ENSMUSG00000026180


Mus musculus

Features
Gene ID: ENSMUSG00000026180
  
Biological name :Cxcr2
  
Synonyms : C-X-C chemokine receptor type 2 / Cxcr2 / P35343
  
Possible biological names infered from orthology : C-X-C motif chemokine receptor 2 / P25025
  
Species: Mus musculus
  
Chr. number: 1
Strand: 1
Band: C3
Gene start: 74153989
Gene end: 74161246
  
Corresponding Affymetrix probe sets: 10347291 (MoGene1.0st)   1421734_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000027372
Ensembl peptide - ENSMUSP00000102512
NCBI entrez gene - 12765     See in Manteia.
MGI - MGI:105303
RefSeq - XM_006495638
RefSeq - NM_009909
RefSeq Peptide - NP_034039
swissprot - P35343
Ensembl - ENSMUSG00000026180
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cxcr2ENSDARG00000054975Danio rerio
 CXCR1ENSGALG00000036627Gallus gallus
 CXCR2ENSG00000180871Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Cxcr1 / Q810W6 / C-X-C chemokine receptor type 1 / P25024* / C-X-C motif chemokine receptor 1*ENSMUSG0000004848058
Ccr4 / P51680 / C-C chemokine receptor type 4 / P51679* / C-C motif chemokine receptor 4*ENSMUSG0000004789835
Ccr6 / O54689 / Mus musculus chemokine (C-C motif) receptor 6 (Ccr6), transcript variant 7, mRNA. / P51684* / C-C motif chemokine receptor 6*ENSMUSG0000004089933
Cxcr5 / Q04683 / C-X-C chemokine receptor type 5 / P32302* / C-X-C motif chemokine receptor 5*ENSMUSG0000004788033
Cxcr3 / O88410 / C-X-C chemokine receptor type 3 / P49682* / C-X-C motif chemokine receptor 3*ENSMUSG0000005023233
Ccr7 / P47774 / C-C chemokine receptor type 7 / P32248* / C-C motif chemokine receptor 7*ENSMUSG0000003794432
Cxcr4 / Mus musculus chemokine (C-X-C motif) receptor 4 (Cxcr4), transcript variant 2, mRNA. / P61073* / C-X-C motif chemokine receptor 4*ENSMUSG0000004538232
Ccr9 / Q9WUT7 / C-C chemokine receptor type 9 / P51686* / C-C motif chemokine receptor 9*ENSMUSG0000002953031
Ccr10 / Q9JL21 / C-C chemokine receptor type 10 / P46092* / C-C motif chemokine receptor 10*ENSMUSG0000004405231
Ccr5 / P51682 / C-C chemokine receptor type 5 / P51681* / C-C motif chemokine receptor 5 (gene/pseudogene)*ENSMUSG0000007922731
Ccr2 / P51683 / C-C chemokine receptor type 2 / P41597* / C-C motif chemokine receptor 2*ENSMUSG0000004910330
Ackr4 / Q924I3 / atypical chemokine receptor 4 / Q9NPB9*ENSMUSG0000007935530
Ccr3 / P51678 / Probable C-C chemokine receptor type 3 / P51677* / C-C motif chemokine receptor 3*ENSMUSG0000003544829
Cx3cr1 / Q9Z0D9 / CX3C chemokine receptor 1 / P49238* / C-X3-C motif chemokine receptor 1*ENSMUSG0000005233629
Ccr1 / P51675 / C-C chemokine receptor type 1 / P32246* / C-C motif chemokine receptor 1*ENSMUSG0000002580428
Ccr8 / P56484 / C-C chemokine receptor type 8 / P51685* / C-C motif chemokine receptor 8*ENSMUSG0000004226228
Ackr2 / O08707 / atypical chemokine receptor 2 / O00590*ENSMUSG0000004453428
Xcr1 / chemokine (C motif) receptor 1 / P46094* / X-C motif chemokine receptor 1*ENSMUSG0000006050928
Cxcr6 / Q9EQ16 / C-X-C chemokine receptor type 6 / O00574* / C-X-C motif chemokine receptor 6*ENSMUSG0000004852127
Ccr1l1 / P51676 / C-C chemokine receptor 1-like protein 1 / CCR1* / P32246* / C-C motif chemokine receptor 1*ENSMUSG0000006403926


