ENSMUSG00000052336


Mus musculus

Features
Gene ID: ENSMUSG00000052336
  
Biological name :Cx3cr1
  
Synonyms : CX3C chemokine receptor 1 / Cx3cr1 / Q9Z0D9
  
Possible biological names infered from orthology : C-X3-C motif chemokine receptor 1 / P49238
  
Species: Mus musculus
  
Chr. number: 9
Strand: -1
Band: F4
Gene start: 119901616
Gene end: 120069879
  
Corresponding Affymetrix probe sets: 10597743 (MoGene1.0st)   1450019_at (Mouse Genome 430 2.0 Array)   1450020_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000063986
Ensembl peptide - ENSMUSP00000136413
Ensembl peptide - ENSMUSP00000150463
NCBI entrez gene - 13051     See in Manteia.
MGI - MGI:1333815
RefSeq - XM_011242934
RefSeq - NM_009987
RefSeq Peptide - NP_034117
swissprot - Q543X3
swissprot - Q9Z0D9
Ensembl - ENSMUSG00000052336
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CX3CR1ENSGALG00000038000Gallus gallus
 CX3CR1ENSG00000168329Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ccr2 / P51683 / C-C chemokine receptor type 2 / P41597* / C-C motif chemokine receptor 2*ENSMUSG0000004910344
Ccr4 / P51680 / C-C chemokine receptor type 4 / P51679* / C-C motif chemokine receptor 4*ENSMUSG0000004789842
Ccr5 / P51682 / C-C chemokine receptor type 5 / P51681* / C-C motif chemokine receptor 5 (gene/pseudogene)*ENSMUSG0000007922741
Ccr3 / P51678 / Probable C-C chemokine receptor type 3 / P51677* / C-C motif chemokine receptor 3*ENSMUSG0000003544840
Ccr1 / P51675 / C-C chemokine receptor type 1 / P32246* / C-C motif chemokine receptor 1*ENSMUSG0000002580438
Ccr8 / P56484 / C-C chemokine receptor type 8 / P51685* / C-C motif chemokine receptor 8*ENSMUSG0000004226238
Ccr1l1 / P51676 / C-C chemokine receptor 1-like protein 1 / CCR1* / P32246* / C-C motif chemokine receptor 1*ENSMUSG0000006403936
Xcr1 / chemokine (C motif) receptor 1 / P46094* / X-C motif chemokine receptor 1*ENSMUSG0000006050933
Ccr6 / O54689 / Mus musculus chemokine (C-C motif) receptor 6 (Ccr6), transcript variant 7, mRNA. / P51684* / C-C motif chemokine receptor 6*ENSMUSG0000004089932
Ackr2 / O08707 / atypical chemokine receptor 2 / O00590*ENSMUSG0000004453432
Cxcr3 / O88410 / C-X-C chemokine receptor type 3 / P49682* / C-X-C motif chemokine receptor 3*ENSMUSG0000005023231
Ccr9 / Q9WUT7 / C-C chemokine receptor type 9 / P51686* / C-C motif chemokine receptor 9*ENSMUSG0000002953030
Ccr7 / P47774 / C-C chemokine receptor type 7 / P32248* / C-C motif chemokine receptor 7*ENSMUSG0000003794430
Cxcr4 / Mus musculus chemokine (C-X-C motif) receptor 4 (Cxcr4), transcript variant 2, mRNA. / P61073* / C-X-C motif chemokine receptor 4*ENSMUSG0000004538230
Cxcr5 / Q04683 / C-X-C chemokine receptor type 5 / P32302* / C-X-C motif chemokine receptor 5*ENSMUSG0000004788030
Cxcr2 / P35343 / C-X-C chemokine receptor type 2 / P25025* / C-X-C motif chemokine receptor 2*ENSMUSG0000002618029
Ccr10 / Q9JL21 / C-C chemokine receptor type 10 / P46092* / C-C motif chemokine receptor 10*ENSMUSG0000004405229
Cxcr1 / Q810W6 / C-X-C chemokine receptor type 1 / P25024* / C-X-C motif chemokine receptor 1*ENSMUSG0000004848029
Ackr4 / Q924I3 / atypical chemokine receptor 4 / Q9NPB9*ENSMUSG0000007935529
Cxcr6 / Q9EQ16 / C-X-C chemokine receptor type 6 / O00574* / C-X-C motif chemokine receptor 6*ENSMUSG0000004852128


