ENSMUSG00000049128


Mus musculus

Features
Gene ID: ENSMUSG00000049128
  
Biological name :Ivl
  
Synonyms : involucrin / Ivl
  
Possible biological names infered from orthology : P07476
  
Species: Mus musculus
  
Chr. number: 3
Strand: -1
Band: F1
Gene start: 92570902
Gene end: 92573735
  
Corresponding Affymetrix probe sets: 10499904 (MoGene1.0st)   1422222_at (Mouse Genome 430 2.0 Array)   1439878_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000059780
NCBI entrez gene - 16447     See in Manteia.
MGI - MGI:96626
RefSeq - XM_006501047
RefSeq - NM_008412
RefSeq - XM_006501046
RefSeq Peptide - NP_032438
swissprot - G3X9D9
Ensembl - ENSMUSG00000049128
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 IVLENSG00000163207Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR009733  Involucrin 2
 IPR019571  Involucrin, N-terminal
 IPR019743  Involucrin, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0030216 keratinocyte differentiation IEA
 biological_processGO:0031424 keratinization IEA
 cellular_componentGO:0001533 cornified envelope IEA
 cellular_componentGO:0005737 cytoplasm IEA


Pathways (from Reactome)
Pathway description
Formation of the cornified envelope


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
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Allelic Composition: Itpr1tm1.1(NCOM)Mfgc/Itpr1tm1.1(NCOM)Mfgc
Genetic Background: C57BL/6N-Itpr1tm1.1(NCOM)Mfgc/Tcp

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Rettm2.1Cos/Ret+
Genetic Background: involves: 129S1/Sv * C57BL/6J * FVB/N

Allelic Composition: Ivltm1Dji/Ivltm1Dji
Genetic Background: either: (involves: 129S4/SvJae * BALB/c) or (involves: 129S4/SvJae * C57BL/6)

 MP:0002727 decreased circulating insulin level "less than normal levels of insulin in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator]
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Allelic Composition: Itpr1tm1.1(NCOM)Mfgc/Itpr1tm1.1(NCOM)Mfgc
Genetic Background: C57BL/6N-Itpr1tm1.1(NCOM)Mfgc/Tcp

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000022218 Tgm1 / transglutaminase 1 / P22735*  / complex / reaction
 ENSMUSG00000034282 Evpl / Q9D952 / Envoplakin / Q92817*  / complex
 ENSMUSG00000039457 Ppl / periplakin / O60437*  / complex






 

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