Protein motifs (from Interpro)
Interpro ID Name
 IPR000057  CXC chemokine receptor 2
 IPR000174  CXC chemokine receptor 1/2
 IPR000276  G protein-coupled receptor, rhodopsin-like
 IPR017452  GPCR, rhodopsin-like, 7TM


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002438 acute inflammatory response to antigenic stimulus IEA
 biological_processGO:0002690 positive regulation of leukocyte chemotaxis IEA
 biological_processGO:0006935 chemotaxis TAS
 biological_processGO:0006968 cellular defense response ISO
 biological_processGO:0007165 signal transduction ISO
 biological_processGO:0007166 cell surface receptor signaling pathway ISO
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IEA
 biological_processGO:0007200 phospholipase C-activating G-protein coupled receptor signaling pathway ISO
 biological_processGO:0007204 positive regulation of cytosolic calcium ion concentration IEA
 biological_processGO:0008284 positive regulation of cell proliferation ISO
 biological_processGO:0010666 positive regulation of cardiac muscle cell apoptotic process IEA
 biological_processGO:0030593 neutrophil chemotaxis ISO
 biological_processGO:0030901 midbrain development IEA
 biological_processGO:0031623 receptor internalization ISO
 biological_processGO:0033030 negative regulation of neutrophil apoptotic process IEA
 biological_processGO:0038112 interleukin-8-mediated signaling pathway IEA
 biological_processGO:0042119 neutrophil activation ISO
 biological_processGO:0043066 negative regulation of apoptotic process IMP
 biological_processGO:0043117 positive regulation of vascular permeability IEA
 biological_processGO:0045766 positive regulation of angiogenesis IEA
 biological_processGO:0070098 chemokine-mediated signaling pathway IEA
 biological_processGO:0072173 metanephric tubule morphogenesis IEA
 biological_processGO:0090023 positive regulation of neutrophil chemotaxis IEA
 cellular_componentGO:0005622 intracellular ISO
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0009986 cell surface ISO
 cellular_componentGO:0016020 membrane ISO
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0042629 mast cell granule ISO
 molecular_functionGO:0004871 obsolete signal transducer activity ISO
 molecular_functionGO:0004918 interleukin-8 receptor activity TAS
 molecular_functionGO:0004930 G-protein coupled receptor activity IEA
 molecular_functionGO:0004950 chemokine receptor activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016494 C-X-C chemokine receptor activity ISO
 molecular_functionGO:0019959 interleukin-8 binding ISO


Pathways (from Reactome)
Pathway description
Chemokine receptors bind chemokines
G alpha (i) signalling events
Neutrophil degranulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000194 hypercalcemia "abnormally high concentration of calcium ions in the circulating blood " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Clrn1tm1.1(KOMP)Vlcg/Clrn1tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Clrn1tm1.1(KOMP)Vlcg/Ucd

 MP:0000218 increased WBC count "greater than normal WBC numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Cxcr2tm1(IL8RB)Dktr/Cxcr2tm1(IL8RB)Dktr
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0000219 increased neutrophil count "greater than normal neutrophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Il4tm2Rao/Il4+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0000220 increased monocyte count "greater than normal monocyte numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Clrn1tm1.1(KOMP)Vlcg/Clrn1tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Clrn1tm1.1(KOMP)Vlcg/Ucd

 MP:0000240 extramedullary hematopoiesis "formation and development of blood cells outside the bone marrow, e.g., in the spleen, liver, or lymph nodes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Cxcr2tm1Mwm/Cxcr2tm1Mwm
Genetic Background: involves: 129S2/SvPas * BALB/c