Protein motifs (from Interpro)
Interpro ID Name
 IPR000276  G protein-coupled receptor, rhodopsin-like
 IPR005387  CX3C chemokine receptor 1
 IPR017452  GPCR, rhodopsin-like, 7TM


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002052 positive regulation of neuroblast proliferation IEA
 biological_processGO:0002282 microglial cell activation involved in immune response IMP
 biological_processGO:0006935 chemotaxis IEA
 biological_processGO:0007155 cell adhesion IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IEA
 biological_processGO:0007613 memory IEA
 biological_processGO:0016525 negative regulation of angiogenesis IMP
 biological_processGO:0019221 cytokine-mediated signaling pathway IMP
 biological_processGO:0021795 cerebral cortex cell migration IMP
 biological_processGO:0030336 negative regulation of cell migration IEA
 biological_processGO:0045766 positive regulation of angiogenesis IEA
 biological_processGO:0048246 macrophage chemotaxis IMP
 biological_processGO:0070098 chemokine-mediated signaling pathway IEA
 biological_processGO:0071222 cellular response to lipopolysaccharide IEA
 biological_processGO:0071560 cellular response to transforming growth factor beta stimulus IEA
 biological_processGO:1900272 negative regulation of long-term synaptic potentiation IEA
 biological_processGO:2001240 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand IMP
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005654 nucleoplasm ISO
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0032809 neuronal cell body membrane IEA
 cellular_componentGO:0043005 neuron projection IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004896 cytokine receptor activity IMP
 molecular_functionGO:0004930 G-protein coupled receptor activity IEA
 molecular_functionGO:0016495 C-X3-C chemokine receptor activity IEA
 molecular_functionGO:0019960 C-X3-C chemokine binding ISO


Pathways (from Reactome)
Pathway description
Chemokine receptors bind chemokines
G alpha (i) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000136 abnormal microglial cell morphology "anomalous structure, number, or composition of the small neuroglial cells, possibly of mesodermal origin, which may become phagocytic, in areas of neural damage or inflammation" [ava:Anna V. Anagnostopoulos , Mouse Genome Informatics Curator, J:71688]
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Allelic Composition: Cx3cl1tm1Lira/Cx3cl1tm1Lira
Genetic Background: involves: C57BL/6

Allelic Composition: Ccl2tm1Rol/Ccl2tm1Rol,Cx3cr1tm1Litt/Cx3cr1tm1Litt
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6J

 MP:0000223 decreased monocyte count "fewer than normal monocyte numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Rasgrf1enu1H/Rasgrf1+
Genetic Background: involves: BALB/c * C3H/HeN * C57BL/6JOlaHsd

 MP:0000753 paralysis "loss of power of voluntary movement in a muscle through injury or disease of its nerve supply" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Cx3cr1tm1Litt/Cx3cr1tm1Litt
Genetic Background: B6.129P2-Cx3cr1tm1Litt

Allelic Composition: Cd1d1tm1Luc/Cd1d1tm1Luc,Cx3cr1tm1Litt/Cx3cr1tm1Litt
Genetic Background: B6.129-Cd1d1tm1Luc Cx3cr1tm1Litt

 MP:0000754 partial paralysis "partial loss of power of voluntary movement in a muscle through injury or disease of it or its nerve supply" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Cx3cr1tm1Litt/Cx3cr1tm1Litt
Genetic Background: B6.129P2-Cx3cr1tm1Litt

 MP:0000921 demyelination "loss of the myelin sheath without loss of axons or fiber tracts" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cx3cr1tm1Litt/Cx3cr1tm1Litt
Genetic Background: B6.129P2-Cx3cr1tm1Litt

 MP:0001325 abnormal retina morphology "structural or developmental anomaly of the thin layer of neural tissue lining the back of the eyeball which contains visual receptors " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Rasgrf1enu1H/Rasgrf1+
Genetic Background: involves: BALB/c * C3H/HeN * C57BL/6JOlaHsd

Allelic Composition: Cx3cr1tm1Zm/Cx3cr1tm1Zm
Genetic Background: C.129-Cx3cr1tm1Zm

