ENSMUSG00000048988


Mus musculus

Features
Gene ID: ENSMUSG00000048988
  
Biological name :Elfn1
  
Synonyms : Elfn1 / Protein ELFN1 / Q8C8T7
  
Possible biological names infered from orthology : extracellular leucine rich repeat and fibronectin type III domain containing 1 / P0C7U0
  
Species: Mus musculus
  
Chr. number: 5
Strand: 1
Band: G2
Gene start: 139907943
Gene end: 139974722
  
Corresponding Affymetrix probe sets: 10526968 (MoGene1.0st)   1442101_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000053869
NCBI entrez gene - 243312     See in Manteia.
MGI - MGI:2442479
RefSeq - XM_017320882
RefSeq - NM_175522
RefSeq - XM_006504703
RefSeq - XM_006504704
RefSeq - XM_006504701
RefSeq - XM_006504702
RefSeq Peptide - NP_780731
swissprot - Q8C8T7
Ensembl - ENSMUSG00000048988
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 elfn1bENSDARG00000074372Danio rerio
 ELFN1ENSGALG00000004209Gallus gallus
 ELFN1ENSG00000225968Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Elfn2 / Q68FM6 / Mus musculus leucine rich repeat and fibronectin type III, extracellular 2 (Elfn2), transcript variant 1, mRNA. / Q5R3F8* / extracellular leucine rich repeat and fibronecti...ENSMUSG0000004346048
Q810B7 / Slitrk5 / SLIT and NTRK-like protein 5 / O94991* / SLIT and NTRK like family member 5*ENSMUSG0000003321415
Q810C0 / Slitrk2 / SLIT and NTRK-like family, member 2 / O96002* / Q9H156*ENSMUSG0000003679014
Q8C110 / Slitrk6 / SLIT and NTRK-like family, member 6 / Q9H5Y7*ENSMUSG0000004587114
Q810B9 / Slitrk3 / Mus musculus SLIT and NTRK-like family, member 3 (Slitrk3), transcript variant 2, mRNA. / O94933* / SLIT and NTRK like family member 3*ENSMUSG0000004830414
Q810B8 / Slitrk4 / SLIT and NTRK-like family, member 4 / Q8IW52*ENSMUSG0000004669913
Q810C1 / Slitrk1 / SLIT and NTRK-like family, member 1 / Q96PX8*ENSMUSG0000007547812
Lrrc19 / Q8BZT5 / Leucine-rich repeat-containing protein 19 / Q9H756* / leucine rich repeat containing 19*ENSMUSG000000497998


Protein motifs (from Interpro)
Interpro ID Name
 IPR000483  Cysteine-rich flanking region, C-terminal
 IPR001611  Leucine-rich repeat
 IPR003591  Leucine-rich repeat, typical subtype
 IPR021157  Cytochrome c1, transmembrane anchor, C-terminal
 IPR032675  Leucine-rich repeat domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0010923 negative regulation of phosphatase activity IEA
 biological_processGO:0032515 negative regulation of phosphoprotein phosphatase activity IEA
 biological_processGO:0050808 synapse organization IMP
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030425 dendrite IEA
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0060076 excitatory synapse IDA
 molecular_functionGO:0004864 protein phosphatase inhibitor activity IEA
 molecular_functionGO:0005515 protein binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000955 abnormal spinal cord morphology "malformation or disorganization of the cylindrical tissue of the vertebral canal that extends from the medulla oblongata to the conus medullaris" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ehmt1tm1b(EUCOMM)Hmgu/Ehmt1+
Genetic Background: C57BL/6N-Ehmt1tm1b(EUCOMM)Hmgu/Nju

 MP:0001364 decreased anxiety-related response "when compared to controls, subjects exhibit fewer responses thought to be indicative of anxiety in behavioral tests" [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator, J:86626, J:85438, J:64043]
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Allelic Composition: Mybl2tm1.1Epr/Mybl2tm1.1Epr,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * CBA * FVB/N

 MP:0001399 hyperactivity "general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125]
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Allelic Composition: Mybl2tm1.1Epr/Mybl2tm1.1Epr,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * CBA * FVB/N

