ENSMUSG00000022218


Mus musculus

Features
Gene ID: ENSMUSG00000022218
  
Biological name :Tgm1
  
Synonyms : Tgm1 / transglutaminase 1
  
Possible biological names infered from orthology : P22735
  
Species: Mus musculus
  
Chr. number: 14
Strand: -1
Band: C3
Gene start: 55700009
Gene end: 55713926
  
Corresponding Affymetrix probe sets: 10420114 (MoGene1.0st)   1451416_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000128090
Ensembl peptide - ENSMUSP00000154744
Ensembl peptide - ENSMUSP00000002389
Ensembl peptide - ENSMUSP00000154784
Ensembl peptide - ENSMUSP00000137642
Ensembl peptide - ENSMUSP00000154239
NCBI entrez gene - 21816     See in Manteia.
MGI - MGI:98730
RefSeq - NM_001161714
RefSeq - NM_001161715
RefSeq - XM_006518808
RefSeq - NM_019984
RefSeq - XM_006518809
RefSeq Peptide - NP_001155186
RefSeq Peptide - NP_001155187
RefSeq Peptide - NP_064368
swissprot - A0A0R4J293
Ensembl - ENSMUSG00000022218
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 tgm1ENSDARG00000017799Danio rerio
 tgm1l1ENSDARG00000102106Danio rerio
 tgm1l2ENSDARG00000101595Danio rerio
 tgm1l3ENSDARG00000005913Danio rerio
 tgm1l4ENSDARG00000101407Danio rerio
 TGM1ENSG00000092295Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
F13a1 / Q8BH61 / Coagulation factor XIII A chain / P00488*ENSMUSG0000003910939
Tgm6 / transglutaminase 6 / O95932*ENSMUSG0000002740332
Tgm5 / Q9D7I9 / Protein-glutamine gamma-glutamyltransferase 5 / O43548* / transglutaminase 5*ENSMUSG0000005367532
Tgm3 / Q08189 / Protein-glutamine gamma-glutamyltransferase E Protein-glutamine gamma-glutamyltransferase E 50 kDa catalytic chain Protein-glutamine gamma-glutamyltransferase E 27 kDa non-ca...ENSMUSG0000002740131
Tgm2 / P21981 / Protein-glutamine gamma-glutamyltransferase 2 / P21980* / transglutaminase 2*ENSMUSG0000003782030
Tgm4 / transglutaminase 4 / P49221*ENSMUSG0000002578728
Tgm7 / protein-glutamine gamma-glutamyltransferase Z / Q96PF1* / transglutaminase 7*ENSMUSG0000007910326
Epb42 / P49222 / Erythrocyte membrane protein band 4.2 / P16452*ENSMUSG0000002321622


Protein motifs (from Interpro)
Interpro ID Name
 IPR001102  Transglutaminase, N-terminal
 IPR002931  Transglutaminase-like
 IPR008958  Transglutaminase, C-terminal
 IPR013783  Immunoglobulin-like fold
 IPR013808  Transglutaminase, active site
 IPR014756  Immunoglobulin E-set
 IPR023608  Protein-glutamine gamma-glutamyltransferase, animal
 IPR036238  Transglutaminase, C-terminal domain superfamily
 IPR036985  Transglutaminase-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0010838 positive regulation of keratinocyte proliferation IEA
 biological_processGO:0018149 peptide cross-linking IEA
 biological_processGO:0030216 keratinocyte differentiation IEA
 biological_processGO:0045787 positive regulation of cell cycle IEA
 cellular_componentGO:0031224 intrinsic component of membrane IEA
 molecular_functionGO:0003810 protein-glutamine gamma-glutamyltransferase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Formation of the cornified envelope


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001190 reddish skin "skin has a more intense ruddy appearance than normal, often due to capillary congestion" [J:65038]
Show

Allelic Composition: Smpd1tm1Wst/Smpd1tm1Wst
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001198 tight skin "skin has a taut, stretched appearance" [J:65038]
Show

Allelic Composition: Smpd1tm1Wst/Smpd1tm1Wst
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001211 wrinkled skin "irregular folds and/or indentations on the skin" [J:19212]
Show

Allelic Composition: Smpd1tm1Wst/Smpd1tm1Wst
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001216 abnormal epidermal layer morphology "anomalous structure or development of the superficial epithelial portion of the skin" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Smpd1tm1Wst/Smpd1tm1Wst
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001242 hyperkeratosis "increased depth of the corneal layer of the epidermis; thickening of the horny layer of the epidermis" [J:1133]
Show

Allelic Composition: Smpd1tm1Wst/Smpd1tm1Wst
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Smpd1tm1Wst/Smpd1tm1Wst
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: Smpd1tm1Wst/Smpd1tm1Wst
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001402 hypoactivity "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]
Show

Allelic Composition: Smpd1tm1Wst/Smpd1tm1Wst
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001429 dehydration "excessive water loss from the body or from an organ or bodily part" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:50053]
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Allelic Composition: Smpd1tm1Wst/Smpd1tm1Wst
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001436 abnormal suckling behavior "reduced ability or inability to exert suction by the mouth, or atypical suckling pattern" [J:16461]
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Allelic Composition: Smpd1tm1Wst/Smpd1tm1Wst
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001438 aphagia "inability to eat " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:30404]
Show

Allelic Composition: Smpd1tm1Wst/Smpd1tm1Wst
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002796 impaired skin barrier function "impaired ability of the skin to regulate water loss; frequently leads to dehydration" [J:56641]
Show

Allelic Composition: Smpd1tm1Wst/Smpd1tm1Wst
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Smpd1tm1Wst/Smpd1tm1Wst
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000049128 Ivl / involucrin / P07476*  / complex / reaction
 ENSMUSG00000034282 Evpl / Q9D952 / Envoplakin / Q92817*  / complex
 ENSMUSG00000039457 Ppl / periplakin / O60437*  / complex






 

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