ENSMUSG00000050350


Mus musculus

Features
Gene ID: ENSMUSG00000050350
  
Biological name :Gpr18
  
Synonyms : Gpr18 / N-arachidonyl glycine receptor / Q8K1Z6
  
Possible biological names infered from orthology : G protein-coupled receptor 18 / Q14330
  
Species: Mus musculus
  
Chr. number: 14
Strand: -1
Band: E5
Gene start: 121911253
Gene end: 121915781
  
Corresponding Affymetrix probe sets: 10422493 (MoGene1.0st)   1439141_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000061410
NCBI entrez gene - 110168     See in Manteia.
MGI - MGI:107859
RefSeq - NM_182806
RefSeq Peptide - NP_877958
swissprot - Q8K1Z6
Ensembl - ENSMUSG00000050350
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 gpr18ENSDARG00000062009Danio rerio
 GPR18ENSGALG00000022750Gallus gallus
 GPR18ENSG00000125245Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Gpr55 / Q3UJF0 / G-protein coupled receptor 55 / Q9Y2T6*ENSMUSG0000004960824
Gpr20 / Q8BYC4 / G-protein coupled receptor 20 / Q99678*ENSMUSG0000004528122
Gpr35 / Q9ES90 / G protein-coupled receptor 35 / Q9HC97*ENSMUSG0000002627119


Protein motifs (from Interpro)
Interpro ID Name
 IPR000276  G protein-coupled receptor, rhodopsin-like
 IPR017452  GPCR, rhodopsin-like, 7TM
 IPR028335  G protein-coupled receptor 18 orphan


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002300 CD8-positive, alpha-beta intraepithelial T cell differentiation IMP
 biological_processGO:0002305 CD8-positive, gamma-delta intraepithelial T cell differentiation IMP
 biological_processGO:0002689 negative regulation of leukocyte chemotaxis IMP
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IEA
 biological_processGO:0032720 negative regulation of tumor necrosis factor production IMP
 biological_processGO:0035025 positive regulation of Rho protein signal transduction IBA
 biological_processGO:0051482 positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway IBA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005887 integral component of plasma membrane IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030659 cytoplasmic vesicle membrane IEA
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity IBA


Pathways (from Reactome)
Pathway description
Class A/1 (Rhodopsin-like receptors)
G alpha (i) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002412 increased susceptibility to bacterial infection "greater likelihood that an organism will develop ill effects from a bacterial infection or from components of or toxins produced by bacteria" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ednrbtm1Nrd/Ednrbtm1Nrd,Gt(ROSA)26Sortm14(CAG-tdTomato)Hze/Gt(ROSA)26Sor+,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6 * CBA/J

 MP:0005165 increased susceptibility to injury "greater than the normal reaction to trauma, especially that by physical means" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ednrbtm1Nrd/Ednrbtm1Nrd,Gt(ROSA)26Sortm14(CAG-tdTomato)Hze/Gt(ROSA)26Sor+,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6 * CBA/J

 MP:0008079 decreased CD8-positive T cell number "reduction in the number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Sh3pxd2aGt(OST445753)Lex/Sh3pxd2aGt(OST445753)Lex
Genetic Background: B6J.129S5-Sh3pxd2aGt(OST445753)Lex

 MP:0008363 decreased CD8-positive, gamma-delta intraepithelial T cell number "reduced number of a CD8-positive, gamma-delta T cell of the columnar epithelia such as in the gastrointestinal tract; intraepithelial T cells often have distinct developmental pathways and activation requirements" [CL:0000803, ISBN:0781735149]
Show

Allelic Composition: Sh3pxd2aGt(OST445753)Lex/Sh3pxd2aGt(OST445753)Lex
Genetic Background: B6J.129S5-Sh3pxd2aGt(OST445753)Lex

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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