ENSMUSG00000050445


Mus musculus

Features
Gene ID: ENSMUSG00000050445
  
Biological name :Cyp8b1
  
Synonyms : Cyp8b1 / cytochrome P450 family 8 subfamily B member 1
  
Possible biological names infered from orthology : Q9UNU6
  
Species: Mus musculus
  
Chr. number: 9
Strand: -1
Band: F4
Gene start: 121914356
Gene end: 121916305
  
Corresponding Affymetrix probe sets: 10597875 (MoGene1.0st)   1449309_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000052989
NCBI entrez gene - 13124     See in Manteia.
MGI - MGI:1338044
RefSeq - NM_010012
RefSeq Peptide - NP_034142
swissprot - A0A0R4J0N7
Ensembl - ENSMUSG00000050445
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cyp8b1ENSDARG00000053068Danio rerio
 cyp8b2ENSDARG00000097556Danio rerio
 cyp8b3ENSDARG00000097559Danio rerio
 CYP8B1ENSGALG00000033511Gallus gallus
 CYP8B1ENSG00000180432Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ptgis / O35074 / prostaglandin I2 (prostacyclin) synthase / Q16647* / prostaglandin I2 synthase*ENSMUSG0000001796940
Cyp7a1 / Q64505 / Cholesterol 7-alpha-monooxygenase / P22680* / cytochrome P450 family 7 subfamily A member 1*ENSMUSG0000002824033
Cyp7b1 / Q60991 / 25-hydroxycholesterol 7-alpha-hydroxylase / O75881* / cytochrome P450 family 7 subfamily B member 1*ENSMUSG0000003951931
Q9JKJ9 / Cyp39a1 / 24-hydroxycholesterol 7-alpha-hydroxylase / Q9NYL5* / cytochrome P450 family 39 subfamily A member 1*ENSMUSG0000002396322


Protein motifs (from Interpro)
Interpro ID Name
 IPR001128  Cytochrome P450
 IPR002403  Cytochrome P450, E-class, group IV
 IPR024204  Cytochrome P450, cholesterol 7-alpha-monooxygenase-type
 IPR030686  Cytochrome P450 8B1
 IPR036396  Cytochrome P450 superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0055114 oxidation-reduction process IEA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005789 endoplasmic reticulum membrane IEA
 cellular_componentGO:0016020 membrane IEA
 molecular_functionGO:0004497 monooxygenase activity IEA
 molecular_functionGO:0005506 iron ion binding IEA
 molecular_functionGO:0008397 sterol 12-alpha-hydroxylase activity IEA
 molecular_functionGO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA
 molecular_functionGO:0020037 heme binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
Synthesis of bile acids and bile salts via 24-hydroxycholesterol
Synthesis of bile acids and bile salts via 27-hydroxycholesterol
Nicotinamide salvaging
Eicosanoids
Sterols are 12-hydroxylated by CYP8B1
Synthesis of Prostaglandins (PG) and Thromboxanes (TX)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000609 abnormal liver physiology "aberrant function of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Gria2tm1Rlh/Gria2tm1Rlh
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002118 abnormal lipid homeostasis "anomaly in the state of equilibrium in the body with respect to lipids in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gria2tm1Rlh/Gria2tm1Rlh
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002647 decreased cholesterol absorption "reduced ability of the body to take in these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Gria2tm1Rlh/Gria2tm1Rlh
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002791 steatorrhea "passage of large amounts of fat in the feces due to the inability to digest and absorb it" [J:75167]
Show

Allelic Composition: Gria2tm1Rlh/Gria2tm1Rlh
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0004772 abnormal bile secretion "any anomaly in the quantity or rate of bile secreted through the bile ducts in a given length of time" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gria2tm1Rlh/Gria2tm1Rlh
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0004774 abnormal bile salt level "anomalous concentration of the steroid salts derived from cholesterol in the liver, produced as bile acids and secreted in the biliary sytem as bile salts; these play an important role in the digestion and absorption of fats" [MESH:D04.808.105, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gria2tm1Rlh/Gria2tm1Rlh
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0005179 decreased total circulating cholesterol level "less than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Gria2tm1Rlh/Gria2tm1Rlh
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0005365 abnormal bile salt homeostasis "anomalous regulation of the steroid salts derived from cholesterol in the liver and which play an important role in the digestion and absorption of fats" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:86154]
Show

Allelic Composition: Gria2tm1Rlh/Gria2tm1Rlh
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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