ENSMUSG00000029371


Mus musculus

Features
Gene ID: ENSMUSG00000029371
  
Biological name :Cxcl5
  
Synonyms : Cxcl5 / C-X-C motif chemokine 5 GCP-2(1-78) GCP-2(9-78) / P50228
  
Possible biological names infered from orthology : CXCL6 / C-X-C motif chemokine ligand 5 / C-X-C motif chemokine ligand 6 / P42830 / P80162
  
Species: Mus musculus
  
Chr. number: 5
Strand: 1
Band: E1
Gene start: 90759360
Gene end: 90761624
  
Corresponding Affymetrix probe sets: 10523120 (MoGene1.0st)   1419728_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000031318
NCBI entrez gene - 20311     See in Manteia.
MGI - MGI:1096868
RefSeq - NM_009141
RefSeq Peptide - NP_033167
swissprot - P50228
Ensembl - ENSMUSG00000029371
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CXCL5ENSG00000163735Homo sapiens
 CXCL6ENSG00000124875Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Cxcl2 / P10889 / C-X-C motif chemokine 2 / CXCL3* / CXCL1* / P19876* / P09341* / P19875* / C-X-C motif chemokine ligand 2* / C-X-C motif chemokine ligand 3* / C-X-C motif chemokine ligand 1*ENSMUSG0000005842733
Cxcl1 / P12850 / Growth-regulated alpha protein KC(5-72) / CXCL3* / CXCL2* / P19876* / P09341* / P19875* / C-X-C motif chemokine ligand 2* / C-X-C motif chemokine ligand 1* / C-X-C motif ch...ENSMUSG0000002938032
Cxcl3 / Q6W5C0 / C-X-C motif chemokine 3 / CXCL1* / CXCL2* / P09341* / P19875* / P19876* / C-X-C motif chemokine ligand 3* / C-X-C motif chemokine ligand 2* / C-X-C motif chemokine ligand 1*ENSMUSG0000002937930
Ppbp / pro-platelet basic protein / P02775*ENSMUSG0000002937227
Cxcl15 / Q9WVL7 / C-X-C motif chemokine 15 ENSMUSG0000002937526


Protein motifs (from Interpro)
Interpro ID Name
 IPR001089  CXC chemokine
 IPR001811  Chemokine interleukin-8-like domain
 IPR018048  CXC chemokine, conserved site
 IPR033899  CXC Chemokine domain
 IPR036048  Chemokine interleukin-8-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001776 leukocyte homeostasis IMP
 biological_processGO:0006935 chemotaxis IEA
 biological_processGO:0006952 defense response IEA
 biological_processGO:0006954 inflammatory response IBA
 biological_processGO:0006955 immune response IBA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IBA
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0030593 neutrophil chemotaxis ISO
 biological_processGO:0032496 response to lipopolysaccharide IMP
 biological_processGO:0032642 regulation of chemokine production IMP
 biological_processGO:0042119 neutrophil activation ISO
 biological_processGO:0042127 regulation of cell proliferation IBA
 biological_processGO:0061844 antimicrobial humoral immune response mediated by antimicrobial peptide ISO
 biological_processGO:0070098 chemokine-mediated signaling pathway IBA
 biological_processGO:0070951 regulation of neutrophil mediated killing of gram-negative bacterium IMP
 biological_processGO:0071222 cellular response to lipopolysaccharide ISO
 biological_processGO:0090023 positive regulation of neutrophil chemotaxis IBA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IEA
 molecular_functionGO:0005125 cytokine activity IEA
 molecular_functionGO:0008009 chemokine activity IBA
 molecular_functionGO:0045236 CXCR chemokine receptor binding IBA


Pathways (from Reactome)
Pathway description
Chemokine receptors bind chemokines
G alpha (i) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000222 decreased neutrophil count "fewer than normal neutrophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cxcl5tm1.1Mkch/Cxcl5tm1.1Mkch
Genetic Background: B6.129P2-Cxcl5tm1.1Mkch