 MP:0000322 increased granulocyte number "greater than expected number of leukocytes that have abundant granules in the cytoplasm: basophils, neutrophils, or eosinophils" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cxcr2tm1Mwm/Cxcr2tm1Mwm
Genetic Background: involves: 129S2/SvPas * BALB/c

Allelic Composition: Cxcr2tm1(IL8RB)Dktr/Cxcr2tm1(IL8RB)Dktr
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0000601 small liver "reduced size of the liver" [J:23170]
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Allelic Composition: Cxcr2tm1Mwm/Cxcr2tm1Mwm
Genetic Background: involves: 129S2/SvPas * BALB/c

 MP:0000691 enlarged spleen "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Il4tm2Rao/Il4+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0000702 enlarged lymph nodes "lymph nodes of increased size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Il4tm2Rao/Il4+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0000920 abnormal myelination "atypical or altered myelination in axon sheaths" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Lalbatm1Jvt/Lalba+
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0000954 reduced oligodendrocyte progenitor number "fewer cells that differentiate into a type of glial cell in the central nervous system" [J:15108]
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Allelic Composition: Lalbatm1Jvt/Lalba+
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0000955 abnormal spinal cord morphology "malformation or disorganization of the cylindrical tissue of the vertebral canal that extends from the medulla oblongata to the conus medullaris" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Lalbatm1Jvt/Lalba+
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0001263 weight loss "progressive reduction of body weight below normal average for age" [J:45400]
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Allelic Composition: Itpr3tm1(NCOM)Mfgc/Itpr3tm1(NCOM)Mfgc
Genetic Background: involves: C57BL/6J * C57BL/6N

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: F3tm1Dco/F3tm1Dco
Genetic Background: Not Specified

 MP:0001273 decreased metastatic potential 
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Allelic Composition: Notch3tm1Ul/Notch3+
Genetic Background: Not Specified

 MP:0001312 abnormal cornea morphology "malformation or absence of the transparent anterior portion of the fibrous coat of the eye that serves as the chief refractory structure " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Dstncorn1/Dstncorn1
Genetic Background: involves: A/WySn * brachy stock * C57BL/6JSmn

 MP:0001601 abnormal myelopoiesis "atypical process of bone marrow cell formation and/or bone marrow-derived blood cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:tc]
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Allelic Composition: Il4tm2Rao/Il4+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

Allelic Composition: Cxcr2tm1Mwm/Cxcr2tm1Mwm
Genetic Background: involves: 129S2/SvPas * BALB/c

 MP:0002281 abnormal respiratory mucosa goblet cell morphology "structural anomaly of the cells of the respiratory epithelial lining that produce and secrete mucins" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Lalbatm1Jvt/Lalba+
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0002334 abnormal airway responsiveness "anomalous response in bronchial provocation tests" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Lalbatm1Jvt/Lalba+
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0002335 decreased airway responsiveness "less easily provoked into bronchoconstriction during bronchial provocation testing" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Lalbatm1Jvt/Lalba+
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0002357 abnormal spleen white pulp morphology "anomalous structure or formation of the splenic area consisting of lymph nodules and diffuse lymphatic tissue" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Il4tm2Rao/Il4+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0002397 abnormal bone marrow morphology "structural anomalies in the soft tissue that fills the cavities of bones" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Il4tm2Rao/Il4+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0002412 increased susceptibility to bacterial infection "greater likelihood that an organism will develop ill effects from a bacterial infection or from components of or toxins produced by bacteria" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Lalbatm1Jvt/Lalba+
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0002418 increased susceptibility to viral infection "greater likelihood that an organism will develop ill effects from a viral infection or from components of or toxins produced by a virus" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Lalbatm1Jvt/Lalba+
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0002442 abnormal leukocyte physiology "abnormal function of any of the white blood cells (basophils, eosinophils, neutrophils, lymphocytes, or monocytes) " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Lalbatm1Jvt/Lalba+
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0002444 abnormal T cell physiology "anomalous response of T lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Lalbatm1Jvt/Lalba+
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0002463 abnormal neutrophil physiology "abnormal function of these granular leukocytes, which stain with neutral dyes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Lalbatm1Jvt/Lalba+
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Cxcr2tm1Mwm/Cxcr2tm1Mwm
Genetic Background: involves: 129S2/SvPas * BALB/c