Allelic Composition: Elfn1tm1.1Jaru/Elfn1tm1.1Jaru
Genetic Background: involves: C57BL/6

 MP:0001405 impaired coordination "reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Mybl2tm1.1Epr/Mybl2tm1.1Epr,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * CBA * FVB/N

 MP:0001473 reduced long term potentiation "less than the normal persistent robust synaptic response induced by synchronous stimulation of pre- and postsynaptic cells " [Principles of Neural Science:ISBN 0-8385-8034-3]
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Allelic Composition: Elfn1tm1.1Jaru/Elfn1tm1.1Jaru
Genetic Background: involves: C57BL/6

 MP:0001900 impaired synaptic plasticity "decreased or inability of the nervous system to change its reactivity as a result of successive activations " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Elfn1tm1.1Jaru/Elfn1tm1.1Jaru
Genetic Background: involves: C57BL/6

 MP:0002064 seizures "sudden and often acute manifestation of epileptic attack, sometimes convulsive" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Mybl2tm1.1Epr/Mybl2tm1.1Epr,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * CBA * FVB/N

 MP:0002757 reduced vertical activity "lesser than average time spent jumping or rearing" [J:82829, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Elfn1tm1.1Jaru/Elfn1tm1.1Jaru
Genetic Background: involves: C57BL/6

 MP:0002906 susceptibility to pharmacologically induced seizures "inability to withstand doses of pharmacological drugs that induce seizure activity in normal animals" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:69504]
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Allelic Composition: Elfn1tm1.1Jaru/Elfn1tm1.1Jaru
Genetic Background: involves: C57BL/6

 MP:0002910 abnormal excitatory postsynaptic currents "defect in the size or duration of currents detected in postsynaptic cells when an excitatory impulse arrives at the synapse causing depolarization" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Elfn1tm1.1Jaru/Elfn1tm1.1Jaru
Genetic Background: involves: C57BL/6

 MP:0002916 increased synaptic depression "increase in the duration of the reduction of effectiveness of synaptic connections between neurons and target after repetitive stimulation" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Elfn1tm1.1Jaru/Elfn1tm1.1Jaru
Genetic Background: involves: C57BL/6

 MP:0003107 abnormal response to novelty "alteration in amount of exploration/investigation of a novel object, situation or environment" [CFG:Center for Functional Genomics, Northwestern University]
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Allelic Composition: Elfn1tm1.1Jaru/Elfn1tm1.1Jaru
Genetic Background: involves: C57BL/6

 MP:0004994 abnormal brain wave pattern "any anomaly in the standard pattern of rhythmic and rapid fluctuation of electrical potential between parts of the brain, often visualized on an electroencephalogram (EEG); the pattern is often measured to diagnose neurological conditions such as seizure disorders (epilepsy)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Elfn1tm1.1Jaru/Elfn1tm1.1Jaru
Genetic Background: involves: C57BL/6

 MP:0009358 environmentally induced seizures "relatively mild but sudden stimulation due to changes in ambient habitat including lighting, sounds, touching, and/ or moving cage" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Elfn1tm1.1Jaru/Elfn1tm1.1Jaru
Genetic Background: involves: C57BL/6

 MP:0009936 abnormal dendritic spine morphology "any structural anomaly of the small membranous protrusion from the dendrite of a neuron that is involved in synaptic transmission; it typically receives input from a single synapse of an axon" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Elfn1tm1.1Jaru/Elfn1tm1.1Jaru
Genetic Background: involves: C57BL/6

 MP:0010053 decreased grip strength "reduced ability to grasp and hold objects, often measured as time spent hanging from an object or wire" [ISBN:0471316393 "Crawley, JN, What s Wrong with my Mouse: Behavioral Phenotyping of Transgenic and Knockout Mice"]
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Allelic Composition: Mybl2tm1.1Epr/Mybl2tm1.1Epr,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * CBA * FVB/N

 MP:0010698 abnormal impulsive behavior control "any anomaly in the ability of an individual to exert restraint over behavior" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Elfn1tm1.1Jaru/Elfn1tm1.1Jaru
Genetic Background: involves: C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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