ENSMUSG00000046814


Mus musculus

Features
Gene ID: ENSMUSG00000046814
  
Biological name :Gchfr
  
Synonyms : Gchfr / GTP cyclohydrolase 1 feedback regulatory protein / P99025
  
Possible biological names infered from orthology : GTP cyclohydrolase I feedback regulator / P30047
  
Species: Mus musculus
  
Chr. number: 2
Strand: 1
Band: E5
Gene start: 119167773
Gene end: 119172390
  
Corresponding Affymetrix probe sets: 10474915 (MoGene1.0st)   1435750_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000060835
NCBI entrez gene - 320415     See in Manteia.
MGI - MGI:2443977
RefSeq - NM_177157
RefSeq Peptide - NP_796131
swissprot - P99025
swissprot - Q4VAF4
Ensembl - ENSMUSG00000046814
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 gchfrENSDARG00000098588Danio rerio
 GCHFRENSGALG00000032239Gallus gallus
 GCHFRENSG00000137880Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR009112  GTP cyclohydrolase I, feedback regulatory protein
 IPR036717  GFRP superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0009890 negative regulation of biosynthetic process IEA
 biological_processGO:0043105 negative regulation of GTP cyclohydrolase I activity IEA
 biological_processGO:0051291 protein heterooligomerization IEA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030425 dendrite IEA
 cellular_componentGO:0031965 nuclear membrane IEA
 cellular_componentGO:0042470 melanosome IEA
 molecular_functionGO:0004857 enzyme inhibitor activity IEA
 molecular_functionGO:0016597 amino acid binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0019899 enzyme binding IEA
 molecular_functionGO:0030742 GTP-dependent protein binding IEA
 molecular_functionGO:0044549 GTP cyclohydrolase binding IEA


Pathways (from Reactome)
Pathway description
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000046814 Gchfr / P99025 / GTP cyclohydrolase 1 feedback regulatory protein / P30047* / GTP cyclohydrolase I feedback regulator*  / complex / reaction
 ENSMUSG00000037580 Gch1 / Q05915 / GTP cyclohydrolase 1 / P30793*  / complex / reaction






 

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