ENSMUSG00000050069


Mus musculus

Features
Gene ID: ENSMUSG00000050069
  
Biological name :Grem2
  
Synonyms : Grem2 / Gremlin-2 / O88273
  
Possible biological names infered from orthology : gremlin 2, DAN family BMP antagonist / Q9H772
  
Species: Mus musculus
  
Chr. number: 1
Strand: -1
Band: H3
Gene start: 174833785
Gene end: 174921819
  
Corresponding Affymetrix probe sets: 10360415 (MoGene1.0st)   1418492_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000049640
NCBI entrez gene - 23893     See in Manteia.
MGI - MGI:1344367
RefSeq - XM_017320448
RefSeq - NM_011825
RefSeq - XM_006496826
RefSeq Peptide - NP_035955
swissprot - Q3TST1
swissprot - O88273
Ensembl - ENSMUSG00000050069
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 grem2aENSDARG00000056057Danio rerio
 grem2bENSDARG00000103092Danio rerio
 GREM2ENSGALG00000010773Gallus gallus
 GREM2ENSG00000180875Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Grem1 / O70326 / Gremlin-1 / O60565* / gremlin 1, DAN family BMP antagonist*ENSMUSG0000007493456
Nbl1 / Q61477 / Neuroblastoma suppressor of tumorigenicity 1 / P41271* / neuroblastoma 1, DAN family BMP antagonist*ENSMUSG0000004112025


Protein motifs (from Interpro)
Interpro ID Name
 IPR004133  DAN
 IPR006207  Cystine knot, C-terminal
 IPR017159  Gremlin-1/2
 IPR029034  Cystine-knot cytokine


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0010172 embryonic body morphogenesis IMP
 biological_processGO:0019221 cytokine-mediated signaling pathway IMP
 biological_processGO:0030514 negative regulation of BMP signaling pathway IMP
 biological_processGO:0038098 sequestering of BMP from receptor via BMP binding IMP
 biological_processGO:0048263 determination of dorsal identity IMP
 biological_processGO:0060300 regulation of cytokine activity IMP
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IMP
 molecular_functionGO:0005125 cytokine activity IEA
 molecular_functionGO:0008201 heparin binding IEA
 molecular_functionGO:0036122 BMP binding IMP
 molecular_functionGO:0042802 identical protein binding IPI
 molecular_functionGO:0042803 protein homodimerization activity IMP


Pathways (from Reactome)
Pathway description
Signaling by BMP


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000062 increased bone density "increased mineral content of bone; indicator of bone strength" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61295]
Show

Allelic Composition: Ddhd1tm1b(KOMP)Katn/Ddhd1tm1b(KOMP)Katn
Genetic Background: involves: C57BL/6J * C57BL/6NCrlj * CBA/JNCrlj

 MP:0000126 brittle teeth "fragile and likely to break teeth" [J:61509]
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Allelic Composition: Ddhd1tm1b(KOMP)Katn/Ddhd1tm1b(KOMP)Katn
Genetic Background: involves: C57BL/6J * C57BL/6NCrlj * CBA/JNCrlj

 MP:0002577 reduced enamel thickness "thin hard coating of the exposed portion of the tooth" [J:71126, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ddhd1tm1b(KOMP)Katn/Ddhd1tm1b(KOMP)Katn
Genetic Background: involves: C57BL/6J * C57BL/6NCrlj * CBA/JNCrlj

 MP:0002818 abnormal dentin morphology "defects in the hard portion of the tooth surrounding the pulp, covered by enamel on the crown and cementum on the root" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Ddhd1tm1b(KOMP)Katn/Ddhd1tm1b(KOMP)Katn
Genetic Background: involves: C57BL/6J * C57BL/6NCrlj * CBA/JNCrlj

 MP:0004592 small mandible "reduced size of the lower bony framework of the mouth where the inferior teeth are held" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Ddhd1tm1b(KOMP)Katn/Ddhd1tm1b(KOMP)Katn
Genetic Background: involves: C57BL/6J * C57BL/6NCrlj * CBA/JNCrlj

 MP:0005358 abnormal incisor morphology "structural defect of the long pointed teeth; most anterior and prominent in the jaw" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:85574]
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Allelic Composition: Ddhd1tm1b(KOMP)Katn/Ddhd1tm1b(KOMP)Katn
Genetic Background: involves: C57BL/6J * C57BL/6NCrlj * CBA/JNCrlj

 MP:0030080 small lower incisors "reduced size of the lower set of long teeth that are the most anterior and prominent in the jaw" [MGI:anna]
Show

Allelic Composition: Ddhd1tm1b(KOMP)Katn/Ddhd1tm1b(KOMP)Katn
Genetic Background: involves: C57BL/6J * C57BL/6NCrlj * CBA/JNCrlj

 MP:0030081 small upper incisors "reduced size of the upper set of long teeth that are the most anterior and prominent in the jaw" [MGI:anna]
Show

Allelic Composition: Ddhd1tm1b(KOMP)Katn/Ddhd1tm1b(KOMP)Katn
Genetic Background: involves: C57BL/6J * C57BL/6NCrlj * CBA/JNCrlj

 MP:0030457 abnormal molar cusp morphology "any structural anomaly of an elevation or mound on the crown of a molar tooth making up a part of the occlusal (masticatory) surface" [https://medical-dictionary.thefreedictionary.com/cusp+of+tooth, MGI:anna]
Show

Allelic Composition: Ddhd1tm1b(KOMP)Katn/Ddhd1tm1b(KOMP)Katn
Genetic Background: involves: C57BL/6J * C57BL/6NCrlj * CBA/JNCrlj

 MP:0030458 abnormal tooth wear "change in the progression or severity of loss of tooth substance, usually resulting from abrasion, attrition and erosion acting singly or concurrently; tooth wear is a normal, age-dependent physiological process that leads to surface loss of dental hard tissues" [https://www.igi-global.com/dictionary/tooth-wear/45534, https://www.slideshare.net/aneeqa_yaqub/tooth-wear-and-its-types, PMID:22240686]
Show

Allelic Composition: Ddhd1tm1b(KOMP)Katn/Ddhd1tm1b(KOMP)Katn
Genetic Background: involves: C57BL/6J * C57BL/6NCrlj * CBA/JNCrlj

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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