ENSMUSG00000050232


Mus musculus

Features
Gene ID: ENSMUSG00000050232
  
Biological name :Cxcr3
  
Synonyms : C-X-C chemokine receptor type 3 / Cxcr3 / O88410
  
Possible biological names infered from orthology : C-X-C motif chemokine receptor 3 / P49682
  
Species: Mus musculus
  
Chr. number: X
Strand: -1
Band: D
Gene start: 101731535
Gene end: 101734269
  
Corresponding Affymetrix probe sets: 10606058 (MoGene1.0st)   1449925_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000052444
NCBI entrez gene - 12766     See in Manteia.
MGI - MGI:1277207
RefSeq - NM_009910
RefSeq Peptide - NP_034040
swissprot - O88410
Ensembl - ENSMUSG00000050232
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cxcr3.1ENSDARG00000007358Danio rerio
 CXCR3ENSG00000186810Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Cxcr5 / Q04683 / C-X-C chemokine receptor type 5 / P32302* / C-X-C motif chemokine receptor 5*ENSMUSG0000004788035
Ccr10 / Q9JL21 / C-C chemokine receptor type 10 / P46092* / C-C motif chemokine receptor 10*ENSMUSG0000004405234
Cxcr1 / Q810W6 / C-X-C chemokine receptor type 1 / P25024* / C-X-C motif chemokine receptor 1*ENSMUSG0000004848033
Cxcr2 / P35343 / C-X-C chemokine receptor type 2 / P25025* / C-X-C motif chemokine receptor 2*ENSMUSG0000002618032
Ccr7 / P47774 / C-C chemokine receptor type 7 / P32248* / C-C motif chemokine receptor 7*ENSMUSG0000003794431
Ccr6 / O54689 / Mus musculus chemokine (C-C motif) receptor 6 (Ccr6), transcript variant 7, mRNA. / P51684* / C-C motif chemokine receptor 6*ENSMUSG0000004089931
Ackr2 / O08707 / atypical chemokine receptor 2 / O00590*ENSMUSG0000004453431
Cxcr4 / Mus musculus chemokine (C-X-C motif) receptor 4 (Cxcr4), transcript variant 2, mRNA. / P61073* / C-X-C motif chemokine receptor 4*ENSMUSG0000004538231
Ccr4 / P51680 / C-C chemokine receptor type 4 / P51679* / C-C motif chemokine receptor 4*ENSMUSG0000004789831
Ccr2 / P51683 / C-C chemokine receptor type 2 / P41597* / C-C motif chemokine receptor 2*ENSMUSG0000004910331
Ccr5 / P51682 / C-C chemokine receptor type 5 / P51681* / C-C motif chemokine receptor 5 (gene/pseudogene)*ENSMUSG0000007922731
Ccr9 / Q9WUT7 / C-C chemokine receptor type 9 / P51686* / C-C motif chemokine receptor 9*ENSMUSG0000002953030
Ccr3 / P51678 / Probable C-C chemokine receptor type 3 / P51677* / C-C motif chemokine receptor 3*ENSMUSG0000003544830
Cx3cr1 / Q9Z0D9 / CX3C chemokine receptor 1 / P49238* / C-X3-C motif chemokine receptor 1*ENSMUSG0000005233630
Ccr1 / P51675 / C-C chemokine receptor type 1 / P32246* / C-C motif chemokine receptor 1*ENSMUSG0000002580429
Cxcr6 / Q9EQ16 / C-X-C chemokine receptor type 6 / O00574* / C-X-C motif chemokine receptor 6*ENSMUSG0000004852127
Ackr4 / Q924I3 / atypical chemokine receptor 4 / Q9NPB9*ENSMUSG0000007935527
Ccr8 / P56484 / C-C chemokine receptor type 8 / P51685* / C-C motif chemokine receptor 8*ENSMUSG0000004226226
Ccr1l1 / P51676 / C-C chemokine receptor 1-like protein 1 / CCR1* / P32246* / C-C motif chemokine receptor 1*ENSMUSG0000006403926
Xcr1 / chemokine (C motif) receptor 1 / P46094* / X-C motif chemokine receptor 1*ENSMUSG0000006050923