Allelic Composition: Cxcr2tm1Rmra/Cxcr2tm1Rmra,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S/SvEv * C57BL/6 * C57BL/6NTac * CBA

 MP:0002465 abnormal eosinophil physiology "abnormal function of the leukocyte that stains with eosin and is involved in clearance of parasitic infections and in allergic reactions " [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Lalbatm1Jvt/Lalba+
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0002497 increased IgE "greater than normal immunoglobulin class E level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Lalbatm1Jvt/Lalba+
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0002768 small adrenal glands "reduced size of endocrine glands located above the kidneys responsible for hormone and epinephrine secretion" [J:78062]
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Allelic Composition: Cxcr2tm1(IL8RB)Dktr/Cxcr2tm1(IL8RB)Dktr
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0002908 delayed wound healing "longer time requirement for the ability to self-repair and close wounds than normal" [J:63037]
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Allelic Composition: Lalbatm1Jvt/Lalba+
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Cxcr2tm1Mwm/Cxcr2tm1Mwm
Genetic Background: C.129S2(B6)-Cxcr2tm1Mwm/J

 MP:0003009 abnormal cytokine secretion "impairment or increase of the cellular release of any of the non-antibody proteins made by inflammatory leukocytes and some non-leukocytic cells that affect the behavior of other cells " [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, smb:Susan M. Bello , Mouse Genome Informatics Curator]
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Allelic Composition: Cxcr2tm1Mwm/Cxcr2tm1Mwm
Genetic Background: C.129S2(B6)-Cxcr2tm1Mwm/J

 MP:0003436 resistance to induced arthritis "less likely to be striken with changes in the synovial membranes and thickening of articular structures, widespread degeneration of the collagen fibers in connective tissues, and by atrophy and rarefaction of bony structures that are induced by inflammatory responses caused by chemical or mechanical agents" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:75303]
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Allelic Composition: Cxcr2tm1Mwm/Cxcr2tm1Mwm
Genetic Background: C.129S2(B6)-Cxcr2tm1Mwm/J

 MP:0003447 reduced tumor growth/size "less than expected development of tumorous growth when compared to controls" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:65383]
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Allelic Composition: Notch3tm1Ul/Notch3+
Genetic Background: Not Specified

Allelic Composition: Cxcr2tm1Mwm/Cxcr2tm1Mwm,Tg(TRAMP)8247Ng/?
Genetic Background: involves: 129S2/SvPas * BALB/c * C57BL/6

 MP:0003448 altered tumor morphology "changes in the expected pathology for a given tumor type compared to controls" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Notch3tm1Ul/Notch3+
Genetic Background: Not Specified

 MP:0003917 increased kidney weight "greater heft of the organs responsible for urine secretion" [RGD:Rat Genome Database submission]
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Allelic Composition: Cxcr2tm1Mwm/Cxcr2tm1Mwm
Genetic Background: involves: 129S2/SvPas * BALB/c

 MP:0003918 decreased kidney weight "reduced heft of the organs responsible for urine secretion" [RGD:Rat Genome Database submission]
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Allelic Composition: Cxcr2tm1(IL8RB)Dktr/Cxcr2tm1(IL8RB)Dktr
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0004647 decreased lumbar vertebrae number "reduced number of the six bony segments of the spine located anterior to the sacral vertebrae and posterior to the thoracic vertebrae" [MESH:National Library of Medicine_Medical Subject Headings]
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Allelic Composition: Crb2tm1a(KOMP)Wtsi/Crb2+
Genetic Background: C57BL/6N-Crb2tm1a(KOMP)Wtsi/Wtsi

