ENSMUSG00000049539


Mus musculus

Features
Gene ID: ENSMUSG00000049539
  
Biological name :Hist1h1a
  
Synonyms : Hist1h1a / Histone H1.1 / P43275
  
Possible biological names infered from orthology : histone cluster 1 H1 family member a / Q02539
  
Species: Mus musculus
  
Chr. number: 13
Strand: 1
Band: A3.1
Gene start: 23763666
Gene end: 23764406
  
Corresponding Affymetrix probe sets: 10404069 (MoGene1.0st)   
  
Cross references: Ensembl peptide - ENSMUSP00000062030
NCBI entrez gene - 80838     See in Manteia.
MGI - MGI:1931523
RefSeq - NM_030609
RefSeq Peptide - NP_085112
swissprot - P43275
Ensembl - ENSMUSG00000049539
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 histh1lENSDARG00000035519Danio rerio
 si:ch1073-153i20.4ENSDARG00000105350Danio rerio
 si:ch1073-159d7.7ENSDARG00000074012Danio rerio
 si:ch211-103n10.5ENSDARG00000077504Danio rerio
 si:ch211-113a14.18ENSDARG00000051735Danio rerio
 si:ch211-113a14.24ENSDARG00000051718Danio rerio
 si:ch73-368j24.11ENSDARG00000105430Danio rerio
 si:ch73-368j24.12ENSDARG00000105502Danio rerio
 si:ch73-36p18.1ENSDARG00000115766Danio rerio
 si:dkey-108k21.10ENSDARG00000075508Danio rerio
 si:dkey-108k21.14ENSDARG00000110841Danio rerio
 si:dkey-108k21.21ENSDARG00000091905Danio rerio
 si:dkey-23a13.17ENSDARG00000105328Danio rerio
 si:dkey-23a13.9ENSDARG00000105431Danio rerio
 si:dkey-261m9.12ENSDARG00000032637Danio rerio
 zgc:110216ENSDARG00000077456Danio rerio
 zgc:110425ENSDARG00000058479Danio rerio
 zgc:153405ENSDARG00000096992Danio rerio
 zgc:163061ENSDARG00000076766Danio rerio
 zgc:163061ENSDARG00000075538Danio rerio
 ENSGALG00000011747Gallus gallus
 HIST1H111RENSGALG00000011783Gallus gallus
 P08284ENSGALG00000031874Gallus gallus
 P08285ENSGALG00000037167Gallus gallus
 P08286ENSGALG00000031159Gallus gallus
 Q02539ENSG00000124610Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
P43276 / Hist1h1b / Histone H1.5 / P16401* / histone cluster 1 H1 family member b*ENSMUSG0000005877371
P43277 / Hist1h1d / Histone H1.3 / P16402* / histone cluster 1 H1 family member d*ENSMUSG0000005256570
P43274 / Hist1h1e / Histone H1.4 / P10412* / histone cluster 1 H1 family member e*ENSMUSG0000005162768
P15864 / Hist1h1c / histone cluster 1, H1c / P16403* / histone cluster 1 H1 family member c*ENSMUSG0000003618165
Gm6970 / P16401* / HIST1H1B* / histone cluster 1 H1 family member b*ENSMUSG0000009123056
Hist1h1t / histone cluster 1 H1 family member t / P22492*ENSMUSG0000003621152


Protein motifs (from Interpro)
Interpro ID Name
 IPR005818  Linker histone H1/H5, domain H15
 IPR005819  Histone H5
 IPR036388  Winged helix-like DNA-binding domain superfamily
 IPR036390  Winged helix DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006334 nucleosome assembly IEA
 biological_processGO:0007283 spermatogenesis IGI
 biological_processGO:0048260 positive regulation of receptor-mediated endocytosis IDA
 cellular_componentGO:0000786 nucleosome IEA
 cellular_componentGO:0000790 nuclear chromatin IEA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005694 chromosome IEA
 cellular_componentGO:0005719 nuclear euchromatin IEA
 cellular_componentGO:0009986 cell surface IDA
 cellular_componentGO:0031982 vesicle IDA
 molecular_functionGO:0003677 DNA binding IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008201 heparin binding IDA
 molecular_functionGO:0031490 chromatin DNA binding IEA


Pathways (from Reactome)
Pathway description
Activation of DNA fragmentation factor
Formation of Senescence-Associated Heterochromatin Foci (SAHF)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000242 impaired fertilization "defect or reduced ability in the process beginning with penetration of the secondary oocyte by the spermatozoon and completed by fusion of the male and female pronucei" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Acrtm1Wen/Acrtm1Wen,Hist1h1atm1Drab/Hist1h1atm1Drab,Smcptm1Wen/Smcptm1Wen
Genetic Background: involves: 129/Sv * C57BL/6J * CD-1

 MP:0001922 reduced male fertility "reduced ability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61340]
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Allelic Composition: Hist1h1ttm1Drab/Hist1h1ttm1Drab
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Hist1h1atm1Drab/Hist1h1a+,Smcptm1Wen/Smcptm1Wen,Tnp2tm1Wen/Tnp2tm1Wen
Genetic Background: involves: 129 * C57BL/6J

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Acrtm1Wen/Acrtm1Wen,Smcptm1Wen/Smcptm1Wen,Tnp2tm1Wen/Tnp2tm1Wen
Genetic Background: involves: 129/Sv * C57BL/6J * CD-1

Allelic Composition: Hist1h1atm1Drab/Hist1h1atm1Drab,Smcptm1Wen/Smcptm1Wen,Tnp2tm1Wen/Tnp2+
Genetic Background: involves: 129 * C57BL/6J

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Col6a1tm1Gmb/Col6a1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Acrtm1Wen/Acrtm1Wen,Hist1h1atm1Drab/Hist1h1atm1Drab,Tnp2tm1Wen/Tnp2tm1Wen
Genetic Background: involves: 129 * C57BL/6J * CD-1

 MP:0002675 asthenozoospermia "loss or reduction of the mobility of the spermatozoa, frequently associated with infertility" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Hist1h1ttm1Drab/Hist1h1ttm1Drab
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Hist1h1atm1Drab/Hist1h1atm1Drab,Smcptm1Wen/Smcptm1Wen,Tnp2tm1Wen/Tnp2tm1Wen
Genetic Background: involves: 129 * C57BL/6J

 MP:0004542 impaired acrosome reaction "abnormality in the cellular exocytosis that allows sperm to penetrate the zona pellucida of ovulated eggs" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hist1h1atm1Drab/Hist1h1atm1Drab,Smcptm1Wen/Smcptm1Wen,Tnp2tm1Wen/Tnp2tm1Wen
Genetic Background: involves: 129 * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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