Protein motifs (from Interpro)
Interpro ID Name
 IPR000276  G protein-coupled receptor, rhodopsin-like
 IPR000355  Chemokine receptor family
 IPR004070  CXC chemokine receptor 3
 IPR017452  GPCR, rhodopsin-like, 7TM


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001525 angiogenesis IEA
 biological_processGO:0001937 negative regulation of endothelial cell proliferation ISO
 biological_processGO:0002685 regulation of leukocyte migration IEA
 biological_processGO:0006935 chemotaxis IEA
 biological_processGO:0006954 inflammatory response IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007166 cell surface receptor signaling pathway IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway ISO
 biological_processGO:0007204 positive regulation of cytosolic calcium ion concentration IEA
 biological_processGO:0008284 positive regulation of cell proliferation ISS
 biological_processGO:0010818 T cell chemotaxis IEA
 biological_processGO:0016525 negative regulation of angiogenesis ISO
 biological_processGO:0019722 calcium-mediated signaling IEA
 biological_processGO:0030816 obsolete positive regulation of cAMP metabolic process ISO
 biological_processGO:0043950 positive regulation of cAMP-mediated signaling ISO
 biological_processGO:0045766 positive regulation of angiogenesis ISS
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II ISO
 biological_processGO:0050921 positive regulation of chemotaxis ISO
 biological_processGO:0051281 positive regulation of release of sequestered calcium ion into cytosol ISO
 biological_processGO:0070098 chemokine-mediated signaling pathway IEA
 biological_processGO:0071954 chemokine (C-C motif) ligand 11 production ISO
 biological_processGO:1900118 negative regulation of execution phase of apoptosis ISS
 biological_processGO:1900119 positive regulation of execution phase of apoptosis ISO
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0009897 external side of plasma membrane IEA
 cellular_componentGO:0009986 cell surface IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity IEA
 molecular_functionGO:0004950 chemokine receptor activity IEA
 molecular_functionGO:0016494 C-X-C chemokine receptor activity IEA
 molecular_functionGO:0019956 chemokine binding IEA
 molecular_functionGO:0019958 C-X-C chemokine binding ISO


Pathways (from Reactome)
Pathway description
Chemokine receptors bind chemokines
G alpha (i) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001859 kidney inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the kidney" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Ercc6tm1Gvh/Ercc6tm1Gvh,Xpatm1Tnka/Xpatm1Tnka
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0001861 lung inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the lung" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Slc17a6tm1.1Kldr/Slc17a6tm1.1Kldr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6

Allelic Composition: Cxcr3tm1Wwh/Y
Genetic Background: B6.Cg-Cxcr3tm1Wwh

 MP:0002020 increased tumor incidence "greater than average number of tumors, usually a specific type" [MGI:cls, J:34193]
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Allelic Composition: Eomestm1.1Bflu/Eomestm1.1Bflu,Tbx21tm1Glm/Tbx21tm1Glm,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * DBA/2 * SJL

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Mad2l1tm1Sorg/Mad2l1+,Usp44tm1.2Pjgl/Usp44tm1.2Pjgl
Genetic Background: involves: 129S2/SvPas * 129S4/SvJae * 129S7/SvEvBrd

 MP:0002410 decreased susceptibility to viral infection "reduced likelihood that an organism will develop ill effects from a viral infection or from components of or toxins produced by a virus " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Slc17a6tm1.1Kldr/Slc17a6tm1.1Kldr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6

 MP:0002871 albuminuria "presence of excess albumin in the urine" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Ercc6tm1Gvh/Ercc6tm1Gvh,Xpatm1Tnka/Xpatm1Tnka
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0003426 pulmonary interstitial fibrosis "formation of fibrous tissue within the interstices of the lung as a result of repair or a reactive process" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:63134]
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Allelic Composition: Slc17a6tm1.1Kldr/Slc17a6tm1.1Kldr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6

