ENSMUSG00000049608


Mus musculus

Features
Gene ID: ENSMUSG00000049608
  
Biological name :Gpr55
  
Synonyms : Gpr55 / G-protein coupled receptor 55 / Q3UJF0
  
Possible biological names infered from orthology : Q9Y2T6
  
Species: Mus musculus
  
Chr. number: 1
Strand: -1
Band: C5
Gene start: 85938318
Gene end: 85961007
  
Corresponding Affymetrix probe sets: 10356299 (MoGene1.0st)   
  
Cross references: Ensembl peptide - ENSMUSP00000084196
NCBI entrez gene - 227326     See in Manteia.
MGI - MGI:2685064
RefSeq - XM_017320337
RefSeq - NM_001033290
RefSeq - XM_006529463
RefSeq Peptide - NP_001028462
swissprot - Q3UJF0
Ensembl - ENSMUSG00000049608
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 gpr55aENSDARG00000043447Danio rerio
 GPR55ENSGALG00000005544Gallus gallus
 GPR55ENSG00000135898Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Gpr35 / Q9ES90 / G protein-coupled receptor 35 / Q9HC97*ENSMUSG0000002627125
Gpr18 / Q8K1Z6 / N-arachidonyl glycine receptor / Q14330* / G protein-coupled receptor 18*ENSMUSG0000005035024
Gpr20 / Q8BYC4 / G-protein coupled receptor 20 / Q99678*ENSMUSG0000004528122


Protein motifs (from Interpro)
Interpro ID Name
 IPR000276  G protein-coupled receptor, rhodopsin-like
 IPR017452  GPCR, rhodopsin-like, 7TM
 IPR028334  G protein-coupled receptor 55 orphan


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IEA
 biological_processGO:0007202 activation of phospholipase C activity IEA
 biological_processGO:0035025 positive regulation of Rho protein signal transduction IEA
 biological_processGO:0038171 cannabinoid signaling pathway IEA
 biological_processGO:0045453 bone resorption IEA
 biological_processGO:0045671 negative regulation of osteoclast differentiation IEA
 biological_processGO:0051482 positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway IBA
 biological_processGO:0070374 positive regulation of ERK1 and ERK2 cascade IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005887 integral component of plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity IEA
 molecular_functionGO:0004949 cannabinoid receptor activity IEA


Pathways (from Reactome)
Pathway description
Class A/1 (Rhodopsin-like receptors)
G alpha (i) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000130 abnormal cancellous bone morphology "structural anomaly of bone that has a latticelike or spongy structure" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Ern1tm1Tiw/Ern1tm1Tiw
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0001541 abnormal osteoclast function "reduced ability or inability of osteoclasts to absorb and remove osseous tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58795]
Show

Allelic Composition: Ern1tm1Tiw/Ern1tm1Tiw
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Nr3c1tm1Gsc/Nr3c1tm1Gsc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004982 abnormal osteoclast morphology "any structural anomaly of the bone resorpting cells that remove bone tissue by degrading the mineralized matrix" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ern1tm1Tiw/Ern1tm1Tiw
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0004984 increased osteoclast cell number "greater than average number of the bone resorpting cells that remove bone tissue by degrading the mineralized matrix" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ern1tm1Tiw/Ern1tm1Tiw
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0004985 decreased osteoclast cell number "reduced number of the bone resorpting cells that remove bone tissue by degrading the mineralized matrix" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ern1tm1Tiw/Ern1tm1Tiw
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0008396 abnormal osteoclast differentiation "atypical production of or inability to produce bone resorpting cells that remove bone tissue by degrading the mineralized matrix" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ern1tm1Tiw/Ern1tm1Tiw
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0008872 abnormal response to xenobiotics "any anomaly in the physiological or morphological changes induced by a foreign compound, such as changes in blood pressure, changes in hormone or protein levels or hypertrophy or hypotrophy of an organ" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ern1tm1Tiw/Ern1tm1Tiw
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0010875 increased bone volume "increased amount of space occupied by bone tissue in the skeleton" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ern1tm1Tiw/Ern1tm1Tiw
Genetic Background: involves: 129S4/SvJae * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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