ENSMUSG00000047517


Mus musculus

Features
Gene ID: ENSMUSG00000047517
  
Biological name :Dmbt1
  
Synonyms : Dmbt1 / Mus musculus deleted in malignant brain tumors 1 (Dmbt1), transcript variant 1, mRNA.
  
Possible biological names infered from orthology : deleted in malignant brain tumors 1 / Q9UGM3
  
Species: Mus musculus
  
Chr. number: 7
Strand: 1
Band: F3
Gene start: 131032053
Gene end: 131121630
  
Corresponding Affymetrix probe sets: 10558159 (MoGene1.0st)   1418287_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000146345
Ensembl peptide - ENSMUSP00000148657
Ensembl peptide - ENSMUSP00000146685
Ensembl peptide - ENSMUSP00000081556
NCBI entrez gene - 12945     See in Manteia.
MGI - MGI:106210
RefSeq - XM_006507307
RefSeq - XM_006507301
RefSeq - XM_006507302
RefSeq - XM_006507303
RefSeq - XM_006507304
RefSeq - XM_006507305
RefSeq - XM_006507306
RefSeq - NM_001347632
RefSeq - NM_007769
RefSeq - XM_006507298
RefSeq - XM_006507299
RefSeq - XM_006507300
RefSeq Peptide - NP_031795
RefSeq Peptide - NP_001334561
swissprot - E9QPG8
swissprot - A0A1D5RM72
swissprot - A0A140LI59
swissprot - A0A140LHB2
Ensembl - ENSMUSG00000047517
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ENSGALG00000038396Gallus gallus
 DMBT1ENSG00000187908Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Cd163 / Q2VLH6 / Scavenger receptor cysteine-rich type 1 protein M130 Soluble CD163 / Q86VB7* / CD163 molecule*ENSMUSG0000000884518
Cd163l1 / CD163 molecule-like 1 / Q4G0T1* / SCART1* / scavenger receptor family member expressed on T cells 1*ENSMUSG0000002546118
5830411N06Rik / RIKEN cDNA 5830411N06 gene / Q4G0T1* / SCART1* / scavenger receptor family member expressed on T cells 1*ENSMUSG0000005467217
Ssc5d / Q8BV57 / Soluble scavenger receptor cysteine-rich domain-containing protein SSC5D / A1L4H1* / scavenger receptor cysteine rich family member with 5 domains*ENSMUSG0000003527915
Q8BZE1 / 5430419D17Rik / Putative DMBT1-like protein ENSMUSG0000000620413
Ssc4d / A1L0T3 / scavenger receptor cysteine rich family, 4 domains / Q8WTU2* / scavenger receptor cysteine rich family member with 4 domains*ENSMUSG0000002969913
O08762 / Prss12 / protease, serine 12 neurotrypsin (motopsin) / P56730* / serine protease 12*ENSMUSG0000002797810
Cd5l / Q9QWK4 / CD5 antigen-like / O43866* / CD5 molecule like*ENSMUSG000000158547


Protein motifs (from Interpro)
Interpro ID Name
 IPR000859  CUB domain
 IPR001190  SRCR domain
 IPR001507  Zona pellucida domain
 IPR017448  SRCR-like domain
 IPR017977  Zona pellucida domain, conserved site
 IPR035914  Spermadhesin, CUB domain superfamily
 IPR036772  SRCR-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006898 receptor-mediated endocytosis IEA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0005044 scavenger receptor activity IEA


Pathways (from Reactome)
Pathway description
Surfactant metabolism


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000521 abnormal kidney cortex "anomalous structure or development of the outer area of the kidney, which contains the glomerular capillaries and the capsula glomeruli that enclose it " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Gt(ROSA)26Sortm1(Notch1)Dam/Gt(ROSA)26Sor+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * CBA

Allelic Composition: Dmbt1tm2Qaa/Dmbt1tm2Qaa,Tg(ATP6V1B1-cre)45Rnel/0
Genetic Background: involves: C57BL/6 * C57BL/6J * CBA

 MP:0000525 renal tubular acidosis "a clinical syndrome characterized by the inability to acidify urine" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:19268]
Show

Allelic Composition: Gt(ROSA)26Sortm1(Notch1)Dam/Gt(ROSA)26Sor+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * CBA