Allelic Composition: Cx3cr1tm1Zm/Cx3cr1tm1Zm
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Ccl2tm1Rol/Ccl2tm1Rol,Cx3cr1tm1Zm/Cx3cr1tm1Zm
Genetic Background: involves: 129 * 129S4/SvJae

Allelic Composition: Ccl2tm1Rol/Ccl2tm1Rol,Cx3cr1tm1Litt/Cx3cr1tm1Litt
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6J

 MP:0001326 retinal degeneration "pathological change in the thin layer of neural tissue lining the back of the eyeball, which contains visual receptors and can result in the impairment or cessation of retinal neural function" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, NMF:Stephanie Pretel, Neuroscience Mutagenesis Facility Curator]
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Allelic Composition: Cx3cr1tm1Zm/Cx3cr1tm1Zm
Genetic Background: C.129-Cx3cr1tm1Zm

Allelic Composition: Cx3cr1tm1Zm/Cx3cr1tm1Zm
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Ccl2tm1Rol/Ccl2tm1Rol,Cx3cr1tm1Litt/Cx3cr1tm1Litt
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6J

 MP:0001847 brain inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the brain" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Cx3cr1tm1Litt/Cx3cr1tm1Litt
Genetic Background: B6.129P2-Cx3cr1tm1Litt

 MP:0001935 reduced litter size "fewer live born pups in a litter compared to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ccl2tm1Rol/Ccl2tm1Rol,Cx3cr1tm1Zm/Cx3cr1tm1Zm
Genetic Background: involves: 129 * 129S4/SvJae

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cx3cr1tm1Litt/Cx3cr1+
Genetic Background: B6.129P2-Cx3cr1tm1Litt

 MP:0002376 abnormal dendritic cell physiology "failure or atypical function of the immunocompetent cells of the lymphoid and hemopoietic systems and skin, which function to process antigens and present them to T cells, thus stimulating cellular immunity" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, J:85808]
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Allelic Composition: Pomctm1Low/Pomctm1Low,Tg(Pomc)#Low/Tg(Pomc)#Low
Genetic Background: involves: 129 * C57BL/6 * CBA * DBA/2 * Swiss Webster

 MP:0002411 decreased susceptibility to bacterial infection "reduced likelihood that an organism will develop ill effects from a bacterial infection or from components of or toxins produced by bacteria " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Runx2tm1.1Yyon/Runx2tm1.1Yyon,Tg(Col2a1-cre)1Star/0
Genetic Background: involves: C57BL/6 * C57BL/6NCrlj * CBA/JNCrlj

 MP:0002442 abnormal leukocyte physiology "abnormal function of any of the white blood cells (basophils, eosinophils, neutrophils, lymphocytes, or monocytes) " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Rasgrf1enu1H/Rasgrf1+
Genetic Background: involves: BALB/c * C3H/HeN * C57BL/6JOlaHsd

Allelic Composition: Cx3cr1tm1Litt/Cx3cr1tm1Litt
Genetic Background: B6.129P2-Cx3cr1tm1Litt

Allelic Composition: Ccr2tm2.1Ifc/Ccr2tm2.1Ifc,Cx3cr1tm1Litt/Cx3cr1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

Allelic Composition: Ccr2tm2.1Ifc/Ccr2tm2.1Ifc,Cx3cr1tm1Litt/Cx3cr1tm1Litt
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

 MP:0002451 abnormal macrophage physiology "abnormal function or response of the phagocytic leukocytes involved in innate immunity, early non-adaptive phases of host-defense, antigen presentation, and which act as effector cells in humoral and cell-mediated immunity" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ccl2tm1Rol/Ccl2tm1Rol,Cx3cr1tm1Litt/Cx3cr1tm1Litt
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6J

 MP:0003203 increased neuron apoptosis "increase in the number of neurons undergoing programmed cell death" [RGD:Rat Genome Database submission]
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Allelic Composition: Cx3cr1tm1Litt/Cx3cr1tm1Litt
Genetic Background: B6.129P2-Cx3cr1tm1Litt