 MP:0004651 increased thoracic vertebrae number "increased number of the thirteen bony segments of the spine located anterior to the lumbar vertebrae and posterior to the cervical vertebrae" [MESH:National Library of Medicine_Medical Subject Headings]
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Allelic Composition: Crb2tm1a(KOMP)Wtsi/Crb2+
Genetic Background: C57BL/6N-Crb2tm1a(KOMP)Wtsi/Wtsi

 MP:0004909 increased seminal gland weight "increase in the weight of one or both of the two folded, sac shaped, glands that is a diverticulum of the ductus deferens" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cxcr2tm1Mwm/Cxcr2tm1Mwm
Genetic Background: involves: 129S2/SvPas * BALB/c

 MP:0004928 increased epididymis weight "increase in the average weight of the elongated structure connected to the posterior surface of the testis that transports, stores, and matures spermatozoa between testis and vas deferens" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cxcr2tm1Mwm/Cxcr2tm1Mwm
Genetic Background: involves: 129S2/SvPas * BALB/c

 MP:0004952 increased spleen weight "greater than average weight of the organ that functions to filter blood and to store red corpuscles and platelets" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cxcr2tm1Mwm/Cxcr2tm1Mwm
Genetic Background: involves: 129S2/SvPas * BALB/c

 MP:0004953 decreased spleen weight "reduction in the average weight of the organ that functions to filter blood and to store red corpuscles and platelets" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cxcr2tm1(IL8RB)Dktr/Cxcr2tm1(IL8RB)Dktr
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0004956 decreased thymus weight "reduction in the average weight of the primary lymphoid organ that is required for maturation of T cells" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cxcr2tm1Mwm/Cxcr2tm1Mwm
Genetic Background: involves: 129S2/SvPas * BALB/c

 MP:0005014 increased B cell number "greater than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Il4tm2Rao/Il4+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0005027 increased susceptibility to parasitic infection "greater likelihood that an organism will develop ill effects from a parasitic infection or from components of or toxins produced by parasites " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Lalbatm1Jvt/Lalba+
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0005292 improved glucose tolerance "better than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin sensitivity; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Clrn1tm1.1(KOMP)Vlcg/Clrn1tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Clrn1tm1.1(KOMP)Vlcg/Ucd

 MP:0005398 decreased susceptibility to fungal infection "reduced likelihood that an organism will develop ill effects from infection by a yeast or mold, or from components of, or toxins produced by, these organisms " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Lalbatm1Jvt/Lalba+
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0005465 abnormal T helper 1 physiology "anomalous response of the subset of helper T cells that enhance cell-mediated immune responses; these cells secrete IL-1 and gamma-IFN and are generally involved in inflammatory responses" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Lalbatm1Jvt/Lalba+
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0005466 abnormal T helper 2 physiology "anomalous response of the subset of T helper cells that enhance humoral immunity and inhibit cell-mediated immune responses; these cells produce IL-4 and induce B cells to produce IgE and IgG1, while also supporting eosinophil and mast cell functions " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Lalbatm1Jvt/Lalba+
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0005478 decreased circulating thyroxine level "less than the normal blood concentration of the major hormone dervied from the thryoid gland; it normally affects cellular metabolism" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Clrn1tm1.1(KOMP)Vlcg/Clrn1tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Clrn1tm1.1(KOMP)Vlcg/Ucd

 MP:0005542 corneal vascularization "formation of blood vessels in the cornea, which normally lacks vessels" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Cxcr2tm1Mwm/Cxcr2tm1Mwm
Genetic Background: C.129S2(B6)-Cxcr2tm1Mwm/J

Allelic Composition: Dstncorn1/Dstncorn1,Cxcr2tm1Mwm/Cxcr2tm1Mwm
Genetic Background: involves: 129S2/SvPas * A/WySn * BALB/c * brachy stock

 MP:0005553 increased circulating creatinine level "greater than the normal blood concentration of this product of creatine catabolism; abnormal levels indicative of renal dysfunction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
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Allelic Composition: Crb2tm1a(KOMP)Wtsi/Crb2+
Genetic Background: C57BL/6N-Crb2tm1a(KOMP)Wtsi/Wtsi

