ENSDARG00000054975


Danio rerio

Features
Gene ID: ENSDARG00000054975
  
Biological name :cxcr2
  
Synonyms : chemokine (C-X-C motif) receptor 2 / cxcr2
  
Possible biological names infered from orthology : C-X-C chemokine receptor type 1 / C-X-C chemokine receptor type 2 / C-X-C motif chemokine receptor 1 / C-X-C motif chemokine receptor 2 / CXCR1 / P25024 / P25025 / P35343 / Q810W6
  
Species: Danio rerio
  
Chr. number: 9
Strand: 1
Band:
Gene start: 48108174
Gene end: 48109197
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000071727
NCBI entrez gene - 796724     See in Manteia.
swissprot - F1Q8T9
ZFIN ID - ZDB-GENE-100414-1
Ensembl - ENSDARG00000054975
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CXCR1ENSGALG00000036627Gallus gallus
 CXCR1ENSG00000163464Homo sapiens
 CXCR2ENSG00000180871Homo sapiens
 Cxcr1ENSMUSG00000048480Mus musculus
 Cxcr2ENSMUSG00000026180Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
si:ch73-54b5.2ENSDARG0000005208838
cxcr3.1 / chemokine (C-X-C motif) receptor 3, tandem duplicate 1 / CXCR3* / O88410* / P49682* / C-X-C motif chemokine receptor 3* / C-X-C chemokine receptor type 3 *ENSDARG0000000735833
cxcr5 / chemokine (C-X-C motif) receptor 5 / P32302* / C-X-C motif chemokine receptor 5*ENSDARG0000001051432
E9QJ73 / cxcr3.2 / chemokine (C-X-C motif) receptor 3, tandem duplicate 2ENSDARG0000004104132
ccr7 / chemokine (C-C motif) receptor 7 / P32248* / P47774* / C-C chemokine receptor type 7 * / C-C motif chemokine receptor 7*ENSDARG0000004456131
ccr9a / chemokine (C-C motif) receptor 9a / CCR9* / Q9WUT7* / P51686* / C-C chemokine receptor type 9 * / C-C motif chemokine receptor 9*ENSDARG0000005518631
cxcr4a / chemokine (C-X-C motif) receptor 4a / CXCR4* / P61073* / C-X-C motif chemokine receptor 4* / Mus musculus chemokine (C-X-C motif) receptor 4 (Cxcr4), transcript variant 2, mRNA.*ENSDARG0000005763331
ackr4b / atypical chemokine receptor 4b / ACKR4* / Q924I3* / Q9NPB9* / atypical chemokine receptor 4*ENSDARG0000004013330
ccr6a / chemokine (C-C motif) receptor 6a / CCR6* / P51684* / O54689* / C-C motif chemokine receptor 6* / Mus musculus chemokine (C-C motif) receptor 6 (Ccr6), transcript variant 7, mRNA.*ENSDARG0000008747430
ccr6b / chemokine (C-C motif) receptor 6b / CCR6* / P51684* / O54689* / C-C motif chemokine receptor 6* / Mus musculus chemokine (C-C motif) receptor 6 (Ccr6), transcript variant 7, mRNA.*ENSDARG0000003896829
cxcr4b / chemokine (C-X-C motif), receptor 4b / CXCR4* / P61073* / C-X-C motif chemokine receptor 4* / Mus musculus chemokine (C-X-C motif) receptor 4 (Cxcr4), transcript variant 2, mRNA.*ENSDARG0000004195928
ackr4a / atypical chemokine receptor 4a / ACKR4* / Q924I3* / Q9NPB9* / atypical chemokine receptor 4*ENSDARG0000007872928
ccr2 / chemokine (C-C motif) receptor 2 / CCR3* / CCR5* / CCR1* / CCR4* / P51681* / P41597* / P51675* / P51676* / P51677* / P51678* / P51679* / P51680* / P51682* / P51683* / Ccr1l1* / P3224...ENSDARG0000007982928
ccr9b / chemokine (C-C motif) receptor 9b / CCR9* / Q9WUT7* / P51686* / C-C chemokine receptor type 9 * / C-C motif chemokine receptor 9*ENSDARG0000009973828
ccr2 / si:ch211-207g17.3 / CCR5* / CCR1* / CCR3* / CCR4* / P51675* / P51676* / P51677* / P51678* / P51679* / P51682* / P51681* / P51683* / P51680* / Ccr1l1* / P32246* / P41597* / C-C motif ...ENSDARG0000010536328
cabz01093075.1 / CCR8* / P51685* / C-C motif chemokine receptor 8*ENSDARG0000008661627
ccr8.1 / chemokine (C-C motif) receptor 8.1 / CCR8* / P56484* / P51685* / C-C chemokine receptor type 8 * / C-C motif chemokine receptor 8*ENSDARG0000009578927
ccr12b.1 / chemokine (C-C motif) receptor 12b, tandem duplicate 1ENSDARG0000005941026
si:cabz01093077.1 / CCR8* / P51685* / C-C motif chemokine receptor 8*ENSDARG0000010546726
ccr12b.2 / chemokine (C-C motif) receptor 12b, tandem duplicate 2ENSDARG0000002641725


Protein motifs (from Interpro)
Interpro ID Name
 IPR000174  CXC chemokine receptor 1/2
 IPR000276  G protein-coupled receptor, rhodopsin-like
 IPR017452  GPCR, rhodopsin-like, 7TM


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006935 chemotaxis IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IEA
 biological_processGO:0042119 neutrophil activation IMP
 biological_processGO:0042742 defense response to bacterium IMP
 biological_processGO:0070098 chemokine-mediated signaling pathway IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity IEA
 molecular_functionGO:0016494 C-X-C chemokine receptor activity IEA
 molecular_functionGO:0051916 granulocyte colony-stimulating factor binding IGI


Pathways (from Reactome)
Pathway description
Chemokine receptors bind chemokines
G alpha (i) signalling events
Neutrophil degranulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000094 blood island blood island has extra parts of type neutrophil , abnormal
Show

 ZFA:0001094 whole organism whole organism decreased life span , exacerbated
Show

 ZFA:0005249 vasculature vasculature circulating cell has fewer parts of type neutrophil , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000104795 cxcl8a / chemokine (C-X-C motif) ligand 8a / CXCL8* / P10145* / C-X-C motif chemokine ligand 8*  / complex / reaction
 ENSDARG00000102776 cxcl19 / chemokine (C-X-C motif) ligand 19 / PPBP* / CXCL2* / CXCL3* / CXCL5* / CXCL6* / CXCL1* / Q9WVL7* / Cxcl15* / P02775* / P09341* / P19875* / P19876* / P42830* / P80162* / C-X-C motif...  / complex / reaction






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2025
contact: otassy@igbmc.fr