 MP:0003224 neuron degeneration "a retrogressive impairment of function or destruction of the functional cells of the nervous system that receive, conduct, and transmit impulses " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Cx3cr1tm1Litt/Cx3cr1+,Psen1tm1Mpm/Psen1tm1Mpm,Tg(APPSwe,tauP301L)1Lfa/0,Tg(Thy1-YFP)HJrs/0
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0003691 abnormal microglial cell function "anomalous activity of the small neuroglial cells, possibly of mesodermal origin, which may become phagocytic, in areas of neural damage or inflammation" [hdene:Howard Dene , Mouse Genome Informatics Curator]
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Allelic Composition: Cx3cr1tm1Litt/Cx3cr1tm1Litt
Genetic Background: B6.129P2-Cx3cr1tm1Litt

Allelic Composition: Cx3cr1tm1Litt/Cx3cr1+,Psen1tm1Mpm/Psen1tm1Mpm,Tg(APPSwe,tauP301L)1Lfa/0,Tg(Thy1-YFP)HJrs/0
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0003728 abnormal photoreceptor layer "malformation/anomalous structure of the photoreceptor layer" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Cx3cr1tm1Zm/Cx3cr1tm1Zm
Genetic Background: C.129-Cx3cr1tm1Zm

Allelic Composition: Cx3cr1tm1Zm/Cx3cr1tm1Zm
Genetic Background: involves: 129 * C57BL/6

 MP:0003730 abnormal photoreceptor inner segments "malformation/anomalous structure of the photoreceptor layer which contains the machinery of the cell (mitochondria, golgi, endoplasmic reticulum, etc)" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Ccl2tm1Rol/Ccl2tm1Rol,Cx3cr1tm1Litt/Cx3cr1tm1Litt
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6J

 MP:0003799 impaired macrophage migration "defect in the ability of macrophages to move up a chemotactic gradient" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Trp53tm1Tyj/Trp53tm1Tyj,Tsg101tm1Mak/Tsg101tm1Mak
Genetic Background: involves: 129P3/J * 129S2/SvPas * C57BL/6 * CD-1

Allelic Composition: Apoetm1Bres/Apoetm1Bres,Cx3cr1tm1Ifc/Cx3cr1tm1Ifc
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

Allelic Composition: Cx3cr1tm1Litt/Cx3cr1tm1Litt
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004042 decreased susceptibility to kidney reperfusion injury "a diminished likelihood or extent of damage to the kidney when the blood supply is restored after a period of ischemia" [brs:Beverly Richards-Smith, Mouse Genome Informatics Curator]
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Allelic Composition: Cx3cr1tm1Litt/Cx3cr1tm1Litt
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004799 increased susceptibility to experimental autoimmune encephalomyelitis "greater likelihood that an organism will develop disease symptoms similar to human multiple sclerosis upon induction with antigens to Myelin Basic Protein (MBP), Proteolipid Protein (PLP), and/or Myelin Oligodendrocyte glycoprotein (MOG)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cx3cr1tm1Litt/Cx3cr1tm1Litt
Genetic Background: B6.129P2-Cx3cr1tm1Litt

Allelic Composition: Cx3cr1tm1Litt/Cx3cr1+
Genetic Background: B6.129P2-Cx3cr1tm1Litt

Allelic Composition: Cd1d1tm1Luc/Cd1d1tm1Luc,Cx3cr1tm1Litt/Cx3cr1tm1Litt
Genetic Background: B6.129-Cd1d1tm1Luc Cx3cr1tm1Litt

 MP:0004800 decreased susceptibility to experimental autoimmune encephalomyelitis "reduced likelihood that an organism will develop disease symptoms similar to human multiple sclerosis upon induction with antigens to Myelin Basic Protein (MBP), Proteolipid Protein (PLP), and/or Myelin Oligodendrocyte glycoprotein (MOG)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ccr2tm2.1Ifc/Ccr2tm2.1Ifc,Cx3cr1tm1Litt/Cx3cr1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

Allelic Composition: Ccr2tm2.1Ifc/Ccr2tm2.1Ifc,Cx3cr1tm1Litt/Cx3cr1tm1Litt
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

 MP:0004883 abnormal blood vessel healing "anomaly in the repair process of blood vessels after injury" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Cx3cr1tm1Litt/Cx3cr1tm1Litt
Genetic Background: B6.129P2-Cx3cr1tm1Litt