 MP:0005560 decreased circulating glucose level "less than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [RGD:Rat Genome Database submission, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Clrn1tm1.1(KOMP)Vlcg/Clrn1tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Clrn1tm1.1(KOMP)Vlcg/Ucd

 MP:0005568 increased circulating total protein level "greater than the average total concentration of these macromolecules in the blood " [RGD:Rat Genome Database submission]
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Allelic Composition: Clrn1tm1.1(KOMP)Vlcg/Clrn1tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Clrn1tm1.1(KOMP)Vlcg/Ucd

 MP:0008040 decreased NK T cell number "reduced number of the distinct lineage of T cells expressing natural killer cell markers and having T cell receptors characterized by the usage of a restricted repertoire of variable region gene segments" [GO:0001865]
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Allelic Composition: Clrn1tm1.1(KOMP)Vlcg/Clrn1tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Clrn1tm1.1(KOMP)Vlcg/Ucd

 MP:0008042 abnormal NK T cell physiology "any functional anomaly of the distinct lineage of T cells expressing natural killer cell markers and having T cell receptors characterized by the usage of a restricted repertoire of variable region gene segments" [GO:0001865]
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Allelic Composition: Cxcr2tm1Mwm/Cxcr2tm1Mwm
Genetic Background: C.129S2(B6)-Cxcr2tm1Mwm/J

 MP:0008079 decreased CD8-positive T cell number "reduction in the number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Clrn1tm1.1(KOMP)Vlcg/Clrn1tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Clrn1tm1.1(KOMP)Vlcg/Ucd

 MP:0008111 abnormal granulocyte differentiaton "atypical production of or inability to produce leukocytes that have abundant granules in the cytoplasm, including basophils, neutrophils, and eosinophils" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Il4tm2Rao/Il4+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0008127 decreased dendritic cell number "reduction in the number of a cells of hematopoietic origin, typically resident in particular tissues, specialized in the uptake, processing, and transport of antigens to lymph nodes for the purpose of stimulating an immune response via T cell activation" [ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Clrn1tm1.1(KOMP)Vlcg/Clrn1tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Clrn1tm1.1(KOMP)Vlcg/Ucd

 MP:0008346 increased gamma-delta T cell number "greater number of immature or mature T cells expressing an gamma-delta T cell receptor complex" [CL:0000798, ISBN:0781735149]
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Allelic Composition: Clrn1tm1.1(KOMP)Vlcg/Clrn1tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Clrn1tm1.1(KOMP)Vlcg/Ucd

 MP:0008542 enlarged cervical lymph nodes "increased size of the lymph nodes found near the neck and shoulders" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Il4tm2Rao/Il4+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0008596 increased circulating interleukin-6 level "increase in the amount in the blood of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506]
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Allelic Composition: Il4tm2Rao/Il4+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0008719 impaired neutrophil recruitment "reduced diffusion or accumulation of neutrophils in tissues or cells in response to a wide variety of substances released at the sites of inflammatory reactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Lalbatm1Jvt/Lalba+
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Cxcr2tm1Mwm/Cxcr2tm1Mwm
Genetic Background: C.129S2(B6)-Cxcr2tm1Mwm/J

 MP:0008720 impaired neutrophil migration "defect in the ability of neutrophils to move along a chemotactic gradient" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Il4tm2Rao/Il4+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

Allelic Composition: Cxcr2tm1Mwm/Cxcr2tm1Mwm
Genetic Background: C.129S2(B6)-Cxcr2tm1Mwm/J

 MP:0008721 abnormal chemokine level "deviation from the normal levels of any of the class of pro-inflammatory cytokines that attract and activate leukocytes" [MESH:D12.644.276.374.200]
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Allelic Composition: Cxcr2tm1Mwm/Cxcr2tm1Mwm
Genetic Background: C.129S2(B6)-Cxcr2tm1Mwm/J

