ENSMUSG00000049281


Mus musculus

Features
Gene ID: ENSMUSG00000049281
  
Biological name :Scn3b
  
Synonyms : Q8BHK2 / Scn3b / sodium channel, voltage-gated, type III, beta
  
Possible biological names infered from orthology : Q9NY72 / sodium voltage-gated channel beta subunit 3
  
Species: Mus musculus
  
Chr. number: 9
Strand: 1
Band: A5.1
Gene start: 40269217
Gene end: 40291618
  
Corresponding Affymetrix probe sets: 10584549 (MoGene1.0st)   1426328_a_at (Mouse Genome 430 2.0 Array)   1435767_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000110606
Ensembl peptide - ENSMUSP00000135470
Ensembl peptide - ENSMUSP00000051627
Ensembl peptide - ENSMUSP00000149616
Ensembl peptide - ENSMUSP00000132933
Ensembl peptide - ENSMUSP00000135096
NCBI entrez gene - 235281     See in Manteia.
MGI - MGI:1918882
RefSeq - NM_001286614
RefSeq - XM_006510234
RefSeq - NM_178227
RefSeq - NM_001083917
RefSeq Peptide - NP_001077386
RefSeq Peptide - NP_001273543
RefSeq Peptide - NP_839941
swissprot - Q8BHK2
swissprot - H3BKP5
swissprot - Q0P666
swissprot - A0A1L1SRT9
swissprot - H3BJR6
Ensembl - ENSMUSG00000049281
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 scn3bENSDARG00000062359Danio rerio
 SCN3BENSGALG00000006490Gallus gallus
 SCN3BENSG00000166257Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Scn1b / P97952 / Sodium channel subunit beta-1 / Q07699* / sodium voltage-gated channel beta subunit 1*ENSMUSG0000001919444


Protein motifs (from Interpro)
Interpro ID Name
 IPR003599  Immunoglobulin subtype
 IPR007110  Immunoglobulin-like domain
 IPR013106  Immunoglobulin V-set domain
 IPR013783  Immunoglobulin-like fold
 IPR027096  Sodium channel subunit beta-3
 IPR027098  Sodium channel subunit beta-1/beta-3
 IPR036179  Immunoglobulin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006814 sodium ion transport IEA
 biological_processGO:0007399 nervous system development IEA
 biological_processGO:0010460 positive regulation of heart rate IMP
 biological_processGO:0010765 positive regulation of sodium ion transport ISO
 biological_processGO:0019233 sensory perception of pain IEA
 biological_processGO:0034765 regulation of ion transmembrane transport IEA
 biological_processGO:0035725 sodium ion transmembrane transport ISO
 biological_processGO:0051899 membrane depolarization ISO
 biological_processGO:0060048 cardiac muscle contraction ISO
 biological_processGO:0060371 regulation of atrial cardiac muscle cell membrane depolarization ISO
 biological_processGO:0060373 regulation of ventricular cardiac muscle cell membrane depolarization ISO
 biological_processGO:0061337 cardiac conduction IMP
 biological_processGO:0065009 regulation of molecular function IEA
 biological_processGO:0072659 protein localization to plasma membrane ISO
 biological_processGO:0086002 cardiac muscle cell action potential involved in contraction ISO
 biological_processGO:0086005 ventricular cardiac muscle cell action potential ISO
 biological_processGO:0086010 membrane depolarization during action potential ISO
 biological_processGO:0086012 membrane depolarization during cardiac muscle cell action potential IEA
 biological_processGO:0086014 atrial cardiac muscle cell action potential ISO
 biological_processGO:0086015 SA node cell action potential IMP
 biological_processGO:0086091 regulation of heart rate by cardiac conduction ISO
 biological_processGO:2000649 regulation of sodium ion transmembrane transporter activity ISO
 cellular_componentGO:0001518 voltage-gated sodium channel complex IEA
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030018 Z disc IDA
 molecular_functionGO:0005244 voltage-gated ion channel activity IEA
 molecular_functionGO:0005272 sodium channel activity IEA
 molecular_functionGO:0017080 sodium channel regulator activity IEA
 molecular_functionGO:0044325 ion channel binding IPI
 molecular_functionGO:0086006 voltage-gated sodium channel activity involved in cardiac muscle cell action potential ISO


Pathways (from Reactome)
Pathway description
Phase 0 - rapid depolarisation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001636 irregular heartbeat "uneven timing of heart contraction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:33038]
Show

Allelic Composition: Osr1tm1Jian/Osr1tm1Jian
Genetic Background: involves: 129S1/Sv

 MP:0003795 abnormal bone structure 
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Allelic Composition: Dixdc1tm1.1(KOMP)Vlcg/Dixdc1tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Dixdc1tm1.1(KOMP)Vlcg/J

 MP:0004215 abnormal myocardial fiber physiology "anomaly in the function of the multinucleated muscle cells of the heart" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Osr1tm1Jian/Osr1tm1Jian
Genetic Background: involves: 129S1/Sv

 MP:0010124 decreased bone mineral content "reduction in the amount (usually in grams/cm) of bone mineral divided by a bone-scanned area" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Dixdc1tm1.1(KOMP)Vlcg/Dixdc1tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Dixdc1tm1.1(KOMP)Vlcg/J

 MP:0010508 abnormal heart electrocardiography waveform feature "any anomaly in the pattern of the graphic record of the integrated action currents of the cardiac cycle represented as changes in voltage; the prominent waves in the ECG correspond to specific conduction activity in areas of the heart and the timing and amplitude of ECG waveforms provide valuable information about heart rate and rhythm" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:20410536]
Show

Allelic Composition: Osr1tm1Jian/Osr1tm1Jian
Genetic Background: involves: 129S1/Sv

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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