 MP:0005025 response to infection "the body s reaction to invasion and multiplication of microorganisms in its tissues, or the body s reaction to components of or toxins produced by pathogenic mircroorganisms " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Pomctm1Low/Pomctm1Low,Tg(Pomc)#Low/Tg(Pomc)#Low
Genetic Background: involves: 129 * C57BL/6 * CBA * DBA/2 * Swiss Webster

 MP:0005103 abnormal retinal pigmentation "anomalous coloring of the thin layer of neural tissue lining the back of the eyeball which contains visual receptors " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ccl2tm1Rol/Ccl2tm1Rol,Cx3cr1tm1Zm/Cx3cr1tm1Zm
Genetic Background: involves: 129 * 129S4/SvJae

Allelic Composition: Ccl2tm1Rol/Ccl2tm1Rol,Cx3cr1tm1Litt/Cx3cr1tm1Litt
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6J

 MP:0005201 abnormal retinal pigment epithelium morphology "anomaly in the epithelial layer of the retina composed of cells containing pigment granules " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Ccl2tm1Rol/Ccl2tm1Rol,Cx3cr1tm1Zm/Cx3cr1tm1Zm
Genetic Background: involves: 129 * 129S4/SvJae

 MP:0005239 abnormal Bruch membrane morphology "anomalous structure of the transparent, nearly structureless inner layer of the choroid in contact with the pigmented layer of the retina" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ccl2tm1Rol/Ccl2tm1Rol,Cx3cr1tm1Zm/Cx3cr1tm1Zm
Genetic Background: involves: 129 * 129S4/SvJae

Allelic Composition: Ccl2tm1Rol/Ccl2tm1Rol,Cx3cr1tm1Litt/Cx3cr1tm1Litt
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6J

 MP:0005240 abnormal amacrine cell morphology "anomalous structure of the interneurons of the retina" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Ccl2tm1Rol/Ccl2tm1Rol,Cx3cr1tm1Litt/Cx3cr1tm1Litt
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6J

 MP:0005341 decreased susceptibility to atherosclerosis "less likely than the norm to develop thickening and loss of elasticity of arterial walls, involving lipid deposition and thickening of intimal layers within arteries" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Apoetm1Bres/Apoetm1Bres,Cx3cr1tm1Ifc/Cx3cr1tm1Ifc
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Cx3cr1tm1Zm/Cx3cr1tm1Zm
Genetic Background: B6.129-Apoetm1Unc Cx3cr1tm1Zm

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Cx3cr1tm1Zm/Cx3cr1+
Genetic Background: B6.129-Apoetm1Unc Cx3cr1tm1Zm

 MP:0005546 choroidal neovascularization "new, abnormal, vessel development of the thin, highly vascularized membrane covering most of the posterior of the eye between the retina and the sclera" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Rasgrf1enu1H/Rasgrf1+
Genetic Background: involves: BALB/c * C3H/HeN * C57BL/6JOlaHsd

Allelic Composition: Cx3cr1tm1Zm/Cx3cr1tm1Zm
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Ccl2tm1Rol/Ccl2tm1Rol,Cx3cr1tm1Zm/Cx3cr1tm1Zm
Genetic Background: involves: 129 * 129S4/SvJae

 MP:0005547 abnormal Muller cell morphology "anomalous structure of the elongated neuroglial cells that traverse all the layers of the retina and that act as supporting elements" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ccl2tm1Rol/Ccl2tm1Rol,Cx3cr1tm1Litt/Cx3cr1tm1Litt
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6J

 MP:0005548 retinal pigment epithelium atrophy "wasting or decreased size of the epithelial layer of the retina composed of cells containing pigment granules " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ccl2tm1Rol/Ccl2tm1Rol,Cx3cr1tm1Zm/Cx3cr1tm1Zm
Genetic Background: involves: 129 * 129S4/SvJae

Allelic Composition: Ccl2tm1Rol/Ccl2tm1Rol,Cx3cr1tm1Litt/Cx3cr1tm1Litt
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6J

 MP:0005549 retinal pigment epithelium hyperplasia "increased numbers of cells in the epithelial layer of the retina composed of cells containing pigment granules " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ccl2tm1Rol/Ccl2tm1Rol,Cx3cr1tm1Zm/Cx3cr1tm1Zm
Genetic Background: involves: 129 * 129S4/SvJae

