1Lira/Ccr6tm1Lira
Genetic Background: involves: 129 * C57BL/6

 MP:0011077 decreased macrophage nitric oxide production "reduced production of macrophage-derived nitric oxide due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ccr6tm1Lira/Ccr6tm1Lira
Genetic Background: involves: 129 * C57BL/6

 MP:0011079 decreased macrophage cytokine production "reduced production of macrophage-derived cytokine(s) due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ccr6tm1Lira/Ccr6tm1Lira
Genetic Background: involves: 129 * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000046354 Defb14 / Q7TNV9 / Beta-defensin 14 / P81534* / DEFB103B* / DEFB103A* / defensin beta 103A* / defensin beta 103B*  / complex / reaction
 ENSMUSG00000044748 Defb1 / P56386 / Beta-defensin 1 / P60022* / defensin beta 1*  / complex / reaction
 ENSMUSG00000026166 Ccl20 / O89093 / C-C motif chemokine 20 / P78556* / C-C motif chemokine ligand 20*  / complex / reaction






 

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