 MP:0008751 abnormal interleukin level "deviation from the normal levels of soluble factors which stimulate growth-related activities of leukocytes as well as other cell types; they enhance cell proliferation and differentiation, DNA synthesis, secretion of other biologically active molecules and responses to immune and inflammatory stimuli" [MESH:D12.644.276.374.465]
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Allelic Composition: Cxcr2tm1Mwm/Cxcr2tm1Mwm
Genetic Background: C.129S2(B6)-Cxcr2tm1Mwm/J

 MP:0009764 decreased sensitivity to induced morbidity/mortality "increase in the amount of an external agent required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Cxcr2tm1Mwm/Cxcr2tm1Mwm
Genetic Background: C.129S2(B6)-Cxcr2tm1Mwm/J

 MP:0009789 decreased susceptibility to bacterial infection induced morbidity/mortality "reduced likelihood that an organism will display the expected moribund state caused by a bacterial invasion or from components of or toxins produced by bacteria" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Cxcl5tm1.1Mkch/Cxcl5tm1.1Mkch
Genetic Background: B6.129P2-Cxcl5tm1.1Mkch

 MP:0010101 increased sacral vertebrae number "increase of any or all of the four bony segments of the spine located posterior to the lumbar vertebrae and anterior to the caudal vertebrae" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Crb2tm1a(KOMP)Wtsi/Crb2+
Genetic Background: C57BL/6N-Crb2tm1a(KOMP)Wtsi/Wtsi

 MP:0010373 myeloid hyperplasia "greater than normal number of nucleated cells of the myeloid lineage (a monocyte, granulocyte, or mast cell), found in blood or other tissue" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Il4tm2Rao/Il4+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0010850 increased effector memory CD8-positive, alpha-beta T cell number "increased number of CD8-positive, alpha beta memory T cells with the phenotype CCR7-negative, CD127-positive, CD45RO-positive, and CD25-negative" [CL:0000913, GO_REF:0000031, GOC:add, GOC:pam, PMID:20146720]
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Allelic Composition: Clrn1tm1.1(KOMP)Vlcg/Clrn1tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Clrn1tm1.1(KOMP)Vlcg/Ucd

 MP:0011225 lymph node medullary cord hyperplasia "increase in the number of normal cells in normal arrangement in the lymph node medullary cords, resulting in a thickening or enlargement of the structure, caused by stimuli including increased physiological demand, inflammatory response, hormonal changes or hormonal dysfunctions, and/or compensation due to a pathological cause elsewhere" [ISBN:0-683-40008-8, MGI:csmith]
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Allelic Composition: Il4tm2Rao/Il4+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0012765 decreased alpha-beta T cell number "reduced number of T cells that expresses an alpha-beta T cell receptor complex" [CL:0000789]
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Allelic Composition: Clrn1tm1.1(KOMP)Vlcg/Clrn1tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Clrn1tm1.1(KOMP)Vlcg/Ucd

 MP:0013424 increased KLRG1-positive gamma-delta T cell number "increase in the number of gamma-delta T cells positive for KLRG1, a marker associated with activation" [IMPC:Saran, PMID:19479342]
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Allelic Composition: Clrn1tm1.1(KOMP)Vlcg/Clrn1tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Clrn1tm1.1(KOMP)Vlcg/Ucd

 MP:0013663 increased myeloid cell number "greater than the expected number of cells of the myeloid lineage" [CL:0000763]
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Allelic Composition: Clrn1tm1.1(KOMP)Vlcg/Clrn1tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Clrn1tm1.1(KOMP)Vlcg/Ucd

 MP:0013772 increased effector memory T-helper cell number "increase in the number of CD4-positive alpha-beta T-helper cells with a CD44-positive, CD62L-negative memory phenotype" [MGI:Saran]
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Allelic Composition: Clrn1tm1.1(KOMP)Vlcg/Clrn1tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Clrn1tm1.1(KOMP)Vlcg/Ucd

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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