 MP:0005595 abnormal vascular smooth muscle physiology "anomalous function of the nonstriated, involuntary muscle tissue of the blood vessels" [RGD:Rat Genome Database submission, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Cx3cr1tm1Litt/Cx3cr1tm1Litt
Genetic Background: B6.129P2-Cx3cr1tm1Litt

 MP:0005671 response to transplant "the body s reaction to the grafting of organs, tissues, or cells taken from the same individual for another area of the body or from another individual" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator, J:52834]
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Allelic Composition: Trp53tm1Tyj/Trp53tm1Tyj,Tsg101tm1Mak/Tsg101tm1Mak
Genetic Background: involves: 129P3/J * 129S2/SvPas * C57BL/6 * CD-1

 MP:0006051 brainstem hemorrhage "bleeding into the brain stem" [smb:Susan M Bello, Mouse Genome Informatics Curator, RGD:Rat Genome Database submission]
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Allelic Composition: Cx3cr1tm1Litt/Cx3cr1tm1Litt
Genetic Background: B6.129P2-Cx3cr1tm1Litt

 MP:0006187 retinal deposits "abnormal accumulation of material on the retina" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Cx3cr1tm1Zm/Cx3cr1tm1Zm
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Ccl2tm1Rol/Ccl2tm1Rol,Cx3cr1tm1Zm/Cx3cr1tm1Zm
Genetic Background: involves: 129 * 129S4/SvJae

 MP:0008045 decreased NK cell number "reduction in the number of non-T, non-B lymphocytes, having a granular morphology and which are important in innate immunity to viruses and other intracellular pathogens; in addition, these cells can kill certain tumor cells" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease"]
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Allelic Composition: Cx3cr1tm1Litt/Cx3cr1tm1Litt
Genetic Background: B6.129P2-Cx3cr1tm1Litt

Allelic Composition: Cd1d1tm1Luc/Cd1d1tm1Luc,Cx3cr1tm1Litt/Cx3cr1tm1Litt
Genetic Background: B6.129-Cd1d1tm1Luc Cx3cr1tm1Litt

 MP:0008108 abnormal small intestinal villus morphology "any structural anomaly of the tiny hair-like projections that protrude from the inside of the small intestine that contain blood vessels that capture digested nutrients that are absorbed through the intestinal wall; the villi increase the absorptive surface area of the small intestine by approximately 30-fold" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Pomctm1Low/Pomctm1Low,Tg(Pomc)#Low/Tg(Pomc)#Low
Genetic Background: involves: 129 * C57BL/6 * CBA * DBA/2 * Swiss Webster

 MP:0008126 increased dendritic cell number "greater number of a cells of hematopoietic origin, typically resident in particular tissues, specialized in the uptake, processing, and transport of antigens to lymph nodes for the purpose of stimulating an immune response via T cell activation" [ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Pomctm1Low/Pomctm1Low,Tg(Pomc)#Low/Tg(Pomc)#Low
Genetic Background: involves: 129 * C57BL/6 * CBA * DBA/2 * Swiss Webster

 MP:0008450 retinal photoreceptor degeneration "a retrogressive impairment of function or destruction of a cell specialized to detect and transduce light, including rods and cones of the retina" [MESH:A08.663.650.650, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ccl2tm1Rol/Ccl2tm1Rol,Cx3cr1tm1Zm/Cx3cr1tm1Zm
Genetic Background: involves: 129 * 129S4/SvJae

Allelic Composition: Ccl2tm1Rol/Ccl2tm1Rol,Cx3cr1tm1Litt/Cx3cr1tm1Litt
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6J

 MP:0008515 thin retinal outer nuclear layer "reduced thickness of the retinal layer that contains the nuclei and cell bodies of rods and cones" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Cx3cr1tm1Zm/Cx3cr1tm1Zm
Genetic Background: involves: 129 * C57BL/6

 MP:0008586 disorganized photoreceptor outer segment "derangement of the pattern of the photoreceptor region that is rich in the visual pigment rhodopsin" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ccl2tm1Rol/Ccl2tm1Rol,Cx3cr1tm1Zm/Cx3cr1tm1Zm
Genetic Background: involves: 129 * 129S4/SvJae

Allelic Composition: Ccl2tm1Rol/Ccl2tm1Rol,Cx3cr1tm1Litt/Cx3cr1tm1Litt
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6J

