ENSMUSG00000048480


Mus musculus

Features
Gene ID: ENSMUSG00000048480
  
Biological name :Cxcr1
  
Synonyms : C-X-C chemokine receptor type 1 / Cxcr1 / Q810W6
  
Possible biological names infered from orthology : C-X-C motif chemokine receptor 1 / P25024
  
Species: Mus musculus
  
Chr. number: 1
Strand: -1
Band: C3
Gene start: 74191785
Gene end: 74194631
  
Corresponding Affymetrix probe sets: 10355550 (MoGene1.0st)   
  
Cross references: Ensembl peptide - ENSMUSP00000049714
Ensembl peptide - ENSMUSP00000139555
NCBI entrez gene - 227288     See in Manteia.
MGI - MGI:2448715
RefSeq - XM_011238503
RefSeq - NM_178241
RefSeq - XM_006495956
RefSeq - XM_011238501
RefSeq Peptide - NP_839972
swissprot - Q810W6
Ensembl - ENSMUSG00000048480
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cxcr2ENSDARG00000054975Danio rerio
 CXCR1ENSGALG00000036627Gallus gallus
 CXCR1ENSG00000163464Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Cxcr2 / P35343 / C-X-C chemokine receptor type 2 / P25025* / C-X-C motif chemokine receptor 2*ENSMUSG0000002618059
Cxcr3 / O88410 / C-X-C chemokine receptor type 3 / P49682* / C-X-C motif chemokine receptor 3*ENSMUSG0000005023234
Ccr7 / P47774 / C-C chemokine receptor type 7 / P32248* / C-C motif chemokine receptor 7*ENSMUSG0000003794433
Ccr6 / O54689 / Mus musculus chemokine (C-C motif) receptor 6 (Ccr6), transcript variant 7, mRNA. / P51684* / C-C motif chemokine receptor 6*ENSMUSG0000004089933
Cxcr5 / Q04683 / C-X-C chemokine receptor type 5 / P32302* / C-X-C motif chemokine receptor 5*ENSMUSG0000004788032
Ccr4 / P51680 / C-C chemokine receptor type 4 / P51679* / C-C motif chemokine receptor 4*ENSMUSG0000004789832
Ccr9 / Q9WUT7 / C-C chemokine receptor type 9 / P51686* / C-C motif chemokine receptor 9*ENSMUSG0000002953031
Ccr10 / Q9JL21 / C-C chemokine receptor type 10 / P46092* / C-C motif chemokine receptor 10*ENSMUSG0000004405231
Ackr2 / O08707 / atypical chemokine receptor 2 / O00590*ENSMUSG0000004453431
Ccr5 / P51682 / C-C chemokine receptor type 5 / P51681* / C-C motif chemokine receptor 5 (gene/pseudogene)*ENSMUSG0000007922731
Ackr4 / Q924I3 / atypical chemokine receptor 4 / Q9NPB9*ENSMUSG0000007935531
Cxcr4 / Mus musculus chemokine (C-X-C motif) receptor 4 (Cxcr4), transcript variant 2, mRNA. / P61073* / C-X-C motif chemokine receptor 4*ENSMUSG0000004538230
Ccr3 / P51678 / Probable C-C chemokine receptor type 3 / P51677* / C-C motif chemokine receptor 3*ENSMUSG0000003544829
Ccr2 / P51683 / C-C chemokine receptor type 2 / P41597* / C-C motif chemokine receptor 2*ENSMUSG0000004910329
Cx3cr1 / Q9Z0D9 / CX3C chemokine receptor 1 / P49238* / C-X3-C motif chemokine receptor 1*ENSMUSG0000005233629
Ccr8 / P56484 / C-C chemokine receptor type 8 / P51685* / C-C motif chemokine receptor 8*ENSMUSG0000004226228
Cxcr6 / Q9EQ16 / C-X-C chemokine receptor type 6 / O00574* / C-X-C motif chemokine receptor 6*ENSMUSG0000004852128
Ccr1 / P51675 / C-C chemokine receptor type 1 / P32246* / C-C motif chemokine receptor 1*ENSMUSG0000002580427
Xcr1 / chemokine (C motif) receptor 1 / P46094* / X-C motif chemokine receptor 1*ENSMUSG0000006050927
Ccr1l1 / P51676 / C-C chemokine receptor 1-like protein 1 / CCR1* / P32246* / C-C motif chemokine receptor 1*ENSMUSG0000006403926


Protein motifs (from Interpro)
Interpro ID Name
 IPR000174  CXC chemokine receptor 1/2
 IPR000276  G protein-coupled receptor, rhodopsin-like
 IPR017452  GPCR, rhodopsin-like, 7TM


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006935 chemotaxis IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007166 cell surface receptor signaling pathway ISO
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IEA
 biological_processGO:0031623 receptor internalization ISO
 biological_processGO:0038112 interleukin-8-mediated signaling pathway IEA
 biological_processGO:0070098 chemokine-mediated signaling pathway IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004918 interleukin-8 receptor activity ISO
 molecular_functionGO:0004930 G-protein coupled receptor activity IEA
 molecular_functionGO:0016494 C-X-C chemokine receptor activity IEA
 molecular_functionGO:0019959 interleukin-8 binding ISO


Pathways (from Reactome)
Pathway description
Chemokine receptors bind chemokines
G alpha (i) signalling events
Neutrophil degranulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ccl11tm1Mer/Ccl11tm1Mer,Ccl24tm1Mer/Ccl24tm1Mer
Genetic Background: 129S.129S6(Cg)-Ccl24tm1Mer Ccl11tm1Mer

 MP:0008040 decreased NK T cell number "reduced number of the distinct lineage of T cells expressing natural killer cell markers and having T cell receptors characterized by the usage of a restricted repertoire of variable region gene segments" [GO:0001865]
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Allelic Composition: Cecr2tm2b(EUCOMM)Hmgu/Cecr2+
Genetic Background: C57BL/6N-Cecr2tm2b(EUCOMM)Hmgu/Tcp

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000029371 Cxcl5 / P50228 / C-X-C motif chemokine 5 GCP-2(1-78) GCP-2(9-78) / CXCL6* / P80162* / P42830* / C-X-C motif chemokine ligand 6* / C-X-C motif chemokine ligand 5*  / complex / reaction






 

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