Allelic Composition: Dmbt1tm2Qaa/Dmbt1tm2Qaa,Tg(ATP6V1B1-cre)45Rnel/0
Genetic Background: involves: C57BL/6 * C57BL/6J * CBA

 MP:0001694 failure to form egg cylinders "inability of inner cell mass cells to grow towards the abembryonic pole to form a cylinder-like structure" [The Atlas of Mouse Development , Revised edition:ISBN 0-12-402035-6, MGI:cls, J:34458]
Show

Allelic Composition: Tbx1tm1.1Dsr/Tbx1tm1.1Dsr
Genetic Background: either: 129/Sv or (involves: 129/Sv * C57BL/6)

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Dmbt1tm1Kumc/Dmbt1tm1Kumc,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * C57BL/6J

Allelic Composition: Dmbt1tm1Kumc/Dmbt1+,Trp53tm1Tyj/Trp53+
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * C57BL/6J

 MP:0002718 abnormal inner cell mass "malformed or absent cells of the blastocyst that develop into the body of the embryo" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Tbx1tm1.1Dsr/Tbx1tm1.1Dsr
Genetic Background: either: 129/Sv or (involves: 129/Sv * C57BL/6)

 MP:0003017 decreased circulating bicarbonate level "reduced concentration of inorganic salts that contain the -HCO3 radical in the circulation, which are an important factor in regulating the pH of the blood " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission]
Show

Allelic Composition: Gt(ROSA)26Sortm1(Notch1)Dam/Gt(ROSA)26Sor+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * CBA

Allelic Composition: Dmbt1tm2Qaa/Dmbt1tm2Qaa,Tg(ATP6V1B1-cre)45Rnel/0
Genetic Background: involves: C57BL/6 * C57BL/6J * CBA

 MP:0004964 absent inner cell mass "absence of the cells of the blastocyst that develop into the body of the embryo" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tbx1tm1.1Dsr/Tbx1tm1.1Dsr
Genetic Background: either: 129/Sv or (involves: 129/Sv * C57BL/6)

 MP:0004965 inner cell mass degeneration 
Show

Allelic Composition: Tbx1tm1.1Dsr/Tbx1tm1.1Dsr
Genetic Background: either: 129/Sv or (involves: 129/Sv * C57BL/6)

 MP:0008537 increased susceptibility to induced colitis "increased severity or induction threshold of colitis upon treatment of an organism with intestinal inflammation agents such as dextran sodium sulfate (DSS)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: PhbGt(BGB069)Byg/Phb+
Genetic Background: involves: 129P2/OlaHsd * C57BL

 MP:0009349 increased urine pH "increased urine alkalinity" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gt(ROSA)26Sortm1(Notch1)Dam/Gt(ROSA)26Sor+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * CBA

Allelic Composition: Dmbt1tm2Qaa/Dmbt1tm2Qaa,Tg(ATP6V1B1-cre)45Rnel/0
Genetic Background: involves: C57BL/6 * C57BL/6J * CBA

 MP:0010380 inner cell mass apoptosis "the cells of the blastocyst that develop into the body of the embryo are undergoing programmed cell death" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tbx1tm1.1Dsr/Tbx1tm1.1Dsr
Genetic Background: either: 129/Sv or (involves: 129/Sv * C57BL/6)

 MP:0011096 complete embryonic lethality before somite formation "death of all organisms of a given genotype in a population between the point of implantation and somite formation (Mus: E4.5 to less than E8)" [MGI:csmith]
Show

Allelic Composition: Tbx1tm1.1Dsr/Tbx1tm1.1Dsr
Genetic Background: either: 129/Sv or (involves: 129/Sv * C57BL/6)

 MP:0012551 metabolic acidosis "decreased pH and bicarbonate concentration in tissues and/or body fluids caused when the body produces too much acid or when the kidneys are not removing enough acid from the body, as in diarrhea or in kidney disease" [ISBN:0-683-40008-8]
Show

Allelic Composition: Gt(ROSA)26Sortm1(Notch1)Dam/Gt(ROSA)26Sor+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * CBA

Allelic Composition: Dmbt1tm2Qaa/Dmbt1tm2Qaa,Tg(ATP6V1B1-cre)45Rnel/0
Genetic Background: involves: C57BL/6 * C57BL/6J * CBA

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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