 MP:0008918 microgliosis "a proliferation or spread of microglia in the area of a degenerative lesion or damaged tissue" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cx3cr1tm1Litt/Cx3cr1tm1Litt
Genetic Background: B6.129P2-Cx3cr1tm1Litt

Allelic Composition: Cx3cr1tm1Litt/Cx3cr1+
Genetic Background: B6.129P2-Cx3cr1tm1Litt

 MP:0008948 decreased neuron number "fewer than normal numbers of the cells of the nervous system that receive, conduct, and transmit impulses" [MESH:A08.663]
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Allelic Composition: Cx3cr1tm1Litt/Cx3cr1+
Genetic Background: B6.129P2-Cx3cr1tm1Litt

 MP:0009333 abnormal splenocyte physiology "any functional anomaly of a cell of the spleen" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Dcxtm1Caw/Dcx+
Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ * Black Swiss

 MP:0009763 increased sensitivity to induced morbidity/mortality "decrease in the amount of an external agent required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Cx3cr1tm1Litt/Cx3cr1tm1Litt
Genetic Background: B6.129P2-Cx3cr1tm1Litt

 MP:0009788 increased susceptibility to bacterial infection induced morbidity/mortality "increased likelihood that an organism will display the expected moribund state caused by a bacterial invasion or from components of or toxins produced by bacteria" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Pomctm1Low/Pomctm1Low,Tg(Pomc)#Low/Tg(Pomc)#Low
Genetic Background: involves: 129 * C57BL/6 * CBA * DBA/2 * Swiss Webster

 MP:0010016 variable depigmentation "absence or loss of normal pigment in the skin in various and irregular patterns" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Ccl2tm1Rol/Ccl2tm1Rol,Cx3cr1tm1Zm/Cx3cr1tm1Zm
Genetic Background: involves: 129 * 129S4/SvJae

 MP:0010053 decreased grip strength "reduced ability to grasp and hold objects, often measured as time spent hanging from an object or wire" [ISBN:0471316393 "Crawley, JN, What s Wrong with my Mouse: Behavioral Phenotyping of Transgenic and Knockout Mice"]
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Allelic Composition: Cx3cr1tm1Litt/Cx3cr1+
Genetic Background: B6.129P2-Cx3cr1tm1Litt

 MP:0010180 increased susceptibility to weight loss "greater decrease in body weight over time when compared to the average decrease in weight in response to dietary modification, fasting or caloric restriction" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cx3cr1tm1Litt/Cx3cr1+
Genetic Background: B6.129P2-Cx3cr1tm1Litt

 MP:0010766 abnormal NK cell physiology "any functional anomaly of a lymphocyte that can spontaneously kill a variety of target cells without prior antigenic activation via germline encoded activation receptors, and also regulate immune responses via cytokine release and direct contact with other cells" [GOC:add, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:15771571]
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Allelic Composition: Trp53tm1Tyj/Trp53tm1Tyj,Tsg101tm1Mak/Tsg101tm1Mak
Genetic Background: involves: 129P3/J * 129S2/SvPas * C57BL/6 * CD-1

Allelic Composition: Cx3cr1tm1Litt/Cx3cr1tm1Litt
Genetic Background: B6.129P2-Cx3cr1tm1Litt

 MP:0011451 increased susceptibility to dopaminergic neuron neurotoxicity "greater than normal amount of dopaminergic neuronal cell death following exposure to a neurotoxic compound, such as MPTP-induced cell death occurring through interference in mitochondrial metabolism" [MGI:csmith]
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Allelic Composition: Cx3cr1tm1Litt/Cx3cr1tm1Litt
Genetic Background: B6.129P2-Cx3cr1tm1Litt

 MP:0020448 increased microglial cell activation "increase in the change in morphology and behavior of a microglial cell resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor, during the maturation to the fully active phagocytic form" [GO:0001774]
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Allelic Composition: Ccl2tm1Rol/Ccl2tm1Rol,Cx3cr1tm1Litt/Cx3cr1tm1Litt
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000031778 Cx3cl1 / O35188 / chemokine (C-X3-C motif) ligand 1 / P78423* / C-X3-C motif chemokine ligand 1*  / complex / reaction






 

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