 MP:0000322 increased granulocyte number "greater than expected number of leukocytes that have abundant granules in the cytoplasm: basophils, neutrophils, or eosinophils" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Atxn1tm1Hzo/Atxn1+
Genetic Background: B6.129S7-Atxn1tm1Hzo

 MP:0002411 decreased susceptibility to bacterial infection "reduced likelihood that an organism will develop ill effects from a bacterial infection or from components of or toxins produced by bacteria " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Atxn1tm1Hzo/Atxn1+
Genetic Background: B6.129S7-Atxn1tm1Hzo

Allelic Composition: Cxcl5tm1.1Mkch/Cxcl5tm1.1Mkch
Genetic Background: B6.129P2-Cxcl5tm1.1Mkch

 MP:0002463 abnormal neutrophil physiology "abnormal function of these granular leukocytes, which stain with neutral dyes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Atxn1tm1Hzo/Atxn1+
Genetic Background: B6.129S7-Atxn1tm1Hzo

 MP:0008561 decreased tumor necrosis factor secretion "reduction in the production or release of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]
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Allelic Composition: Cxcl5tm1.1Mkch/Cxcl5tm1.1Mkch
Genetic Background: B6.129P2-Cxcl5tm1.1Mkch

 MP:0008563 decreased interferon-alpha secretion "increase in the production or release of one of the type I interferons produced by peripheral blood leukocytes or lymphoblastoid cells that has antiviral activity and activates natural killer cells and B cells" [MESH:D12.644.276.374.440.890.250]
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Allelic Composition: Cxcl5tm1.1Mkch/Cxcl5tm1.1Mkch
Genetic Background: B6.129P2-Cxcl5tm1.1Mkch

 MP:0008597 decreased circulating interleukin-6 level "reduction in the amount in the blood of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506]
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Allelic Composition: Atxn1tm1Hzo/Atxn1+
Genetic Background: B6.129S7-Atxn1tm1Hzo

 MP:0008655 decreased interleukin-1 alpha secretion "reduction in the production or release of an interleukin-1 subtype that occurs as a membrane-bound pro-protein form that is cleaved by proteases to form a secreted mature form; both membrane-bound and secreted forms of interleukin-1alpha are biologically active" [MESH:D12.644.276.374.465.501.300]
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Allelic Composition: Cxcl5tm1.1Mkch/Cxcl5tm1.1Mkch
Genetic Background: B6.129P2-Cxcl5tm1.1Mkch

 MP:0008706 decreased interleukin-6 secretion "reduction in the production or release of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506]
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Allelic Composition: Cxcl5tm1.1Mkch/Cxcl5tm1.1Mkch
Genetic Background: B6.129P2-Cxcl5tm1.1Mkch

 MP:0008734 decreased susceptibility to endotoxin shock "less than the expected early reaction of the microcirculation to endotoxins such as LPS, characterized by movement of fluid and leukocytes from the blood into extravascular tissues and often resulting in death" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Atxn1tm1Hzo/Atxn1+
Genetic Background: B6.129S7-Atxn1tm1Hzo

 MP:0009789 decreased susceptibility to bacterial infection induced morbidity/mortality "reduced likelihood that an organism will display the expected moribund state caused by a bacterial invasion or from components of or toxins produced by bacteria" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Atxn1tm1Hzo/Atxn1+
Genetic Background: B6.129S7-Atxn1tm1Hzo

Allelic Composition: Cxcl5tm1.1Mkch/Cxcl5tm1.1Mkch
Genetic Background: B6.129P2-Cxcl5tm1.1Mkch

 MP:0010209 abnormal circulating chemokine level "deviation from the normal levels of any of the class of pro-inflammatory cytokines that attract and activate leukocytes in the circulation" [MESH:D12.644.276.374.200, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Atxn1tm1Hzo/Atxn1+
Genetic Background: B6.129S7-Atxn1tm1Hzo

Allelic Composition: Cxcl5tm1Gscw/Cxcl5tm1Gscw,Ackr1tm1Scp/Ackr1tm1Scp
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000048480 Cxcr1 / Q810W6 / C-X-C chemokine receptor type 1 / P25024* / C-X-C motif chemokine receptor 1*  / complex / reaction






 

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