Allelic Composition: Cxcr3tm1Wwh/Y
Genetic Background: B6.Cg-Cxcr3tm1Wwh

 MP:0003710 abnormal physiological neovascularization "anomalies in the development of new blood vessels in restoration of blood circulation during the healing process " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Slc17a6tm1.1Kldr/Slc17a6tm1.1Kldr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6

Allelic Composition: Cxcr3tm1Wwh/Y
Genetic Background: B6.Cg-Cxcr3tm1Wwh

 MP:0003721 increased tumor growth/size "greater than expected development of tumorous growth when compared to controls" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Ccl2tm1Rol/Ccl2tm1Rol
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0003799 impaired macrophage migration "defect in the ability of macrophages to move up a chemotactic gradient" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Slc17a6tm1.1Kldr/Slc17a6tm1.1Kldr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6

Allelic Composition: Cxcr3tm1Wwh/Y
Genetic Background: B6.Cg-Cxcr3tm1Wwh

 MP:0004751 increased length of allograft survival "compared to controls, a greater length of time that transplanted tissue, in which the donor and recipient are genetically similar (same species) but not genetically identical, retains function and/or remains alive" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Slc17a6tm1.1Kldr/Slc17a6tm1.1Kldr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6

Allelic Composition: Cxcr3tm1Wwh/Y
Genetic Background: B6.Cg-Cxcr3tm1Wwh

 MP:0005166 decreased susceptiblity to injury "less than the normal reaction to trauma, especially that by physical means" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ercc6tm1Gvh/Ercc6tm1Gvh,Xpatm1Tnka/Xpatm1Tnka
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0005554 decreased circulating creatinine level "less than the normal blood concentration of this product of creatine catabolism; abnormal levels indicative of renal dysfunction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
Show

Allelic Composition: Ercc6tm1Gvh/Ercc6tm1Gvh,Xpatm1Tnka/Xpatm1Tnka
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0005559 increased circulating glucose level "greater than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, RGD:Rat Genome Database submission]
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Allelic Composition: Gabra3tm1Dgen/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005566 decreased blood urea nitrogen level "low circulating concentration of nitrogen, in the form of urea; commonly used to measure renal function" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Ercc6tm1Gvh/Ercc6tm1Gvh,Xpatm1Tnka/Xpatm1Tnka
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0008750 abnormal interferon level "deviation from the normal levels of proteins secreted by vertebrate cells in response to a wide variety of inducers; they confer resistance against many different viruses, inhibit proliferation of normal and malignant cells, impede multiplication of intracellular parasites, enhance macrophage and granulocyte phagocytosis, augment natural killer cell activity, and show several other immunomodulatory functions" [MESH:D12.644.276.374.440]
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Allelic Composition: Slc17a6tm1.1Kldr/Slc17a6tm1.1Kldr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6

Allelic Composition: Cxcr3tm1Wwh/Y
Genetic Background: B6.Cg-Cxcr3tm1Wwh

 MP:0009790 decreased susceptibility to viral infection induced morbidity/mortality "reduced likelihood that an organism will display the expected moribund state caused by a viral invasion or from components of or toxins produced by a virus" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Slc17a6tm1.1Kldr/Slc17a6tm1.1Kldr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6

 MP:0009858 abnormal cellular extravasation "any anomaly in the migration of leukocytes from the blood vessels into the surrounding tissue" [GO:0045123]
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Allelic Composition: Slc17a6tm1.1Kldr/Slc17a6tm1.1Kldr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6

Allelic Composition: Cxcr3tm1Wwh/Y
Genetic Background: B6.Cg-Cxcr3tm1Wwh

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000034855 Cxcl10 / P17515 / C-X-C motif chemokine 10 / P02778* / C-X-C motif chemokine ligand 10*  / complex / reaction
 ENSMUSG00000029417 Cxcl9 / P18340 / C-X-C motif chemokine 9 / Q07325* / C-X-C motif chemokine ligand 9*  / complex / reaction






 

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